Kant claims that “empirical psychology must always remain outside the rank of a natural science properly so called.” What led him to this conclusion? Kant first points out that if we take nature to be the totality of things insofar as they can be objects of our senses, then the doctrine of nature will contain two parts corresponding to the two forms of our sensibility: a doctrine of body and a doctrine of mind. But an “historical doctrine of nature comprising (...) nothing but systematically ordered facts” must be distinguished from natural science properly so called. For “only that can properly be called science whose certainty is apodictic; cognitions which can only have empirical certainty are only improperly called science”. Since the chemistry of his day consisted of “mere laws of experience,” Kant held that it was not really a science; the explanations it gives in terms of such laws leave us “unsatisfied because no a priori grounds can be given for these accidental laws which mere experience has taught”. There can be no proper natural science, so Kant argues, without “a pure part on which the apodictic certainty, which reason seeks in it, can be based”. This metaphysical foundation of science is transcendental insofar as it is concerned with the concept of nature in general. If we specify it further by introducing the empirical concept of body, or of mind, the a priori cognitions which can then be established will constitute a pure part of physics, or of psychology, “in which transcendental principles are applied to the two types of objects of our senses”. (shrink)

How can reasons explain actions? What is the force of "because" in "He did this because..." followed by a statement of the agent's intentions? The answer involves some concept of what can count as explanation, and the history of science indicates that the acceptability of explanations depends, in part, on a scientific community which has decided to pursue its inquiries in one direction rather than another. The first part of this paper examines this pragmatic aspect of explanations; the second part (...) draws on this examination in the hope of elucidating the way reasons explain actions. The possibility of eliminating our ordinary, "purposive," explanations of actions in favor of some "mechanistic," neuro-physiological, account is then considered. (shrink)

Mutations in growth factor receptor signaling pathways are common in cancer cells, including the highly lethal brain tumor glioblastoma (GBM) where they drive tumor growth through mechanisms including altering the uptake and utilization of nutrients. However, the impact of changes in micro‐environmental nutrient levels on oncogenic signaling, tumor growth, and drug resistance is not well understood. We recently tested the hypothesis that external nutrients promote GBM growth and treatment resistance by maintaining the activity of mechanistic target of rapamycin complex 2 (...) (mTORC2), a critical intermediate of growth factor receptor signaling, suggesting that altered cellular metabolism is not only a consequence of oncogenic signaling, but also potentially an important determinant of its activity. Here, we describe the studies that corroborate the hypothesis and propose others that derive from them. Notably, this line of reasoning raises the possibility that systemic metabolism may contribute to responsiveness to targeted cancer therapies. (shrink)

The 2014 Tanner Symposium features a panel of speakers discussing current research in the areas of volition and self-control and the effects of that research for issues of public policy.