Pharmaceutical firms seek to fulfill their responsibilities to stakeholders by developing drugs that treat diseases. We evaluate the social and financial costs of developing new drugs relative to the realized benefits and find the industry falls short of its potential. This is primarily due to legislation-mandated reliance on animal test results in early stages of the drug development process, leading to a mere 10 percent success rate for new drugs entering human clinical trials. We cite hundreds of biomedical studies from (...) journals including Nature, Science, and the Journal of the American Medical Association to show animal modeling is ineffective, misleading to scientists, unable to prevent the development of dangerous drugs, and prone to prevent the development of useful drugs. Legislation still requires animal testing prior to human testing even though the pharmaceutical sector has better options that were unavailable when animal modeling was first mandated. We propose that the U.S. Food and Drug Administration and Congress should work together to abolish regulations and policies that require animal use. Doing so will benefit pharmaceutical industry stakeholders, including patients whose health depends on drugs and the many people who rely on the financial well-being of pharmaceutical firms. (shrink)

_Interpreting Music_ is a comprehensive essay on understanding musical meaning and performing music meaningfully—“interpreting music” in both senses of the term. Synthesizing and advancing two decades of highly influential work, Lawrence Kramer fundamentally rethinks the concepts of work, score, performance, performativity, interpretation, and meaning—even the very concept of music—while breaking down conventional wisdom and received ideas. Kramer argues that music, far from being closed to interpretation, is ideally open to it, and that musical interpretation is the paradigm of interpretation in (...) general. The book illustrates the many dimensions of interpreting music through a series of case studies drawn from the classical repertoire, but its methods and principles carry over to other repertoires just as they carry beyond music by working _through_ music to wider philosophical and cultural questions. (shrink)

§1. Introduction. Asymptotic cones of metric spaces were first invented by Gromov. They are metric spaces which capture the ‘large-scale structure’ of the underlying metric space. Later, van den Dries and Wilkie gave a more general construction of asymptotic cones using ultrapowers. Certain facts about asymptotic cones, like the completeness of the metric space, now follow rather easily from saturation properties of ultrapowers, and in this survey, we want to present two applications of the van den Dries-Wilkie approach. Using ultrapowers (...) we obtain an explicit description of the asymptotic cone of a semisimple Lie group. From this description, using semi-algebraic groups and non-standard methods, we can give a short proof of the Margulis Conjecture. In a second application, we use set theory to answer a question of Gromov.§2. Definitions. The intuitive idea behind Gromov's concept of an asymptotic cone was to look at a given metric space from an ‘infinite distance’, so that large-scale patterns should become visible. In his original definition this was done by gradually scaling down the metric by factors 1/nfornϵ ℕ. In the approach by van den Dries and Wilkie, this idea was captured by ultrapowers. Their construction is more general in the sense that the asymptotic cone exists for any metric space, whereas in Gromov's original definition, the asymptotic cone existed only for a rather restricted class of spaces. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Historical Narratives and the Meaning of NationalismLloyd KramerThe vast, expanding literature on nationalism may well defy every generalization except a familiar, general theme of intellectual history: texts about nationalism have always drawn their perspectives and passions from the evolving political and cultural contexts in which their authors have lived. Modern accounts of nationalism show the unmistakable traces of political, military, and cultural conflicts in every decade of the twentieth (...) century—from the era of nationalist rivalries before World War I to the redefinitions of gender, literature, and history that have emerged in contemporary postmodernism, postcolonialism, and multiculturalism.This connection between the texts of nationalist scholarship and the modern contexts of politics and culture suggests why historical narratives of nationalism have become part of the history of nationalism itself. Nationalism’s scholarly interpreters cannot easily separate themselves from the objects of their analysis, and their interpretations are often as diverse and fragmented as the nations they describe. This essay enters the debate on nationalism, describes recurring themes in the historical literature, and replicates a key characteristic of the historiography by stressing that the complexity of nationalism and its interpreters resists every simplifying, comprehensive definition. Histories of nationalism provide a striking example of how the history of ideas never reaches a point of uncontested closure and never finally escapes the political and cultural contexts in which all historical narratives are produced.Like most analysts of nationalism, I assume that it is one of the decisive forces in modern history and that its significance demands careful, critical analysis. It also calls for always incomplete definitions, one of which can be drawn from the German historian Peter Alter. Nationalism is “both an ideology and a political movement which holds the nation and sovereign nation-state to be crucial indwelling values, and which manages to mobilize the political will of [End Page 525] a people or a large section of the population.”1 Nationalist ideas are thus a distinctive form of modern thought that shapes the political actions and cultural identities of individuals as well as groups. The meanings of nationalism and national identity typically depend on various dichotomies that define the nation in terms of its differences from other places or people—the dynamic process of identity formation that has received wide attention in contemporary cultural studies. My own view of the “oppositional” structures in nationalist thinking coincides with the concise description by Peter Sahlins: “National Identity is a socially constructed and continuous process of defining ‘friend’ and ‘enemy’.... National identities... do not depend on the existence of any objective linguistic or cultural differentiation but on the subjective experience of difference.”2 Sahlins thus assumes that something called national identity is “there,” but he also insists that national consciousness is a “constructed” identity. Nationalism, in short, does not express or reflect a natural, primordial reality.The assumption that nationalisms are historical rather than natural phenomena shapes most of the scholarly literature, so that the study of nationalism leads to historical analysis rather than to biology or physical geography. Although there have been countless historical studies of nationalism in different periods, cultures, and conflicts,3 my discussion will refer to a small number of narratives that have made especially significant theoretical claims about the nature of nationalism. There is of course no way to analyze such theories without exclusions and generalizations, which I shall provide by focusing mostly on works about Europe and dividing the patterns of historical analysis into the following broad categories: (1) the description of nationalism as a central component of modernization, reflecting and also shaping intellectual, cultural, economic, social, and political transitions from premodern to modern history; (2) the claim that nationalisms are modern religious movements, related to but also displacing earlier religions; (3) the argument that nationalism is a linguistic, literary construction that depends on new forms of communication, intellectuals, and narratives; (4) the description of nationalism as a discourse of gender and ethnicity that shapes individual identities and also expresses anxieties about sexuality, culture, and respectability; and (5) the argument that nationalisms can be divided into categories (good/bad, Western/Eastern, [End Page 526] political/cultural) and phases that represent sharp differences in the development of modern... (shrink)

Visual culture has normalized systemic and institutional cruelty toward animals in North America through an iconography of oppression. Certain kinds of images that sanitize and celebrate the consumption of animal bodies through our contemporary food systems are constantly repeated through marketing channels. In doing so, they help us to avoid addressing the very ethical questions at the heart of these practices. In contrast to this, a number of contemporary artists have relied on visual culture to disrupt this pattern of representation (...) and to challenge the status quo. The following discussion explores some recent attempts to reimagine human–animal relationships in nonspeciesist terms through imagery and artistic practice. (shrink)

The volume comprises 24 chapters by leading historians who discuss conceptions of and approaches to the human past in the ancient, medieval, early modern and ...

Expression and truth are traditional opposites in Western thought: expression supposedly refers to states of mind, truth to states of affairs. _Expression and Truth_ rejects this opposition and proposes fluid new models of expression, truth, and knowledge with broad application to the humanities. These models derive from five theses that connect expression to description, cognition, the presence and absence of speech, and the conjunction of address and reply. The theses are linked by a concentration on musical expression, regarded as the (...) ideal case of expression in general, and by fresh readings of Ludwig Wittgenstein’s scattered but important remarks about music. The result is a new conception of expression as a primary means of knowing, acting on, and forming the world. “Recent years have seen the return of the claim that music’s power resides in its ineffability. In _Expression and Truth_, Lawrence Kramer presents his most elaborate response to this claim. Drawing on philosophers such as Wittgenstein and on close analyses of nineteenth-century compositions, Kramer demonstrates how music operates as a medium for articulating cultural meanings and that music matters too profoundly to be cordoned off from the kinds of critical readings typically brought to the other arts. A tour-de-force by one of musicology’s most influential thinkers.”—Susan McClary, _Desire and Pleasure in Seventeenth-Century Music_. (shrink)

From the winds of Mars to a baby's first laugh, a prolific philosopher-composer reflects on the profound imperative of sound in everyday life. Experiencing Sound presents its subject, the one sense we can never stop using, as fundamental to all experience-sensation, perception, and understanding. Lawrence Kramer turns on its head the widespread notion that vision takes pride of place among the senses and demonstrates how paying attention to sound can transform how we make meaning out of experience. Through a series (...) of brief, lyrical forays, Experiencing Sound shows that sound is the object of a primary need and an essential component in the sensation of being alive and the perception of time. It is something that we may suffer-or be made to suffer-as well as enjoy. Like its predecessor, The Hum of the World, this book ranges widely across music, philosophy, literature, art, media, and history, from classical antiquity to the present, as it invites us to experience sound anew. (shrink)

Lecture 1. What is intellectual history? -- Lecture 2. The scientific origins of the Enlightenment -- Lecture 3. The emergence of the modern intellectual -- Lecture 4. The cultural meaning of the French Revolution -- Lecture 5. The new conservatism in post-revolutionary Europe -- Lecture 6. The new German philosophy -- Lecture 7. Hegel's philosophical conception of history -- Lecture 8. The new liberalism -- Lecture 9. The literary culture of Romanticism -- Lecture 10. The meaning of the romantic hero (...) -- Lecture 11. The Industrial Revolution and classical economics -- Lecture 12. Early critiques of industrial capitalism -- Lecture 13. Hegelianism and the young Marx -- Lecture 14. Marx's social critique -- Lecture 15. Feminism in the 19th century culture -- Lecture 16. Women's rights in a man's world -- Lecture 17. Tocqueville & Mill, rethinking liberal theory -- Lecture 18. Nationalisms and national identities -- Lecture 19. The novel as art and social criticism -- Lecture 20. Science and its literary critics -- Lecture 21. Charles Darwin and the new biology -- Lecture 22. Controversies of social Darwinism -- Lecture 23. The heroic critic in mass society -- Lecture 24. Nietzsche's critique of European culture. (shrink)

§1. Introduction. Asymptotic cones of metric spaces were first invented by Gromov. They are metric spaces which capture the ‘large-scale structure’ of the underlying metric space. Later, van den Dries and Wilkie gave a more general construction of asymptotic cones using ultrapowers. Certain facts about asymptotic cones, like the completeness of the metric space, now follow rather easily from saturation properties of ultrapowers, and in this survey, we want to present two applications of the van den Dries-Wilkie approach. Using ultrapowers (...) we obtain an explicit description of the asymptotic cone of a semisimple Lie group. From this description, using semi-algebraic groups and non-standard methods, we can give a short proof of the Margulis Conjecture. In a second application, we use set theory to answer a question of Gromov.§2. Definitions. The intuitive idea behind Gromov's concept of an asymptotic cone was to look at a given metric space from an ‘infinite distance’, so that large-scale patterns should become visible. In his original definition this was done by gradually scaling down the metric by factors 1/nfornϵ ℕ. In the approach by van den Dries and Wilkie, this idea was captured by ultrapowers. Their construction is more general in the sense that the asymptotic cone exists for any metric space, whereas in Gromov's original definition, the asymptotic cone existed only for a rather restricted class of spaces. (shrink)

Inventors in the age of the Enlightenment created lifelike androids capable of playing music on real instruments. _Music and the Forms of Life_ examines the link between such simulated life and music, which began in the era's scientific literature and extended into a series of famous musical works by Haydn, Mozart, and Beethoven. Music invented auditory metaphors for the scientific elements of life (drive, pulse, sensibility, irritability, even metabolism), investigated the affinities and antagonisms between life and mechanism, and explored questions (...) of whether and how mechanisms can come to life. The resulting changes in the conceptions of both life and music had wide cultural resonance at the time, and those concepts continued to evolve long after. A critical part of that evolution was a nineteenth-century shift in focus from moving androids to the projection of life in motion, culminating in the invention of cinema. Weaving together cultural and musical practices, Lawrence Kramer traces these developments through a collection of case studies ranging from classical symphonies to modernist projections of waltzing specters by Mahler and Ravel to a novel linking Bach's _Goldberg Variations_ to the genetic code. The publisher gratefully acknowledges the generous support of the AMS 75 PAYS Fund of the American Musicological Society, supported in part by the National Endowment for the Humanities and the Andrew W. Mellon Foundation. (shrink)

_The Hum of the World_ is an invitation to contemplate what would happen if we heard the world as attentively as we see it. Balancing big ideas with playful wit and lyrical prose, this imaginative volume identifies the role of sound in Western experience as the primary medium in which the presence and persistence of life acquire tangible form. The positive experience of aliveness is not merely in accord with sound, but inaccessible, even inconceivable, without it. Lawrence Kramer’s poetic book (...) roves freely over music, media, language, philosophy, and science from the ancient world to the present, along the way revealing how life is apprehended through sounds ranging from pandemonium to the faint background hum of the world. Easily moving from reflections on pivotal texts and music to the introduction of elemental concepts, this warm meditation on auditory culture uncovers the knowledge and pleasure made available when we recognize that the world is alive with sound. (shrink)

Very few nineteenth-century works are unintelligible in terms of a dual structure. Consider a Chopin Ballade or Etude as an example. Such pieces, with their continuous chromatic mutation and rhapsodic form, make little sense in classical terms. Yet once one grasps that the process of chromatic alteration is their norm, not a mode of deviation, they become perfectly and immediately intelligible. Their autonomy is in no way compromised, nor do the pieces require extrinsic support from language; any competent listener will (...) recognize that their structural tensions derive from the contrast between a continual attack on the stability of their tonal centers and the continual resilience of those centers as sources of structure. Chopin, like Schumann after him, may go so far as to treat the major and minor modes of one key as interchangeable; but even that only emphasizes the simultaneity of tonal stability and tonal instability which informs their works and clarifies their structures. Similarly, one can find in Brahms a deliberate return to the "premise structure" of classical music, as filtered through Beethoven; and Brahms' music clearly attempts to mediate between this structure and the normative instability of nineteenth-century harmony. Subotnik, however, is pressed by her thesis to deny the autonomy and dual structure of Brahms' music. So she says of him that "Those of his instrumental works which achieved popularity allowed the majority of listeners to perceive nothing in them beyond the individuality of Brahms' themes, gestures, and instrumental colors; within his works the classical identity of subjectively designed gesture and objectively rigorous structure was no longer generally audible."1 Subotnik offers no evidence in support of this claim nor does she mention a single work of Brahms in connection with it. In view of such transparently "classical" structures as the Variations and Fugue on a Theme of Handel, the Passacaglia of the Fourth Symphony, the Rondo of the Violin Concerto, and dozens of others, the claim seems improbable at best. · 1. Rose Rosengard Subotnik, "The Cultural Message of Musical Semiology: Some Thoughts on Music, Language, and Criticism since the Enlightenment," Critical Inquiry 4 : 761. Lawrence Kramer has written various articles on nineteenth- and twentieth-century poetry and on the relation between poetry and music. An assistant professor of English at Fordham University, he has written a book on Wordsworth and Keats. (shrink)

What, exactly, is knowledge of music? And what does it tell us about humanistic knowledge in general? _The Thought of Music_ grapples directly with these fundamental questions—questions especially compelling at a time when humanistic knowledge is enmeshed in debates about its character and future. In this third volume in a trilogy on musical understanding that includes _Interpreting Music_ and _Expression and Truth_, Lawrence Kramer seeks answers in both thought _about_ music and thought _in_ music—thinking in tones. He skillfully assesses musical (...) scholarship in the aftermath of critical musicology and musical hermeneutics and in view of more recent concerns with embodiment, affect, and performance. This authoritative and timely work challenges the prevailing conceptions of every topic it addresses: language, context, and culture; pleasure and performance; and, through music, the foundations of understanding in the humanities. The publisher gratefully acknowledges the Joseph Kerman Endowment of the American Musicological Society, funded in part by the National Endowment for the Humanities and the Andrew W. Mellon Foundation. (shrink)

James Madison University Harrisonburg, VA 22807 USA Tel: 540-568-3212 Fax: 540-568-3010 Email: [email protected].

The literature on speculative bubbles in foreign exchange rates is voluminous, with much of it failing to reject the presence of bubbles in many exchange markets.1 Serious testing of this issue began with the work of Meese (1986), Evans (1986), and Woo (1987). Each used a different approach, and each found evidence failing to reject the presence of bubbles in at least some exchange markets.