Dolphins exhibit both action-level imitation (ALI) and program-level imitation (PLI). Dolphins may use ALI primarily for social cohesion, whereas PLI seems more likely to occur in goal-directed, problem-solving contexts. Both PLI and insightful problem solving require a recognition of the functional relations between actions and outcomes. Insightful problem solving, however, involves the creation of a program in the absence of a model, and therefore requires a higher order appreciation and application of the relations between actions and outcomes.

While the United States is an important Asia-Pacific actor, its engagement with the region is complex and often difficult. Not only must US regionalism balance the diverse requirements of an ambitious policy agenda, but also US policy norms and priorities often clash with those of other regional actors. This has important implications for the capacity of the United States to provide regional leadership. Recent years have seen growing policy convergence between the United States and other Asia-Pacific actors, particularly in economic (...) terms, but US regionalism continues to feature competition alongside collaboration. (shrink)

That style which modern scholars have called “curial” or “clergial” is an elaborate fifteenth-century prose style practiced most notoriously by William Caxton in works published during the last decades of the century. It is often assumed that he learned the style from French courtly models. This view has recently suffered modification through the work of Diane Bornstein, whose study of the Tale of Melibee revealed that Chaucer had an independent grasp of many features of the style almost a hundred years (...) before Caxton used it. Although she was successful in demonstrating the use at an early date of these stylistic features, Bornstein did not question or discuss the sources of Chaucer's evident competence. It could be reasonably assumed, as had been assumed for Caxton, that they lay in French literary texts, since features of the style are present in the source of Melibee, the Livre de Mellibee et de Prudence, and they could be presumed to have occurred also in other literary texts of French origin with which Chaucer was doubtless familiar. (shrink)

It is widely agreed that a new conception of history was developed in the early nineteenth century: the past came to be seen in a new light, as did the way of studying the past. This article discusses the nature of this collective revision, focusing on one of its first and most important manifestations: Ranke's 1824 Geschichten der romanischen und germanischen Völker. It argues that, in Ranke's case, the driving force of the revision was religious, and that, subsequently, an understanding (...) of the nature of Ranke's religious attitude is vital to any interpretation of his historical revision. Being aesthetic-experiential rather than conceptual or "positive," this religious element is reflected throughout Ranke's enterprise, in source criticism and in historical representation no less than in the conception of cause and effect in the historical process. These three levels or aspects of the historical enterprise correspond to the experience of the past, and are connected by the essence of the experience: visual perception. The highly individual character of the enterprise, its foundation in sentiments and experiences of little persuasive force that only with difficulty can be brought into language at all, explains the paradoxical nature of the Rankean heritage. On the one hand, Ranke had a great and lasting impact; on the other hand, his approach was never re-utilized as a whole, only in its constituent parts—which, when not in the relationship Ranke had envisioned, took on a new and different character. This also suggests the difference between Ranke's revision and a new paradigm: whereas the latter is an exemplary solution providing binding regulations, the former is unrepeatable. (shrink)

XLRI, in association with a few Tata Group companies, established the XLRI-JRD Tata Foundation in Business Ethics in 1991 to mark their long-standing commitment and contribution to business ethics in India. The foundation seeks to address this by publicly affirming the urgent need for ethics in business and the need to bring about a conducive culture in which it can thrive.

Thus the passage is printed in the Teubner edition of Seneca's Dialogues by E. Hermes, who, on the strength of Aen. 8. 702 f. , adds a note on the quotation ‘versus sunt Vergilii a Seneca licenter mutati’. Now the imputation to Seneca of such gross alteration of Virgil can only be supported if we disregard or eject the evidence to the contrary. As only the last five words are actually Virgilian; as Seneca himself says ‘aput vate nostra?’; as out (...) at the beginning of the second line may introduce a second quotation ; and as est, which Gertz secluded, has a part to play if the lines are by different poets, it is safer to take a step backwards and dispose the passage thus. (shrink)

‘Shameful are the scars inflicted by the sin of fraternal strife! What has ourunconscionable generation shunned, what abomination left undone? Ourgodless soldiery has held nothing sacred. I pray that Fortune may, on a new anvil, give our blunted swords another shape, to use against Massagetae andArabs!‘.

This book is designed to explore the various kinds of association found in Chaucer's lexical usage, and so to alert the reader to the wider implications of ...

Pleidooi voor een metafysische visie op hedendaagse sociale en economische problemen.

The aim of this systematic review was to summarize and assess the quality of asthma intervention health economic studies from 2002 to 2007, compare the study findings with clinical management guidelines, and suggest avenues for future improvement of asthma health economic studies. Forty of the 177 studies met our inclusion criteria. We assessed the quality of studies using The Quality of Health Economic Studies validated instrument (total score range: 0-100). Six studies (15%) had quality category 2, 26 studies (65%) achieved (...) quality category 3, and the remaining eight (20%) studies were scored as the highest quality level, category 4. Overall, the findings from this review are in line with the Global Initiative for Asthma clinical guidelines. Many asthma health economic studies lacked appropriate long term time horizons to match the chronic nature of the disease and suffered from using effectiveness measures that did not capture all disease related risks and benefits. We recommend that new asthma simulation models: be flexible to allow for long term time horizons, focus on using levels of asthma control in their structure, and estimate both long term asthma specific outcomes like well-controlled time as well as generic outcomes such as quality adjusted survival. (shrink)

Background: Omalizumab, an anti-immunoglobulin E antibody, reduces exacerbations and symptoms in uncontrolled allergic asthma. The study objective was to estimate the costs and consequences of omalizumab compared to usual care from a US payer perspective. Methods: We estimated payer costs, quality-adjusted survival (QALYs), and the incremental cost-effectiveness ratio (ICER) of omalizumab compared to usual care using a state-transition simulation model that included sensitivity analyses. Every 2 weeks, patients could transition between chronic asthma and exacerbation health states. The best available evidence (...) informed the clinical and cost input estimates. Five years of omalizumab treatment followed by usual care was assumed to estimate a lifetime horizon. Omalizumab responders (60.5% of treated) were modeled as a separate scenario where nonresponders reverted back to usual care after 16 weeks of active treatment. Results: The mean lifetime discounted costs and QALYs were $83 400 and 13.87 for usual care and $174 500 and 14.19 for omalizumab plus usual care resulting in $287 200/QALY (95% interval: $219 300, $557 900). The ICER was $172 300/QALY when comparing omalizumab to usual care in the responder scenario. One-way sensitivity analyses indicated that the results were sensitive to the difference in treatment-specific utilities for the chronic state, exacerbation-associated mortality, omalizumab price, exacerbation rates, and response definition. Conclusions: The results suggest that adding omalizumab to usual care improves QALYs at an increase in direct medical costs. The cost-effectiveness of omalizumab is similar to other chronic disease biologics. The value increases when omalizumab response is used to guide long-term treatment. (shrink)

Open peer commentary on the target article “Who Conceives of Society?” by Ernst von Glasersfeld. Excerpt: Von Glasersfeld’s presupposition that all organisms are isolated subjective knowers can thus remain viable within a framework that sees the personal and social as mutually informing. Implying that isolated knowers coordinate the ways in which they “bump” into one another – and that this coordination impacts the kinds of perturbations that arise within them – constitutes a perfectly rational variation on von Glasersfeld’s theory of (...) rational knowing. (shrink)