Metabolomics, including lipidomics, is emerging as a quantitative biology approach for the assessment of energy flow through metabolism and information flow through metabolic signaling; thus, providing novel insights into metabolism and its regulation, in health, healthy ageing and disease. In this forward‐looking review we provide an overview on the origins of metabolomics, on its role in this postgenomic era of biochemistry and its application to investigate metabolite role and (bio)activity, from model systems to human population studies. We present the challenges (...) inherent to this analytical science, and approaches and modes of analysis that are used to resolve, characterize and measure the infinite chemical diversity contained in the metabolome (including lipidome) of complex biological matrices. In the current outbreak of metabolic diseases such as cardiometabolic disorders, cancer and neurodegenerative diseases, metabolomics appears to be ideally situated for the investigation of disease pathophysiology from a metabolite perspective. (shrink)

The article examines the conquest of the New World in the focus of interaction of different types of thinking in the clash and conflict of two civilizations, which develop in different ways and which are at different levels of social and economic development. The result of this clash was the destruction of the material, spiritual and intellectual traditions of indigenous cultures that existed on the American continent. The conquest of America is one of the most revealing examples of the clash (...) of civilizations, analyzing which, with particular clarity, one can observe contradictions between different types of world perception. The answer to questions about what kind of knowledge Nahua-speaking people possessed, what role knowledge played in their society, who was the creator, carrier and translator of knowledge about the world, reveals one of the main reasons that led to a rapid and irretrievable destruction of culture of “metaphors and numbers.” The author reveals the role of Catholic monks in preserving the spiritual, scientific and philosophical heritage of the Mexican culture, thanks to which we have the opportunity to touch the thought of the Nahua people, existing not in the form of traditional texts but in the form of an oral tradition, which accompanied visual images of graphic semantic writing. It shows how important the system of education and upbringing in the society of pre-Columbian Mexico was, how it solved the tasks of preparing young people for the performance of social functions. The destruction, as a result of the con- quest, of the system that regulated the daily life of each person and determined the ultimate destiny of the people in the shortest possible time led to the death of the entire civilization. (shrink)

RESUMEN Se aborda el pensamiento de E.M. Cioran desde la perspectiva de un sinsabor vital denominado sentimiento de muerte. El término, aunque aparece solo en su primer escrito, es transversal a toda su obra, puesto que para el autor los seres humanos nos intuimos como posesos de la muerte en cada momento de nuestra existencia. Esto cambia el tono normal de la vida, al poner frente a la persona una realidad carente de sentido y dominada por circunstancias radicales y limitantes (...) como el dolor y la agonía, que culmina en una atmósfera gobernada por la intuición trágica de la vida. ABSTRACT The article addresses the thought of E.M. Cioran from the perspective of that vital uneasiness known as the sentiment of death. Although the term appears only in his first book, the idea cuts across his entire work given that, for Cioran, human beings intuit themselves as possessed by death at every moment of their lives. When persons are faced with a meaningless reality, dominated by radical and limiting circumstances such as pain and agony, the whole tenor of life changes until it becomes a tragic intuition of life. (shrink)

Este artículo propone una revisión crítica sobre los alcances del transhumanismo en la esfera de la Psicología. Para ello, se expondrán antecedentes y se definirá lo que se entiende por transhumanismo y el resultado de éste, denominado poshumanismo. A través de características humanas tan básicas y diversas como la cognición, el sufrimiento y la identidad, se discute sobre los inéditos cambios que la ejecución y logro de las propuestas transhumanistas significarían para la sociedad, el cómo la psicología podría prever y (...) anticipar un escenario así de radical, y la necesidad y urgencia de nuevas teorías éticas que ayuden a comprender los fenómenos en cuestión. (shrink)

Magnífico libro ha tenido a bien reeditar la editorial madrileña Encuentro, situándolo como el primer volumen de la colección Mínima Política. En él, además de realizar algunas correcciones y estructurar la obra de forma más manejable para el lector, se ha encargado del estudio preliminar el profesor Jerónimo Molina, como ya hiciera con otras obras del mismo autor, Teoría y sistema de las formas políticas e Introducción al Derecho político actual, hace unos pocos años. En esta introducción, se nos ofrece (...) un recorrido biográfico, intelectual y político por Francisco Javier Conde, sencillo, directo y profundo. Propio de quien tiene un riguroso conocimiento del autor y de su obra. Con su lectura conseguiremos enmarcar correctamente este libro en la trayectoria vital e intelectual de Conde, entre la actitud intelectual del realismo político, el fracaso en la vida de actividad política y el olvido arrastrado hasta casi nuestros días. Y digo casi, porque, según lo que hemos dicho, no son pocos los que honran a Conde y su trabajo intelectual, de gran mérito. No en vano señala el profesor Molina que este libro es un pequeño clásico contemporáneo. (shrink)

The comparative study of synchronic occurrences of a particular construction in interactional corpora from different languages can provide a complete understanding of the development of the construction as a response to some basic intimately associated set of interactional moves and cognitive demands. A comparative formal analysis of lists in Spanish and English conversations shows that in both languages the construction has developed a stylized intonation pattern based on the holding of tones by means of lengthening of nuclear syllables, a durable (...) syntactic organization based on parataxis and an almost identical inventory of lexicalized expressions to index the end of the list. A parallel analysis of lists in their interactional contexts shows that in both English and Spanish conversation the formal properties of lists emerge as adaptations to a recurrent set of communicative tasks. The first type of `framing' lists is used for its incremental structure in the negotiation of common background between interlocutors, whereas the second type of `demonstrative' lists is used for its rhetorical structure to provide evidence for a claim and is directed to obtaining agreement. (shrink)

In this article, I argue that the main contribution of Hegel's philosophy of right to the contemporary political debate is that it opens a window on the idea that liberalism and individual freedom are incompatible. My main thesis is that the liberal conception of the State and law, structured from a nonrelational account of singularity, ends up denying the individual freedom that it claims to defend. I begin by reconstructing the Hegelian concept of freedom from its most general lines, showing (...) that being free consists in wanting to become someone and not so much in wanting to do something. After showing that the purpose of becoming someone can only be fulfilled in a social medium, I focus on Hegel's critique of the liberal state (as expounded in the section on “civil society”). I argue that civil society structurally impedes individuals from realizing their purpose of becoming someone: the economical interactions of civil society give rise to impersonal and inscrutable mechanisms, which take the social conditions of people's individuation beyond their control. Finally, I claim that (rational) individual freedom consists in being able to thematize and democratically control the very social conditions of individuation through the State and law. (shrink)

The article discusses the problems of philosophical geography, philosophical multipolarity, georationality. The debates on these issues are becoming interdisciplinary. Specialists in Eastern philosophies and cross-cultural communications as well as epistemologists, scientific methodologists, cognitive scholars, synergists became participants of the discussion held at the Institute of Philosophy of the Russian Academy of Sciences. The problem of Eurocentrism in academic philosophy has become the main topic of discussion. The opponents of the “regional” multipolarity argued that the Western European tradition of rationality was (...) an example of the rationality per se. The proponents, who relied heavily on the ad professionem arguments, advocated multipolarity and demonstrated the irreducibility of the world-pictures, languages and ontologies of philosophical systems. A point of view was expressed that Eurocentrism had an ideological background. The disputants noted that there was need to redefine or clarify such fundamental concepts as logic, rationality, scientific rationality, universalism, processuality. The redefinition of the concept of rationality is for the studies of various types of rationality outside European cultures. Methodologists of science drew attention that the cognitive problems of intercultural communications turned out to be similar to the problems faced by theory of complexity. The analysis of philosophical, logical and other cases in various “zones of exchange” reveals a plurality of directions in the global and local socio-cultural spaces. The panelists raised the question of the role of philosophy in the global world and its responsibility in uniting nations. The authors of the article draw attention to many functions that the Western European conceptual system performs in the formation of philosophical language, mentality and communication. The dynamics of philosophical discussions, the dialogue of the West and the East lead to the clarification of philosophical positions, the emergence of new concepts and meanings as well as the formation of discourses of the future. (shrink)

The article is devoted to Miguel Servet (Michael Servetus, Spain – Miguel Serveto, also known as Miguel Servet, Miguel Serveto, Revés, or Michel de Villeneuve) – the XVI century Spanish thinker who was recognized as a heretic and burnt at the stake in Geneva in 1553.The author discusses the specifics of Servet’s philosophical system, the scientific background of his system, and his key ideas that have become a matter for auto-da-fė. The author argues that Servet’s concept was aimed to reconstruct (...) the “pure” Christian dogma, although he was not a professional theologist. The author claims that Servet used the deep knowledge in geography, astronomy, medicine, linguistics to create his complex system which was aimed to rescue the mankind from total destruction (Apocalypse). The author claims that Servet’s system could be considered as an example of interdisciplinary approach in the pre-disciplinary epoch. Moreover, Servet’s approach to the problem of personal salvation and the transformation of the humane nature is based on empirical scientific data. Hence, it is appropriate to consider his philosophical system as a mixture of theology, natural science and humanities. (shrink)

In contrast to individualistic explanations of social injustice that appeal to implicit attitudes, structural explanations are unintuitive: they appeal to entities that lack clear ontological status, and the explanatory mechanism is similarly unclear. This makes structural explanations unappealing. The present work proposes a structural explanation of one type of injustice that happens in conversations, discursive injustice. This proposal meets two goals. First, it satisfactorily accounts for the specific features of this particular kind of injustice; and second, it articulates a structural (...) explanation that overcomes their unattractiveness. The main idea is that discursive injustice is not the result of biased interlocutors, but of problematic discursive norms. (shrink)

In this volume, we have chosen to highlight the importance of education to human rights by reprinting two articles written by Paulo Freire in 1970 for the _Harvard Educational Review_. These articles contain many of Freire's original ideas on human rights and education—issues that are central to his work. Freire was a pioneer in promoting the universal right to education and literacy as part of a commitment to people's struggle against oppression. As Jerome Bruner recognized after Freire's death in May (...) 1997, Freire left as a legacy his commitment to basic human rights: "He was a brave man as well as a far-sighted one. He made us aware of our mindless cruelties, and now the challenge to all of us is to do something about those cruelties.". (shrink)

The ultimate source of explanation in biology is the principle of natural selection. Natural selection means differential reproduction of genes and gene combinations. It is a mechanistic process which accounts for the existence in living organisms of end-directed structures and processes. It is argued that teleological explanations in biology are not only acceptable but indeed indispensable. There are at least three categories of biological phenomena where teleological explanations are appropriate.

The analysis of social networks has remained a crucial and yet understudied aspect of the efforts to measure Triple Helix linkages. The Triple Helix model aims to explain, among other aspects of knowledge-based societies, “the current research system in its social context” (Etzkowitz and Leydesdorff 2000:109). This paper develops a novel approach to study the research system from the perspective of the individual, through the analysis of the relationships among researchers, and between them and other social actors. We develop a (...) new set of techniques and show how they can be applied to the study of a specific case (a group of academics within a university department). We analyse their informal social networks and show how a relationship exists between the characteristics of an individual’s network of social links and his or her research output. (shrink)

Tras la lectura de esta obra, reconocemos que su autora, Stephanie Graf, mantiene una signatura o estilo constante en cada parte, capítulo y subtítulo, pues le interesa plantear una trama, un tablero para dialogar con el trabajo de Walter Benjamin y de Theodor W. Adorno, ante uno de los desafíos más urgentes de nuestro tiempo: ¿Cómo entender la supervivencia de la teología en un mundo secular? En específico, ¿de qué forma el escándalo del mal, sobre todo del mal excesivo en (...) Auschwitz, nos remite inevitablemente a la metafísica, a la creación, la revelación, la redención, aun cuando estos pensadores judíos se ubican en el campo del materialismo histórico y la sola responsabilidad humana? De ahí el llamado a la inversión. (shrink)

Therapy for metaphysics -- Concepts, rules, and the spirit of recognition -- Meaning and meanings -- Reference and presence -- Truth and correspondence -- Emancipating theology.

Este trabajo plantea un ejercicio de interpretación del relato bíblico de los macabeos, su rebelión y resistencia religiosa, política y militar frente a la imposición imperial desde algunas perspectivas recogidas de los escritos de Walter Benjamin sobre la juventud. Se ponen de relieve temas como la situación religiosa ante el horizonte de la Ilustración; la relevancia que tiene la religión en los movimientos sociales juveniles; el mesianismo reinterpretado por el movimiento romántico de los intelectuales judíos de la Mitteleuropa, según lo (...) ha estudiado el académico Michael Löwy para, finalmente, ensayar una reflexión sobre la ideología de la soberanía militar en contraste con el mesianismo utópico. (shrink)

Se ofrece una interpretación teórico-política de la fusión de horizontes de Gadamer. Se argumenta que el diálogo político, desde un punto de vista hermenéutico, debe entenderse como el proceso de cuestionamiento y disputa de los horizontes de sentido en donde descansan las prácticas sociales. Asimismo, se sostiene que el diálogo instituye una pregunta-escenario-común que abre el horizonte social de sentido hacia la contingencia e incertidumbre, así como que este nunca busca un consenso procedimental o sustancial que subsane los conflictos y (...) concilie las diferentes perspectivas en un punto de vista homogéneo. (shrink)

Se ofrece una interpretación teórico-política de la fusión de horizontes de Gadamer. Se argumenta que el diálogo político, desde un punto de vista hermenéutico, debe entenderse como el proceso de cuestionamiento y disputa de los horizontes de sentido en donde descansan las prácticas sociales. Asimismo, se sostiene que el diálogo instituye una pregunta-escenario-común que abre el horizonte social de sentido hacia la contingencia e incertidumbre, así como que este nunca busca un consenso procedimental o sustancial que subsane los conflictos y (...) concilie las diferentes perspectivas en un punto de vista homogéneo. The article provides a theoretical-political interpretation of Gadamer's fusion of horizons, arguing that, from a hermeneutical point of view, political dialogue should be understood as the process of questioning and challenging the horizons of meaning underlying social practices. Likewise, the article holds that dialogue establishes a common question-scenario that opens up the social horizon of meaning to contingency and uncertainty, and that it never seeks a procedural or substantial consensus that eliminates conflicts and reconciles different perspectives in a homogeneous point of view. Neste artigo, oferece-se uma interpretação teórico-política da fusão de horizontes de Gadamer. Argumenta-se que o diálogo político, sob um ponto de vista hermenêutico, deve ser entendido como o processo de questionamento e disputa dos horizontes de sentido em que descansam as práticas sociais. Além disso, sustentase que o diálogo institui uma pergunta-cenário-comum que abre o horizonte social de sentido à contingência e incerteza, bem como que este nunca procura um consenso procedimental ou substancial que ressarça os conflitos e concilie as diferentes perspectivas num ponto de vista homogêneo. (shrink)

RESUMEN Este artículo presenta una reconstrucción argumentativa del primer capítulo de la tercera sección de la Doctrina de la Esencia de la Ciencia de la Lógica de Hegel, el cual lleva como título "Lo Absoluto". Su hipótesis es que la critica de la metafísica contenida en este capítulo no solo aboga por una ontología relacional del proceso, sino que también establece implícitamente una distinción entre una teoría de lo absoluto de primer orden y una de segundo orden. La teoría de (...) lo absoluto de primer orden tiene como objetivo una exposición de lo absoluto libre de contradicciones analíticas. Por su parte, la teoría de lo absoluto de segundo orden no solo expone en qué consiste lo absoluto, sino que pretende también incluir el pensamiento y la teoría de lo absoluto en lo absoluto mismo. ABSTRACT This paper aims to reconstruct the arguments of the first chapter within the third section of the Doctrine of Essence, namely "The Absolute". Its hypothesis is that the critic of metaphysics within this chapter not only champions a relational process-ontology, but also states an implicit distinction between first and second order theories of the Absolute. The first-order theory of the Absolute purports to present a definition of the Absolute without analytic contradictions. The second-order theory of the Absolute not only sets out the nature of the Absolute, but also seeks to include the thought and the theory of the Absolute within the Absolute itself. (shrink)

The aim of this study was to analyze the explanatory level of the variables advertising influence, verbal messages, social models and social situations as regards body dissatisfaction, weight worry, and bodily discomfort. The study was conducted in a convenience sample of 206 Mexican women with an average age of 22.12 years. Structural equation modeling was used to analyze the direct and indirect effects of the independent variables on the dependent ones in three hypothetical models proposed. In the case of the (...) model proposed for body dissatisfaction, it was found that the set of variables had 79% of variance explained and showed adequate goodness-of-fit indices. The model for weight worry had 62% of variance explained and an acceptable goodness of fit. Finally, the model for bodily discomfort had 72% of variance explained and showed adequate goodness of fit. It is concluded that social influences have a significant impact on body image. Verbal messages had the strongest impact on the variables studied. (shrink)

El trabajo forma parte de! Proyecto HISTELEA y propone una historia social de la lectura y escritura como campo de estúdio interdisciplinaria que supere la mirada diacrónica de la didáctica. Invita a combinar la historia de la escritura y su tecnologia con la historia de la lectura y sus variaciones desde la oralidad residual de la lectura colectiva en alta voz de! catecismo em las aulas conventuales, hasta la ruminatío que preanunciaba la lectura silenciosa individual moderna. La escuela fue erigida (...) como e! espacio privilegiado para curnplir con el objetivo de la producción masiva de Jectores ai constituirse los sistemas educativos nacionales euro-occidentales a fines del Sigla XIX, y siglas de prácticas sociales de escritura y lectura pasaron a condensarse en e! manual escolar, el libra de lectura, el discurso de! método como integrante del discurso pedagógico naciente, y con ello, la aparición de la escena de lectura escolar. (shrink)