The testimonia concerning weight in early Greek atomism appear to contradict one another. Some reports assert that the atoms do have weight, while others outright deny weight as a property of the atoms. A common solution to this apparent contradiction divides the testimonia into two groups. The first group describes the atoms within a κόσμος, where they have weight; the second group describes the atoms outside of a κόσμος, where they are weightless. A key testimonium for proponents of this solution (...) is Aëtius 1.3.18. It apparently denies weight as a property of the atoms, and supposedly describes the atoms when they are outside of a κόσμος. I argue against this interpretive solution by demonstrating, first, that Aëtius 1.3.18 does not deny that weight is a property of the atoms. Second, I argue that the report does not describe the atoms when they are outside of a κόσμος. Although these are largely negative conclusions, I contend that we are not left without a solution to the present interpretive difficulty. Once our testimonia concerning weight in early Greek atomism are examined thoroughly, it is clear that there is no conflict among them. (shrink)

Ecological developmental biology (eco‐devo) explores the mechanistic relationships between the processes of individual development and environmental factors. Recent studies imply that some of these relationships have deep evolutionary origins, and may even pre‐date the divergences of the simplest extant animals, including cnidarians and sponges. Development of these early diverging metazoans is often sensitive to environmental factors, and these interactions occur in the context of conserved signaling pathways and mechanisms of tissue homeostasis whose detailed molecular logic remain elusive. Efficient methods for (...) transgenesis in cnidarians together with the ease of experimental manipulation in cnidarians and sponges make them ideal models for understanding causal relationships between environmental factors and developmental mechanisms. Here, we identify major questions at the interface between animal evolution and development and outline a road map for research aimed at identifying the mechanisms that link environmental factors to developmental mechanisms in early diverging metazoans.Also watch the Video Abstract. (shrink)

Clown characters have always played a decisive role when depicting social conflicts. Wearing their masks, they embody and reveal cultural anxieties.

Endothelial cells line the inside of all blood vessels, forming a structurally and functionally heterogenous population of cells. Their complexity and diversity has long been recognized, yet very little is known about the molecules and regulatory mechanisms that mediate the heterogeneity of different endothelial cell populations. The constitutive organ‐ and microenvironment‐specific phenotype of endothelial cells controls internal body compartmentation, regulating the trafficking of circulating cells to distinct vascular beds. In contrast, surface molecules associated with the activated cytokine‐inducible endothelial phenotype play (...) a critical role in pathological conditions including inflammation, tumor angiogenesis, and wound healing. Differentiation of the endothelial cell phenotypes appears to follow similar mechanisms to the differentiation of hematopoietic cells, with the exception that endothelial cells maintain transdifferentiating competence. The present review offers a scheme of endothelial cell differentially expressed endothelial cell molecules as targets for directed therapeutic intervention. (shrink)

What is Leucippus and Democritus’ theory of the beginning of life? How, if at all, did Leucippus and Democritus distinguish different kinds of living things? These questions are challenging in part because these Atomists claim that all living beings – including plants – have a share of reason and understanding. We answer these questions by examining the extant evidence concerning their views on embryology, the soul and respiration, and sense perception, thereby giving an overview of life and lifeforms in early (...) Greek atomism. We show, first, that the generation of all living beings happens through the combining of miniature copies of their parents’ atomic structures. Second, we argue that the Atomists take respiration to mark the beginning of life. Yet they do not consider respiration nor being ensouled to distinguish humans, animals, and plants from each other. Finally, because Leucippus and Democritus make little distinction between sense perception and thought, these too cannot sharply distinguish between different kinds of living beings. We conclude that Leucippus and Democritus advocated a less anthropocentric and more holistic view of the cosmos. (shrink)

According to Epicurus, philosophy’s sole task is to ensure the well-being of the soul. Human souls are often riddled with diseases; the most serious are the fear of the gods and the fear of death. Thus, the Epicureans offered several arguments designed to demonstrate that, for instance, “death is nothing to us,” and should therefore not be feared. Since their creation there has been much discussion, both in antiquity and by contemporary philosophers, about these arguments. In this thesis, I argue (...) that Epicurean philosophical arguments are patient-relative; they necessarily adapt themselves so as to be therapeutically effective for their intended audience. The end result is that when we evaluate Epicurean philosophical arguments, we must do so in light of the audience for whom they were intended. (shrink)

This festschrift for Teddy Seidenfeld is a collection of newly commissioned essays on imprecise probability by leading experts in the field. Each contribution touches on Teddy’s seminal contributions to the field of imprecise probability, and gives an up-to-date state of the field that cannot be found elsewhere. The title, “a reflection on the foundations of probability and statistics”, calls back to Teddy’s seminal book, “Rethinking the Foundations of Probability and Statistics”, bookends to a career that has made fundamental contributions to (...) the foundations of probability and statistics, and shaped the field of imprecise probability. It is aimed at scholars engaged in probability and statistics. (shrink)

While each Form is what it is to be F, some Forms also instantiate F (or “self-instantiate”). Here I consider whether the explanation for a Form’s instantiating F should be the Form’s participating in itself. First, I motivate the need for an explanation of self-instantiation. Second, I consider the advantages and disadvantages of self-participation alongside an alternative explanation—that the Form’s being what it is to be F is a sufficient explanation of its instantiation of F. The result is not a (...) conclusive case for self-participation, but only some initial considerations in favor of it. (shrink)

What is Leucippus and Democritus’ theory of the beginning of life? How, if at all, did Leucippus and Democritus distinguish different kinds of living things? These questions are challenging in part because these Atomists claim that all living beings – including plants – have a share of reason and understanding. We answer these questions by examining the extant evidence concerning their views on embryology, the soul and respiration, and sense perception, thereby giving an overview of life and lifeforms in early (...) Greek atomism. We show, first, that the generation of all living beings happens through the combining of miniature copies of their parents’ atomic structures. Second, we argue that the Atomists take respiration to mark the beginning of life. Yet they do not consider respiration nor being ensouled to distinguish humans, animals, and plants from each other. Finally, because Leucippus and Democritus make little distinction between sense perception and thought, these too cannot sharply distinguish between different kinds of living beings. We conclude that Leucippus and Democritus advocated a less anthropocentric and more holistic view of the cosmos. (shrink)