Maintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF‐β‐activated kinase 1 (TAK1) is a key protein, which coordinates the activation of multiple signaling pathways. Recently, it was discovered that TAK1 is essential for the maintenance of skeletal muscle mass and myofiber hypertrophy following mechanical overload. Forced activation of TAK1 in skeletal muscle causes hypertrophy and attenuates denervation‐induced muscle (...) atrophy. TAK1‐mediated signaling in skeletal muscle promotes protein synthesis, redox homeostasis, mitochondrial health, and integrity of neuromuscular junctions. In this article, we have reviewed the role and potential mechanisms through which TAK1 regulates skeletal muscle mass and growth. We have also proposed future areas of research that could be instrumental in exploring TAK1 as therapeutic target for improving muscle mass in various catabolic conditions and diseases. (shrink)

Sorensen presents a general theory of thought experiments: what they are, how they work, what are their virtues and vices. On Sorensen's view, philosophy differs from science in degree, but not in kind. For this reason, he claims, it is possible to understand philosophical thought experiments by concentrating on their resemblance to scientific relatives. Lessons learned about scientific experimentation carry over to thought experiment, and vice versa. Sorensen also assesses the hazards and pseudo-hazards of thought experiments. Although he grants that (...) there are interesting ways in which the method leads us astray, he attacks most scepticism about thought experiments as arbitrary. They should be used, he says, as they generally are used--as part of a diversified portfolio of techniques. All of these devices are individually susceptible to abuse, fallacy, and error. Collectively, however, they provide a network of cross-checks that make for impressive reliability. (shrink)

Now acknowledged as a classic in the philosophy of science, A Realist Theory of Science is one of the very few books to transform not only our understanding of science, but that of the nature of the world it studies. The book has inspired the multi-disciplinary and international movement of thought known as critical realism. Re-issued with a new introduction.

The eclipse riddle -- Seeing surfaces -- The disappearing act -- Spinning shadows -- Berkeley's shadow -- Para-reflections -- Para-refractions : shadowgrams and the black drop -- Goethe's colored shadows -- Filtows -- Holes in the light -- Black and blue -- Seeing in black and white -- We see in the dark -- Hearing silence.

Since its original publication in 1979, The Possibility of Naturalism has been one of the most influential works in contemporary philosophy of science and social science. It is one of the cornerstones of the critical realist position, which is now widely seen as offering perhaps the only viable alternative to positivism and post positivism. This fourth edition contains a new foreword from Mervyn Hartwig, who is founding editor of the Journal of Critical Realism and editor and principal author of the (...) Dictionary of Critical Realism. (shrink)

To understand lying, we naturally focus on small scale lies involving one speaker, one listener, one assertion. This methodology confers artificial plausibility upon the requirement that liars intend to deceive. For it excludes principal-agent conflicts that emerge from linguistic division of labor. When an employee lies for her boss, she need not inherit his motive to deceive. She displays loyalty even if her lie does not deceive. Focus on a single lie in isolation also blinds us to tactical deceptions such (...) as telling a lie which is intended to be caught to advance another lie. Many of these complexities arise from situations that approximate common knowledge without quite crystallizing into this uniform transparency. (shrink)

The aim of this paper is to show how thought experiments help us learn about laws. After providing examples of this kind of nomic illumination in the first section, I canvass explanations of our modal knowledge and opt for an evolutionary account. The basic application is that the laws of nature have led us to develop rough and ready intuitions of physical possibility which are then exploited by thought experimenters to reveal some of the very laws responsible for those intuitions. (...) The good news is that natural selection ensures a degree of reliability for the intuitions. The bad news is that the evolutionary account seems to limit the range of reliable thought experiment to highly practical and concrete contexts. In the fifth section, I provide reasons for thinking that we are not as slavishly limited as a pessimistic construal of natural selection suggests. Nevertheless, I promote the idea that biology is a promising source of predictions and diagnoses of thought experiment failures. (shrink)

My thesis is that you can lie with ‘ P therefore Q ’ without P or Q being lies. For you can lie by virtue of not believing that P supports Q. My thesis is reconciled with the principle that all lies are assertions through H. P. Grice’s account of conventional implicatures. These semantic cousins of conversational implicatures are secondary assertions that clarify the speaker’s attitude toward his primary assertions. The meaning of ‘therefore’ commits the speaker to an entailment thesis (...) even though the speaker does not enter that commitment into the text. Insincere conventional implicatures are akin to insincerely asserted footnotes. An absence of lies in the text is compatible with the presence of lies in the meta-text. (shrink)

Immanuel Kant promised, ‘as Your Majesty's loyal subject’, to abstain from all public lectures about religion. All past commentators agree this phrase permitted Kant to return to the topic after the King died. But it is not part of the ‘at-issue content’. Consequently, ‘as Your Majesty's loyal subject’ is no more an escape clause than the corresponding phrase in ‘I guarantee, as your devoted fan, that these guitar strings will not break’. Just as the guarantee stands regardless of whether the (...) guarantor ceases to be your devoted fan, the compliance conditions of Kant's promise are not affected by Kant's ceasing to be the king's loyal subject. For good or ill, Kant made a lying promise to King Friedrich Wilhelm II in 1794. (shrink)

Despite its internal divisions and the uncertainty surrounding many of its foundations, there is a growing consensus that the on‐going search for an alternative model of the mind finds a minimal theoretical identity in the pursuit of an anti‐Cartesian conception of mental phenomena. Nevertheless, this anti‐Cartesianism remains more or less explicitly committed to the neo‐Brentanian idea that intentionality is an essential feature of the mental—an idea that has prevailed since the advent of modern cognitive science in the 1950s. An issue (...) of compatibility is thereby raised, as neo‐Brentanism arguably sides with cognitive Cartesianism. The main goal of the paper is to put into full light one specific aspect of this largely unperceived problem of compatibility by arguing that the neo‐Brentanian property of intentionality is an essentially representational one that runs counter to the salient anti‐representationalism of anti‐Cartesianism. And, that this representational essence confronts the search for alternative models of the mind of an anti‐Cartesian kind with the following theoretical issue: To what extent is it possible to devise a non‐Brentanian property of intentionality, particularly one that is fully dissociated from the property of representation? This issue is shown to be much deeper and more difficult than it looks once the nature of representation is properly apprehended; it seems to be still waiting for an answer in the current search for an alternative model of the mind, if only because it has not yet be set in fully adequate terms. (shrink)

Kripshe treats ‘god’ as an empty natural kind term such as ‘unicorn’. She applies Saul Kripke's fresh views about empty natural kinds to ‘god’. Metaphysically, says Kripshe, there are no possible worlds in which there are gods. Gods could not have existed, given that they do not actually exist and never did. Epistemologically, godlessness is an a posteriori discovery. Kripshe dismisses the gods in the same breath that she dismisses mermaids. Semantically, the perspective Kripshe finds most perspicacious, no counterfactual situation (...) is properly describable as one in which there are gods. Perhaps it is not quite a necessary truth that there are no gods. According to Saul Kripke, failed natural kind terms are ill-defined. Incorporating ill-defined terms into declarative sentences yields only mock propositions. Just as the meteorologist has no professional interest in mock thunder, the logician has no professional interest in mock propositions. Kripshe disagrees with agnostics who assign a low probability to ‘There is at least one god’. The bearers of probabilities must be propositions. Despite this deference to science, Kripshe agrees with the a priori atheist that, necessarily, no future experience could constitute an encounter with a god. Divine revelation is impossible. Kripshe's a posteriori necessary atheism compares favorably to familiar forms of atheism and to non-cognitivists. It reveals interesting challenges to a coherent formulation of atheism. (shrink)

Our society has long sanctioned, at least tacitly, a degree of conflict of interest in medical practice and clinical research as an unavoidable consequence of the different interests of the physician or clinical investigator, the patient or clinical research subject, third party payers or research sponsors, the government, and society as a whole, to name a few. In the past, resolution of these conflicts has been left to the conscience of the individual physician or clinical investigator and to professional organizations. (...) The public is no longer willing to allow health care providers to wholly govern their own conflicts of interest for several reasons. These include: new forms of health care financing and delivery that provide innovative and lucrative opportunities for physician or insurer enrichment at patient expense; the increased importance of commercial research support as peer-reviewed governmental research support has decreased; evidence that physicians and clinical investigators too frequently resolve conflicts of interest in their own favor; and a general societal mistrust of authority. This volume represents a multidisciplinary effort, drawing from philosophy, medicine, law, economics and public policy to identify and categorize conflicts of interest in medical practice and clinical research, and, where possible, to offer a mechanism for resolving them. Part I addresses conflicts of interest from a theoretical perspective, offering basic concepts and analytical frameworks. The second part discusses two topics prominent in current health care policy debates--self-referral and financial incentives to limit care. Part III examines conflicts of interest generated by pharmaceutical industry involvement in clinical practice and research. The final section deals with conflicts of interest in clinical research in several contexts, including institutional reviews boards, clinical trials, Cooperative Research and Development Agreements between government and private researchers, brokerage of research subjects by Contract Research Organizations, and cost-effectiveness studies. (shrink)

Islamic building codes require mosques to face Mecca. The further Islam spreads, the more apt are believers to fall into a quandary. X faces Y only when the front of X is closer to Y than any other side of X. So the front of the mosque should be oriented along a shortest path to Mecca. Which way is that? Does the path to Mecca tunnel through the earth? Or does the path follow the surface of the earth?

Creationists believe that C. K. Chesterton created Father Brown in his detective stories. Since creating implies a creation, Father Brown exists. Atheists object that the same reasoning could prove the existence of God. But creationists such as Jonathan Schaffer insist atheists do believe that God exists. Serious metaphysics rarely concerns existence. The disagreement between the theist and the atheist is about the nature of God, not His existence. Schaffer underestimates the religious imagination. There could be a religion that explicitly regarded (...) God as a fictional character. The tenets of this, presently hypothetical, religion are developed in a dialogue. (shrink)

Philosophy and Contemporary Issues contains contemporary readings of philosophical significance designed to introduce philosophy to college and university students. The authors' goal is to demonstrate how philosophy illuminates and helps solve some of the important problems facing contemporary man. This edition contains additional readings.

Stepping into the other guy's shoes works best when you resemble him. After all, the procedure is to use yourself as a model: in goes hypothetical beliefs and desires, out comes hypothetical actions and revised beliefs and desires. If you are structurally analogous to the empathee, then accurate inputs generate accurate outputs-just as with any other simulation. The greater the degree of isomorphism, the more dependable and precise the results. This sensitivity to degrees of resemblance suggests that the method of (...) empathy works best for average people. The advantage of being a small but representative sample of the population will create a bootstrap effect. For as average people prosper, there will be more average descendants and so the degree of resemblance in subsequent generations will snowball. Each increment in like-mindedness further enhances the reliability and validity of mental simulation. With each circuit along the spiral, there is tighter and tighter bunching and hence further empowerment of empathy. The method is self-strengthening and eventually molds a population of hyper-similar individuals-which partly solves the problem of other minds. (shrink)

My thesis is that ‘rational’ is an absolute concept like ‘flat’ and ‘clean’. Absolute concepts are best defined as absences. In the case of flatness, the absence of bumps, curves, and irregularities. In the case of cleanliness, the absence of dirt. Rationality, then, is the absence of irrationalities such as bias, circularity, dogmatism, and inconsistency.

Glowacki's work meshes well with our view of human nature as having evolved to use culture to improve survival and reproduction. Peace is a cultural achievement, requiring advances in social organization and control, including leaders who can implement policies to benefit the group, third-party mediation, and intergroup cooperation. Cultural advances shift intergroup interactions from negative-sum (war) to positive-sum (trade).

In theories which contribute to the understanding of uncertainty in entrepreneurial action, scholars have traditionally attributed a negative connotation to uncertainty. This paper seeks to posit an understanding of uncertainty derived from Greek and Indian philosophy, where action of the human agent is not deterred by uncertainty, and rather, occurs despite uncertainty. This idea may be beneficial in making future entrepreneurs less apprehensive about uncertainty, by helping them locate the lessons from philosophy. I look at existing ideas that explore uncertainty (...) in entrepreneurial motivation, and present a multidisciplinary approach which sees uncertainty as a force that increases intent of action, rather than deterring it by drawing on the understanding of consequence and action in Aristotelean thought and Hindu philosophy, and extend the concepts of tuche and karma to posit a theoretical position which sees uncertainty as a factor that encourages entrepreneurial action and motivation. The understanding of uncertainty in management literature has been approached primarily from two disciplinary positions - economics and organisational theory. In economics, the classical understanding of uncertainty which commenced with Frank Knight’s Risk, Uncertainty and Profit (1921), was largely abandoned in later years for a more quantifiable approach of calculating risk. Uncertainty, characteristically nebulous and difficult to grapple with, is unquantifiable. It is defined, in fact, by Knight, as something which cannot be predicted and quantified. Thus, in academics, where almost all disciplines try to make sense of the way the world works, uncertainty has always been a problematic concept. (shrink)

Ockham's razor is popularly phrased as a prohibition against multiplying entities beyond necessity. This prohibition should extend to the receptacle for these entities. To state my thesis more positively and precisely, both qualitative and quantitative parsimony apply to space, time, and possibility. All other things equal, we ought to prefer a hypothesis that postulates less space. Smaller is better. Admittedly, scientists are ambivalent about economizing on the void. They praise simplicity. Yet astronomers have a history of helping themselves to as (...) much empty space as they wish—staggering common sense with the vastness of the universe. This largesse is abetted by an aesthetic bias for sublime hypotheses. Whereas abductions based on beauty converge with parsimony, abductions based on the sublime diverge from parsimony. Awe stifles our inner accountant. Both types of abduction are popular. Both are dubious because we lack independent assurance that the universe is beautiful or sublime. The analogy between space and time supports an extension of parsimony to time. Uniformitarian geologists regarded time as a free resource. However, geologists and cosmologists must justify their postulation of an immense past. Possibility follows suit. Contrary to David Lewis, possible worlds should be minimized. Parsimony about possibilities provides a rationale for parsimony about absences. Absences are possibilities that are not actual. So proliferation of absences entails proliferation of possibilities. We should admit only those absences which do explanatory work. (shrink)

Bumped from a flight? Relax with this defense of the big business practice of deliberately promising more services than one will provide. On a small scale, over‐promising yields a toxic moral dilemma and a lie. At a large scale, the dilemma becomes dilute, and the lie completely disappears. Overbooking is honest because there is a sufficiently high probability of fulfilling each promise. Overbooking is socially beneficial because the promised resources are used more efficiently. There are fewer wasted seats on jumbo (...) jets and hence cheaper tickets with less pollution. Widespread disapproval of overbooking is a fallacious scaling error. Instead of there being too much overbooking, there is too little. (shrink)

Since 1970, a United States prosecutor can prove perjury without specifying which statement is perjurious. A bold prosecutor could concede ignorance of which statement is false. A bolder prosecutor could further concede that the witness himself does not know. The boldest prosecutor could concede there is no specific lie. Instead of there being a statement that is intrinsically perjurious, the perjury is relational. Just as two statements can be inconsistent without either being inconsistent, two statements can be perjurious without either (...) being perjurious. These consequences are reconciled with the generalisation that all perjury involves lying. Corollaries about culpability are drawn from the phenomenon of nonspecific perjury. The reasoning is generalised to other forms of illegal lying. (shrink)

If you read this abstract, then you will understand what my essay is about. Under what conditions would the preceding assertion be a lie? Traditional definitions of lying are always applied to straight declaratives such as ‘The dog ate my homework’. This one sided diet of examples leaves us unprepared for sentences in which conditional probability governs assertibility. The truth-value of conditionals does not play a significant role in the sincere assertion of conditionals. Lying is insincere assertion. So the connection (...) between lying and falsehood is broken when lying with conditionals. Drawing on Frank Jackson's account of indicative conditionals. I argue that it is possible to lie with true conditionals by virtue of their false conventional implicatures. False conversational implicatures only guarantee misleading assertions, not lies. Lying remains a semantic rather than a pragmatic affair. (shrink)

For most of his career, Kant accepts Augustine's requirement that lying requires an intention to deceive. However, he eventually converts to Aquinas, following him in rejecting this requirement in favor of Aristotle's teleological conception of lying. This change of view amounts to an improvement, for it makes room for the possibility of lying to an omniscient being—and such lies, we argue, are indeed possible. We accompany these historical and philosophical theses with a biographical thesis taking the form of the following (...) story. Kant believed that in his youth he had lied to God, largely because of his religious training. He adopted policies designed to help him resist the habit of lying to God. However, this program conflicted with his desire to lead a well‐rounded life as a public intellectual. This worldly ambition led him to forego the Quaker solution to the problem of lying to God: refuse to swear any oath to God, avoid set prayers and hymns, decline offers of intercession by clergy. Kant's worldly compromise served him well, but as he entered his twilight years, he came to worry that his only surviving argument for theism—the moral argument—might constitute a relapse into the vice of lying to God. (shrink)

This paper is devoted to a solution to Moore's problem. After explaining what Moore's problem is and after considering the main approaches toward solving the problem, I provide a definition of Moorean sentences in terms of pure Moorean propositions. My solution to Moore's problem essentially involves a description of how one can contradict oneself without uttering a contradiction, and a set of definitions that exactly determines which sentences are Moorean and which are close relatives of Moorean sentences.