Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis which has infected one third of the mankind and causes 2–3 million deaths worldwide each year. The persistence of the infection ensues from the ability of M. tuberculosis to subvert host immune responses in favor of survival and growth of mycobacteria in macrophages. The mechanisms by which M. tuberculosis manipulates the host immune system have only recently come to light. These activities are attributed to lipoarabinomannans (LAM) and their precursors lipomannans (LM), (...) two predominant glycolipids of M. tuberculosis cell wall. LM are able to skew anti‐mycobacterial immune responses into un‐protective ones, while LAM evoke immunosupression upon binding to macrophage and dendritic cell receptors specialized in binding to “self” host components. A newly emerging idea implicates plasma membrane rafts in LM and LAM signaling. Depending on acylation patterns, the glycolipids may either directly incorporate into the raft membrane via mannosylphosphatidylinositol anchors or interact with raft‐associated proteins to affect the assembly of receptor signaling complexes. BioEssays 30:943–954, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Appealing to imagination for modal justification is very common. But not everyone thinks that all imaginings provide modal justification. Recently, Gregory and Kung :620–663, 2010) have independently argued that, whereas imaginings with sensory imageries can justify modal beliefs, those without sensory imageries don’t because of such imaginings’ extreme liberty. In this essay, I defend the general modal epistemological relevance of imagining. I argue, first, that when the objections that target the liberal nature of non-sensory imaginings are adequately developed, those objections (...) also threaten the sensory imaginings. So, if we think that non-sensory imaginings are too liberal for modal justification, we should say the same about sensory imaginings. I’ll finish my defense by showing that, when it comes to deciding between saying that all imaginings are prima facie justificatory and saying that no imaginings are justificatory, there is an independent reason for accepting the former. (shrink)

"The importance of questions is beyond doubt. But the degree of attention paid to them in logic and linguistics is still less than they deserve." What is a question? How to represent questions in formal languages? How to model reasoning in which questions are involved? Can we prove anything by means of pure questioning? How to model goal-directed problem solving? These are the main issues of Andrzej Wi niewski's "Questions, Inferences, and Scenarios." This book offers a state-of-the-art exposition of (...) Inferential Erotetic Logic, that is, an approach to the logic of questions focused on inferences which lead to questions as conclusions. Wi niewski characterizes semantic relations which determine validity of these inferences within the framework of Minimal Erotetic Semantics, applicable to a wide range of formal languages. He elaborates in detail the concept of erotetic search scenario, a tool for modelling problem solving. Moreover, the author presents some applications of Inferential Erotetic Logic in proof theory. Andrzej Wi niewski is one of the most prominent contemporary researchers in the logic of questions. Currently, he is a full professor at the Department of Logic and Cognitive Science, Institute of Psychology, Adam Mickiewicz University in Pozna, Poland. (shrink)

This article discusses the peculiar features of quantum entanglement and quantum non-locality within the algebraic approach to relativistic quantum field theory (RQFT). The debate on the ontology of RQFT is considered in the light of these well-known but little discussed features. In particular, this article examines the ontic structural realist understanding of quantum entanglement and quantum non-locality and its contribution to this debate.

The formalist point of view maintains that formal derivations underlying proofs, although usually not carried out in practice, contribute to the confidence in mathematical theorems. Opposing this opinion, the main claim of the present paper is that such a gain of confidence obtained from any link between proofs and formal derivations is, even in principle, impossible in the present state of knowledge. Our argument is based on considerations concerning length of formal derivations. Thanks to Jody Azzouni for enlightening discussions concerning (...) the subject of this paper and to anonymous referees whose important remarks permitted us to correct the arguments and improve presentation. The remaining flaws remain, of course, solely the responsibility of the author. This research was partially supported by NSERC discovery grant and by the Research Chair in Distributed Computing at the Université du Québec en Outaouais. CiteULike Connotea Del.icio.us What's this? (shrink)

Musik stellt heute soziale Beziehungen her, die kein Eigentum mehr verlangen. Aber sie kann trotzdem nicht systemunabhängig agieren, ohne selbst Teil einer kapitalen Verwertungslogik zu sein. Dieser unauflösbare Konflikt ist die Basslinie für einen Mix, den Andrzej Steinbach und Achim Szepanski in Ultrablack of Music: Feindliche Übernahme vorlegen. Steinbach montiert drei unterschiedliche Texte: Eine TV-Talkshow als Kammerspiel, eine Namensliste aller RAF-Mitglieder in Form einer Partitur und einen Computercode einer zerhackten McKinsey Werbung. 1971 hatte der WDR die Sendung "Ende offen: (...) Pop und Co - die andere Musik zwischen Protest und Kommerz!" ausgestrahlt, bei der Nikel Pallat, Mitglied der Band Ton Steine Scherben, eine Axt unter seiner Jacke hervorholte und mehrmals mit voller Kraft auf den Tisch einschlug. Er ging dabei nicht kaputt, aber die Geste war unmissverständlich. (shrink)

The global seafood industry is a vital source of food, income, livelihoods, and culture. Seafood demand is steadily rising due to growth in the global human population, affluence, and per capita consumption. Seafood supply is also growing, despite declining wild fish stocks, with phenomenal advances in aquaculture, that is, the cultivation of aquatic organisms. Aquaculture supplied 42 % of the world’s fish in 2012 and is forecast to eclipse capture fisheries production by 2030. The balance between these two seafood production (...) systems has profound implications for global food security, income distribution, and ecological sustainability. Here, a qualitative analysis of the ethics and sustainability of capture fisheries and aquaculture is presented. An innovative practical ethics approach is introduced which adapts the ethical matrix, a conceptual tool for analyzing the wellbeing, autonomy, and justice of different interest groups, and Rapfish, a rapid appraisal technique used to evaluate the sustainability of fisheries along six performance modalities, including ethics. Using case studies of global large- and small-scale capture fisheries and generalized carnivorous and omnivorous aquaculture systems, I show that human institutions and social actors interact in complex governance processes to influence seafood ethics and sustainability. (shrink)

This paper analyses the ethical performance of foreign-investment enterprises operating in China in comparison to that of the indigenous state-owned enterprises, collectives and private enterprises. It uses both the deontological approach and the utilitarian approach in conceptualization, and applies quantitative and econometric techniques to ethical evaluations of empirical evidences. It shows that according to various ethical performance indicators, foreign-investment enterprises have fared well in comparison with local firms. This paper also tries to unravel the effect of a difference in business (...) culture and competitive market forces on ethical performance by comparing the behavior of foreign-investment enterprises with that of the indigenous state-owned enterprises and collectives on the one hand, and with that of the indigenous private enterprises on the other. (shrink)

This is the first, out of two papers, in which we identify all logics between C1 and S5 having the same theses without iterated modalities. All these logics canbe divided into certain groups. Each such group depends only on which of thefollowing formulas are theses of all logics from this group:,,, ⌜∨ ☐q⌝,and for any n > 0 a formula ⌜ ∨ ⌝, where has not the atom ‘q’, and and have no common atom. We generalize Pollack’s result from [12],where (...) he proved that all modal logics between S1 and S5 have the same theseswhich does not involve iterated modalities. (shrink)

This is the second, out of two papers, in which we identify all logics between C1 and S5 having the same theses without iterated modalities. All these logics can be divided into certain groups. Each such group depends only on which of the following formulas are theses of all logics from this group:,,, ⌜∨☐q⌝, and for any n > 0 a formula ⌜ ∨ ⌝, where has not the atom ‘q’, and and have no common atom. We generalize Pollack’s result (...) from [1], where he proved that all modal logics between S1 and S5 have the same theses which does not involve iterated modalities. (shrink)

In this paper we show that some standard topological constructions may be fruitfully used in the theory of closure spaces (see [5], [4]). These possibilities are exemplified by the classical theorem on the universality of the Alexandroff's cube for T 0-closure spaces. It turns out that the closure space of all filters in the lattice of all subsets forms a generalized Alexandroff's cube that is universal for T 0-closure spaces. By this theorem we obtain the following characterization of the consequence (...) operator of the classical logic: If is a countable set and C: P() P() is a closure operator on X, then C satisfies the compactness theorem iff the closure space ,C is homeomorphically embeddable in the closure space of the consequence operator of the classical logic.We also prove that for every closure space X with a countable base such that the cardinality of X is not greater than 2 there exists a subset X of irrationals and a subset X of the Cantor's set such that X is both a continuous image of X and a continuous image of X. (shrink)

This book presents the theory of the validity of legal norms, aimed at the practice of law, in particular the jurisdiction of the constitutional courts. The postpositivist concept of the validity of statutory law, grounded on a critical analysis of the basic theories of legal validity elaborated up to now, is introduced. In the first part of the book a contemporary German nonpositivist conception of law developed by Ralf Dreier and Robert Alexy is analysed in order to answer the question (...) whether the juristic concept of legal validity should include moral standards or criteria. In the second part, a postpositivist concept of legal validity and an innovative model of validity discourse, based on the juristic presumption of the validity of legal norms, are proposed. The book is a work on analytical legal theory, written from a postpositivist, detached point of view. (shrink)

Visages de l'histoire. Essais de l'entour de la méthodologie et d'histoire de l'historiographie.

Commentary by the translator on the publication of HLA Hart, ‘The New Challenge to Legal Positivism ’ 36 Oxford Journal of Legal Studies 459.

The practice of giving the wealthy perpetual control of their assets is re-emerging in an era of great wealth inequality, long after it had been banned in common law countries. The philosophical justification for such control rests on the claim that there are posthumous rights to wealth, and that such rights do not extend in problematic way to other goods, such as political suffrage. On the basis of such a claim, we give people freedom of testation, and deem them vulnerable (...) to posthumous harm. I present a short history of legally sanctioned posthumous control of property in common law, and I argue that its philosophical justification is untenable. No principled case for posthumous rights to wealth survives scrutiny, and the large and powerful institutions that enforce such rights are morally illegitimate. (shrink)

The article attempts to characterize three key doctrinal controversies in the Carolingian Renaissance, namely: the disputes over the Eucharist, the so-called trina deitas, and predestination. The core of the article is an exposition of the controversy concerning predestination, whose main protagonist is Gottschalk of Orbais. The article discusses four crucial issues related to the problem: (i) the concept of God, (ii) the understanding of grace, nature and free will, (iii) the relation of foreknowledge to predestination, and (iv) the doctrine of (...) redemption, i.e., specifically the relationship betweenjustice and mercy. The article is largely an attempt at an interpretation of the texts of the epoch, mainly those of Gottschalk of Orbais and his adversary, Hincmar of Reims. The conclusions point to difficulties in the issues discussed and outline what attempts at solving this problem have taken place in the coming centuries. (shrink)

The author reflects on the Warsaw Uprising and its effects on his contemporaries and subsequent generations. The Uprising has evoked conflicting emotions, the hottest debates whether it was justified in light of the ensuing losses and the destruction of Warsaw. A frequently-asked question is whether it was worth sacrificing so many people for an obviously lost cause.The Warsaw Uprising also functions as a national legend of selflessness, sacrifice, solidarity, and courage, its protagonists displaying uncommon determination and perseverence in their struggle (...) to free their country. A legend which successive generations of Poles have kept alive despite the years that have elapsed. (shrink)

D. Scott in his paper [5] on the mathematical models for the Church-Curry -calculus proved the following theorem.A topological space X. is an absolute extensor for the category of all topological spaces iff a contraction of X. is a topological space of Scott's open sets in a continuous lattice.

Union security has long been an industrial relations controversy. While compulsory unionism supporters say it benefits the working class, right-to-work advocates denounce it as an unethical infringement of individual rights and freedom. Unfortunately, neither side has adequately addressed the shortcomings of their viewpoint, nor the broader worker concerns about effective representation beyond just "unionism". In this paper, we examine the ethical and practical problems of compulsory and voluntary unionism and propose a new resolution, compulsory proportional representation, that has the advantages (...) of: ensuring workers' freedom to associate or not associate, promoting freedom to contract, allowing free competition in representation in line with anti-trust principles, improving industrial peace and efficiency, enhancing fairness and social justice, and addressing the employer-employee power imbalance. It is superior to either voluntary unionism, which often lead to management unilateralism, or compulsory unionism, where workers are compelled to join unions against their will. (shrink)

Earth system science (ESS) and modelling have given rise to a new conceptual framework in the recent decades, which goes much beyond climate science. Indeed, Earth system science and modelling have the ambition “to build a unified understanding of the Earth”, involving not only the physical Earth system components (atmosphere, cryosphere, land, ocean, lithosphere) but also all the relevant human and social processes interacting with them. This unified understanding that ESS aims to achieve raises a number of epistemological issues about (...) interdisciplinarity. We argue that the interdisciplinary relations in ESS between natural and social / human sciences are best characterized in terms of what is called ‘scientific imperialism’ in the literature and we show that this imperialistic feature has some detrimental epistemic and non-epistemic effects, notably when addressing the issue of values in ESS. This paper considers in particular the core ESS concepts of Anthropocene, planetary boundaries and tipping points in the light of the philosophy of science discussions on interdisciplinarity and values. We show that acknowledging the interconnections between interdisciplinarity and values suggests ways for ESS to move forward in view of addressing the climate and environmental challenges. (shrink)

Quantum gravity’s suggestion that spacetime may be emergent and so only exist contingently would force a radical reconception of extant analyses of laws of nature. Humeanism presupposes a spatiotemporal mosaic of particular matters of fact on which laws supervene; primitivism and dispositionalism conceive of the action of primitive laws or of dispositions as a process of ‘nomic production’ unfolding over time. We show how the Humean supervenience basis of non-modal facts and primitivist or dispositionalist accounts of nomic production can be (...) reconceived, avoiding a reliance on fundamental spacetime. However, it is unclear that naturalistic forms of Humeanism can maintain their commitment to there being no necessary connections among distinct entities. Furthermore, non-temporal conceptions of production render this central concept more elusive than before. In fact, the challenges run so deep that the survival of the investigated analyses into the era of quantum gravity is questionable. (shrink)

National healthcare systems in all countries do not act effectively. Therefore, especially strategies for introducing organizational innovation to public organization should be considered. The problem is how to organize the research in this field. One of the generally accepted solutions is the systemic approach to healthcare systems. In this paper multiagent systems theory and autonomous systems theory are applied to the analysis of main types of healthcare systems. Such analysis allows us to consider the system properties: the level of the (...) autonomy, energy dissipation in the system, the payoff specificity, functional role of the agents in the system, the level of the agents’ cooperation, and delays in flows of money, requests, rules, and controls. As a result, some new functionalities of the healthcare system on the national level have been found and analysed. The aforementioned parameters are good tools to analyse the system functionality. (shrink)

In this paper, we want to present the genesis of Stanisław Leśniewski’s mereology. Although ‘mereology’ comes from theword ‘part’, mereology arose as a theory of collective classes. That is why we present the differences between the concepts of being a distributive class and being a collective class. Next, we present Leśniewski’s original mereology from 1927, but with a modern approach. Leśniewski was inspired to create his concept of classes and their elements by Russell’s antinomy. To face it, Leśniewski had to (...) define the concept of being an element of based on the concept of being part of. Leśniewski showed that in his theory, there is no equivalent to Russell’s antinomy. We will show that his solution has nothing to do with the original approach because, in both cases, we are talking about objects of a different kind. Russell’s original antinomy concerned distributive classes, and Leśsniewski’s considerations concerned collective classes. (shrink)

We give an idea of uniform approach to the problem of characterization of absolute extensors for categories of topological spaces [21], closure spaces [15], Boolean algebras [22], and distributive lattices [4]. In this characterization we use the notion of retract of the closure space of filters in the lattice of all subsets.

The Philosophy of Hermann Cohen: An Attempt to SystematizeThe article adressess the problem of evolution of Hermann Cohen’s thinking. In the first part, the evolution is shown in the historical-problematic context and the main idea is to show the basic concepts organizing the author’s most important books. Part two is an attempt to capture the motives of his understanding of philosophy and the central concept is the logic of validity Geltungslogik. As a result it is shown that throughout his whole (...) life Cohen struggled with the problem of such an understanding of philosophy. (shrink)

We will present an elementary theory in which we can speak of mereological sets composed of distributive classes. Besides the concept of a distributive class and the membership relation , it will possess the notion of a mereological set and the relation of being a mereological part. In this theory we will interpret Morse’s elementary set theory (cf. Morse [11]). We will show that our theory has a model, if only Morse’s theory has one.

In introductory logic courses the authors often limit their considerations to the truth-value operators. Then they write that conditionals and biconditionals of natural language ("if" and "if and only if") may be represented as material implications and equivalences ("⊃" and "≡"), respectively. Yet material implications are not suitable for conditionals. Lewis' strict implications are much better for this purpose. Similarly, strict equivalences are better for representing biconditionals (than material equivalences). In this paper we prove that the methods from standard first (...) courses in logic can be used for testing arguments with strict implications, strict equivalences and other operators which may represent connectives from natural language. (shrink)

The protagonist of Thomas Mann’s short story "The Clown" cannot became an artist because he hasn’t got enough talent. He is also unable to live among people as an ordinary citizen because his social competencies haven’t been completely developed. That is why he can be regarded as a literary figure who tries to leave the real world and to penetrate the literary world. The devil who appears in Charles Gounod’s opera "Faust" based on Johann Wolfgang Goethe’s drama "Faust" and who (...) is watching the protagonist from the stage during the opera performance seems to be the only person who can help him to find his existential space. (shrink)

In the vast literature on architectural theory and practice, the ways in which architectural knowledge is actually taught, debated, and understood are too often ignored. The essays collected in this groundbreaking volume address the current state of architecture as an academic and professional discipline. The issues considered range from the form and content of architectural education to the architect's social and environmental obligations and the emergence of a new generation of architects. Often critical of the current paradigm, these essays offer (...) a provocative challenge to accepted assumptions about the production, dissemination, and reception of architectural knowledge. Contributors: Sherry Ahrentzen, U of Wisconsin-Milwaukee; Stanford Anderson, MIT; Carol Burns, Harvard U; Russell Ellis, UC Berkeley; Thomas Fisher, U of Minnesota; Linda Groat, U of Michigan; Kay Bea Jones, Ohio State U; David Leatherbarrow, U of Pennsylvania; A. G. Krishna Menon, TVB School of Habitat Studies, India; Garth Rockcastle, U of Minnesota; Michael Stanton, American U, Beirut; Sharon E. Sutton, U of Washington; David J. T. Vanderburgh, Université Catholique de Louvain, Belgium; and Donald Watson, Rensselaer Polytechnic Institute. (shrink)

The current system of international law is experiencing profound transformations. Indeed, the simultaneous processes of globalization combined with the disintegration of international systems of governance and law-making pose complex challenges for legal scholarship. The doctrinal response to these challenges has been theorized within two seemingly contradictory discourses in international law: fragmentation and constitutionalisation. This book takes an innovative approach to international law, viewing the processes of the fragmentation and constitutionalisation as being profoundly interconnected and reflective of each other. It brings (...) together a select group of contributors, including both established and emerging scholars and practitioners, in order to explore the ways in which the problems of fragmentation and constitutionalisation are viscerally linked one to the other and thus mutually conditioning and stimulating. The book considers the theory and practice of international law looking at the two phenomena in relation to the various fields of international law such as international criminal law, cultural heritage law and international environmental law. (shrink)

For a complete Heyting lattice , we define a category Etale (). We show that the category Etale () is equivalent to the category of the sheaves over , Sh(), hence also with -valued sets, see [2], [1]. The category Etale() is a generalization of the category Etale (X), see [1], where X is a topological space.

Karl Popper’s falsificationist epistemology that all knowledge advances through a process of conjectures and refutations carries profound implications for politics and education. In this article, I first argue that, on a political level, it is necessary to establish and maintain an open society by fostering not only five core values, viz. freedom, tolerance, respect, rationalism, and equalitarianism, but also three crucial practices, viz. democracy, state interventionism, and piecemeal social engineering. Then, considering that an open society places great political, and thus (...) educational, demands upon its members, I examine the role played by education in its establishment and maintenance, focusing on its educational aims, curriculum, and pedagogy. (shrink)

There have been major developments in the understanding of children’s nonhuman concepts, particularly God concepts, within the past two decades, with a body of cross-cultural studies accumulating. Relatively less research has studied those of non-Christian faiths or children’s concepts of popular occult characters. This paper describes two studies, one in Spain and one in England, examining 5- to 10-year-olds’ human and nonhuman agent beliefs. Both settings were secular, but the latter comprised a Muslim majority. Children were given a false-belief task (...) in which they were asked to infer about three humans, three animals and three supernatural beings. Similar false beliefs about humans, with subtle differences in inferences about animals and supernatural beings, were found between the two locations. In London different patterns for God between participants with a family religion, in particular Muslims, and non-affiliates, were identified as well as an association between religious beliefs and practice and inferences about God. Findings are discussed in the light of theory and research on the role of sociocultural inputs in children’s theory of mind development and understanding of agency. (shrink)