The osmotic activity produced by internal, non‐permeable, anionic nucleic acids and metabolites causes a persistent and life‐threatening cell swelling, or cellular edema, produced by the Gibbs‐Donnan effect. This evolutionary‐critical osmotic challenge must have been resolved by LUCA or its ancestors, but we lack a cell‐physiology look into the biophysical constraints to the solutions. Like mycoplasma, early cells conceivably preserved their volume with Cl−, Na+, and K+‐channels, Na+/H+‐exchangers, and a light‐dependent bacteriorhodopsin‐like H+‐pump. Here, I simulated protocells having these ionic‐permeabilities and inhabiting (...) an oceanic pond before the Great‐Oxygenation‐Event. Protocells showed better volume control and stable resting potentials at lower external pH and higher temperatures, favoring a certain type of extremophile life. Prevention of Na+‐influx at night, with low bacteriorhodopsin activity, required deep shutdown of highly voltage‐sensitive Na+‐channels and extremely selective K+‐channels, two conserved features essential for modern neuronal encoding. The Gibbs‐Donnan effect universality implies that extraterrestrial cells, if they exist, may reveal similar volume‐controlling mechanisms. (shrink)

In this sequel to Healing Civilization, Dr. Naranjo addresses the cultural and ecological crisis of the 21st Century. He reviews a number of theories and approaches to bettering society and advocates, in particular, the innovation of making the educational system more ethically and spiritually directed--more inner directed than devoted to sustaining current economic or cultural models for society. Naranjo examines the relationship between past historical eras and cultural progress and the growth and development of the individual child from (...) infancy to maturity and old age. While sober in tone regarding these various global crises, the author maintains an optimistic view based on the continuing spiritual development of humanity. (shrink)

Inception module is one of the most used variants in convolutional neural networks. It has a large portfolio of success cases in computer vision. In the past years, diverse inception flavours, differing in the number of branches, the size and the number of the kernels, have appeared in the scientific literature. They are proposed based on the expertise of the practitioners without any optimization process. In this work, an implementation of population-based incremental learning is proposed for automatic optimization of the (...) hyperparameters of the inception module. This hyperparameters optimization undertakes classification of the MNIST database of handwritten digit images. This problem is widely used as a benchmark in classification, and therefore, the learned best configurations for the Inception module will be of wide use in the deep learning community. In order to reduce the carbon footprint of the optimization process, policies for reducing the redundant evaluations have been undertaken. As a consequence of this work, an evaluation of configurations of the inception module and a mechanism for optimizing hyperparameters in deep learning architectures are stated. (shrink)

Neste ensaio, gostaria de esclarecer, por meio da filosofia de Mayz Vallenilla, a estreita relação que existe entre técnica e alienação, como uma filosofia da técnica que se preocupa com o comportamento do homem, portanto, com sua alienação. Como resultado, este ensaio será dividido em três partes: na primeira seção, será desenvolvido um diálogo entre um historiador e um sociólogo, para construir uma breve história da técnica; na segunda seção apresentarei um diálogo sobre o conceito de alienação entre Marx e (...) Heidegger a partir do pensamento do filósofo venezuelano Mayz Vallenilla e na última seção apresentarei a conexão entre ética e meta-técnica como alternativa atraente à alienação técnica. (shrink)

Colombia padece la imagen de que, desde sus inicios como colonia española hasta el presente, el país ha sido controlado por la oligarquía. Este ensayo examinará las evidencias que apuntan a esta alegación y confirmará que en sus inicios la Nación sí fue dominado por un grupo élite y reducido. Sin embargo, en años modernos, la oligarquía persiste pero que un grupo más extendido--una para-oligarquía o el Establecimiento--tiene mayor incidencia en las determinaciones en el progreso del país a través de (...) los factores psico-sociales de cooptación y transfuguismo. (shrink)

Pese a que Gibbon sigue siendo ampliamente reconocido como un historiador excepcional, además de como un escritor magnífico, pocos historiadores de la Antigüedad tardía comparten hoy el paradigma interpretativo del _decline and fall _del Imperio romano. Autores como Peter Brown y Henri-Irenée Marrou combatieron con éxito el “prejuicio decadentista” a la hora de abordar el estudio de la Antigüedad tardía. Si tuviéramos que resumir en un solo término el paradigma interpretativo predominante en nuestros días en el estudio de este período, (...) este sería el de “continuidad”: continuidad (en los niveles administrativo, jurídico, cultural, etc.) entre los reinos post-imperiales del Occidente latino y el precedente imperial y continuidad también entre la cultura cristiana (cultura popular y cultura de los Padres de la Iglesia) y la cultura grecorromana. (shrink)

Unlike many dominant images of thought that are centered on searching for foundations whose coherence is found in binary logics or biunivocal relations, Gilles Deleuze and Félix Guattari’s philosophy constitutes a way of thinking through machines that produce pure multiplicities by virtue of intensive differences. What is important with regards to machines is to refrain from any attempt at defining or understanding them—they cannot be delimited and are a-signifying—and to try to make them work, such that various flows of thought (...) may circulate through them, intermingling with and interrupting each other. Even though any machine groups together many heterogeneous elements, literary machines are interesting insofar as they can reach a level of the fragmentary whereby the determinant potency of intensive differences can be expressed. This article experiments with Maurice Blanchot’s literary machine—especially with his idea of the neuter—to discover operations that could help to dismantle the foundations of dominant images of thought. (shrink)

The first clear and precise statement of the axioms of qualitative probability was given by de Finetti ([1], Section 13). A more detailed treatment, based however on more complex axioms for conditional qualitative probability, was given later by Koopman [5]. De Finetti and Koopman derived a probability measure from a qualitative probability under the assumption that, for any integer n, there are n mutually exclusive, equally probable events. L. J. Savage [6] has shown that this strong assumption is unnecessary. More (...) precisely, he proves that if a qualitative probability is only fine and tight, then there is one and only one probability measure compatible with it. No property equivalent to countable additivity has been used as yet in the development of qualitative probability theory. However, since the concept of countable additivity is of such fundamental importance in measure theory, it is to be expected that an equivalent property would be of interest in qualitative probability theory, and that in particular it would simplify the proof of the existence of compatible probability measures. Such a property is introduced in this paper, under the name of monotone continuity. It is shown that, if a qualitative probability is atomless and monotonely continuous, then there is one and only one probability measure compatible with it, and this probability measure is countably additive. It is also proved that any fine and tight qualitative probability can be extended to a monotonely continuous qualitative probability, and therefore, contrary to what might be expected, there is no loss in generality if we consider only qualitative probabilities which are monotonely continuous. At the present time there is still a controversy over the interpretation which should be given to the word probability in the scientific and technical literature. Although the present writer subscribes to the opinion that this interpretation may be different in different contexts, in this paper we do not enter into this controversy. We simply remark that a qualitative probability, as a numerical one, may be interpreted either as an objective or as a subjective probability, and therefore the following axiomatic theory is compatible with both interpretations of probability. (shrink)

RESUMEN El objeto de este trabajo es, por un lado, recopilar los principales estudios teóricos y filosóficos que han servido para diferenciar entre reglas regulativas y reglas constitutivas y, por otro, realizar una revisión de dichas propuestas para efectos de cuestionar la posibilidad de una distinción tajante entre ambos tipos de reglas. La primera parte del texto corresponde a una exposición de los postulados de los autores enunciados. En seguida, se formulan cuestionamientos a los criterios que se advierten en el (...) apartado precedente. Finalmente, se expone la viabilidad de una distinción concluyente entre ambos tipos de reglas. ABSTRACT The aim of this article is, on the one hand, to compile the main theoretical and philosophical studies that has been used to differentiate between regulative norms and constitutive norms, and on the other hand, to make a review of these proposals to question the possibility of a sharp distinction between both types of rules. The first part of this work is an exposition of the postulates of the mentioned authors. The second part of the text introduces questions against the criteria noted in the previous section. Finally, the feasibility of a conclusive distinction between both types of rules is exposed. (shrink)

Dominant development discourse and policy are based on crucial misconceptions about peasants and their livelihoods. Peasants are viewed as inherently poor and hungry and their farming systems are considered inefficient, of low productivity, and sometimes even environmentally degrading. Consequently, dominant development policies have tried to transform peasants into something else: industrialised commercial farmers, wage labourers, urban workers, etc. This article seeks to deconstruct three key misconceptions about peasants by explaining how and why marginalised peasants around the world face poverty and (...) hunger. An explanation of the process of marginalisation of peasants through the influence of five “mediating factors” is put forward. It is contended that by addressing the mediating factors through policies devised with the active participation of peasants, the marginalisation of peasants would be reduced or eliminated. This would allow peasants to forge an adequate livelihood in rural areas based on their independent farming, and thereby contribute to the achievement of food sovereignty. (shrink)

A number of biologists and philosophers have noted the diversity of interpretations of evolvability in contemporary evolutionary research. Different clusters of research defined by co-citation patterns or shared methodological orientation sometimes concentrate on distinct conceptions of evolvability. We examine five different activities where the notion of evolvability plays conceptual roles in evolutionary biological investigation: setting a research agenda, characterization, explanation, prediction, and control. Our analysis of representative examples demonstrates how different conceptual roles of evolvability are quasi-independent and yet exhibit important (...) relationships across scientific activities. It also provides us with the resources to detail two distinct strategies for how evolvability can help to synthesize disparate areas of research and thereby potentially serve as a unifying concept in evolutionary biology. (shrink)

We present a new metaphysical framework for physics that is conceptually clear, ontologically parsimonious, and empirically adequate. This framework relies on the notion of self-subsisting structure, that is, a set of fundamental physical elements whose individuation and behavior are described in purely relational terms, without any need for a background spacetime. Although the specification of the fundamental elements of the ontology depends on the particular physical domain considered---and is thus susceptible to scientific progress---, the empirically successful structural features of the (...) framework are preserved through theory change. The kinematics and dynamics of these self-subsisting structures are technically implemented using the theoretical framework of Pure Shape Dynamics, which provides a completely relational physical description of a system in terms of the intrinsic geometry of a suitably defined space called shape space. (shrink)

Well known as a mystic, Catherine of Siena has been credited with pope Gregory XI’s return to Rome from Avignon, with convincing him to pursue a crusade and with playing a major role in making peace between the Papal League and Italian City states. This narrative ascribes these accomplishments to Catherine’s extraordinary gifts, a fruit of her mystical experience. Contemporary historical research, however, shows that Catherine was chosen by ecclesiastical authorities to advocate for papal policies. She was guided to causes (...) and policies she should pursue, which were already determined by the pope and his advisors. In light of this historical research and from the perspective of Christian spirituality studies, I examined Catherine’s letters to pope Gregory XI to analyse and interpret her spirituality of political engagement. Her multiple authoritative exhortations to Gregory XI telling him how her wisdom applied to the choices before him can be read as a spirituality of papal governance and as ‘formation’ for his critical leadership of the church. By means of this article I have shown that Catherine’s advice was intended for the salvation and transformation of others and for the good of the church so that it might best mediate salvation. This goal was her interpretation of the mission entrusted to her through her spiritual advisor. Her own spirituality in daring to forcefully ‘form’ the pope and in espousing papal causes by preaching her creative integration of Gospel wisdom was witness to an unselfconscious courage and utter trust in God acting through her; a fruit of her own profound journey of transformation.Contribution: This article offers a new interpretation of Catherine of Siena’s engagement in papal politics and related spirituality. Catherine was chosen for this task by ecclesiastical authorities, then construed this mission as a call to ‘form’ the pope; thus, her letters to Gregory XI are interpreted as a spirituality of papal governance. (shrink)

This paper investigates how the introduction of AI to decision making increases moral distance and recommends the ethics of care to augment the ethical examination of AI decision making. With AI decision making, face-to-face interactions are minimized, and decisions are part of a more opaque process that humans do not always understand. Within decision-making research, the concept of moral distance is used to explain why individuals behave unethically towards those who are not seen. Moral distance abstracts those who are impacted (...) by the decision and leads to less ethical decisions. The goal of this paper is to identify and analyze the moral distance created by AI through both proximity distance (in space, time, and culture) and bureaucratic distance (derived from hierarchy, complex processes, and principlism). We then propose the ethics of care as a moral framework to analyze the moral implications of AI. The ethics of care brings to the forefront circumstances and context, interdependence, and vulnerability in analyzing algorithmic decision making. (shrink)

La narrativa de José Saramago es centro de análisis reciente para todos aquel que incursionen en la literatura contemporánea. A través de La caverna, el escritor expone un sinnúmero de situaciones que deben ser reflexionadas y que en el presente artículo se abordan desde la perspectiva de los estudios culturales. Entre otros, se resalta el uso del lenguaje popular, la dialéctica entre lo rural y lo urbano, y finalmente la exclusión social y el consumismo. Este es, por lo tanto, un (...) estudio de análisis crítico de la obra La caverna de José Saramago, apoyado además en los trabajos interdisciplinarios que otros pensadores han ofrecido al respecto. El aporte desde los estudios culturales y la crítica realizada por Saramago no son ajenos a la preocupación por el ser, pues este se ve acorralado por las dinámicas que la sociedad impone. (shrink)

La mirada del envejecimiento, desde una visión de derechos, tiene como antecedente la Segunda Asamblea Mundial sobre Envejecimiento, de la cual se derivó el Plan Internacional de Acción en Envejecimiento de Madrid, que ha sido un documento clave de seguimiento en las reuniones regionales intergubernamentales y no gubernamentales sobre envejecimiento en la región latinoamericana. Adicionalmente, existen dos instrumentos claves a considerar en las políticas de envejecimiento de la región: el Consenso de Montevideo y la Convención Interamericana para la Protección de (...) los Derechos de las Personas Mayores. En todos estos documentos, se abordan las siguientes áreas prioritarias: la situación económica de las personas mayores; salud y bienestar; y entornos sociales y físicos favorables. En este artículo, se analiza cómo ha sido el tratamiento, en las distintas reuniones regionales, del tema de cuidados, el cual se inserta en el área sobre salud y bienestar, además de discutir cómo se han traducido los distintos señalamientos sobre cuidados en la normativa de México. (shrink)

Jose Marti contributed greatly to Cuba's struggle for independence from Spain with words as well as revolutionary action. Although he died before the formation of an independent republic, he has since been hailed as a heroic martyr inspiring Cuban republican traditions.

Condicionada por el modo económico de cada formación social, la pintura ha participado -y no en menor medida- de la adaptación; sus imágenes rectoras han dado cuerpo y forma a los engranajes ideológicos, y su valor funcional se ha reconducido a la mera relación fetichista; de esta manera, en el instante en que hay pintura, deja de haberla propiamente. Por otro lado, el arte tiene por condición autonomía y libertad, y en el artista no es decisiva la conciencia armónica, puesto (...) que carece de libertad, puesto que está en dialéctica con la realidad social, éste interviene en su transformación. El presente artículo intenta dar cuenta cómo la vida y la obra de John Singer Sargent remiten a dicha naturaleza antinómica, que nos hace recordar la idea y la realidad, de la propia libertad. Palabras clave: fetichismo, transformación, arte, artista, naturaleza. (shrink)

Evolutionary developmental biology (evo-devo) is often vindicated by theoreticians of the field as a mechanistic science that brings a mechanistic perspective into evolutionary biology. Usually, it is also portrayed as stressing the causal role that development plays in the evolutionary process. However, mechanistic studies in evo-devo typically refer to lineage-specific transformations and lack the generality that evolutionary explanations usually aim for. After reviewing the prospects and limits of a mechanistic view of evo-devo and their studies of homology and novelty, in (...) this chapter I propose a way to combine the mechanistic view of evo-devo with the population-level inclination of more classical approaches to evolution. Such a proposal provides a philosophical framework for understanding the causal role of development in evolution both as mechanistic and as generalizable, population-level. (shrink)

En este ensayo propongo una aproximación al contenido de Del arte de la guerra de Maquiavelo desde la pregunta por el enemigo: ¿quién es el enemigo en Del arte de la guerra? ¿Quién es el adversario del ejército que Maquiavelo busca organizar en el libro? Dentro de la literatura secundaria sobre el florentino identifico tres tipos de respuesta a esta pregunta, lo que llamo aquí tres diferentes manifestaciones del enemigo. Según estas lecturas, el enemigo de la milicia maquiaveliana es a) (...) el cristianismo, el modo de vida instituido por esta religión; b) lo imprevisible, los accidentes cuya ocurrencia no se puede anticipar, es decir, la fortuna, y c) los grandes, cuyo deseo es el de dominar al pueblo. (shrink)

La racionalidad crítica es una actitud que hay que desarrollar de manera preferencial en esta época signada por la incertidumbre. Un ejemplo de lo que ella significa lo encontramos en los filósofos presocráticos, en su modo de enfrentar y resolver problemas de orden epistemológico. Contraejemplos históricos lo representan los desarrollos de la filosofía socrática platónica y aristotélica. En la filosofía medieval, se puede ilustrar este mismo caso con lo que desarrollaron los seguidores principalmente de Santo Tomás. Está probado que la (...) lealtad a ultranza a una filosofía, una hipótesis, una idea, se constituye en un suicidio para el investigador o para el filósofo. Sólo la crítica razonable permite la escogencia de la mejor opción. La invitación por lo tanto es a ejercer esta actitud con responsabilidad, con la confianza en que por esta vía encontraremos las soluciones – provisionales – a los problemas que nos acotan. Pero es también una actitud que exige del compromiso serio de quien investiga: su ejercicio es la salvaguarda contra actitudes fanáticas e intolerantes. (shrink)

Building a civilization of love -- The practice of values in various settings -- The superiority complex of Filipino women -- The value of doing good business -- The value of living the virtues -- The virtues of icons, role models and personalities -- The value of spirituality -- Filipino values, yesterday, today and tomorrow.

En la vida cotidiana del ejercicio del derecho, ya sea en el campo de la judicatura, ora en el del litigio, bien sea en el de la academia, o en actividades administrativas, es bastante común que se hable de la prueba sumaria; pero desafortunadamente no es común que se tenga plena conciencia de su entidad, alcances y usos conforme a su propia naturaleza. Es preocupante observar la peligrosa y antijurídica ligereza, con la cual se acude a la prueba sumaria; pero (...) no para darle su natural uso, sino para superar omisiones de los sujetos procesales con interés de parte en el cumplimiento de las cargas probatorias. La prueba sumaria es utilizada en forma deliberada para conseguir ciertas ventajas probatorias en el proceso, con evidente desmedro del derecho de prueba de la contraparte, afectación de la garantía de la igualdad real de las partes en el proceso, y conculcación del derecho de defensa en toda su extensión. En realidad, el mal uso de la prueba sumaria implica violar los principios probatorios de necesidad, publicidad, contradicción, legalidad y formalidad de la prueba. En otros términos, la utilización indiscriminada de la prueba sumaria, sin el cuidado y la estrictez exigidos expresamente por el mismo legislador para poder usarla, constituye una manifiesta violación al derecho constitucional fundamental al debido proceso. (shrink)

I. Teoría del derecho.--II. Teoría del estado.

This study focuses on the influence of the quality of services received by thalassotherapy customers on their global satisfaction and the relationship between this and the word of mouth. This study uses a hybrid SEM—classification tree analysis. The empirical findings reveal a significant relationship between the quality of each offered service and global satisfaction. This study contributes to identify tourist’s satisfaction or delight on received thalasso services through a proposed methodology. The main contribution of this work consists of the proposal (...) of a methodology to identify objectively through the opinion of tourists if they were satisfied or had reached delight. This work demonstrates, confirming what has been found in previous literature, that global satisfaction is related to the different experiences provided by the service. Thus, all hypotheses are accepted, supporting the hypotheses that relate the pool, the staff, the treatments, and the environment to satisfaction. In addition, the hypotheses that link satisfaction with the word of mouth are also supported. This theoretical implication has important practical implications for managers of the type of facilities such as those studied in this paper, since it shows that it is not enough to do well in one of the services provided if the environment or the interaction with the staff is not right. (shrink)

El objetivo del presente artículo es fortalecer el aprendizaje y la calidad educativa en el trabajo colaborativo, evaluando estrategias didácticas y aplicando la estrategia de diseño de textos académicos en la licenciatura de Mercadotecnia, respondía a la cuestión ¿De qué manera la debilidad en el aprendizaje y baja calidad educativa en el trabajo colaborativo repercuten en las deficiencias de la aplicación de la estrategia didáctica del diseño de textos académicos? La investigación es de tipo mixto, la metodología de la Investigación–Acción. (...) El estudio dio resultados en el trabajo colaborativo porque ayudo a los alumnos a adquirir conocimientos. (shrink)

Autor podejmuje próbę skonstruowania syntaksy i semantyki języka tworzonego dla ujęcia dążeń wyrażonych przez J. Barwise'a i J. Perry'ego w ich dziele "Situations and Attitudes" (Cambridge, 1963). Idąc przy tym za sugestią van Benthema, przedstawia ten język jako typ języka znany z pragmatyki R. Montague. Istnieją już, jak wiadomo, próby takiego przekładu na struktury typu Montague (J. Bacon, 1968). Autor wyraża pogląd, że jego prezentacja, niewątpliwie uproszczona i odwołująca się także do idei zawartych implicite w tych dwu teoriach, nie prowadzi (...) jednak do wątpliwych wyborów interpretacyjnych. (shrink)

We extend the gap 1 cardinal transfer theorem → to any language of cardinality ≤λ, where λ is a regular cardinal. This transfer theorem has been proved by Chang under GCH for countable languages and by Silver in some cases for bigger languages . We assume the existence of a coarse -morass instead of GCH.

Este trabajo es un ejercicio de aproximación a la bildung de un personaje, Simón Rodríguez. La bildung de un extaño según nuestra mirada. Un ejercicio otro, distinto, al menos, sobre un venezolano, latinoamericano por antonomasia, un pensador cosmopolita; del cual se ha dicho que fue el filósofo (el Sócrates de Caracas y/o de América), un político, un educador. En él realizamos una suerte de hermenéutica del texto escrito, narrado, y de la acción contada por testigos oculares. La carta, la biografía, (...) el ensayo filosófico y pedagógico no sirvieron de pretextos para presentar a un Rodríguez, además del estraño, escritor. Finalmente, puede decirse, que se intenta contribuir, en alguna medida, con el estudio de la vida, del pensamiento y de la obra del así llamado, Don Simón Rodríguez. (shrink)

This paper applies philosophical tools from the causalists/statisticalists debate to the evo-devo idea of variational tendencies as propensities biasing phenotypic change. It contends that variational properties are present in a statistical sense in some population dynamics models, particularly quantitative genetics ones, providing ultimate variational explanations. It further argues that these properties, contrary to some recent views, cannot be subsumed under natural selection. Finally, it advocates for a causalist interpretation of these explanations, where variational statistical properties indirectly refer to evo-devo’s variational (...) propensities. (shrink)

The origin of Being as a live concept is one of the most difficult questions in history of metaphysics and ontology. This work analyses the postulate that being is constructed by the interaction of terms. In fact, being and the idea of Being has come from the possibility of relations. It is known that metaphysics and ontology has overestimated think Being like something that never change, a substance unchangeable. Reduce Being as ousía, translated as substance, does not understand central affirmation (...) of Aristotle that “The term “being” is used in various senses, but with reference to one central idea and one definite characteristic, and not as merely a common epithet.”. The usually interpretation of relations make them one of those ways, however the concept of Being is always under a relation. Is reconsidered the role of relations in the basis of ontological thinking, taking the renewal of metaphysics, of the French philosopher Jean Wahl, and postulating that Being as totality is the relation that involves beings, Change and Time. (shrink)

The paper considers how the logic of settler colonialism, the active and ongoing dispossession of Indigenous peoples, shapes scholarship on migration, race and citizenship in Canada. It draws on the insights of settler colonial theory and critiques of methodological nationalism to do so. The concept of differential inclusion and assemblages methodology are proposed as a way to understand the relationship between Indigeneity and migration in a settler colonial context. The paper develops this conceptual proposal through an analysis of a single (...) place over time: Scarborough, Ontario. Authors present portraits of Scarborough, Ontario, Canada to understand how migration and Indigenous sovereignty are narrated and regulated in convergent and divergent ways. Together, the portraits examine historical stories, media discourses, photography and map archives, fieldwork and interviews connected to Scarborough. They reveal how the differential inclusion of migrant, racialized and Indigenous peoples operates through processes of invisibilization and hypervisibilization, fixity and erasure, and memorialization. They also illustrate moments of disruption that work to unsettle settler colonial dispossession. (shrink)