The Somatic Mutation Theory has been challenged on its fundamentals by the Tissue Organization Field Theory of Carcinogenesis. However, a recent publication has questioned whether TOFT could be a valid alternative theory of carcinogenesis to that presented by SMT. Herein we critically review arguments supporting the irreducible opposition between the two theoretical approaches by highlighting differences regarding the philosophical, methodological and experimental approaches on which they respectively rely. We conclude that SMT has not explained carcinogenesis due to severe epistemological and (...) empirical shortcomings, while TOFT is gaining momentum. The main issue is actually to submit SMT to rigorous testing. This concern includes the imperatives to seek evidence for disproving one’s hypothesis, and to consider the whole, and not just selective evidence. (shrink)

The use of conventional manufacturing methods is mainly limited by the size of the production run and the geometrical complexity of the component, and as a result we are occasionally forced to use processes and tools that increase the final cost of the element being produced. Additive manufacturing techniques provide major competitive advantages due to the fact that they adapt to the geometrical complexity and customised design of the part to be manufactured. The following may also be achieved according to (...) field of application: lighter weight products, multimaterial products, ergonomic products, efficient short production runs, fewer assembly errors and, therefore, lower associated costs, lower tool investment costs, a combination of different manufacturing processes, an optimised use of materials, and a more sustainable manufacturing process. Additive manufacturing is seen as being one of the major revolutionary industrial processes of the next few years. Additive manufacturing has several alternatives ranging from simple RepRap machines to complex fused metal deposition systems. This paper will expand upon the structural design of the machines, their history, classification, the alternatives existing today, materials used and their characteristics, the technology limitations, and also the prospects that are opening up for different technologies both in the professional field of innovation and the academic field of research. It is important to say that the choice of technology is directly dependent on the particular application being planned: first the application and then the technology. (shrink)

In this study, we examine the influence of senior leadership on firms’ corporate social responsibility. We integrate upper echelons research that has investigated either the influence of the CEO or the top management team on CSR. We contend that functional experience complementarity between CEOs and TMTs in formulating and implementing CSR strategy may underlie differentiated strategies in CSR. We find that when CEOs who have predominant experience in output functions are complemented by TMTs with a lower proportion of members who (...) have experience in output functions, there is a pronounced effect on the community, product, and diversity dimensions of CSR. In turn, when output-oriented CEOs are complemented by output-oriented TMTs, we observe an effect on the employee relations dimension of CSR. Interestingly, we find no influence of CEO-TMT complementarity on the environment dimension of CSR. In general, our empirical results support the relevance of the interaction between CEOs and their TMTs in defining their firms’ CSR profile. (shrink)

Die Schlusssatze von Darwins Entstehung der Arten formulieren ein Prinzip, das weit uber die Biologie hinaus einflussreich wurde: "Es ist wahrlich eine grossartige Ansicht, dass der Schopfer den Keim allen Lebens, das uns umgibt, nur wenigen oder nur einer einzigen Form eingehaucht habe, und dass... aus so einfachem Anfang sich eine endlose Reihe immer schonerer und vollkommenerer Wesen entwickelt hat und noch fort entwickelt." Die Autoren dieses Bandes beschaftigen sich mit dem Evolutionsgedanken im Christentum und Islam, gehen dem Zusammenhang von (...) Religion und der Entwicklung des Bewusstseins nach und setzen sich mit dem Prinzip Evolution in Philosophie und Religionstheorie auseinander. (shrink)

El presente libro es un trabajo de investigación conjunto del Departamento de Filosofía de la Universidad de Navarra y el Instituto K. J. Somaiya Bharatiya Sanskriti Peetham. Se trata de un estudio centrado en cinco filósofos que abarcan el período que va del siglo VIII hasta el siglo XVI; los filósofos estudiados pertenecen a la Escuela Vedanta cuyo objetivo principal es analizar la naturaleza del Ser Absoluto y sus relaciones con el universo increado de seres materiales y espirituales. La obra (...) pretende mostrar una parte de esa búsqueda de la verdad, a nivel teórico y práctico, que ha caracterizado la filosofía en el subcontinente indio. (shrink)

First published in 1917 and 1918, with a second edition in 1946, this is the first English translation of Santi Romano's classic work, L'ordinamento giuridico. The main focus of The Legal Order is the notion of institution, which Romano considers to be both the core and distinguishing feature of law. After criticising accounts of the nature of law centred on notions of rule, coercion or authority, he offers a compelling conception, not merely of law as an institution, but of the (...) institution as 'the first, original and essential manifestation of law'. Romano advances a definition of a legal institution as any group who share rules within a bounded context: for example, a family, a firm, a factory, a prison, an association, a church, an illegal organisation, a state, the community of states, and so on. Therefore, this understanding of legal institutionalism at the same time provides a ground-breaking theory of legal pluralism whereby 'there are as many legal orders as institutions'. The acme of a jurisprudential current long overlooked in the Anglophone environment, The Legal Order not only proposes what Carl Schmitt described as a 'very significant theory', but, more importantly, it offers precious insights for a thorough rethinking of the relationship between law and society in today's world. (shrink)

Transhumanism is a scientific and philosophical movement that proposes to overcome, through new technologies, the restrictions imposed on us by our biological condition. Some transhumanists assume that the struggle against natural limits could lead to a radical change in our body or even to its replacement. Other authors, such as Nicholas Agar, propose a moderate enhancement that does not exceed the framework of what we understand to be human. In this article, I will offer a plausible interpretation of the project (...) of human enhancement from a Thomistic perspective. To carry out my analysis, I will focus on three fundamental metaphysical and anthropological questions: How do advocates of radical enhancement understand the relationship between limits, imperfections and evils in human nature? How is this relationship understood from moderate positions? And Is any of these proposals compatible with Aquinas’ anthropology? I will conclude that the identification of limits with imperfections and evils assumed by radical positions is incompatible with Aquinas’ anthropology. Nevertheless, this does not entail that any bio-modification is unacceptable. Aquinas’ peculiar metaphysics, together with its anthropology in which the natural, the supernatural and the preternatural realms intertwine, can offer an interesting framework to assess the human enhancement project. (shrink)

Tu duca, tu signore, e tu maestro». Con estas palabras se inicia una relación educativa entre Virgilio y Dante que manifiesta de manera concreta una visión sobre el maestro de permanente validez y actualidad. El viaje de Dante permite descubrir en la Divina Comedia la existencia de unos principios universales que fundamentan la acción del maestro. No obstante, dichos principios no son del todo originales, sino que permiten evidenciar la influencia que Tomás de Aquino ha ejercido en Dante. El Aquinate (...) no solo es mencionado en el Paraíso en los cantos X al XIV, sino que los principios pedagógicos tomistas, especialmente los contenidos en la Suma de Teología, informan la relación concreta entre los dos poetas. En este estudio intentaremos explicitar la visión del maestro propuesta por Dante, a la vez que se buscará mostrar que Tomás de Aquino es la fuente principal de la que Dante se nutre para labrar esa específica relación entre maestro y discípulo. (shrink)

El presente artículo se propone cotejar dos lecturas antimodernas de Platón y la tradición platónica, la de Joseph de Maistre (1753-1821) y la de Joris-Karl Huysmans (1848-1907) que resultan a la vez complementarias e inversas. Estas apropiaciones, que abren y cierran el siglo XIX, expresan el auge y el declive del “platonismo romántico”. De Maistre recurre intensamente a los diálogos de Platón, a los que cita, comenta, traduce y reescribe, así como a diversos textos del neoplatonismo antiguo y de la (...) tradición platónica moderna. Por su parte los textos de Huysmans, en particular _À rebours_ (1884), la novela más representativa de la sensibilidad decadente, expresa la crisis de ese platonismo romántico, tal como se advierte en cuestiones tales como el nihilismo, el recurso a la figura del simulacro y el replanteo del tópico del andrógino. El platonismo y su crisis interrogan la temporalidad histórica, desde la aceleración revolucionaria hasta la decadencia finisecular. (shrink)

In developed countries, companies are now substantially reliant on the skills and abilities of their leaders to tackle a variety of complex issues. There is a growing consensus that leadership development training and assessment methods should adopt more holistic methodologies, including those associated with the emotional and neuroendocrine aspects of learning. Recent research into the assessment of leadership competencies has proposed the use of objective methods and measurements based on neuroscience. One of the challenges to be faced in the development (...) of a performance-based methodology to measure leadership skills is how to generate real-life situations with triggers that allow us to study management competencies under controlled laboratory conditions. A way to address this question is to take advantage of virtual environments to recreate real-life situations that might arise in performance-based assessments. We propose virtual reality (VR) as a very promising tool to observe various leadership related behavioral patterns during dynamic, complex and realistic situations. By seamlessly embedding assessment methods into virtual learning environments, VR can provide objective assessment methods with high ecological validity. VR also holds unlimited opportunities for leadership training providing subjects with intelligent tutoring systems that adapts situations in real time according to the observed behaviors. (shrink)

Different cell lineages growing in microgravity undergo a spontaneous transition leading to the emergence of two distinct phenotypes. By returning these populations in a normal gravitational field, the two phenotypes collapse, recovering their original configuration. In this review, we hypothesize that, once the gravitational constraint is removed, the system freely explores its phenotypic space, while, when in a gravitational field, cells are “constrained” to adopt only one favored configuration. We suggest that the genome allows for a wide range of “possibilities” (...) but it is unable per se to choose among them: the emergence of a specific phenotype is enabled by physical constraints that drive the system toward a preferred solution. These findings may help in understanding how cells and tissues behave in both development and cancer. In microgravity, cells undergo spontaneous and reversible transitions between different phenotypes. In the absence of physical constraints, living systems could yield bi-stable decisions. On the contrary, physical ‘boundaries’ constrain cells to acquire only a specific configuration by selecting and shaping different gene expression patterns provided by the intrinsic genetic stochasticity. (shrink)

Ionizing radiation is present in various situations in the contemporary world. Defining the quantities and units for this field is a complex scientific task, especially the quantities used in radiological protection (RP) to estimate the damage caused to individuals exposed to radiation (detriment). This article highlights the lack of consensus in the scientific RP community regarding the quantities and units employed in practice from the perspective of the philosophy of science. The basic concepts related to the system of quantities are (...) presented, followed by the problems and criticisms addressed by experts in the field. Several reasons for these problems are identified. The article discusses the scant interest on the part of philosophy of science in RP. The philosophy of science is still dominated by an analytical–conceptual perspective that pays little attention to the actual influence of certain structures better understood when considered from the institutional viewpoint, which is here exemplified by the International Commission on Radiological Protection (ICRP) and the International Atomic Energy Agency (IAEA). (shrink)

This article problematizes the recent comeback of the exceptionalist jargon as it is conjured by both critics and sympathizers. While in the last decades governments across the globe had recourse to emergency measures to cope with far-reaching emergencies, from terrorism to the COVID-19 pandemic, the received view has it that political power takes advantage of states of emergency as they put themselves in the position to circumvent constitutional limitations. Carl Schmitt is claimed to be the major advocate of this conception (...) of emergency politics in that he elaborated on the concept of the state of exception as the heart of the state political power. This article contends that the received view is doubly wrong. First, soon after his espousal of exceptionalism, Schmitt realized that emergency legislation is an ineffective and costly governmental device that should be transitory and is as unstable as the crisis it is meant to overcome. Second, the received view neglects how Schmitt came to his model of ultraconservative substantive constitutionalism as he maintained that the main task of politics is to protect the normative life of a limited set of state-sponsored institutions as well as the substantive contents they produce. (shrink)

Según reza la tradición, la filosofía nació del asombro. El mundo, pleno de verdad y de belleza, invitaba a la contemplación. Pero esta actitud reverente fue abandonada por las ideologías, que redefinieron a la filosofía como un programa de acción. El pensamiento devino praxis, programa transformador dirigido a eliminar los males y alienaciones, construyendo, por fin, el paraíso en la tierra. El TH puede interpretarse como una reedición de este espíritu ideológico, que apuesta por la tecnología como instrumento para la (...) revolución más radical: la transformación de la biología humana. En cuanto a lo metodológico, mi trabajo tiene dos partes. La primera (secciones 1 a 5) es una presentación general, que incluye una consideración acerca de la relevancia de la cuestión, su contexto filosófico, antecedentes, definición, y una alusión a las formas habituales en que el TH se autojustifica. En la segunda parte (secciones 6, 7 y 8) propongo un análisis teórico. En la sección 6, introduzco mi interpretación del TH como ideología. En la sección 7, analizo la dificultad fundamental del TH, esto es, su tendencia a colapsar, bajo el rótulo de aspectos indeseables e innecesarios de la naturaleza humana, verdaderos males con límites constitutivos. Ya en el apartado conclusivo, expongo cómo las dificultades ontológicas y epistémicas del progresismo radical de las ideologías afectan también al TH. (shrink)

El proyecto del _Vocabulaire européen des philosophies. Dictionnaire des intraduisibles _(_VEP_, 2004) es el primer abordaje a gran escala del problema de la traducción en el discurso filosófico. Su principal animadora, Barbara Cassin, postula, a partir de la revalorización del relativismo sofístico, que la traducción implica un “saber hacer con las diferencias” de alcances éticos y comunitarios a escala transnacional. Sin embargo, más allá del pluralismo que supone la “logología sofística”, se insinúa en la traducción al castellano del _VEP_, el (...) _Vocabulario de las Filosofías Occidentales_ (_VFO_, 2018), una imagen de Latinoamérica estereotipadamente eurocéntrica, que entra en conflicto con otras narrativas también presentes en la edición española. El objeto de este trabajo es pues analizar la cartografía de la filosofía mundial que traza el _VFO_, lo cual supone revisar la teoría de la traducción de Cassin y establecer conexiones con las posiciones que tomaron la filósofa y algunos de sus colaboradores en las discusiones que se dieron en los últimos años en la Argentina en torno a la adopción del “modelo sudafricano” como forma de tramitar la violencia del pasado reciente. (shrink)

Dentro de las diversas relecturas de la literatura latina 'decadente' del fin-desiècle, Le latin mystique de Remy DE GOURMONT ocupa un lugar excepcional, en la medida en que no se trata solamente de un texto crítico sino también de una antología comentada y traducida. Le latin mystique, texto que se plantea como la exploración de una literatura no estudiada por críticos y profesores, es una obra clave para comprender aspectos de la sensibilidad fin-de-siècle y las lecturas 'no académicas' que escritores (...) del siglo XX, tales como Ezra POUND o Jorge Luis BORGES, harán de la latinidad clásica y medieval. Among the various fin-de-siècle reinterpretations of the 'decadent' latin literature, Le latin mystique of Remy DE GOURMONT has a singular place, because is not only a critical essay but also an annotated and translated anthology. Le latin mystique, book that reviews a literature supposedly not studied by critics and scholars, is a key text for understanding aspects of the fin-de-siècle sensibility and the 'non-academic' readings that twentieth century writers, like Ezra POUND or Jorge Luis BORGES, will make of the classical and medieval latin literature. (shrink)

Popper's philosophy is usually interpreted as a fallibilist epistemology that, when applied to the social theory, serves as the foundation of the open society. It is argued here that the reverse is also true, namely that Popper's theory of knowledge has some ethical roots whose analysis provides us with a better understanding of Popper's thought.

Husserl va haciéndose consciente de que el ideal “racionalista” de la razón no hace justicia por sí solo a la riqueza de la vida moral. La vida lograda no consistiría solamente en conducir ésta de acuerdo con el ideal de la razón, sino en dejarse mover por el amor. Éste presenta dos características: revela la individualidad de la persona que ama y de la persona amada y funda una “comunidad del tender” con la(s) persona(s) amada(s).

Este trabajo tiene por objetivo analizar Hch 16 en tanto relato organizado por el autor en base a las tensiones de las ἐκκλησίαι de inicios del siglo II. Identificaremos en la narración cómo se representan las inquietudes por el liderazgo comunitario y la forja de una identidad grupal. En el primer caso, la interacción de Pablo con los οἶκοι filipenses propicia una reflexión acerca de la relación entre ministros y fieles. En el segundo, las diferentes designaciones que recibe Pablo en (...) el capítulo evidenciarían no solo la compleja identidad de los creyentes, sino la propuesta comunitaria del autor. (shrink)