Theiler's virus is a picornavirus of mouse which causes an acute encephalomyelitis followed by a persistent infection of the white matter resulting in chronic inflammation and demyelination. This disease has been studied as a model for multiple sclerosis. Inbred strains of mice are either resistant--they clear the infection after the acute encephalomyelitis--or susceptible to persistent infection and demyelination. Susceptibility is a polygenic trait which has been analyzed using methods of association with “candidate” genes, and linkage analysis after a complete (...) genome scan. The H-2Db gene is responsible for an efficient CTL response which makes some strains resistant. Non H-2 genes responsible for the susceptibility of other strains have been mapped by linkage analysis to the Ifng and, possibly, the Mbp loci. The analysis of a set of congenic mice ruled out the possiblity that the relevant gene codes for interferon gamma, and showed that the region around Ifngprobably contains two susceptibility genes. The analysis of mutant mice showed further that the Mbp gene, which codes for the myelin basic protein, has a major effect on viral persistence. BioEssays 20:627–633, 1998. © 1998 John Wiley & Sons Inc. (shrink)

This contribution continues the comparison between ancient and modern beliefs on scientific cosmology which began in a previous article in this Journal. I begin with a brief survey of contemporary theories on Big Bang cosmology, followed by a study of the cosmological theories of the Presocratic thinker Pherecydes of Syros. The second part of my paper studies the ramifications of the basic Platonic principle that bonum est diffusivum sui. I begin by studying the vicissitudes of this theory in the Patristic (...) thought of Origen, the Arians, and Athanasius. Following Willy Theiler, I suggest that similarities between the views of Origen and the Neoplatonist philosopher Porphyry of Tyre may be traceable to Plotinus' teacher Ammonius Saccas. Finally, following Endress, I study the way the Arabic translation of some propositions from Proclus' Elements of Theology were accompanied by interpolated glosses derived from the Christian Neoplatonist John Philoponus, which were designed to make Proclus' thought more acceptable to a creationist, Monotheistic belief system such as Islam. Philoponus' theories of instantaneous creation were taken up, thanks to al-Kindi, by the Neoplatonica Arabica, whence they exerted an important influence on the development of Islamic thought. An Appendix of texts with translation and bibliography completes the article. (shrink)

Plato's views on the nature of the soul, by W.K.C. Guthrie.--Die Erneuerung der Philosophie in der Zeit Ciceros, von O. Gigon.--Gott und Seele im kaiserzeitlichen Denken, von W. Theiler.--Interprétations néo-platonisantes du livre VI de l'Énéide, par P. Courcelle.--Der Platonismus und die altchristliche Gedankenwelt, von J.H. Waszink.--Humanisme et christianisme chez Clément d'Alexandrie d'après le "Pédagogue," par H.I. Marrou.--Some aspects of Platonism in Islamic philosophy, by R. Walzer.

This paper is an overview of the contemporary discussions in interdisciplinary studies of meaning of natural language expressions. The paper discusses the latest work published in two interdisciplinary journals «Linguistics and Philosophy» and «Natural Language Semantics» most relevant for philosophy of language. The paper focuses on two general topics: the semantics of singular terms (proper names, pronouns, demonstratives) and the semantics of belief-reports. The paper discusses the recent proposal about the interpretation of pronouns by [Stojnic et al., 2019] according to (...) which such interpretation is strictly determined by the linguistic rules and does not depend on the context. According to this proposal, the referent of a pronoun is determined by a specific coherence relationship the sentence it occurs in has to the previous sentence in a discourse unless it is preceded by a pointing gesture. The paper discuses some issues with this proposal. Specifically, it discusses its difficulties with explaining the cases where the referent of a pronoun stands out in a context and, thus, no pointing gesture or previous discourse is required for the referent identification. It also discusses cases where a coherence relationship (such as Narration) between two sentences allows flexibility with respect to the referent identification and points at pragmatic factors that can be relevant in this respect. The paper also presents some other recent research on proper names, demonstratives and pronouns both linguistically and philosophically oriented.The paper also presents informally some work on belief-reports in linguistics and discussed its relevance for philosophy of language. It discusses the recent work on restrictions on the types of embeddings of propositional attitude verbs and the general approach that derives those restrictions from the predicted meanings of the relevant sentences, such as [Theiler et al., 2019]. The paper discussed the relevance of this issue to a more general question about the nature of a natural language and the relationship between language and logic. (shrink)

In 1943 one of the authors of this paper set out a case for the view that the sixth book of Polybius' Histories contained two layers, written at different times, and indicating a change in the historian's assessment of the achievements and merits of the Roman hegemony. The arguments there put forward met with some acceptance; but the recent burst of interest in the problems of the sixth book has shown that unanimity is still remote. Among scholars writing since 1943, (...) one, G. B. Cardona, is a ‘separatist’ who accepts the views of De Sanctis; another, W. Theiler, believes that three ‘layers’ of composition can be detected and isolated; three, E. Mioni, H. Erbse, and H. Ryffel, are ‘Unitarians’, but vary in the date they assign to the composition of the Histories; and K. Ziegler in his R.E. article on Polybius argues for composition in the sixties followed by a revision and publication before 146. (shrink)

In 1943 one of the authors of this paper set out a case for the view that the sixth book of Polybius' Histories contained two layers, written at different times, and indicating a change in the historian's assessment of the achievements and merits of the Roman hegemony. The arguments there put forward met with some acceptance; but the recent burst of interest in the problems of the sixth book has shown that unanimity is still remote. Among scholars writing since 1943, (...) one, G. B. Cardona, is a ‘separatist’ who accepts the views of De Sanctis; another, W. Theiler, believes that three ‘layers’ of composition can be detected and isolated; three, E. Mioni, H. Erbse, and H. Ryffel, are ‘Unitarians’, but vary in the date they assign to the composition of the Histories; and K. Ziegler in his R.E. article on Polybius argues for composition in the sixties followed by a revision and publication before 146. (shrink)

There is no agreement about the supplement at the end of the first line. almost certainly refers to marriage, discussion of which is postponed till something becomes black or turns dark. Theiler's hardly fits thecontext, and Burkert's with the sense ‘when the grapes ripen’ is not convincing. A metaphorical sense for ‘grapes’ is preferable, e.g. or, better,,, ‘when youwill be old enough to marry’; but the phrase comes with a jolt in the absence of any preparation or immediate follow-up: (...) in the passages of Philodemus andHorace quoted as parallel by Ebert-Luppes the metaphor is not simply a singleword but is extended over two or three lines. (shrink)

There is no agreement about the supplement at the end of the first line. almost certainly refers to marriage, discussion of which is postponed till something becomes black or turns dark. Theiler's hardly fits thecontext, and Burkert's with the sense ‘when the grapes ripen’ is not convincing. A metaphorical sense for ‘grapes’ is preferable, e.g. or, better, , , ‘when youwill be old enough to marry’; but the phrase comes with a jolt in the absence of any preparation or (...) immediate follow-up: in the passages of Philodemus andHorace quoted as parallel by Ebert-Luppes the metaphor is not simply a singleword but is extended over two or three lines. (shrink)

O artigo analisa a hipótese emitida por Willy Theiler em 1965 e retomada por John Dillon em 1992, segundo a qual o termo ἀμφίστομος (‘com dois rostos’, ‘com duas bocas’) empregado por Plotino uma única vez na primeira parte da sua tetralogia antignóstica, isto é, no Tratado 30 (III, 8), 9, 31, constitui uma expressão característica dos Oráculos Caldáicos. Afim de examinar essa hipótese, nós resumimos o debate entre especialistas a respeito dessa hipótese e analisamos os diferentes sentidos implicados (...) no uso da expressão ἀμφίστομος nos Oráculos Caldáicos e em Plotino a partir do contexto polêmico no qual ela é citada. Nossa conclusão é que o estudo da metafísica medioplatônica dos Oráculos Caldáicos pode trazer uma melhor compreensão do diálogo entre os pensamentos plotiniano e gnóstico, e que a presença de uma polêmica medioplatônica nesse tratado antignóstico torna plausível uma referência direta da parte de Plotino à um termo característico do vocabulário dos Oráculos Caldáicos. (shrink)

Numenius and Ammonius, by E. R. Dodds.--Plotin zwischen Platon und Stoa, von W. Theiler.--Être, vie, pensée chez Plotin et avant Plotin, par P. Hadot.--Plotin et les gnostiques, par H. C. Puech.--Die Frage nach dem Transzendenten im Mittelplatonismus, von H. Dörrie.--Mito e poesia nelle Enneadi di Plotino, di V. Cilento.--Quelle oder Tradition? Von R. Harder.--"Bewusst" und "unbewusst" bei Plotin, von H. R. Schwyzer.--The background of the doctrine "That the intelligibles are not outside the intellect," by A. H. Armstrong.--Une comparaison chez (...) Aristote, Alexandre et Plotin, par P. Henry. (shrink)

Die Schultradition im Mittelplatonismus und Porphyrios, von H. Dörrie.--Porphyrios und Numenios, von J. H. Waszink.--Ammonios und Porphyrios, von W. Theiler.--La métaphysique de Porphyre, par P. Hadot.--Die Lehre von der Seele, von H. Dörrie.--Porfirio commentatore di Platone, di A. R. Sodano.--Porphyre, exégète d'Homère, par J. Pépin.--Porphyry and the Arabic tradition, by R. Walzer.