Roughly, the Central Dogma of molecular biology states that DNA codes for protein, not the other way around. This principle, which is still heralded as an important element of contemporary biological theory, has received much critical attention since its original formulation by Francis Crick in 1958. Some have argued that the principle should be rejected, on the grounds that it fails to fully capture the ins-and-outs of protein synthesis, while others have argued that the Dogma is predicated on notions of (...) information that are simply implausible. Yet, despite all this criticism, there is much about the Dogma that has not been said. Existing discussions, for example, gloss over the many distinct, logically independent readings of the Central Dogma that have been defended in the philosophical and biological literature, making it difficult to see which dogma is being criticized. Additionally, this oversight makes it unclear what the overall upshot of these discussions should be taken to be. My aim in this paper is to fix this. (shrink)

The Central Dogma of molecular biology, which holds that DNA makes protein and not the other way around, is as influential as it is controversial. Some believe the Dogma has outlived its usefulness, either because it fails to fully capture the ins-and-outs of protein synthesis (Griffiths and Stotz, 2013; Stotz, 2006), because it turns on a confused notion of information (Sarkar, 2004), or because it problematically assumes the unidirectional flow of information from DNA to protein (Gottlieb, 2001). This paper evaluates (...) an underexplored defense of the Dogma, which relies on the assumption that the Dogma and the Inheritance of Acquired Traits, a principle which dates as far back as Jean Baptiste-Lamarck, are incompatible principles (Smith, 1993; Judson, 1979; Dawkins, 1970; Cobb, 2017; Wilkins, 2002; Graur, 2018). By appealing to empirical evidence in molecular science, I argue that this apparent incompatibility is indeed merely apparent. I conclude by briefly demonstrating how these considerations bear on the topic of conceptual pluralism in the philosophy of science (Stencel and Proszewska, 2018; Lu and Bourrat, 2018). (shrink)

There is no denying the Central Dogma’s impact on the biological sciences. Since the Dogma’s formulation by Francis Crick in 1958, however, many have debated the Dogma’s empirical adequacy. My aim is to move beyond these discussions, and instead consider the Central Dogma’s significance to contemporary biological practice. To do this, I consider four distinct approaches for determining the non-descriptive methodological significance of a scientific principle. I argue that these approaches fail to vindicate the Central Dogma, and that, under many (...) of these approaches, the Dogma amounts to a triviality. (shrink)

According to Denis Noble, one of the greatest illusions of the Modern Synthesis is embodied in the Central Dogma, a principle first formulated by Francis Crick in 1958. The principle holds that DNA makes protein, not the other way around. For Noble, the Dogma has contributed to the illusion that genes alone are responsible for the development and evolution of an organism’s phenotype. Though I am largely sympathetic to Noble’s critique, I argue that there may be alternative grounds for accepting (...) the plausibility of the Central Dogma and also the illusion it perpetuates. (shrink)

The attention to ethics has gradually become a concurrent topic of modern companies’ management. In the last years Social Responsibility has become a key issue in the strategic agenda of competitive agriculture cooperatives. However, reputation management has not been a visible strength in the cooperative enterprises. First of all, this work theoretically analyzes the relationship between Social Responsibility and reputation in cooperatives. Later, from a practical point of view, we carry on an empirical analysis focused on the olive oil cooperatives (...) in the south of Spain, in the province of Jaén. With respect to the previous studies on the topic, this work reveals a main reason of interest reinforcing the role of research in addressing real problems of cooperatives. The article points out the characteristics of this kind of agribusiness and shows the importance of the adoption of a responsible orientation in fostering reputation for creating sustainable competitive advantages. (shrink)

In this comprehensive collection of essays, most of which appear for the first time, eminent scholars from many disciplines—philosophy, economics, sociology, political science, demography, theology, history, and social psychology—examine the causes, nature, and consequences of present-day consumption patterns in the United States and throughout the world.

Understanding the causes of maize landrace loss in farmers’ field is essential to design effective conservation strategies. These strategies are necessary to ensure that genetic resources are available in the future. Previous studies have shown that this loss is caused by multiple factors. In this longitudinal study, we used a collection of 93 maize landrace accessions from Morelos, Mexico, and stored at the International Maize and Wheat Improvement Center Maize Germplasm Bank, to trace back to the original 66 donor families (...) after 50 years and explore the causes for why they abandoned or conserved their seed lots. We used an actor-centered approach, based on interviews and focus group discussions. We adopt a Multi-Level Perspective framework to examine loss as a process, accommodating multiple causes and the interactions among them. We found that the importance of maize landrace cultivation had diminished over the last 50 years in the study area. By 2017, 13 families had conserved a total of 14 seed lots directly descended from the 1967 collection. Focus group participants identified 60 accessions that could still be found in the surrounding municipalities. Our findings showed that multiple interconnected changes in maize cultivation technologies, as well as in maize markets, other crop markets, agricultural and land policies, cultural preferences, urbanization and climate change, have created an unfavorable environment for the conservation of maize landraces. Many of these processes were location- and landrace-specific, and often led to landrace abandonment during the shift from one farmer generation to the next. (shrink)

Intervention studies with developmental samples are difficult to implement, in particular when targeting demographically diverse communities. Online studies have the potential to examine the efficacy of highly scalable interventions aimed at enhancing development, and to address some of the barriers faced by underrepresented communities for participating in developmental research. During the COVID-19 pandemic, we executed a fully remote randomized controlled trial language intervention with third and fourth grade students from diverse backgrounds across the United States. Using this as a case (...) study, we discuss both challenges and solutions to conducting an intensive online intervention through the various phases of the study, including recruitment, data collection, and fidelity of intervention implementation. We provide comprehensive suggestions and takeaways, and conclude by summarizing some important tradeoffs for researchers interested in carrying out such studies. (shrink)

Understanding the causes of maize landrace loss in farmers’ field is essential to design effective conservation strategies. These strategies are necessary to ensure that genetic resources are available in the future. Previous studies have shown that this loss is caused by multiple factors. In this longitudinal study, we used a collection of 93 maize landrace accessions from Morelos, Mexico, and stored at the International Maize and Wheat Improvement Center (CIMMYT) Maize Germplasm Bank, to trace back to the original 66 donor (...) families after 50 years and explore the causes for why they abandoned or conserved their seed lots. We used an actor-centered approach, based on interviews and focus group discussions. We adopt a Multi-Level Perspective framework to examine loss as a process, accommodating multiple causes and the interactions among them. We found that the importance of maize landrace cultivation had diminished over the last 50 years in the study area. By 2017, 13 families had conserved a total of 14 seed lots directly descended from the 1967 collection. Focus group participants identified 60 accessions that could still be found in the surrounding municipalities. Our findings showed that multiple interconnected changes in maize cultivation technologies, as well as in maize markets, other crop markets, agricultural and land policies, cultural preferences, urbanization and climate change, have created an unfavorable environment for the conservation of maize landraces. Many of these processes were location- and landrace-specific, and often led to landrace abandonment during the shift from one farmer generation to the next. (shrink)

Before Euro-American settlement, many Native American nations intercropped maize (_Zea mays_), beans (_Phaseolus vulgaris_), and squash (_Cucurbita pepo_) in what is colloquially called the “Three Sisters.” Here we review the historic importance and consequences of rejuvenation of Three Sisters intercropping (3SI), outline a framework to engage Native growers in community science with positive feedbacks to university research, and present preliminary findings from ethnography and a randomized, replicated 3SI experiment. We developed mutually beneficial collaborative research agendas with four Midwestern US Native (...) American nations. Ethnographic data highlighted a culturally based respect for 3SI as living beings, the importance it holds for all cultural facets of these Native nations, and the critical impact the practice has on environmental sustainability. One concern expressed by Native growers during ethnographic research was improving soil health—part of the rationale for establishing the 3SI agronomic experiment. To address this, we collaboratively designed a 3SI experiment. After 1 year, 3SI increased short-term soil respiration by 24%, decreased salt-extractable nitrate by 54%, had no effect on soil microbial biomass (but increased its carbon-to-nitrogen ratio by 32%) compared to the average of monoculture crops. The overarching purpose of this collaborative project is to develop a deeper understanding of 3SI, its cultural importance to Native communities, and how reinvigorating the practice—and intercropping in general—can make agroecosystems more sustainable for people and the environment. (shrink)

Desde la publicación de la encíclica Laudato si ‘(LS) del Papa Francisco en 2015, se han llevado a cabo múltiples acciones para fomentar una visión integral de la ecología en la Iglesia Católica. El objetivo fue el desarrollo de una propuesta curricular que incluye el desarrollo sostenible e integral en la enseñanza de la religión católica. El curso CHANCES ofrece un nuevo paradigma de la enseñanza de la religión católica, mostrando cómo desde ella se pueden descubrir motivaciones profundas, y potenciar (...) actitudes y virtudes, que pueden contribuir al desarrollo de competencias en sostenibilidad. (shrink)

Cooperative learning encourages the development of interpersonal skills and motivates students to participate more actively in the teaching and learning process. This study explores the impact of cooperative learning on the academic goals influencing university students’ behavior and leading to the attainment of a series of academic objectives. To this end, a quasi-experimental pretest-posttest control group design was used, with a sample of 509 university students from Preschool, Primary and Social Education undergraduate degree courses. Using the Academic Goals Questionnaire, pretest (...) and posttest measures were taken via self-reports to evaluate three types of academic goals: learning goals, social reinforcement goals and achievement goals. The results show that cooperative learning is an effective tool for encouraging university students to develop academic goals that motivate them to fully engage with the tasks they are set in order to acquire knowledge and skills. In addition, when students are asked to work as part of a team on an autonomous basis without the structure and supervision necessary to ensure a minimum standard of cooperation, they display a greater tendency toward social reinforcement goals than toward learning and achievement goals. These findings contribute new knowledge to the conceptual framework on cooperative learning. Goals may be considered one of the most important variables influencing students’ learning and the use of cooperative learning techniques in university classrooms creates the necessary conditions for encouraging students to develop goals oriented toward learning. (shrink)

Caracterización de un grupo de comités de ética en investigación en Colombia Caracterização de um grupo de comitês de ética em pesquisa na Colômbia In the last decades, controlled clinical trials sponsored by the pharmaceutical industry have increased considerably. This has led to the need for greater control and assistance by regulators and ethics committees to ensure appropriate compliance with established ethical standards and good clinical practices in general. In Colombia, the National Food and Drug Surveillance Institute, the regulator in (...) the country, controls and monitors the operation of clinical research with drugs. In 2008, this entity issued Resolution 2378, which provides and regulates research actors in Colombia, including ethics committees. After being in force for several years, it is necessary to know whether research ethics committees in Colombia operate in accordance with this regulation and to determine the status of implementation of the requirements therein. For this purpose, a survey was designed to be voluntarily answered and a response was obtained from 25 of the 69 certified committees in Colombia. Twenty-two of them could be analyzed because their information was complete. Compared with previous studies, favorable changes in development and organization were observed in accordance with the current proposed regulation. Para citar este artículo / To reference this article / Para citar este artigo Suárez-Obando F, Reynales H, Urina M, Camacho J, Viteri M. Caracterización de un grupo de comités de ética en investigación en Colombia. pers. bioét. 2018; 22: 303-318. DOI: 10.5294/pebi.2018.22.2.8. (shrink)

Summary The fragmentary inscription on the ludi saeculares contains mention of two senatus consulta of year 17 BCE. This paper gives new arguments for identifying the five known consulars heading the drafting commission of the senatus consultum of 17 February: M. Iunius Silanus, Cn. Cornelius Lentulus, L. Marcius Censorinus, C. Asinius Pollio and L. Vinicius. This list challenges the accepted notion that senators named as members of the drafting commissions of senatus consulta were always arranged according to their seniority. Such (...) an open new approach could question or even significantly alter the chronology of Roman magistracies that has been accepted on the basis of seniority hierarchy so far. (shrink)

Against the modern theory of representation, which makes the world opaque, Polo Suggests reviviting the classical theory of ilumination. Intentionality of knowledge, according to Polo, makes possibe the "deveiling" of reality, and shows its radical dependence from God.

Against contemporary philosophy, Leonardo Polo's thought is a defense of realism. This realism is neither the forgetfullness of Modern Philosophy (mere approbation of classic philosophy) nor a critic-realism. The author calls "methodic realism". Between Modern Philosophy and traditional metaphysic, L. Polo's philosophy can be called metaphisics.

El artículo parte de la distinción poliana entre ser creado y ser increado y expone, a partir de ahí, la distinción Dios-criatura que permite el estudio metafisico de la finitud. En un segundo momento se aproxima a la interpretación que L. Polo ha dado de M. Eckhart en lo que se refiere al estatuto ontológico de lo finito; para este asunto, se acerca a la comprensión de la criatura en el Logos creador, cuestión que es tratada, con sus diferencias (...) respectivas, en Tomás de Aquino, Eckhart y Leonardo Polo. (shrink)

La biografía griega puede asociarse a dos polos principales: en uno predomina el eje sintagmático, con sucesión, y en el otro el paradigmático, sin sucesión. El primero se relaciona con la historiografía, tiene un método cercano a la investigación o ἱστορία y tiene su tipo ideal más difundido en la biografía energética o peripatética ; el segundo se liga a la retórica demostrativa, su método es próximo al del anticuarianismo y aparece en la biografía alejandrina. Esta contribución sugiere que en (...) la hagiografía típica esta oposición se verifica en un tratamiento relativamente separado de “vida” y “conducta” –sintetizada habitualmente en los títulos como Βίος καὶ πολιτεíα–: la sucesión de hechos situados en el tiempo en los que se manifiesta un carácter más o menos intemporal. Para ello, discute las características principales de la biografía; expone el sistema de F. Leo sobre la biografía clásica; se detiene en el cronotopo de M. Bajtín sobre biografía y autobiografía antigua, y en su deuda con autores como Leo o G. Misch; expone ciertas características del discurso hagiográfico y de su particular cronotopo; ofrece una breve conclusión. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Jane Austen normally avoids discussing appearance throughout her works. Persuasion constitutes the exception to the rule, as the story focuses on the premature aging experienced by her protagonist, Anne Elliot, seemingly due to disappointed love. Much has been written about Anne’s “loss of bloom,” but never from the perspective of psychoneuroimmunology, the field that researches the interrelation between psychological processes and the nervous and immune systems. In this paper, we adopt a perspective of psychoneuroimmunology to argue that Austen established a (...) connection between psychological distress, specifically lovesickness, and the development of early senescence signs, and vice versa, since the recovery of love is associated with happiness and physical glow. From a gender perspective, we discuss how Austen brightly reflected these interrelationships through the story of Anne, when the latest psychoneuroimmunological research has actually shown that women age earlier than men as a consequence of psychological turmoil. (shrink)

ABSTRACTEmotion regulation substantially develops during the childhood years. This growth includes an increasing awareness that certain ER strategies are more appropriate in some contexts than...

Los documentos del Concilio Vaticano II tienen profundas consecuencias sociales para la misión evangelizadora de la Iglesia. En el posconcilio, la revista Vida Nueva, especializada en la información social y religiosa, acoge el mensaje conciliar e intenta aplicarlo a las circunstancias de la Iglesia y sociedad de aquel momento. Este estudio analiza los contenidos de los editoriales publicados por Vida Nueva de 1968 a 1975. Los resultados muestran la repercusión del Concilio en el enfoque editorial de una revista que, comprometida (...) con el orden temporal, analiza la actualidad política; fomenta el ejercicio de las libertades; defiende los derechos humanos; presta una atención preferencial a las personas más vulnerables; promueve la libertad y veracidad informativa; apuesta por una actividad económica puesta al servicio de los ciudadanos; aborda temas relativos a la moral de la persona discutidos en el seno de la Iglesia; mantiene una postura dialogante con la cultura, la ciencia y la tecnología; y propone cambios en los derechos, metodología y contenidos del sector educativo. (shrink)

En el presente trabajo se analizan tres piezas de Rodolfo Usigli bajo la perspectiva del chantaje que impulsa la confrontación de dos fuerzas axiológicas que son la verdad y la mentira; sin embargo, no se trata sólo de dos antagonismos que determinan la temática de su teatro, sino además son dos términos cuya confrontación construye la estructura de la mayor parte de sus dramas. Esta confrontación entre verdad y mentira Rodolfo Usigli la maneja desde distintas aristas, como es la desinformación, (...) la obediencia a la autoridad y la gubernamentalidad. (shrink)

Early in animal development, gradients of secreted morphogenic molecules, such as Sonic hedgehog (Shh), Wnt and TGFβ/Bmp family members, regulate cell proliferation and determine the fate and phenotype of the target cells by activating well‐characterized signalling pathways, which ultimately control gene transcription. Shh, Wnt and TGFβ/Bmp signalling also play an important and evolutionary conserved role in neural circuit assembly. They regulate neuronal polarization, axon and dendrite development and synaptogenesis, processes that require rapid and local changes in cytoskeletal organization and plasma (...) membrane components. A key question then is whether morphogen signalling at the growth cone uses similar mechanisms and intracellular pathway components to those described for morphogen‐mediated cell specification. This review discusses recent advances towards the understanding of this problem, showing how Shh, Wnt and TGFβ/Bmp have adapted their ‘classical’ signalling pathways or adopted alternative and novel molecular mechanisms to influence different aspects of neuronal circuit formation. (shrink)