The discovery of the signal peptides that direct proteins to localize at the nucleolus is described here. The nucleolar targeting signal termed the NOS consists of clustered basic amino acids organized such that a portion also functions as the nuclear transporting signal. Although a NOS has been identified within the regulatory genes of human retroviruses, HTLV‐I and HIV‐I, signals of similar function in cellular proteins – such as heat shock proteins – may be induced through the configurational change of protein (...) structure by heat or stress. (shrink)

Specular reflections and refractive distortions are complex image properties of solid transparent objects, but despite this complexity, we readily perceive the 3D shapes of these objects. We have found in past work that relevant sources of scene complexity have differential effects on 3D shape perception, with specular reflections increasing perceived thickness, and refractive distortions decreasing perceived thickness. In an object with both elements, such as glass, the two optical properties may complement each other to support reliable perception of 3D shape. (...) We investigated the relative dominance of specular reflection and refractive distortions in the perception of shape. Surprisingly, the ratio of specular reflection to refractive component was almost equal to that of ordinary glass and ice, which promote correct percepts of 3D shape. The results were also explained by the variance in local RMS contrast in stimulus images but may depend on overall luminance and contrast of the surrounding light field. (shrink)

Recent discussions around education for global citizenship continues to retrace notions of cosmopolitanism first laid out in Europe. Ostensibly seeking global inclusivity, much of this work ultimately returns to a rather narrow set of ontological and epistemic themes, primarily Stoicism and Pauline Christianity. The Kyoto School offers a constructive reconstruction of these core premises of European cosmopolitanism. In resisting the ontologizing of autonomous individualism and abstract universalism, Kyoto School thinkers offered an alternative tripartite structure that drew greater attention to the (...) specific : individual and universal are inevitably mediated by the ‘logic’ of specific histories, languages, institutions, and communities. Rather than naïve nationalism, this view emerged within a radically relational worldview: ‘continuity-in-discontinuity’ emplaced within absolute nothingness. Kimura Motomori, a leading Kyoto School educational thinker, explicitly extended these Nishidian ideas to challenge Rousseau’s contracting individualism, Kantian abstract universalism, and Hegelian teleological temporality, thus offering a fresh vision of cosmopolitanism: self-aware citizens engaging concretely in the task of opening their specific societies. In conclusion, in part to demonstrate the very forms of critique we envisage, we trace historically the impacts of Kyoto School cosmopolitanism ideas on postwar policy in Japan and lament the recent regressive closing. (shrink)

本書は、生活者のハピネス(豊かさや幸せ)の視点から科学技術や社会の変革を考える『因果関係から相関へ、個別技術からシステムへ』と題した『武田シンポジウム2018』の内容をまとめたものです。昨今最も注目を 浴びている科学技術である「AI」、「免疫システム研究」、「民間宇宙ロケット開発」の3つと異なる切り口から、ビッグデータと言われる時代の科学の方法論、個の集積以上の意味をもつシステムとしてのアプローチに ついて立体的に考察します。.

A sense of agency (SoA) is the experience of subjective awareness regarding the control of one’s actions. Humans have a natural tendency to generate prediction models of the environment and adapt their models according to changes in the environment. The SoA is associated with the degree of the adaptation of the prediction models, e.g., insufficient adaptation causes low predictability and lowers the SoA over the environment. Thus, identifying the mechanisms behind the adaptation process of a prediction model related to the (...) SoA is essential for understanding the generative process of the SoA. In the first half of the current study, we constructed a mathematical model in which the SoA represents a likelihood value for a given observation (sensory feedback) in a prediction model of the environment and in which the prediction model is updated according to the likelihood value. From our mathematical model, we theoretically derived a testable hypothesis that the prediction model is updated according to a Bayesian rule or a stochastic gradient. In the second half of our study, we focused on the experimental examination of this hypothesis. In our experiment, human subjects were repeatedly asked to observe a moving square on a computer screen and press a button after a beep sound. The button press resulted in an abrupt jump of the moving square on the screen. Experiencing the various stochastic time intervals between the action execution button-press) and the consequent event square jumping caused gradual changes in the subjects' degree of their SoA. By comparing the above theoretical hypothesis with the experimental results, we concluded that the update (adaptation) rule of the prediction model based on the SoA is better described by a Bayesian update than by a stochastic gradient descent. (shrink)

Al-Kind la littcrivant sur les mcouverte des trcrivit sur ce sujet a survditions et des traductions de l'un et l'autre textes, ainsi que les deux traductions latines faites du chapitre dans Les quarantes chapitres et des commentaires de la proce par al-Kindī.