Background Forward-looking, democratically oriented governance is needed to ensure that human genome editing serves rather than undercuts public values. Scientific, policy, and ethics communities have recognized this necessity but have demonstrated limited understanding of how to fulfill it. The field of bioethics has long attempted to grapple with the unintended consequences of emerging technologies, but too often such foresight has lacked adequate scientific grounding, overemphasized regulation to the exclusion of examining underlying values, and failed to adequately engage the public. Methods (...) This research investigates the application of scenario planning, a tool developed in the high-stakes, uncertainty-ridden world of corporate strategy, for the equally high-stakes and uncertain world of the governance of emerging technologies. The scenario planning methodology is non-predictive, looking instead at a spread of plausible futures which diverge in their implications for different communities’ needs, cares, and desires. Results In this article we share how the scenario development process can further understandings of the complex and dynamic systems which generate and shape new biomedical technologies and provide opportunities to re-examine and re-think questions of governance, ethics and values. We detail the results of a year-long scenario planning study that engaged experts from the biological sciences, bioethics, social sciences, law, policy, private industry, and civic organizations to articulate alternative futures of human genome editing. Conclusions Through sharing and critiquing our methodological approach and results of this study, we advance understandings of anticipatory methods deployed in bioethics, demonstrating how this approach provides unique insights and helps to derive better research questions and policy strategies. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

This chapter contains sections titled: Socrates Café Café Philosophique Philosophy for Everyone Sophistry The Examined Life Oblivion Conclusion (Who is Ben's Mom?).

According to Pew Research studies, most Americans think religion always conflicts with science. The popular writings of scientists such as Richard Dawkins, Sam Harris, and Lawrence Krauss reinforce this idea, as do books by writers such as Christopher Hitchens and Daniel Dennet. Furthermore, the two versions of the enormously popular television show Cosmos, hosted by Carl Sagan in 1980 and Neil deGrasse Tyson in 2014, present a history of science in which religion has always acted as a barrier to (...) scientific development, with scientists frequently persecuted or even executed for their work. "Gods, Philosophers, and Scientists" shows that just because an idea is popular, doesn't mean it's correct. By examining the historical record from the time of the Ancient Greeks to today, readers are able to see that religion and science have been allies more often than enemies, and when conflict does occur it's too simplistic to view it as coming from something inherent to either science or religion. Instead, as with the case of Greek philosophy or the reception of Darwinian evolution, complex social forces are to blame, and in cases such as the infamous one of Galileo's conflict with the Catholic Church, clashing personalities are at least as important as those social forces. Anyone interested in the history of science or religion, who is curious about how science works, or who wants to have a better understanding of the world should read this book. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:_Russell_ journal (home office): E:CPBRRUSSJOURTYPE2502\REVIEWS.252 : 2006-02-27 11:52  Reviews REPLY TO PINCOCK S S Philosophy / U. of Southern California Los Angeles,  -,  @. write to correct errors in Christopher Pincock’s review of my discussion of IRussell. First, according to Pincock, I attempt to “undermine Moore’s views on ethics in Part One, [and] Russell’s conception of analysis in Part Two” by charging them with a (...) pre-Kripkean conflation of necessity with apriority and analyticity. Not so. Although I do show that such conflation had negative consequences for the views of several philosophers, Moore and Russell are not among them. Moore’s error—which marred the defence of his thesis that conclusions about goodness are never consequences of purely descriptive premisses —was in tacitly assuming that all necessary/a priori relations among concepts arise from definitions (see my : –). A similar problem occurs in Russell, but only tangentially in connection with one possible route to his problematic principle () in Our Knowledge of the External World, the critique of which was not a part of any attack on his general conception of analysis (: –). () If the occurrence of sense-data constitutes verification of S, then S must be (at least partly) about sense-data.  Philosophical Analysis in the Twentieth Century, Vol. : The Dawn of Analysis (Princeton: Princeton U. P., ), pp. –.  Russell, n.s.  (winter –): – (at ).  Except when otherwise indicated, all references to OKEW will be to the revised,  Allen and Unwin edition. Although this was the edition I used in writing my chapter on OKEW, my bibliographical citation was a confused amalgam of different editions. The work was originally published in  by Open Court; there was a second printing in ; and in  Allen and Unwin re-issued it by purchasing extra sheets of the  printing, and binding them. In , Russell revised the work, which Allen and Unwin then published as a revised edition. That edition is identical to the Routledge paperback edition now in print and used by students. (Russell revised the  edition again for Norton’s  edition, which was reset for the Mentor paperback.) Except at one point, which I will identify later, the difference between the  and the  editions doesn’t affect my dispute with Pincock. Thanks to the editor, Kenneth Blackwell, for kindly sharing his extensive knowledge of the bibliographical history with me, and to Ross Scimeca, the head librarian at the incomparable Hoose Philosophy Library at , for furnishing me with copies of the editions I needed to sort this out. _Russell_ journal (home office): E:CPBRRUSSJOURTYPE2502\REVIEWS.252 : 2006-02-27 11:52 Reviews  Evidently, Pincock has confused the error about definition, which I expose, with a pre-Kripkean conflation of necessity with apriority and analyticity, which is not mentioned in Parts One and Two. This is a blunder. The advances in our understanding of crucial logical, semantic, epistemological, and modal notions which I identify as paramount achievements of the analytic tradition are not limited to those made by Kripke. To suggest otherwise is a distortion. Second, Pincock errs when he objects that in citing () as a source for the view that sense-data statements give the content of material-object statements, I ascribe “some form of latent verificationism” to Russell. If the objection is that Russell was no verificationist—since he didn’t hold that S is meaningful only if S is verifiable—the reply is that I never suggested otherwise. What I said is that () together with () Verification always consists in the occurrence of sense-data constituted a historical precursor to verificationism (: ). Perhaps, then, Pincock objects to my reconstruction of Russell’s argument: since (i) truths of physics and common sense are known by being verified, (ii) it follows from () and () that our knowledge of them is knowledge of sense-data. Perhaps, Pincock thinks that Russell would reject (i). Citing Russell … if there is any knowledge of general truths at all, there must be some knowledge of general truths which is independent of empirical evidence, i.e. does not depend upon the data of sense. (OKEW, pp. –; OKEW, p. ) Pincock concludes that scientific knowledge, for Russell, is justified partly by sense-data, and partly by associated logical principles about relations... (shrink)

A number of philosophers think that grounding is, in some sense, well-founded. This thesis, however, is not always articulated precisely, nor is there a consensus in the literature as to how it should be characterized. In what follows, I consider several principles that one might have in mind when asserting that grounding is well-founded, and I argue that one of these principles, which I call ‘full foundations’, best captures the relevant claim. My argument is by the process of elimination. For (...) each of the inadequate principles, I illustrate its inadequacy by showing either that it excludes cases that should not be ruled out by a well-foundedness axiom for grounding, or that it admits cases that should be ruled out. (shrink)

Realists about universals face a question about grounding. Are things how they are because they instantiate the universals they do? Or do they instantiate those universals because they are how they are? Take Ebenezer Scrooge. You can say that Scrooge is greedy because he instantiates greediness, or you can say that Scrooge instantiates greediness because he is greedy. I argue that there is reason to prefer the latter to the former. I develop two arguments for the view. I also respond (...) to some concerns one might have about the view defended. I close by showing that analogous views regarding the truth of propositions and the existence of facts are supported by analogs of one of these arguments. (shrink)

Kit Fine (2000) breaks with tradition, arguing that, pace Russell (e.g., 1903: 228), relations have neither directions nor converses. He considers two ways to conceive of these new "neutral" relations, positionalism and anti-positionalism, and argues that the latter should be preferred to the former. Cody Gilmore (2013) argues for a generalization of positionalism, slot theory, the view that a property or relation is n-adic if and only if there are exactly n slots in it, and (very roughly) that each slot (...) may be occupied by at most one entity. Slot theory (and with it, positionalism) bears the full brunt of Fine's (2000) symmetric completions and conflicting adicities problems. I fully develop an alternative, plural slot theory (or pocket theory), which avoids these problems, key elements of which are first considered by Yi (1999: 168 ff.). Like the slot theorist, the pocket theorist posits entities (pockets) in properties and relations that can be occupied. But unlike the slot theorist, the pocket theorist denies that at most one entity can occupy any one of them. As a result, she must also deny that the adicity of a property or relation is equal to the number of occupiable entities in it. By abandoning these theses, however, the pocket theorist is able to avoid Fine's problems, resulting in a stronger theory about the internal structure of properties and relations. Pocket theory also avoids a serious drawback of anti-positionalism. (shrink)

Partial grounding is often thought to be formally analogous to proper parthood in certain ways. Both relations are typically understood to be asymmetric and transitive, and as such, are thought to be strict partial orders. But how far does this analogy extend? Proper parthood is often said to obey the weak supplementation principle. There is reason to wonder whether partial grounding, or, more precisely, proper partial grounding, obeys a ground-theoretic version of this principle. In what follows, I argue that it (...) does not. The cases that cause problems for the supplementation principle for grounding also serve as counterexamples to another principle, minimality, defended by Paul Audi. (shrink)

The website Rotten Tomatoes, located at www.rottentomatoes.com, is primarily an online repository of movie reviews. For each movie review document, the site provides a link to the full review, along with a brief description of its sentiment. The description consists of a rating (“fresh” or “rotten”) and a short quotation from the review. Other research (Pang, Lee, & Vaithyanathan 2002) has predicted a movie review’s rating from its text. In this paper, we focus on the quotation, which is a main (...) attraction to site users. A Rotten Tomatoes quotation is typically about one sentence in length and expresses concisely the reviewer’s opinion of the movie. To illustrate, Curtis Edmonds’s review of the documentary Spellbound is encapsulated, “Hitchcock couldn’t have asked for a more suspenseful situation.” A.O. Scott’s review of Once upon a Time in Mexico is encapsulated, “A noisy, unholy mess, with moments of wit and surprise that ultimately make its brutal tedium all the more disappointing.” A reader can infer from these statements whether or not the overall sentiment is favorable, and get an impression about why. Consequently, we refer to them as sentiment summaries. (shrink)

There are at least three vaguely atomistic principles that have come up in the literature, two explicitly and one implicitly. First, standard atomism is the claim that everything is composed of atoms, and is very often how atomism is characterized in the literature. Second, superatomism is the claim that parthood is well-founded, which implies that every proper parthood chain terminates, and has been discussed as a stronger alternative to standard atomism. Third, there is a principle that lies between these two (...) theses in terms of its relative strength: strong atomism, the claim that every maximal proper parthood chain terminates. Although strong atomism is equivalent to superatomism in classical extensional mereology, it is strictly weaker than it in strictly weaker systems in which parthood is a partial order. And it is strictly stronger than standard atomism in classical extensional mereology and, given the axiom of choice, in such strictly weaker systems as well. Though strong atomism has not, to my knowledge, been explicitly identified, Shiver appears to have it in mind, though it is unclear whether he recognizes that it is not equivalent to standard atomism in each of the mereologies he considers. I prove these logical relationships which hold amongst these three atomistic principles, and argue that, whether one adopts classical extensional mereology or a system strictly weaker than it in which parthood is a partial order, standard atomism is a more defensible addition to one’s mereology than either of the other two principles, and it should be regarded as the best formulation of the atomistic thesis. (shrink)

Speaks defends the view that propositions are properties: for example, the proposition that grass is green is the property being such that grass is green. We argue that there is no reason to prefer Speaks's theory to analogous but competing theories that identify propositions with, say, 2-adic relations. This style of argument has recently been deployed by many, including Moore and King, against the view that propositions are n-tuples, and by Caplan and Tillman against King's view that propositions are facts (...) of a special sort. We offer our argument as an objection to the view that propositions are unsaturated relations. (shrink)

Once one accepts that certain things metaphysically depend upon, or are metaphysically explained by, other things, it is natural to begin to wonder whether these chains of dependence or explanation must come to an end. This essay surveys the work that has been done on this issue—the issue of grounding and infinite descent. I frame the discussion around two questions: (1) What is infinite descent of ground? and (2) Is infinite descent of ground possible? In addressing the second question, I (...) will consider a number of arguments that have been made for and against the possibility of infinite descent of ground. When relevant, I connect the discussion to two important views about the way reality can be structured by grounding: metaphysical foundationalism and metaphysical infinitism. (shrink)

Maureen Donnelly’s (2016) relative positionalism correctly handles any fixed arity relation with any symmetry such a relation can have, yielding the intuitively correct way(s) in which that relation can apply. And it supplies an explanation of what is going on in the world that makes this the case. But it has at least one potential shortcoming — one that its opponents are likely to seize upon: it can only handle relations with fixed arities. It is unable to handle relations with (...) variable arities. I argue that, all else being equal, relative positionalism ought nonetheless to be preferred to its closest competitors — at least to the extent that the explanation it supplies of relational application is plausible — even though those competitors can handle variable arity relations in addition to fixed arity relations. (shrink)

Human neural and behavioral activities have been reported to exhibit fractal dynamics known as 1/f noise, which is more aptly named 1/f scaling. Some argue that 1/f scaling is a general and pervasive property of the dynamical substrate from which cognitive functions are formed. Others argue that it is an idiosyncratic property of domain‐specific processes. An experiment was conducted to investigate whether 1/f scaling pervades the intrinsic fluctuations of a spoken word. Ten participants each repeated the word bucket over 1,000 (...) times, and fluctuations in acoustic measurements across repetitions generally followed the 1/f scaling relation, including numerous parallel yet distinct series of 1/f fluctuations. On the basis of work showing that 1/f scaling is a universal earmark of metastability, it is proposed that the observed pervasiveness of 1/f fluctuations in speech reflects the fact that cognitive functions are formed as metastable patterns of activity in brain, body, and environment. (shrink)

We describe an approach that enables a more complete evaluation of the validity of emotional intelligence measures. We argue that a source of evidence for validity is often overlooked by researchers and test developers, namely, evidence based on response processes. This evidence can be obtained through a definition of the ability, a description of the mental processes that operate when a person uses the ability, the development of a theory of response behaviour that links variation in the construct with variation (...) on the responses to the items of a measure, and a test of the theory of response behaviour through one or more strategies that we describe. (shrink)

Based on the assumption that confrontation with one’s physical reflection can be aversive, we explored the appeal of possible “escape routes” when incidentally exposed to one’s mirror image. Compared to their no-exposure peers, individuals who felt less chronically “trapped” in their bodies showed increased interest in flow experiences and decreased interest in experiences involving low-level thinking or a subjective sense of meaning when exposed to their reflection. Mirror exposure also increased overall interest in “pure consciousness events,” wherein the transcendence of (...) space and time figures centrally. The aversive effects of even implicit confrontation with one’s reflection therefore seem more diverse than anticipated based on existing frameworks such as Objective Self-Awareness theory, so additional theoretical development seems warranted. (shrink)

To test whether emotional empathy is linked to altered perceptions of self in relation to other and/or context, participants read one of two tragic news stories and then completed a self-report empathy measure, as well as an abridged version of Hood’s Mysticism scale either before or after the article. Exposure to a needy other in the story tended to result in greater self-reported mystical experience. Men with a history of mystical experience reported more empathy, but the latter was disconnected from (...) on-line reports of mystical experience. Women’s history of mystical experience did not predict empathic responding overall, but their reported empathy was linked to on-line experiences of oneness, absorption into something larger, and space-time distortion with imputed religious significance. Directions for future research, including the possible facilitative role of oxytocin, are discussed. (shrink)

We begin by discussing some logical constraints on the psychological approach to personal identity. We consider a problem for the psychological approach that arises in fission cases. The problem engenders the need for a non-branching clause in a psychological account of the co-personality relation. We look at some difficulties in formulating such a clause. We end by rejecting a recently proposed formulation of non-branching. Our criticism of the formulation raises some interesting questions about the individuation of person stages.

Derek Parfit has offered numerous arguments in an attempt to establish that identity is not what matters. Jens Johannson has recently argued that Parfit's various arguments for the claim that identity is not what matters fail to establish what Parfit takes such arguments to establish. Johannson contends that this is due in part to the invalidity of one of Parfit's key arguments, and the fact that Parfit ignores a position that is compatible with the conclusions of his successful arguments and (...) the claim that identity is in fact what matters, namely, that I survive fission as either one of the fission products or the other, but it is indeterminate which one I survive as. I aim to establish here that both of Johannson's assertions are problematic. As a corollary of this task, I hope to shed some light on the relationship between indeterminacy and fission-based arguments for the claim that identity is not what matters. (shrink)

The literature on coordination within and between individuals is reviewed, with an emphasis on the inherent transience of coordination patterns in behavioral activity. This transience is integral to understanding cognitive activity as flexible patterns of coordination in brain, body, and environment. Kello reviews the articles in this special issue as contributions to understanding the role of context in shaping or interpreting coordination patterns in human behavior.

This article explores four topics raised by Eyal Zamir and Barak Medina's treatment of constrained deontology. First, it examines whether mathematical threshold functions are the proper way to think about limits on deontology, given the discontinuities of our moral judgments and the desired phenomenology of rule-following. Second, it asks whether constrained deontology is appropriate for public as well as private decision-making, taking issue with the book's conclusion that deontological options are inapplicable to public decision-making, whereas deontological constraints are applicable. Third, (...) it examines the issue of the relationship between deontology and efficiency, asking whether deontological constraints should yield in situations where everyone would expect to benefit from their suspension, either ex ante or ex post . Finally, the article concludes that constrained deontology is susceptible to political abuse because of the many degrees of freedom involved in identifying constrained actions and the point at which those constraints yield to consequentialist benefits. (shrink)

_ Source: _Volume 5, Issue 1, pp 55 - 60 Peter Murphy has argued that effective skeptical scenarios all have the following feature: the subject involved in the scenario does not know that some ordinary proposition is true, even if the proposition is true in the scenario. So the standard “false belief” conception of skeptical scenarios is wrong, since the belief of the targeted proposition need not be mistaken in the scenario. Murphy then argues that this observation engenders a problem (...) for skeptical arguments: they require the KK principle. We respond to this criticism on behalf of the skeptic in our paper. (shrink)

Buprenorphine is a form of opioid agonist treatment that has been demonstrated to be an effective medication for opioid addiction. It is available in different formulations and marketed under various trade names, including commonly as a buprenorphine/naloxone combination. This paper provides an overview of existing literature on the supply of buprenorphine treatment, the ability of people to access treatment with buprenorphine, and the quality of treatment received. We argue that better data for each of these aspects of treatment could inform (...) policy to expand effective treatment with buprenorphine, and we suggest steps to obtain and act on such data. (shrink)

Those who endorse a knowledge-first program in epistemology claim that rather than attempting to understand knowledge in terms of more fundamental notions or relations such as belief and justification, we should instead understand knowledge as being in some sense prior to such concepts and/or relations. If we suppose that this is the correct approach to theorizing about knowledge, we are left with a residual question about the nature of those concepts or relations, such as justification, that were thought to be (...) first but are now second. Jonathan Jenkins Ichikawa has recently proposed that we understand justification in terms of potential knowledge. Ichikawa combines his view of knowledge and justification with what initially seems to be a natural complement, epistemological disjunctivism. While Ichikawa focuses on hallucination, I shift the focus to illusion. I argue that the combination of justification as potential knowledge and epistemological disjunctivism entails that perceptual beliefs that arise from illusions are not justified. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This chapter focuses on synaesthesia research in the 21st century. It begins by giving counts of publications and these are further broken down by type, focus, and measures used. Then, there is a review of major questions being addressed by current research in the area of synaesthesia. The amount of research being done in this area is growing rapidly, and is incorporating a number of different research approaches to address a wide variety of questions.

Name der Zeitschrift: Das Mittelalter Jahrgang: 21 Heft: 1 Seiten: 145-158.

TOC -/- 0. Introduction (SN/CW) -/- I. Revisiting vitalist themes in 19th-century science -/- 1. Guido Giglioni (Warburg Institute) – Jean-Baptiste Lamarck and the Place of Irritability 2. in the History of Life and Death 3. Joan Steigerwald (York) – Rethinking Organic Vitality in Germany at the Turn of the Nineteenth Century 4. Juan Rigoli (Geneva) –The “Novel of Medicine” 5. Sean Dyde (Cambridge) – Life and the Mind in Nineteenth-Century Britain. Somaticism in the Wake of Phrenology. -/- II. Twentieth (...) century debates on vitalism in science and philosophy -/- 6. Brian Garrett (McMaster) – Vitalism versus Emergent Materialism 7. Christophe Malaterre (Paris) – Life as an Emergent Phenomenon: from an Alternative to Vitalism to an Alternative to Reductionism 8. Sebastian Normandin (Montreal) – Wilhelm Reich: Vitalism and Its Discontents 9. Chiara Elettra Ferrario (Wellington) and Luigi Corsi (Pisa) – Kurt Goldstein: Vitalism and the Organismic Approach 10. Giuseppe Bianco (Paris/Warwick) – The Origins of Canguilhem’s “Vitalism”. Against the Anthropology of Irritation -/- III. Vitalism and contemporary biological developments -/- 11. William Bechtel (UCSD) — Dynamic Mechanistic Explanation: Addressing the Vitalists’ Objections to Mechanistic Science 12. John Dupré and Maureen O’Malley (Exeter) – Varieties of living things: Life at the intersection of lineage and metabolism 13. J. Scott Turner (Syracuse) – Homeostasis and the forgotten vitalist roots of adaptation -/- . (shrink)

Experimental research has shown that pairs of stimuli which are congruent and assumed to 'go together' are recalled more effectively than an item presented in isolation. Will this multisensory memory benefit occur when stimuli are richer and longer, in an ecological setting? In the present study, we focused on an everyday situation of audio-visual learning and manipulated the relationship between audio guide tracks and viewed portraits in the galleries of the Tate Britain. By varying the gender and narrative style of (...) the voice-over, we examined how the perceived congruency and assumed unity of the audio guide track with painted portraits affected subsequent recall. We show that tracks perceived as best matching the viewed portraits led to greater recall of both sensory and linguistic content. We provide the first evidence that manipulating crossmodal congruence and unity assumptions can effectively impact memory in a multisensory ecological setting, even in the absence of precise temporal alignment between sensory cues. (shrink)

Both in the pre-war and the post-war period right-wing extremism was not very strong in Britain. Historians, political scientist and politicians have suggested a whole range of elements to explain this failure. In the light of this limited success the victory of the British National Party in an election of the Millwall district in the London Bourough of Tower Hamlets was indeed a surprise. lt raised the question whether this was the beginning of something similar to what happened earlier in (...) France, Germany, Belgium and the Netherlands. The very specific characteristics of the London East End and ofthe Millwall district in particular make the BNP victory however quite exceptional, and do not enable a generalization of the phenomenon. This is supported by the electoral results for the London Borough and District Council of May 5 1994. Yet one can still argue that the specific danger of the BNP is not its electoral potential, but the impact of its local activities on the relations between the ethnic groups in the neighbourhoods where it is present. (shrink)

There is an apparent problem stemming from the factivity of knowledge that seems to afflict both contextualism and subject-sensitive invariantism . 1 In this article, we will first explain how the problem arises for each theory, and then we will propose a uniform resolution.1. The factivity problem for contextualismLet K t stands for X knows _ at t. Let h stand for S has hands. According to contextualism, ‘K t’ is true as uttered in some ordinary conversational contexts. Let O (...) be such a context. So we have ‘K t’ is true in O.Consider a demanding conversational context D . Let S* be a participant in D. We have ‘K t’ is not true in D.In prose: ‘S* knows at t that S has hands’ is not true in D. 2 , 3 Let us suppose that S* has a favourable epistemic status with respect to , as follows: ‘K t[S*,‘K t’ is true in O]’ is true in D. says that a certain sentence about S*'s epistemic status at t is true in D. S*'s epistemic status with respect to which proposition? A certain metalinguistic proposition concerning the truth in O of the sentence ‘K t’. That sentence in turn concerns S's epistemic status at t with respect to the proposition that S has hands. Got it? 4The factivity of ‘knows’ yields the following consequence : ‘K t’ is true in O → hThis metalinguistic factivity claim is licensed by the fact that any sentence of the …. (shrink)

The concentration of low‐density lipoprotein (LDL) cholesterol (C) in plasma is a key determinant of cardiovascular disease risk and human genetic studies have long endeavoured to elucidate the pathways that regulate LDL metabolism. Massive genome‐wide association studies (GWASs) of common genetic variation associated with LDL‐C in the population have implicated SORT1 in LDL metabolism. Using experimental paradigms and standards appropriate for understanding the mechanisms by which common variants alter phenotypic expression, three recent publications have presented divergent and even contradictory findings. (...) Interestingly, although these reports each linked SORT1 to LDL metabolism, they did not agree on a mechanism to explain the association. Here, we review recent mechanistic studies of SORT1 – the first gene identified by GWAS as a determinant of plasma LDL‐C to be evaluated mechanistically. (shrink)