Two essays on utilitarianism, written from opposite points of view, by J. J. C. Smart and Bernard Williams. In the first part of the book Professor Smart advocates a modern and sophisticated version of classical utilitarianism; he tries to formulate a consistent and persuasive elaboration of the doctrine that the rightness and wrongness of actions is determined solely by their consequences, and in particular their consequences for the sum total of human happiness. In Part II Bernard Williams offers a sustained (...) and vigorous critique of utilitarian assumptions, arguments and ideals. He finds inadequate the theory of action implied by utilitarianism, and he argues that utilitarianism fails to engage at a serious level with the real problems of moral and political philosophy, and fails to make sense of notions such as integrity, or even human happiness itself. This book should be of interest to welfare economists, political scientists and decision-theorists. (shrink)

Michael J. Zimmerman explores whether and how our ignorance about ourselves and our circumstances affects what our moral obligations and moral rights are. He rejects objective and subjective views of the nature of moral obligation, and presents a new case for a 'prospective' view.

Jian Zhou,* Weiqiang Ju,* Xiaopeng Yuan, Xiaofeng Zhu, Dongping Wang, Xiaoshun HeOrgan Transplant Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China *These authors contributed equally to this work: Hyperosmolar nonketotic hyperglycemic coma is a serious, rare complication induced by methylprednisolone pulse therapy for acute rejection after orthotopic liver transplantation. Herein, we report an unusual case of a 58-year-old woman who experienced acute rejection at 30 months after OLT, only one case in which HNKHC resulted in MP (...) pulse therapy for acute rejection in all 913 recipients in our center. The general morbidity of HNKHC was 1.09‰ in this study. HNKHC is characterized by rapid onset, rapid progression, and a lack of specific clinical manifestations. High-dose MP management was a clear risk factor. The principle of treatment included rapid rehydration, low-dose insulin infusion, and correcting disorders of electrolytes and acidosis. In conclusion, clinicians considering MP pulse therapy after OLT should be alert to the occurrence of HNKHC. Keywords: liver transplantation, complications, hyperosmolar nonketotic hyperglycemic coma, methylprednisolone pulse therapy, principle of treatment. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

J.N. Findlay was a South African philosopher who published from the late 1940s into the 1980s. He had a prestigious international academic career, holding many academic posts around the world. This article uses a textual comparative approach and focuses on Findlay’s Gifford Lecture at St Andrews University between 1965 and 1970. The objective of the article is to highlight the extent to which Findlay’s philosophical writings were influenced by Mahāyāna Buddhism. Although predominantly a Platonist, Findlay drew influence from Asian philosophy (...) and religion, particularly Mahāyāna Buddhism. In these lectures, he applies the metaphor of the Platonic Cave to investigate Hegelian and Husserlian approaches to knowledge. Though he was a leading Hegel and Husserl scholar, his reading of these two philosophers is strongly influenced by Mahāyāna Buddhism, resulting in a unique mystical interpretation of these two philosophers. Revisiting Findlay’s writings is significant for two reasons; firstly, he investigated Buddhism prior to the Asian religions being included in Religious Studies departments’ purview in South African universities, and secondly, his interpretation of two prominent Western philosophers along Buddhist lines provides an early attempt at decolonising the predominance of Western philosophical views of knowledge.Contribution: This contribution forms part of a larger collection of essays investigating philosophical works that have had a significant impact on the study of religion. This contribution investigates the Buddhist influence on J.N. Findlay’s philosophical readings of Husserl and Hegel. (shrink)

This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotransplantation into the clinical setting. The symposium was the first of its kind in the UK for 20 years. This paper (...) summarises the content of the expert lectures showcasing the progress which has been made in xenotransplantation including—the history of xenotransplantation, advances in gene edited animals and progress towards clinical xenotransplantation. We then set out the ethical and legal issues still to be resolved. Finally, we report the themes of the roundtable discussion highlighting areas of consensus and controversy. While the detail of the legal discussion was directed towards the UK, the principles and summary reported here are intended to be applicable to any jurisdiction seeking to implement clinical xenotransplantation. (shrink)

The topic of truth has long been thought to be connected to scientific realism and its opposition. In this essay, I discuss the various ways that truth might be related to realism. First, I consider how truth might be of use when defining scientific realism and its opposition. Second, I consider whether various stances regarding realism require specific stances on the nature of truth. I survey "neutralist" views that argue that one's stance on realism is independent of one's view on (...) truth, and partisan positions that claim that one's attitude on realism is, in part, determined by one's theory of truth. Though partisan views have been popular, and defended by seminal figures such as Thomas Kuhn, Richard Rorty, Hilary Putnam, and Arthur Fine, I raise a number of objections for them. (shrink)

A selection of conversations which the author had with people from all over the world, as recorded in his notebooks. These encounters look at some of the most challenging and confusing questions of human existence. Throughout, the author stresses the necessity of a still mind.

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

In a recent paper, Haig and Borsboom explore the relevance of the theory of truth for psychological science. Although they conclude that correspondence theories of truth are best suited to offer the resources for making sense of scientific practice, they leave open the possibility that other theories might accomplish those same ends. I argue that deflationary theories of truth, which deny that there is any substantive property that unifies the class of truths, makes equally good sense of scientific practice as (...) the correspondence theory, but at lesser theoretical cost. I also argue that the considerations Haig and Borsboom draw on are better thought of as issues relevant to realism, and thus separate from the theory of truth. I conclude that while they are correct to engage questions about what makes true the various claims that arise in psychological research, they may do so without saddling themselves with a correspondence theory. (shrink)

Language, Duty, and Value Jonathan Dancy, J. M. E. Moravcsik James Opie Urmson, Edited by Jonathan Dancy, J. M. E. Moravcsik, and C. C. W. Taylor. reasons in general. This is freedom in the sense of acting on reasons, yet not those ...

Explanation has played myriad roles in truthmaker theory. The notion of explanation is sometimes thought to give content to the very idea of truthmaking, and is sometimes used as a weapon to undermine the entire point of truthmaker theory. I argue that the notion of explanation is dialectically useless in truthmaker theory: while it’s true that truthmaking offers a form of explanation, this claim is theoretically unilluminating, and leaves truthmaker theorists vulnerable to various kinds of attack. I advocate an alternative (...) approach to truthmaker theory that downplays the role of explanation, and show how it releases the enterprise from a variety of problematic commitments that have troubled truthmaker theorists. The “ontology-first” approach to truthmaking that I advocate not only restores the initial impulse behind truthmaking, but also has a number of theoretical advantages. Most prominently, it dodges the infamous problem of negative existentials, and lessens truthmaker theory’s dependence on contentious intuitive judgments about both explanation and truthmaking. (shrink)