A model of an intentional self-observing system is proposed based on the structure and functions of astrocyte-synapse interactions in tripartite synapses. Astrocyte-synapse interactions are cyclically organized and operate via feedforward and feedback mechanisms, formally described by proemial counting. Synaptic, extrasynaptic and astrocyte receptors are interpreted as places with the same or different quality of information processing described by the combinatorics of tritograms. It is hypothesized that receptors on the astrocytic membrane may embody intentional programs that select corresponding (...) synaptic and extrasynaptic receptors for the formation of receptor-receptor complexes. Basically, the act of self-observation is generated if the actual environmental information is appropriate to the intended observation processed by receptor-receptor complexes. This mechanism is implemented for a robot brain enabling the robot to experience environmental information as “its own”. It is suggested that this mechanism enables the robot to generate matches and mismatches between intended observations and the observations in the environment, based on the cyclic organization of the mechanism. In exploring an unknown environment the robot may stepwise construct an observation space, stored in memory, commanded and controlled by the intentional self-observing system. Finally, the role of self-observation in machine consciousness is shortly discussed. (shrink)

The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular (...) calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. (shrink)

The self, Joseph LeDoux tells us, is “the totality of the living organism”. Most disciplines in the natural sciences focus on only one or two levels of organization. Indeed, Dmitri Mendeleev figured out the periodic table of the elements without knowing any of the underlying quantum mechanics or stereochemistry. There are, however, at least a dozen levels of organization within the neurosciences — and, if we use a metaphor, we temporarily create yet another. This leads to considerable confusion and arguments (...) at cross purposes over whether learning is an alteration at the level of gene expression, ion channels, synapses, neurons or circuits. Each neuron has thousands of synapses, which produce currents that summate to form an impulse train. But only rarely is the activity of a single neuron sufficient to cause a perception or trigger an action. Neurons usually act as members of ‘committees’ — what Donald Hebb in 1949 called cellassemblies. Just as in academia, one individual may function in different committees on different occasions. A concept, including any explicit memory that we can talk about, is probably formed by such a committee. Implicit memories are less differentiated — they are part of the ‘feltwork’, together with motivations and emotions, that biases the choice of one’s next act. In this well-written 400-page appreciation of behavioural neuroscience, LeDoux argues that synapses are the seat of self. He says, in effect, that you are your memories; that it is the uniqueness of an array of synaptic strengths that distinguishes one twin from another. Fair enough, but why not instead focus on one’s unique array of ion channels? Or neurons, because a neuron is the closest thing we have to a computational unit? Or one’s unique arrangement of those overlapping, redundant hebbian committees? None of these make for a catchy book title, but relating other things to the synapses proves to be a good way of covering a lot of fascinating material at the overlying levels, including a few updates to LeDoux’s earlier book The Emotional Brain. (shrink)

Phillips & Silverstein emphasize the gain-control properties of NMDA synapses in cognitive coordination. We endorse their view and suggest that NMDA synapses play a crucial role in biased attentional competition and (visual) working memory. Our simulations show that NMDA synapses can control the storage rate of visual objects. We discuss specific predictions of our model about cognitive effects of NMDA-antagonists and schizophrenia.

This article describes the tripartite structure, a formative style used in the redaction of some sugyot in Tractate Eruvin. The attitude to the tripartite structure is portrayed here as reflected by commentators and researchers who mentioned this pattern, whether directly or indirectly. The purpose of the article is to present several select examples of the tripartite structure in some sugyot in Tractate Eruvin. This will have the significant effect of illuminating different literary forms worthy of exploration, such (...) as the tripartite structure here, as well as in other Talmudic sugyot whose focus is mainly halakhic. Sometimes the form utilized has a considerable effect on redaction of the contents, for example for understanding the sugya or solving various difficulties that it contains. These patterns are also evident in other additional sugyot and they constitute an important research foundation for examining their application in additional sugyot in the different tractates. (shrink)

No overarching hypotheses tie the basic mechanisms of mitochondrial reactive oxygen species (ROS) production to activity dependent synapse pruning—a fundamental biological process in health and disease. Neuronal activity divergently regulates mitochondrial ROS: activity decreases whereas inactivity increases their production, respectively. Placing mitochondrial ROS as innate synaptic activity sentinels informs the novel hypothesis that: (1) at an inactive synapse, increased mitochondrial ROS production initiates intrinsic apoptosis dependent pruning; and (2) at an active synapse, decreased mitochondrial ROS production masks (...) intrinsic apoptosis dependent pruning. Immature antioxidant defense may enable the developing brain to harness mitochondrial ROS to prune weak synapses. Beyond development, endogenous antioxidant defense constrains mitochondrial (ROS) to mask pruning. Unwanted age‐related synapse loss may arise when mitochondrial ROS aberrantly recapitulate developmental pruning. Placing mitochondrial ROS with their hands on the shears is beneficial in early but deleterious in later life. (shrink)

This selective review explores biologically inspired learning as a model for intelligent robot control and sensing technology on the basis of specific examples. Hebbian synaptic learning is discussed as a functionally relevant model for machine learning and intelligence, as explained on the basis of examples from the highly plastic biological neural networks of invertebrates and vertebrates. Its potential for adaptive learning and control without supervision, the generation of functional complexity, and control architectures based on self-organization is brought forward. Learning without (...) prior knowledge based on excitatory and inhibitory neural mechanisms accounts for the process through which survival-relevant or task-relevant representations are either reinforced or suppressed. The basic mechanisms of unsupervised biological learning drive synaptic plasticity and adaptation for behavioral success in living brains with different levels of complexity. The insights collected here point toward the Hebbian model as a choice solution for “intelligent” robotics and sensor systems. Keywords: Hebbian learning; synaptic plasticity; neural networks; self-organization; brain; reinforcement; sensory processing; robot control . (shrink)

. Progress in technology has allowed dynamic research on the development of the human brain that has revolutionized concepts. Particularly, the notions of plasticity, neuronal selection, and the effects of afferent stimuli have entered into thinking about brain development. Here I focus on development from the age of four years to early adulthood, during which a 30 percent reduction in some brain synapses occurs that is out of proportion to changes in neuronal numbers. This corresponds temporally with changes in normal (...) child behavior from the loose‐associative, almost schizoid, thinking and art of the four‐year‐old to the more trained, or disciplined, or acculturated—and restrained—personality of the young adult. I propose that the synaptic changes can best be thought of as a winnowing process likely subject to environmental influences. Acquisition of language and the ability to link linguistic cognition to the plastic development of the brain provide a potentially powerful means of explaining the evolutionally explosive development of human cognition and culture. Schizophrenia, a disease that can be envisioned as representing a derangement of synaptic maturation, may provide an entry into the search for genes controlling the processes mediating the unprecedented development of Homo sapiens over the past 40,000 to 70,000 years. The recently completed mapping of the genome of the chimpanzee provides a new frame of reference that may speed the search. (shrink)

In this paper I argue that, despite what many commentators have concluded, Plato’s division of three psychological “causes” of criminal behavior at Laws 863b1-e3 (anger, pleasure, and ignorance) is not intended to invoke the tripartite theory of the soul. I suggest that the focus of the division is on an alternative moral psychological picture, one which is better suited to the criminal penology of Book 9. However, I argue, this alternative picture is nonetheless consistent with tripartite theory.

Many philosophers today approach important psychological phenomena, such as weakness of the will and moral motivation, using a broadly Humean distinction between beliefs, which aim to represent the world, and desires, which aim to change the world. On this picture, desires provide the ends or goals of action, while beliefs simply tell us how to achieve those ends. In the Republic, Socrates attempts to explain the phenomena using a different distinction: he argues that the human soul or psyche consists in (...) reason, spirit, and appetite. It is initially tempting to assimilate Socrates’ picture to the standard belief ⁄ desire model, and to think that reason’s role in motivating action is restricted to calculating the best means for satisfying spirited and appetitive desires. But this would be a mistake, since Socrates thinks that each element in the soul is capable of setting the ends of action. But then how exactly should we understand these elements? My aim in this essay is to introduce the reader to Plato’s theory of the tripartite psychology. In part 2, I present Socrates’ argument for the claim that the soul has three elements. In part 3, I provide a general characterization of reason, spirit, and appetite, respectively. I then turn to discuss two central interpretive issues. In part 4, I discuss the sense in which Socrates considers the appetitive and spirited elements to be non-rational. And in the final part of the essay, I discuss the issue of how we ought to conceive of the parts of the soul, and more specifically, whether we should think of them as agent-like parts, or in some other way. (shrink)

Offers a conception of love and why it is meaningful.

The classical account of federalism is bipartite. Federal systems are understood to have a dual nature: on the one hand, there is the central government, and on the other hand, there are the constituent units. We argue instead for a tripartite model of federalism. In this model, a third institutional pillar is added to federal systems. This third pillar deals exclusively with matters related to the institutional architecture of the system. We argue for tripartite federalism on three grounds: (...) a tripartite structure would be better suited to accommodate political communities where citizens might currently feel misrecognized by the central government, it would provide a more efficient way to adjust the federal architecture and it would be able to do so in a more democratic manner. We conclude our article with a reflection on the distance between our ideal-typical tripartite model and actual reality. (shrink)

As concerns over the negative social and environmental impacts of industrial agriculture become more widespread, efforts to define and regulate sustainable agriculture have proliferated in the US. Whereas the USDA spearheaded previous efforts, today such efforts have largely shifted to Tripartite Standards Regimes (TSRs). Using a case study of the Leonardo Academy’s initiative to develop a US sustainable agriculture standard, this paper examines the standards-development process and efforts by agribusiness to influence the process. Specifically, we analyze how politics operate (...) in seemingly “depoliticized” TSRs, and how agribusiness and the USDA use “framing practices” and procedural complaints to influence the standard-development process. We contend that although governance mechanisms are a potentially powerful tool for advocates of alternative agrifood, their efficacy may be constrained by science-based requirements, an agribusiness countermovement, and a captured state. (shrink)

This article deals with a tripartite structure applied to a Tannaitic source. This structure is designed in the form of a difficulty and a short resolution, bringing one example for each of the three parts of the Tannaitic source. The uniform formative-stylistic phrasing gives the discussion of the Tannaitic source's three parts a tripartite form. The Tannaitic source utilises a chaining of examples from the first to the second part and from the second to the third part.

We recently described a novel form of stress‐associated bidirectional plasticity at GABA synapses onto hypothalamic parvocellular neuroendocrine cells (PNCs), the apex of the hypothalamus‐pituitary‐adrenal axis. This plasticity may contribute to neuroendocrine adaptation. However, this GABA synapse plasticity likely does not translate into a simple more and less of inhibition because the ionic driving force for Cl−, the primary charge carrier for GABAA receptors, is dynamic. Specifically, stress impairs a Cl− extrusion mechanism in PNCs. This not only renders the steady‐state (...) GABA response less hyperpolarizing but also makes PNCs susceptible to the activity‐dependent accumulation of Cl−. Accordingly, GABA synapse plasticity impacts both the robustness of GABA voltage response and dynamic Cl− loading, imposing nonlinear influences on PNC excitability during circuit activities. This theoretical consideration predicts roles for GABA transmission far more versatile than canonical inhibition. We propose potential impacts of GABA synapse plasticity on the experience‐dependent fine‐tuning of neuroendocrine stress responses. (shrink)

The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much debate. Non-bilaterian metazoans, both with and without neurons and their closest relatives already contain many components of the molecular toolkits for synapse functions. The origin of these components and their assembly into ancient synaptic signaling machineries are particularly important in light of recent findings on the phylogeny of non-bilaterian metazoans. The evolution of synapses and neurons are often discussed only from a metazoan perspective leaving a (...) considerable gap in our understanding. By taking an integrative approach we highlight the need to consider different, but extremely relevant phyla and to include the closest unicellular relatives of metazoans, the ichthyosporeans, filastereans and choanoflagellates, to fully understand the evolutionary origin of synapses and neurons. This approach allows for a detailed understanding of when and how the first pre- and postsynaptic signaling machineries evolved. The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much debate. Most of our knowledge and recent discussions are biased towards a metazoan perspective, leaving a considerable gap in our understanding. Recent work has now revealed important insights into the emergence and co-regulation of complex synaptic signaling machineries from studies in the closest unicellular relatives of metazoans. (shrink)

Robert Cummins [(1996) Representations, targets and attitudes, Cambridge, MA: Bradford/MIT, p. 1] has characterized the vexed problem of mental representation as "the topic in the philosophy of mind for some time now." This remark is something of an understatement. The same topic was central to the famous controversy between Nicolas Malebranche and Antoine Arnauld in the 17th century and remained central to the entire philosophical tradition of "ideas" in the writings of Locke, Berkeley, Hume, Reid and Kant. However, the scholarly, (...) exegetical literature has almost no overlap with that of contemporary cognitive science. I show that the recurrence of certain deep perplexities about the mind is a systematic and pervasive pattern arising not only throughout history, but also in a number of independent domains today such as debates over visual imagery, symbolic systems and others. Such historical and contemporary convergences suggest that the fundamental issues cannot arise essentially from the theoretical guise they take in any particular case. (shrink)

Here we explore, through conversation, our experience, as programme coordinators, of delivering degree-level apprenticeships. Although relatively ‘young’, the Degree Apprenticeship model has grown significantly since its inception in 2015 and such programmes continue to be supported politically in a way which suggests a long-term future. However, our experience has been one where two different domains of practice have collided—that of ‘Higher Education’ and that of ‘Apprenticeship’—in a way which, for us, has not been comfortable.Our conversation explores the issues of working (...) within a triangular relationship between apprentice, employer and the university, in the context of the Apprenticeship framework in England. In addition, the idea of apprenticeship and work-based learning is considered from our direct experience as we reflect on how our current teaching practice has been informed by our early careers. Grounded by the notion of an apprenticeship ideal that is supposed to exist, we consider the apparent tensions that are inherent in offering apprenticeships within a university context. (shrink)

Recent experiments have begun to decipher the molecular dialog that mediates differentiation at sites of synaptic between neurons and their targets. It had been hypothesized that the protein agrin is released by axon terminals at embryonic neuromuscular junctions and binds to a receptor on the myofiber surface to trigger postsynaptic differentiation. Now a genetic ‘Knockout’ experiment has confirmed the essential role of agrin in signaling between developing nerve and muscle(1). A second ‘knockout’ has shown that the muscle‐specific receptor tyrosine kinase (...) MuSK is a critical element in the agrin‐induced signaling cascade(2). Additional results suggest that MuSK may comprise a portion of the agrin receptor(3). (shrink)

Belief and credence are often characterized in three different ways—they ought to govern our actions, they ought to be governed by our evidence, and they ought to aim at the truth. If one of these roles is to be central, we need to explain why the others should be features of the same mental state rather than separate ones. If multiple roles are equally central, then this may cause problems for some traditional arguments about what belief and credence must be (...) like. I read the history of formal and traditional epistemology through the lens of these functional roles, and suggest that considerations from one literature might have a role in the other. The similarities and differences between these literatures may suggest some more general ideas about the nature of epistemology in abstraction from the details of credence and belief in particular. (shrink)

In the Republic, Phaedrus, and Timaeus, Socrates holds that the psyche is complex, or has three distinct and semi-autonomous sources of motivation, which he calls the reasoning, spirited, and appetitive parts. While the rational part determines what is best overall and motivates us to pursue it, the spirited and appetitive parts incline us toward different objectives, such as victory, honor, and esteem, or the satisfaction of our desires for food, drink, and sex. While it is obvious that Socrates primarily characterizes (...) and distinguishes the parts in terms of what each desires and pursues, what is less often brought to the fore is that he also characterizes and distinguishes the parts in terms of how they think. More specifically, he claims that the rational part forms its beliefs on the basis of rational calculation, while the spirited and appetitive parts form their beliefs on the basis of how things appear, without scrutinizing those appearances. Socrates’ dual characterization of the parts of the soul raises a question: why does he characterize each part as having the particular desires and cognitive abilities that he does? In general, how do facts about what a part desires relate to facts about how it thinks? In this paper, I suggest an answer to this question, one that I hope sheds light on the nature of the parts of the soul and so on Plato’s theory of tripartition more generally. I conclude by showing that Socrates’ theory bears a notable resemblance to contemporary dual process theories of judgment, according to which we have two distinct processes for forming judgments, one which is broadly akin to reflection and another to intuition. (shrink)

A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the (...) neuromuscular junction is proposed and the basic selective aspect of learning emphasized. (shrink)

A dualistic approach to consciousness is presented that employs Hebbian synaptic dynamics and the basic notion of measurement in science to bridge the so-called explanatory gap between first-person consciousness and third-person science. Unconscious processing by neural circuitry characterizes (i) the neuron as a measuring instrument and (ii) the neural signal as the quantity to be measured. Hebbian synaptic dynamics, effectuating the storage of information, implements the role of an observer of a measurement outcome. The approach extends physical renormalization techniques, as (...) applied to phase changes, to biology. This leads to the proposal of a ramification process in neural systems (brains) from a primitive form of sensation associated with the Hebbian synapse toward more elaborate experiential forms of consciousness (feelings, qualia) associated with hierarchies of neuronal assemblies. Characterizing sensation as a form of mutual information at the synaptic level motivates a relation between consciousness and phase changes of information. (shrink)

The developing neuromuscular junction has provided an important paradigm for studying synapse formation. An outstanding feature of neuromuscular differentiation is the aggregation of acetylcholine receptors (AChRs) at high density in the postsynaptic membrane. While AChR aggregation is generally believed to be induced by the nerve, the mechanisms underlying aggregation remain to be clarified. A 43‐kD protein (43k) normally associated with the cytoplasmic aspect of AChR clusters has long been suspected of immobilizing AChRs by linking them to the cytoskeleton. In (...) recent studies, the AChR clustering activity of 43k has, at last, been demonstrated by expressing recombinant AChR and 43k in non‐muscle cells. Mutagenesis of 43k has revealed distinct domains within the primary structure which may be responsible for plasma membrane targeting and AChR binding. Other lines of study have provided clues as to how nerve‐derived (extracellular) AChR‐cluster inducing factors such as agrin might activate 43k‐driven postsynaptic membrane specialization. (shrink)

Chinese philosophy has long recognized the importance of the body and emotions in extensive and diverse self-cultivation traditions. Philosophical debates about the relationship between mind and body are often described in terms of mind-body dualism and its opposite, monism or some kind of "holism." Monist or holist views agree on the unity of mind and body, but with much debate about what kind, whereas mind-body dualists take body and mind to be metaphysically distinct entities. The question is important for several (...) reasons. Several humanistic and scientific disciplines recognize embodiment as an important dimension of the human condition. One version, the problem of mind-body dualism, is central to the history of both philosophy and religion. Some account of relations between body and mind, spirit or soul is also central to any understanding of the self. Recent work in cognitive and neuroscience underscores the importance of our somatic experience for how we think and feel. (shrink)

There are remarkable behavioral, neural, and genetic similarities between the way songbirds learn to sing and human infants learn to speak. Furthermore, the brain regions involved in birdsong learning, perception, and production have been identified and characterized in detail. In particular, the caudal medial nidopallium (the avian analog of the mammalian auditory‐association cortex) has been found to contain the neural substrate of auditory memory, paving the way for analyses of the underlying molecular mechanisms. Recently, the zebra finch genome was sequenced, (...) and annotated cDNA databases representing over 15,000 unique brain‐expressed genes are available, enabling high‐throughput gene expression analyses. Here we review the involvement of immediate early genes (e.g. zenk and arc), their downstream targets (e.g. synapsins), and their regulatory signaling pathways (e.g. MAPK/ERK) in songbird memory. We propose that in‐depth investigations of zenk‐ and ERK‐dependent cascades will help to further unravel the molecular basis of auditory memory. (shrink)

Plato’s tripartite soul plays a central role in his account of justice in the Republic. It thus comes as a surprise to find him apparently abandoning this model at the end of the work, when he suggests that the soul, as immortal, must be simple. I propose a way of reconciling these claims, appealing to neglected features of the city-soul analogy and the argument for the soul’s division. The original true soul, I argue, is partitioned, but in a finer (...) manner than how we encounter it in our everyday lives. (shrink)

A consensus holds that guanxi, understood as dyadic connections consolidated affectively and mobilized to achieve the purposes of members, exists in three forms (family guanxi, friendship guanxi, and acquaintance guanxi) distinguished by the strength of felt obligation between participants. It is also held that through practices of fictive kinship friendship guanxi may merge with family guanxi. This article challenges these propositions and the assumptions underlying them. Obligations of kinship and guanxi obligations are fundamentally dissimilar and the term “family guanxi” is (...) redundant. Pseudo-family ties do not provide access to kin relations and their resources but instead affirm the distinction between family- and friendship-ties. Finally, because guanxi is cultivated by its participants, friendship guanxi and acquaintance guanxi are not distinct forms but rather are different possible stages of guanxi formation. The article goes on to consider the sources of these confusions, namely, common-language terms employed in sociological analysis, certain assumptions concerning Chinese culture, and finally methodological commitments that privilege latent structures of strong ties. The strength of guanxi ties, on the other hand, volitionally cultivated and indifferent to structural determination, fluctuates through agentic practices. (shrink)

How do human infants learn the causal dependencies between events? Evidence suggests that this remarkable feat can be achieved by observation of only a handful of examples. Many computational models have been produced to explain how infants perform causal inference without explicit teaching about statistics or the scientific method. Here, we propose a spiking neuronal network implementation that can be entrained to form a dynamical model of the temporal and causal relationships between events that it observes. The network uses spike-time (...) dependent plasticity, long-term depression, and heterosynaptic competition rules to implement Rescorla–Wagner-like learning. Transmission delays between neurons allow the network to learn a forward model of the temporal relationships between events. Within this framework, biologically realistic synaptic plasticity rules account for well-known behavioral data regarding cognitive causal assumptions such as backwards blocking and screening-off. These models can then be run as emulators for state inference. Furthermore, this mechanism is capable of copying synaptic connectivity patterns between neuronal networks by observing the spontaneous spike activity from the neuronal circuit that is to be copied, and it thereby provides a powerful method for transmission of circuit functionality between brain regions. (shrink)

This article is a theoretical treatment of feminist epistemology of crime, which advocates the centrality of gender as a theoretical starting point for the investigating of digital crimes. It does so by exploring the synergy between the feminist perspectives and the Tripartite Cybercrime Framework (TCF) (which argues that three possible factors motivate cybercrimes – socioeconomic, psychosocial, and geopolitical) to critique mainstream criminology and the meaning of the term “cybercrime”. Additionally, the article examines gender gaps in online harassment, cyber‐bullying, cyber‐fraud, (...) revenge porn, and cyber‐stalking to demonstrate that who is victimised, why, and to what effect are the critical starting points for the analysis of the connections between gender and crimes. In turn, it uses the lens of intersectionality to acknowledge that, while conceptions of gender and crime interact, they intersect with other categories (e.g., sexuality) to provide additional layers of explanation. To nuance the utilitarian value of the synergy between the TCF and the feminist perspectives, the focus shifts to a recent case study (which compared socioeconomic and psychosocial cybercrimes). The article concludes that, while online and offline lives are inextricably intertwined, the victimisations in psychosocial cybercrimes may be more gendered than in socioeconomic cybercrimes. These contributions align the TCF to the feminist epistemology of crime in their attempt to move gender analysis of digital crimes “from margin to centre”. (shrink)