Human B cell stimulatory factor 2 (originally designated BSF2) was initially characterized and isolated as a T cell‐derived factor that caused the terminal maturation of activated B cells to immunoglobulin producing cells. Molecular cloning of the cDNA has revealed that BSF2 is identical with 26 kD protein, interferon β2, plasmacytoma growth factor and hepatocyte stimulating factor and the designation “IL‐6” has been proposed for this molecule. It is now known that BSF2/IL‐6 has a wide variety of biological functions and that (...) abnormal regulation of BSF2/IL‐6 expression may be related to the pathogenesis of certain autoimmune diseases such as rheumatoid arthritis and multiple myeloma. (shrink)

I tested the hypothesis that, in infant-mother-sibling interactions, infants with older siblings aged 11 to 24 months produce deictic gestures when they are proximal to, or engaging in joint attention with, their mothers more frequently than same-aged infants without siblings. Fifteen infant-mother dyads and 10 infant-mother-sibling triads were individually observed for 15 minutes in a playroom full of toys. Infants involved in infant-mother-sibling interactions produced more deictic gestures when they were proximal to their mothers than infants in infant-mother interactions. Further, (...) infants involved in infant-mother-sibling interactions accompanied their gestures with vocalizations at a higher rate than infants in infant-mother interactions. This result suggests that infants with older siblings monitor their mothers more carefully in interactions in which their sibling is also present, and that they produce deictic gestures in order to effectively elicit joint action with their mothers. (shrink)

Automated neuropsychiatric batteries have been used in research and clinical practice, including for chronic diseases, such as Systemic Lupus Erythematosus. The Pediatric Automated Neuropsychological Assessment Metrics battery, originally developed for use in American-English speaking individuals, allows tracking of cognitive functions. It can be applied to people over 9 years old. The aim of this study was to translate and present initial validation data from the Ped-ANAM into Brazilian-Portuguese. We translated the battery according to Beaton’s guidelines. Psychometric properties were tested, internal (...) consistency was analyzed by Cronbach’s alpha coefficient, test-retest reliability by the intraclass correlation coefficient. Further, we measured the test execution speed at both times as a temporal stability. Principal component analysis was used for structural validity. Evidence of construct validity was assessed through assessment of the relationships with the Wechsler Intelligence Scales. All participants prior to the start of study related activities signed an informed consent form approved by the local ethics committee. A sample of 230 individuals [mean of age: 23 years; 65% females] was included; a subset of 51 individuals [mean of age: 18 years, 59% female] completed the Ped-ANAM twice to assess test-retest reliability, and another subset of 54 individuals [mean of age: 20.4 years; 67% female] completed the Wechsler Intelligence Scales for Children and Adult for assessment of the Ped-ANAM’s construct validity. Our results suggest that the internal consistency of the Ped-ANAM and its subtest test-retest reliability were excellent. There was no clustering in the Principal Components Analysis, suggestive of non-grouping of the evaluated variables. Construct validity assessment to the Wechsler Scales showed expected ranges of low to strong correlations. We concluded that, based on the results of this study, a cross-culturally validated Brazilian-Portuguese version of the Ped-ANAM has been developed and it is a reliable tool for the screening cognitive function. (shrink)

O artigo objetiva refletir acerca dos embates vivenciados pelos acadêmicos do curso de Pedagogia, durante o momento de Estágio Supervisionado na Educação Infantil, buscando identificar a contribuição desta disciplina no curso de Pedagogia para a formação dos futuros profissionais. Para isso, partimos da importância do estágio supervisionado na formação inicial de professores e sustentamos a reflexão a partir da análise documental do plano de ensino da disciplina e de dezenove relatórios de estágio, no contexto de uma instituição pública de Ensino (...) Superior. As análises estão respaldadas em autores como Kishimoto, Pimenta, dentre outros que contribuem para pensarmos a relevância do estágio, como elemento formador. Dadas as necessidades e o franco desenvolvimento vivido pelas crianças na faixa etária da Educação Infantil, torna-se necessária uma formação inicial consistente em que os futuros docentes sejam capacitados a trabalhar fomentando nas crianças habilidades sociais, intelectuais, físicas e afetivas. Os dados evidenciaram um distanciamento entre o contexto estudado na universidade e o cotidiano nas instituições de Educação Infantil, condição que torna menos qualificada a experiência do estágio supervisionado, mas não reduz sua importância como momento de reflexão e aproximação com o campo de trabalho. Embora exista uma relação entre o plano de ensino da disciplina e os relatórios analisados, ainda persiste uma grande distância entre a formação oferecida no âmbito acadêmico e a prática das instituições. Isso, ao contrário de oferecer um descrédito à formação, demonstra uma necessidade de melhor preparo e espaço para as discussões acerca da Educação Infantil, nos cursos de formação de docentes. (shrink)