In eukaryotic cells, messenger RNAs are formed by extensive posttranscriptional processing of primary transcripts, assembled with a large number of proteins and processing factors in ribonucleoprotein complexes. The protein moiety of these complexes mainly constitutes a class of about 20 major polypeptides called heterogeneous nuclear ribonucleoproteins or hnRNPs. The function and the mechanism of action of hnRNPs is still not fully understood, but the identification of RNA binding domains and RNA binding specificities, and the development of new functional assays, has (...) stimulated interest in them. In contrast to previous models that hypothesised a mere structural (histone‐like) function, a more diversified and dynamic role for these proteins is now emerging. In fact, they can be viewed as a subset of the trans‐acting pre‐mRNA maturation factors. They might actively participate in post‐transcriptional events such as regulated splicing and mRNA export. Moreover, recent data suggest an involvement of some of these proteins in molecular diseases. Here we present an overview of the most relevant properties of hnRNPs and discuss some emerging ideas on theiir roles. (shrink)

Although in Italy there is currently no effective law on physician-assisted suicide or euthanasia, Decision No. 242 issued by the Italian Constitutional Court on September 25, 2019 established that an individual who, under specific circumstances, has facilitated the implementation of an independent and freely-formed resolve to commit suicide by another individual is exempt from criminal liability. Following this ruling, some citizens have submitted requests for assisted suicide to the public health system, generating a situation of great uncertainty in the application (...) processes. As a matter of fact, shared and defined procedures are lacking as Decision 242/2019 merely added some principles on which the legislature will have to base its future intervention. This paper analyses the advisory role that the Decision attributes to territorial ethics committees with the aim of stimulating discussions on their role in oversight mechanisms. The proposed conclusion is that the envisaged role does not appear consistent with the functions of these bodies and is ultimately substantially undefined and unjustified. (shrink)

Radical Enactivism holds that the best explanation of basic forms of cognition is provided without involving information of any sort. According to this view, the ability to perceive visual affordances should be accounted for in terms of extensional covariations between variables spanning the agent’s body and the environment. Contrary to Radical Enactivism, I argue that the intensional properties of cognition cannot be ignored, and that the way in which an agent represents the world has consequences on the explanation of basic (...) sensorimotor abilities. To support this claim, I show that the perception of visual affordances is not segregated from higher forms of cognition; rather, it is modulated by the agent’s ability to recognize the semantic identity of the visual target. Accordingly, since the semantic recognition of an object involves a way of representing it under a certain description, it can be inferred that the perception of visual affordances cannot be accounted for without considering the intensional properties of cognition. This poses an explanatory issue for Radical Enactivism. (shrink)

My work is an epistemological analysis that concern some philosophical questions about scientific realism. Central in these pages is the defence of a distinction between methaphisical and empirical approach to the notion of reality. In this direction I have considered some aspects of contemporary debate, specially the so called “Inference to the Best Explanation”, and a constitutive theory of empirical objectivity.

Post-Gibson attempts to set out a definition of affordance generally agree that this notion can be understood as a property of the environment with salience for an organism’s behavior. According to this view, some scholars advocate the idea that affordances are dispositional properties of physical objects that, given suitable circumstances, necessarily actualize related actions. This paper aims at assessing this statement in light of a theory of affordance perception. After years of discontinuity between strands of empirical and theoretical research, the (...) time is ripe for addressing the question of whether the dispositional interpretation of affordance is in accordance with some recent evidence from cognitive science and neuroscience. Following this line, I clarify that there are some cases of affordance-related effects that neither require the actualization of an action, nor the presence of an action-related property bearer in the environment, and that the identification of affordance with physical properties provides only a partial explanation of the wide range of affordance-related effects. Accordingly, I argue in favor of a more general account of affordance perception based on the ability to directly detect perceptual patterns in the environment. (shrink)

Riassunto: Il dibattito in filosofia della mente è caratterizzato dal crescente interesse per nuove forme di eliminativismo, note con il nome di teorie enattiviste radicali della mente. Secondo la concezione enattivista radicale, il contenuto intenzionale di uno stato mentale è empiricamente sottodeterminato, pertanto non può essere utilizzato quale elemento di una spiegazione naturalistica del comportamento. Tuttavia, sebbene il riferimento ai contenuti intenzionali non sia conciliabile con il naturalismo ontologico, esso è invece compatibile con una forma di naturalismo metodologico. Seguendo l’analisi (...) semantica proposta da Carnap per i termini teorici, è possibile concepire uno stato mentale come un veicolo simbolico il cui significato è stabilito per mezzo di osservazioni e scelte convenzionali. Attraverso un caso di studio riguardante le funzioni cognitive della corteccia somatosensoriale, l’articolo fornisce le indicazioni programmatiche per un’interpretazione delle spiegazioni intenzionali del comportamento in accordo con la metodologia delle scienze naturali. Parole chiave: Contenuto mentale; Enattivismo radicale; Intenzionalità; Naturalismo; Teleosemantica; Teoria della spiegazione T he Methodological Status of Intentional Contents: The philosophy of mind debate is characterized by increasing consensus regarding a new type of eliminativism, also known as the radical enactivist theory of mind. According to the radical enactivist view, the intentional content of a mental state is empirically undetermined, therefore it cannot figure as part of a naturalistic explanation of behavior. However, although the notion of intentional content is not compatible with any form of ontological naturalism, it is compatible with a form of methodological naturalism. Following Carnap’s semantic analysis of theoretical concepts, it is possible to conceive of intentional mental states as a symbolic vehicles whose meaning can be conventionally established on the basis of empirical observation. In order to support this claim, I refer to a case study on the cognitive functions of somatosensory cortex. This article provides arguments for building an intentional explanation of behavior based on methodological approaches in the natural sciences. Keywords: Mental Content; Radical Enactivism; Intentionality; Naturalism; Teleosemantics; Theory of Explanation. (shrink)

It is well known that common objects in the environment can evoke possibilities of action, but what about their bi-dimensional representation? Do pictures or paintings that represent action-related objects evoke the same possibilities of actions of the objects that they represent? In contemporary cognitive science, there are two contrasting views on this issue. On the one hand, the ecological-dispositional approach to perception supports the idea that viewing depicted objects as endowed with the potential for action is nothing but an illusion. (...) On the other hand, recent findings show that our motor system is activated by the perception of both real and depicted action-related objects, and this activation plays a functional role in planning motor acts. A broad analysis reveals that the activation of the motor system during perceptual tasks plays a crucial rule in processing the practical meaning of the concrete objects and of the abstract representations of them. This evidence has consequences to our understanding of the way we experience pictures and paintings. (shrink)

Devices of direct democracy are an important structural element in Switzerland's political system. In this article, institutions and functions of Switzerland's direct democracy will be presented. Then the author will pursue whether the direct democracy can be used as a device to prevent a dysfunctional parliamentary system of government. He comes to the conclusion that Switzerland's direct democracy is not an exportable good. We know from the Swiss experience that there is no single model that describes how initiatives and referendums (...) function in every state. (shrink)

Los fondos de inversión se han convertido en los últimos años en un mecanismo frecuente que los clubes de fútbol utilizan para financiar el fichaje de jugadores. Aunque muchos autores han destacado sus efectos beneficiosos al permitir que los clubes adquieran jugadores que de otra manera no podrían conseguir, en este trabajo nos centramos en enfatizar dos problemas que pueden plantear. En primer lugar, hemos tratado de mostrar que pueden generar un progresivo alejamiento de los aficionados. En segundo lugar, a (...) través del dilema del prisionero nos hemos propuesto mostrar que pueden contribuir a aumentar a largo plazo la deuda de los clubes y amenazar el fair play financiero.Investment funds have become in recent years a frequent mechanism football clubs use to finance signing of football players. Although many authors have highlighted their beneficial effects by allowing clubs to acquire players who otherwise they would not get, in this paper we focus on two problems. First, we have tried to show that they can generate a progressive distancing from the fans. Secondly, through the prisoner’s dilemma we intend to show that they can contribute to increasing long-term clubs debt and threaten the financial fair play. (shrink)

El principal objetivo de este estudio consiste en dar cuenta de cómo se enmarca la forma de tratamiento nominal marico en el habla de jóvenes universitarios de Caracas, Venezuela, dentro de la Teoría de la cortesía, según la perspectiva ofrecida por los hablantes. Igualmente, se busca documentar qué cambios está presentando en los contextos de uso así como en sus funciones pragmáticas. Los participantes fueron 60 estudiantes universitarios, 30 mujeres y 30 hombres, de 17 a 21 años. Tradicionalmente, la palabra (...) marico se ha usado como agresión verbal vulgar y ha sido, generalmente, considerada un insulto. Luego del análisis cualitativo de los datos, se plantea que esta FTN se halla en una fase de transición de insulto a marcador pragmático anticortés que indica solidaridad dentro de un grupo etario específico y está perdiendo su carácter agraviador. En la actualidad, la juventud caraqueña emplea esta FTN no solo para implicar lazos de amistad, sino para expresar emociones como sorpresa y enojo, crear efectos de intriga, hacer bromas, abrir y cerrar oraciones e, incluso, sustituir otras FTN que nunca han sido consideradas insultos en el español de Venezuela. La metodología empleada fue el cuestionario y el análisis cualitativo de reportes en primera persona. Las variables de edad y sexo son factores determinantes, puesto que parece haber tendencia entre los jóvenes entrevistados a no emplear esta forma nominal con hablantes que están fuera de su grupo etario y las mujeres siguen siendo conservadoras al restringir, más que los hombres, el uso de este vocablo. (shrink)

La relación entre lengua y sexualidad recién ha comenzado a cobrar importancia dentro de los estudios socioculturales. Este trabajo explora las distintas pistas lingüísticas encriptadas en el cuento La búsqueda de Elizabeth, de Marta Pessarrodona, para desenmascarar la velada identidad sexual del personaje central. Un análisis referente al proceso de reconocimiento, búsqueda y aceptación de una identidad sexual no canónica de la protagonista validará los cuatro principios propuestos por Bucholtz y Hall : afloramiento, indexicalidad, relacionalidad y parcialidad.