Name der Zeitschrift: Der Islam Jahrgang: 93 Heft: 2 Seiten: 532-580.

The present Festschrift was born as a tribute to the scientific production of Rémi Brague. This study collects the interventions of several thinkers, with different scientific profiles, who, fond of reality, have reflected on, and been in dialogue with his thought. Brague has explored many spheres: anthropology, metaphysics, religion, history of religions, aesthetics, ethics, politics, and cosmology – where he recalled those anchors in the sky where mankind throws its roots. We have decided to entitle this collection Europa cura te (...) ipsam! inspired by on the admonition of the famous Medice cura te ipsum. As Brague has repeatedly obser- ved, and recently with no little pessimism, it is now up to Europeans to recover their history and look to their future. We hope that the present work can be a stimulus for today’s thinkers and for generations to come, certain that the search for truth is an endless inquiry where harmony and cooperation among thinkers constitute progress. -/- Contributors: Leonardo Allodi, Rafael Alvira, Jean Baechler, Damiano Bondi, Thomas Buchheim, Virgil Ciomos, Rocio Daga Portillo, Marco Damonte, Chantal Delsol, Phil Devine, Thérèse-Anne Druart, Travis Dumsday, David C. Flatto, Michal Gierycz, Elisa Grimi, John F. X. Knasas, Hans Maier, Sante Maletta, Fr Antonio Malo, Fr Giulio Maspero, Ilaria Vigorelli, Fr Piotr Mazurkiewicz, Isabelle Moulin, José Ignacio Gómez Murillo, Maurits Potappel, John M. Rist, H. Em. Card. Angelo Scola, Hans Seitschek, Wilhelm Vossenkuhl. (shrink)

Background Ethical conflicts generate difficulties in daily clinical activity. Which methods of ethical advice are most frequently used to resolve them among Spanish doctors has not been studied. The objective of this study is to describe what methods hospital internal medicine physicians in Spain use to resolve their ethical doubts and which they consider most useful. Design A cross-sectional observational study was conducted through a voluntary and anonymous survey and distributed through an ad hoc platform of the Spanish Society of (...) Internal Medicine. Measures We measured methods by which to resolve doubts, types of tools sought, frequency of consulting the Clinical Ethics Committees, and satisfaction with resolution of ethical issues. Results Of 261 internists surveyed, 86 per cent resolve their ethical doubts with assistance, the most frequently used method being consultation with colleagues (58.6 per cent), followed by using specific protocols or guides (11.8 per cent) and consultation with experts in bioethics (9.6 per cent). The most preferred tools are the creation of protocols (30.3 per cent) and the establishment of a consultant/expert in bioethics (27.8 per cent). Conclusions Internists in Spain usually seek assistance to resolve their ethical doubts. Consulting colleagues is the most frequently adopted method. The majority regard tools to resolve ethical conflicts as necessary, seeking above all protocols and consultants/experts in bioethics. (shrink)

Cancer is a chronic disease that causes the most deaths in the world, being a public health problem nowadays. Even though breast cancer affects the daily lives of patients, many women become resilient after the disease, decreasing the impact of the diagnosis. Based on a positive psychology approach, the concept of co-vitality arises understood as a set of socio-emotional competencies that enhance psychological adaptation. In this sense, emotional intelligence is one of the main protective factors associated with resilience. However, it (...) is not always as beneficial as it seems, and can lead to collateral effects on psychological adjustment. Given this controversy, this study aims to find the specific processes through which the dimensions of Perceived Emotional Intelligence can act as a risk or protective factor in the development of resilience. The total sample was 167 women, 46.7% were breast cancer survivors, and 53.3% were healthy controls. The selection of women with breast cancer carries out randomly, recruited through the Oncology Units. The sample completed measures of resilience and PEI, through Resilience Scale and TMMS-24. The results showed that breast cancer survivors showed higher age and greater levels of resilience and mood repair than healthy women. The mediation analysis revealed that breast cancer survival and PEI predicted 28% of the variance of resilience. The direct effects showed that emotional clarity and mood repair increased resilience levels. Although breast cancer did not predict resilience directly, it does through mood repair by an indirect process. Besides, the analysis showed that emotional attention played a role in vulnerability, decreasing mood repair, and resilience. These research support theories that point to a possible dark side of PEI, thus, a great level of emotional attention makes dark the positive effect of mood repair and personal growth if a clear perception of emotions does not complement it. These results provide empirical support concerning the need to work complementary each dimension of PEI to avoid unwanted effects on intrapersonal adjustment. (shrink)

This research looks into absurdity focusing on its etymology as well as its relationship with the concepts "sense" and "meaning", looks into the concepts of "context" and "decontextualization" so as to understand the nature of absurd decontextualization. Considering the different meanings of absurdity in literature, philosophy and humour, this research is also meant to provide a breakdown of the architecture of nonsense.

El duelo anticipado es un tema al que la filosofía ha prestado muy poca atención, a diferencia de lo que ocurre con el duelo que sigue a la muerte. Una peculiaridad obvia del primero es que sucede mientras todavía existe una relación interpersonal entre el doliente y aquel por quien se duele. En este artículo examino el impacto que el duelo anticipado puede tener en dicha relación, particularmente con respecto a las actitudes reactivas de sanción, propias del conflicto interpersonal.

En Chile se ha otorgado importancia al aprendizaje del inglés en la enseñanza superior, y en la mayoría de las universidades se ha incorporado, en los perfiles de egreso, una competencia relacionada con el idioma inglés. Las mediciones actuales según, la escala del Marco Común Europeo indican un logro de nivel A1 o A2 de este idioma. La motivación es reconocida como una variable psicológica multifacética que impacta, entre otros aspectos, en el proceso de aprendizaje de una segunda lengua. En (...) este sentido, el objetivo de este estudio es analizar la relación entre la variable motivación y rendimiento académico de estudiantes universitarios en una asignatura de inglés. Se realizó un estudio descriptivo-correlacional, con un diseño no experimental de carácter transversal. Se aplicó el instrumento Attitude/Motivation Test Battery (AMTB) de Sandoval Pineda (2011) a una muestra de 53 estudiantes pertenecientes a la carrera de Pedagogía Media en Inglés de una universidad regional en Chile. Los resultados demostraron que la subdimensión de la variable motivación que obtuvo el promedio más alto fue la _Orientación Integrada_ (OINT) (M = 6.712; _DE_ = 0.456). El promedio obtenido por la variable rendimiento académico es M= 5.117 y la desviación estándar DE= 0.917. De acuerdo con la rúbrica de evaluación, el nivel de desempeño de los estudiantes es _Good_, que se describe como: _Student utilizes topic-related vocabulary in an accurate manner for the situation given__,_ aunque los resultados muestran una alta dispersión. En relación con el análisis de la correlación entre las subdimensiones de la variable motivación y rendimiento académico, no se observó una relación significativa (r = 0.072 y un p-valor de 0.610). Algunos de los hallazgos muestran que, los estudiantes reflejaron altos niveles de motivación hacia el aprendizaje del inglés, aunque no se demostró una relación significativa entre la motivación y las calificaciones. (shrink)

This essay develops a loosely understood Marxist notion of material conditions in light of the Caribbean plantation complex. The racial order endemic to the plantation and its continuation in post-emancipation contexts undermines any spurious base/superstructure distinction at work in an understanding of material conditions even in some accounts of racial capitalism. Material conditions are as ideological as they are “infrastructural” (Sylvia Wynter) in being ongoingly articulated by anti-black coordinates of sense. The ongoing actualization of the racial order of slavery is (...) understood not as required by altered material conditions, but rather as altering material conditions. The essay considers the continuity of the racial order of the plantation through the contract in a specific site, namely, post-emancipation Puerto Rico. (shrink)

Este trabajo analiza los conceptos de justicia social y felicidad en la filosofía de Julián Marías con el fin de alcanzar tres metas: comprender su sentido; mostrar cómo pudo llegar a visiones originales de ellos gracias a que su teoría está fundamentada en una metafísica, y alumbrar cómo esta es un método para que podamos seguir pensando. Para ello, se revisan las tres grandes perspectivas filosóficas de Marías –la estructura analítica, la empírica y la de la persona– para indagar qué (...) se entiende por justicia social y felicidad. Asimismo, desde cada uno de estos puntos de vista se buscan las conexiones entre ambos temas. Finalmente se analiza si es verosímil esperar que haya una vida tras la muerte biológica, puesto que, según el filósofo, la perduración es una condición necesaria para que sea posible tanto la verdadera felicidad como la justicia social derivada de ella. (shrink)

Los summaria alexandrinorum (conocidos como ǧawāmiʿ al-iskandarāniyyīn en árabe) son resúmenes de obras galénicas que solo sobreviven en versiones hebreas o árabes. Tradicionalmente, estas traducciones se han atribuido a Ḥunayn ibn Isḥāq (s. IX) y se han vinculado a la enseñanza de la medicina en la Alejandría de los siglos VI y VII. En este artículo presentamos la edición de uno de estos ǧawāmiʿ al-iskandarāniyyīn, en concreto el compendio árabe del De simplicium medicamentorum facultatibus de Galeno que se conserva en (...) el manuscrito Huntington 600/2 de la Bodleian Library de Oxford. Con la publicación de este texto inédito pretendemos contribuir a comprender mejor la naturaleza y el origen de este tipo de textos, así como a facilitar su consulta y estudio por parte de otros especialistas. Añadimos una breve introducción sobre los summaria alexandrinorum y su importancia en la enseñanza y la transmisión de la medicina en la Edad Media, seguida de una serie de apuntes acerca del De simpl. med. fac. A continuación, se describe el manuscrito fuente tanto en forma como en contenido y se fijan los criterios de edición. Asimismo, se han extraído del texto los usos y las características más comunes de la farmacopea galénica. Con el fin de ofrecer una edición rigurosa, se ha cotejado el texto con la traducción completa del De simpl. med. fac. al árabe, así como con otros tratados de simples andalusíes. (shrink)

RESUMEN En este artículo exploro subversiones caribeñas de la deuda enfocándome en el caso de Puerto Rico. Desde 2016, la Colectiva Feminista en Construcción ha configurado un terreno y un imaginario político novedoso que ejemplifica la subversión de la deuda en Puerto Rico. Las tácticas de la Colectiva se ubican en la deuda para subvertirla, invirtiendo las posiciones de poder distintivas de la deuda. Elaboro esta inversión/subversión como una expresión de resistencia a través del "desvío", como lo entiende Édouard Glissant (...) en El Discurso Antillano. Imprescindible aquí es el trabajo sobre el sistema mundo colonial de género en el Caribe, en particular en la República Dominicana, de Yuderkys Espinosa Miñoso y Celenis Rodríguez Moreno. El trabajo de Rodríguez Moreno en torno a la "formación de género mimética", nos permite precisar la interrupción de la operación de la colonialidad en cuanto al deseo, el tiempo, y el espacio clave para las acciones de la Colectiva. ABSTRACT In this essay, Caribbean subversions of debt are explored, focusing on the case of Puerto Rico. Since 2016, the Colectiva Feminista en Construcción has designed a new ground and political imaginary that exemplifies the subversion of debt in Puerto Rico. The Collectiva's tactics subvert indebtedness, reversing the positions of power that debt generates. This inversion/subversion is elaborated as an expression of resistance through "detour", as Édouard Glissant understands it in Caribbean Discourse. The work ofYuderkys Espinosa Miñoso and Celenis Rodriguez Moreno on the colonial/modern gender system in the Caribbean, particularly in the Dominican Republic, is essential. Furthermore, the work of Rodríguez Moreno on the "mimetic formation of gender" allows pinpointing the interruption of coloniality regarding the desire, the time, and the space for the actions of la Colectiva. (shrink)

Grounding refers to expressions that establish a connection between the ground and the content evoked by a nominal or finite clause. In this paper we report on two grammatical implementations of nominal grounding in Argentine Sign Language: pointing and placing. For pointing constructions, we also examine distal-proximal pointing and directive force. We introduce the concept of placing, in which a sign is produced at a specific meaningful location in space. Two types of placing are discussed: Placing-for-Creating, in which a new (...) meaningful location is created, and Placing-by-Recruiting, which recruits an existing meaningful location. We suggest that our analysis of pointing and placing provides an account of nominal grounding unified by general cognitive principles as described within the theory of Cognitive Grammar. Pointing is known to occur in all signed languages studied to date. Although previously undocumented, we suggest that placing is also common to many, perhaps all, signed languages. (shrink)

The current study analyzed how trait emotional intelligence (trait EI) mediates the relationship between self-esteem and state anxiety (STAI-S) and trait anxiety (STAI-T). The sample was composed of 153 undergraduate students from the University of Cádiz, Spain (71.9% women and 28.1% men). Students completed measures of self-esteem, STAI-S, STAI-T, and trait EI. Mediation analyses were completed with three trait EI dimensions (emotional attention -EA-, emotional clarity -EC-, and mood repair -MR) as mediating variables, self-esteem as the independent variable, and STAI-S (...) and STAI-T as the dependent ones. Our results confirmed that self-esteem scores explained and predicted both, STAI-S and STAI-T values (13% for STAI-S and 21% for STAI-T). This explanatory capacity is increased by 8% when accounting for all trait EI dimensions. Considering STAI-S, the results of the direct effects showed that a decrease in their levels is predicted through the increases in the levels of both, self-esteem and MR. Regarding STAI-T, the results of the direct effects showed that a decrease in their levels is predicted, in addition to an increment of self-esteem and MR values, by an increase of EC and a decrease of EA. Conversely, indirect effects revealed that higher levels of self-esteem were associated with worse scores in EA and worse MR, which in turn would enhance both STAI-S and STAI-T levels. Moreover, regarding STAI-T higher levels of self-esteem were associated with worse scores in EA and worse EC, therefore increasing STAI-T levels. As shown, the negative association found between self-esteem and EA becomes a key element. The effect of self-esteem on EA and the influence that the latter had on EC and MR exerts an indirect mediated effect with the power to invert the influence that self-esteem wields on both types of anxiety. In this sense, the apparent protective role of self-esteem changed, turning into a risk factor that promotes higher anxiety values. (shrink)

This paper deals with the methodological role played by the term «motivation» in young Heidegger’s early hermeneutic transformation of phenomenology. To that effect, I shall start analyzing the concept of motivation in Husserl’s phenomenology so as to better understand its hermeneutical variation in young Heidegger’s philosophy. Subsequently, I will pay special attention to the relevance exhibited by motivation in the emergence of the most important methodological notions of hermeneutical phenomenology as «destruction», «formal indication» and «preconception». To conclude, I shall explore (...) the possibility of reshaping the phenomenological problem of the motivation to reduction in hermeneutical terms. That is to say: a motivation to reduction in factical life experience is always needed to access to the primordial sphere of meaning. Accordingly, I will finally suggest that the philosophical basic experience of radical questioning can be read as a hermeneutical epoche, which is, however, directly linked to the concern for one’s own existence. (shrink)

En el duelo frecuentemente rememoramos con pesar los sufrimientos que le causamos a la persona fallecida, pero algunos de esos apesadumbrados recuerdos nos desconciertan y hasta pueden hacernos dudar de la sinceridad de nuestro amor por ella porque, aunque lamentamos profundamente haberla hecho sufrir, no nos arrepentimos de haber actuado como actuamos. En este artículo examino las características, tipos y naturaleza de la emoción a la que Bernard Williams llamó «_agent-regret»_ (lamentación o pesadumbre del agente), para sostener que aquella experiencia (...) del doliente puede entenderse como una instancia particular de esta emoción. Además, hago algunas consideraciones acerca de cómo el proceso mismo del duelo complica la de por sí difícil experiencia de lamentarse como agente. (shrink)

En la primera parte de este estudio desarrollamos una idea de la ciencia islámica que hace posible comprender su integración en la esfera de la metafísica. En la segunda parte, desarrollamos algunas nociones centrales de la fi losofía natural de ibn Sina que muestran de qué modo la realidad humana está unida a la concepción científi ca de la naturaleza e inserta plenamente en ella, a diferencia de lo que acontece en el paradigma científi co moderno.

The origin of the Third Sector (TS) in Spain is rooted in the defence of social rights and demands made of the State regarding social transformation. With the development of the Welfare State, the role of the TS has progressively changed, becoming primarily a provider of services to Public Administrations (PAs), and moving away from its roots advocating and demanding social justice. This article examines the distance between the original intentions (‘ought’) and the current day-to-day actions (‘is’) of the TS (...) in the case of the region of Andalusia (Spain), focusing on a three-dimensional analysis: the objectives that mark its action, its funding model, and relations within the organisation. Using a qualitative methodology based on Thematic Content Analysis, the discourses of actors involved in the TS (managers, professionals, volunteers, users, public administration professionals, and other actors) have been analysed and linked, concluding that the gap generated between intention and deed, or ‘ought’ and ‘is’, are the result of external contextual elements, but also of decisions made within the TS. (shrink)

Hadrian’s agonistic calendar, as it was found inscribed in a stele of Alexandria Troad, mentions within its fourth Olympic year the “games of the Koinon of the Achaeans and Arcadians which are celebrated in Mantinea”. Following the interpretation of the editors of the stele, G. Petzl and E. Schwertheim, this article aims to identify these games as those which were organized by the city in honour of Antinous. The epigraphic sources that mention the Mantinean games, mainly those related to the (...) agonothetai and winners of the contests, will be used to explore the relationship between Hadrian and the Arcadian cults, and similarities between the sequence of games in the athletic palmares and Hadrian’s calendar in order to further support the identification as the Antinoeia of Mantinea. (shrink)

In response to recent work on the nature of human aggression, and to shed light on the proximate, as opposed to ultimate, causes of tribal warfare, we present a record of events leading to a fatal Waorani raid on a family from another tribe, followed by a detailed first-person observation of the behavior of the raiders as they prepared themselves for war, and upon their return. We contrast this attack with other Waorani aggressions and speculate on evidence regarding their hormonal (...) underpinnings. On-the-ground ethnographic observations are examined in light of the neuroendocrinological literature. The evidence suggests a chain of causality in launching lethal violence, beginning with a perceived injury, culminating in a massacre, and terminating in rejoicing. Although no blood or saliva samples were taken at the time of this raid, the behaviors were consistent with a deliberate initiation of the hormonal cascade characterizing the “fight-or-flight” response, along with other hormonal changes. We conclude with observations on the stratified interrelationships of the cognitive, social, emotional, and neuroendocrinological causes of aggression leading to coalitional male homicide. (shrink)

La vida de cada cual es contingente, pero es una contingencia necesaria para una porción de vidas; aunque me atrevo a decir, incluso, que así es para la creación en continuidad. Creo que nosotros tenemos misión. La misión implica que aquello que no haga alguien quedará sin hacerse tal y como lo podría hacer esa persona. En otras palabras, la misión de cada cual, como la propia vida, exige y es disyunción,―o esto o aquello, así o de otro modo. Y (...) si tenemos en cuenta, que la realidad es sistemática, y que un sistema es orden de los elementos que se ve afectado por entero en caso de que suceda algo a alguno de los que lo componen, entonces para estar viviendo tal y como vivimos se nos revelan los otros como contingencias necesarias, imprescindibles. Bien podría hacer una aproximación a Pablo Posada desde la razón vital y algo habrá de ello a lo largo de estos párrafos, pero eso es una tarea prematura, como su muerte. (shrink)

Children and adolescents are not indifferent to the dramatic impact of the COVID-19 pandemic, and the need to be forced to live in confinement. The change in life to which they have been abruptly subjected forces us to understand the state of their mental health in order to adequately address both their present and future needs. The present study was carried out with the intention of studying the consequences of confinement on anxiety, sleep routines and executive functioning of 1,028 children (...) and adolescents, aged from 6 to 18 years, residing in Spain to; assess if there are differences regarding these consequences in terms of sex and age; how anxiety affects executive functioning in males and females; and to examine the possible correlations between the measured variables. For this purpose, an online questionnaire containing five sections was designed: the first section gathers information on sociodemographic and health data, while the following sections gather information from different standardized scales which measure anxiety, sleep and executive functions, whose items were adapted in order to be completed by parents, and/or legal guardians. The statistical analyzes carried out highlights significant differences in executive functioning between males and females. In turn, in regards to age, greater difficulties were detected in anxiety in the 9 to 12 age group and greater sleep disturbances between 13 and 18 year olds. On the other hand, significant differences were found in intra-sexual executive functioning depending on whether they presented greater or lesser anxiety, with executive functioning being more tendentiously maladjusted in males than in females, revealing a significantly relevant effect size. Positive correlations are obtained between state anxiety and sleep and executive functioning alterations. Finally, through Path Analysis, it is verified that state anxiety is the variable with the greatest weight within the model that would explain the alteration in the executive functioning of the present sample. (shrink)

The purpose of this article is to argue in favor of a private employer’s right to discriminate amongst job applicants on any basis he chooses, and this certainly includes unlawful characteristics such as race, sex, national origin, sexual preference, religion, etc. John Locke and many after him have argued that people have natural rights to life, liberty, and property or the pursuit of happiness. In this view, law should be confined to protecting these rights and be limited to prohibiting other (...) people from transgressing those rights. The law should not hinder an employer’s ability to discriminate, any more than it should compel people to marry against their wishes. These laws generally emerge from a moral perspective that people think should be imposed on everyone else. But those who don’t welcome those morals are in effect being coerced to abide by them against their will; this is unethical. Finally, it will be argued that the free market has mechanisms by which discrimination will, be rendered powerless to harm its victims. (shrink)

Al recorrer nuestro espacio nos encontramos diariamente con múltiples marcas territoriales que hemos naturalizado, las mismas se han convertido en parte de nuestro paisaje hasta el punto que pocas veces nos preguntamos cuáles son sus orígenes. En esta entrevista, hablamos con la Dra. Natalia Cabanillas, quien busca recuperar la importancia de la desmonumentalización, pensada desde la relación intrínseca entre las marcas simbólicas y las prácticas concretas que evidencian las relaciones de poder. Para ello, analiza dos casos: Rhodes Must Fall en (...) Ciudad del Cabo (Sudáfrica) y los monumentos en Redenção (Brasil), las resistencias ante la crítica y las problemáticas que allí se ponen en juego. (shrink)

Some mutual funds not only apply the usual asset management and custodial fees, but also front loads and redemption fees as a kind of ‘toll charge’ payable on entering and/or leaving the fund. The aim of this work is to examine the implications of the different loads and fees applied to mutual fund investors in the Spanish market. The results show that there is a relationship between the various charges and fees. The fact that load fund companies charge higher management (...) and custody fees proves the potential of the fund companies to impose higher fees on a segment of the clientele. The investors in load funds, which tend to be large in number of shareholders and belonging to banks and savings banks, are small investors who show a low cost sensitivity. A lower level of financial sophistication may be the reason for the apparent lower price awareness. The problem is that the investors in load funds are not financially compensated for the extra cost represented by the front‐load and redemption fees. The only beneficiary seems to be the financial institution itself. On this view, the survival of load funds seems to depend on the lack of financial sophistication of their clientele, combined with market inefficiencies. It is worth asking about the ethics of a situation of market segmentation that allows managing institutions to benefit from the segment of the least sophisticated investors. (shrink)

El presente artículo aborda el análisis curricular de la Lic. en Psicología de la UAQ. Valora elementos que se consideran por parte de los organismos evaluadores y acreditadores, y se recuperan los principales que deben ser atendidos en la evaluación curricular y el rediseño de las áreas de la licenciatura. Palabras clave: Análisis curricular, psicología, organismos evaluadores, organismos acreditadores, evaluación curricular.

En este estudio, en el que hemos tomado como centro de referencia el catálogo (ai-Fihrist) del erudito musulmán del siglo X de nuestra era Muhammad Ibn Ishak an-Nadí'm, nos proponemos trazar, en primer lugar, las líneas del desarrollo del pensamiento matemático y del pensamiento astronómico en el mundo del Islam desde el siglo VIII hasta el siglo XVII; y, en segundo lugar, y al hilo de nuestra traducción al texto de Ibn an-Nadí'm, indicar en lo posible y de acuerdo a (...) las investigaciones más recientes, los aportes individuales de los matemáticos y astrónomos que vivieron entre Jos siglos VIII y IX de la era cristiana. Con ello pretendemos ofrecer un capítulo casi olvidado de algunos aspectos del cultivo de la ciencia en un determinado período de su historia dentro de un determinado ámbito cultural a partir de sus propias fuentes. Asimismo, pretendemos dar un balance del estado actual de las investigaciones en este campo con el fin de llamar la atención sobre el profundo cambio de perspectivas que se está realizando en la historia de la ciencia2 y que, en Jo tocante al legado musulmán, encuentra su punto de giro en la obra del gran erudito turco, profesor de la Universidad de Frankfurt, Fuad Sezgin•. (shrink)

The sequencing of the human genome has opened the way for using bioinformatics to identify sets of genes controlled by specific regulatory signals. Here, we review the unexpected diversity of DNA response elements mediating transcriptional regulation by estrogen receptors (ERs), which control the broad physiological effects of estrogens. Consensus palindromic estrogen response elements are found in only a few known estrogen target genes, whereas most responsive genes contain only low‐affinity half palindromes, which may also control regulation by other nuclear receptors. (...) ERs can also regulate gene expression in the absence of direct interaction with DNA, via protein–protein interactions with other transcription factors or by modulating the activity of upstream signaling components, thereby significantly expanding the repertoire of estrogen‐responsive genes. These diverse mechanisms of action must be taken into account in screening for potential estrogen‐responsive sequences in the genome or in regulatory regions of target genes identified by expression profiling. BioEssays 24:244–254, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10066. (shrink)

La cuestión que quiero ensayar se inspira en el «giro helenístico» que protagoniza Epicuro, pero versa sobre un problema de estricta actualidad: ¿cómo hacer ciudad al margen de la ciudad? A partir de esta pregunta se esboza un diagnóstico de la actualidad en clave metafórica. La tensión es clara: por un lado la convicción de que la ciudad es insostenible ¾ante lo cual el rural ofrece una alternativa prometedora¾, por otro lado la conciencia sobre la condición de posibilidad de la (...) política entendida al modo republicano: toda política requiere de polis ¾por definición. Sin embargo, tal vez la polis no es la urbe, y donde la ciudad imposibilita, la ausencia de ciudad favorece. Así, el texto trata de recuperar el gesto epicúreo de fundar comunidad donde no hay, no queremos que haya o, sencillamente, ya no puede haber ciudad. (shrink)