Alzheimer's disease remains the most common form of dementia. Dementia symptoms vary depending on individual personality, life experience, and social and cultural influences. As dementia progresses, involvement of multi-disciplinary health care professionals is needed to manage the disease. Alzheimer research is progressing rapidly. While 5% of all Alzheimer's disease may be genetically determined, the majority is not. Susceptibility genes can reveal the risk of contracting Alzheimer's disease. Early life risk factors such as education, nutrition, and vascular disease may increase the (...) likelihood of dementia in later life. In the United States, two acetylcholinesterase inhibitors have been approved as cognitive enhancers. Possible prevention and symptomatic treatment interventions have focused on estrogen replacement therapy, antioxidants, and anti-inflammatory medications. Research advances have improved the clinical management of dementia. Ethical implications to the patient, family, and society are multiple and remain challenging. (shrink)

ABSTRACTThis article examines the Trinitarian anthropology inherent in the ‘charism of unity’ that characterizes the Focolare Movement stemming from the mystical experience of Chiara Lubich. After describing the theological cornerstones of this charism―namely the evangelical centrality of the commandment of reciprocal love, the circularity between theology and anthropology and Jesus Forsaken as the Christological key to understanding and achieving unity―the article studies its cultural implications as reflected in the philosophical and theological contribution of Klaus Hemmerle. In dialogue with modern thought, (...) Hemmerle in fact draws from and develops the anthropological meaning of the charism of unity as a feasible way to respond to the most acute challenges of today. (shrink)

(2000). The Evolutionary challenge for the Enterprise. World Futures: Vol. 55, Challenges of Evolution at the Turn of the Millennium: Part III: The Chllenges of Globalization and Sustainability, pp. 159-171.

Introduction -- The form of happiness -- Affirmation -- Beauty is everywhere -- Love of life -- Fundamental OK -- The uniqueness of each moment -- Taste -- Spontaneity -- The reality of reality -- Healing -- Beauty cures -- Creative expression -- Nature and music -- The invisible ally -- The heart of beauty -- Sharing -- The beauty of the soul -- Good and beautiful -- Aesthetics and biology -- Knowledge -- Mind and beauty -- Revelation -- Hidden (...) resonance -- Trascendence -- Self, nature, and society -- Abuse vs. awe -- Beauty is the opposite of war. (shrink)

These proceedings collect the selected contributions of participants of the First Karl Schwarzschild Meeting on Gravitational Physics, held in Frankfurt, Germany to celebrate the 140th anniversary of Schwarzschild's birth. They are grouped into 4 main themes: I. The Life and Work of Karl Schwarzschild; II. Black Holes in Classical General Relativity, Numerical Relativity, Astrophysics, Cosmology, and Alternative Theories of Gravity; III. Black Holes in Quantum Gravity and String Theory; IV. Other Topics in Contemporary Gravitation. Inspired by the foundational principle ``By (...) acknowledging the past, we open a route to the future", the week-long meeting, envisioned as a forum for exchange between scientists from all locations and levels of education, drew participants from 15 countries across 4 continents. In addition to plenary talks from leading researchers, a special focus on young talent was provided, a feature underlined by the Springer Prize for the best student and junior presentations. (shrink)

Saggio straordinariamente felice, analizza l'uomo e la donna da prima della nascita a dopo la morte. Ecco i titoli dei venti capitoli: Incontro - Nessuno nasce solo - Metamorfosi - Dramma del vagito - Novecento giorni - Magie della parola - Abbaco e abbiccì - Efebo ingrato - Rischi di Ebe - Scelta del personaggio - Diritti del cuore - La coppia umana - Homo familiaris - Ognuno fra la gente - Desti nel sonno - Madre o suocera - Mezzo (...) secolo - La vetta longeva - La gran Madre antica - Elogio dell'uomo. Questa edizione definitiva è stata riveduta dall'autore nel 1983 con l'aggiunta di importanti accrescimenti e di significative modifiche. (shrink)

Aristotle began his great study on causes, which he called Metaphysics, with a simple connection to physics: "All men by nature desire to know. An indication of this is the delight we take in our senses." Catholic high school physics teacher Matt D'Antuono makes a similar connection in his own teaching. While discussing the nature of science with his physics students, Matt pointed out that their topic of conversation was technically not science any more. Instead, when they were talking (...) about the nature of science, they were doing philosophy. The students then wanted Matt to teach them some philosophy, and Philosophy Fridays became a classroom tradition. Every secondary school teacher will find within this book the kind of practical wisdom that enlightens the young mind and engages their students in the act of contemplating all the wonders of our world, both physical and metaphysical. (shrink)

Jason Brennan has argued that democracy is intrinsically unjust, for it grants voting power to politically incompetent individuals, thus exposing people to an undue risk of harm. He claims democracy should be replaced by epistocracy, i.e., the rule of the knowers. In this paper, I show that his argument fails. First, Brennan mistakes voters’ competence for voters’ trustworthiness. Second, despite Brennan's claim to the contrary, an epistocracy may not reduce people’s exposure to an undue risk of harm. Third, Brennan overlooks (...) the fact that citizens are not equally affected by ‘bad voting.’ Fourth, far from being a defence of libertarian ideals, Brennan's argument supports paternalism. (shrink)

Many believe that a citizen who engages in civil disobedience is not exempt from the sanctions that apply to standard law-breaking conduct. Since he is responsible for a deliberate breach of the law, he is also liable to punishment. Focusing on a conception of responsibility as answerability, I argue that a civil disobedient is responsible (i.e. answerable) to his fellows for the charges of wrongdoing, yet he is not liable to punishment merely for breaching the law. To support this claim, (...) I defend an account of political obligation framed in terms of respect for (rather than mere obedience to) the law, and argue that the mere illegality of civil disobedience does not suffice to establish wrongdoing. I then discuss and reject three objections to my argument. (shrink)

Préambule : science et herméneutique du mal Je voudrais mettre en exergue de cette intervention sur science et barbarie, sur le caractère d’oxymore du rapprochement de ces termes, et, à l’opposé, sur leur contiguïté historique, sur la contaminatio, qui s’est produite historiquement entre science et barbarie, les paroles de Hans Blumenberg : Toute méconnaissance des insurpassables services que la science moderne a rendus à la vie… me paraît indigne. L’affectation...

Protein aggregation has been studied for at least 3 decades, and many of the principles that regulate this event are relatively well understood. Here, however, we present a different perspective to explain why proteins aggregate: we argue that aggregation may occur as a side‐effect of the lack of one or more natural partners that, under physiologic conditions, would act as chaperones. This would explain why the same surfaces that have evolved for functional purposes are also those that favour aggregation. In (...) the course of reviewing this field, we substantiate our hypothesis with three paradigmatic examples that argue for the generality of our proposal. An obvious corollary of this hypothesis is, of course, that targeting the physiological partners of a protein could be the most direct and specific approach to designing anti‐aggregation molecules. Our analysis may thus inform a different strategy for combating diseases of protein aggregation and misfolding. (shrink)

The fair-play theory of punishment claims that the state is justified in imposing additional burdens on law-breakers, to remove the unfair advantage the latter have enjoyed by disobeying the law. From this perspective, punishment reestablishes a fair distribution of benefits and burdens among all citizens. In this paper, I object to this view by focusing on the case of civil disobedience. I argue that the mere illegality of this conduct is insufficient to establish the agent’s unfair advantage over his lawabiding (...) fellows, hence the imposition of additional burdens upon him through legal punishment. I articulate a broader account of citizens’ fair-play duties, able to capture disobedience as well as obedience to the law. While claiming that some law-breakers may not be treated as free-riders, I also gesture at the fact that some law-obeying citizens may not be ‘playing fair’: in some cases, a failure to engage in civil disobedience represents a failure to do one’s own part within the cooperative scheme of society. (shrink)