Alzheimer's disease remains the most common form of dementia. Dementia symptoms vary depending on individual personality, life experience, and social and cultural influences. As dementia progresses, involvement of multi-disciplinary health care professionals is needed to manage the disease. Alzheimer research is progressing rapidly. While 5% of all Alzheimer's disease may be genetically determined, the majority is not. Susceptibility genes can reveal the risk of contracting Alzheimer's disease. Early life risk factors such as education, nutrition, and vascular disease may increase the (...) likelihood of dementia in later life. In the United States, two acetylcholinesterase inhibitors have been approved as cognitive enhancers. Possible prevention and symptomatic treatment interventions have focused on estrogen replacement therapy, antioxidants, and anti-inflammatory medications. Research advances have improved the clinical management of dementia. Ethical implications to the patient, family, and society are multiple and remain challenging. (shrink)

In spite of its importance in European Union decision making, research on the functioning of the Council is scarce. Based on empirical findings this article gives some new insights in the way Council decision making is institutionalized. The first part focusses on the characteristics of Council working groups and the different positions of actors in the decision making network. Our findings confirm the definition of the Council as a highly bureaucratized institution. Interesting is that the diversity of tasks of the (...) different actors strengthens the impact of national administrations in Council decision making. The second part explores the reasons for this impact. This article adds to the functional approach, which over-emphasizes the adaptive character of the Council, the perception of the Council as an intergovernmental component in a supranational system. (shrink)

This contribution deals with the consequences of European integration for the relation between civil servants and policians. Data of Belgian senior servants who are not involved in European policy networks are compared with data of Belgian officals who are in charge of European negotiations.This comparison shows firstly that officials are more central in European policy networks than in national policy networks. Politicians have only a limited and indirect access to these European networks. Secondly, the more civil servants are involved in (...) these European policy networks, the less their political alienation. Furthermore, the organisational self-esteem do not affect the communication networks among civil servants and politicians. Finally, alienation and self-esteem do not affect the communication networks among civil servants and politicians. The exposure to politics and anciennity seem to be more important predictors. (shrink)

Belgium is generally perceived as being one of the most fervent supporters of European integration. It is supposed that this is equally true for both, the Belgian political elite and the Belgian population. Unlike in other EU member states, no large public discussion on EU integration has taken place. Therefore, it is generally supposed that Lindberg's concept of the permissive consensus applies to the Belgians. This article aims, first, at challenging empirically the existence ofa permissive consensus in Belgium. In 1997 (...) both qualitative and quantitative data on the policy position on EU issues ofabout 130 Belgian social organisations have been collected. Content analysis ofthese positions shows that the existence ofa permissive consensus seems to be dependent on a number of variables and that a general observation of a permissive consensus has to be relaxed. Second, if permissive consensus is declining, why is it, then, that no open political controversy on European integration has emerged? In answering this, thefocus is on two explanatory variables: the resources of those that would liketo mobilise are quite limited and their opinion on European politics is rather heterogeneous and undeveloped. (shrink)

The Belgian Presidency is generally seen as being a success. On many difficult questions, the Belgians succeeded in forging compromises between the member states. There is a risk however, that the apparent successes of this Presidency will lead to an over-estimation of the role which a EU-president can play. Therefore, it is important to pay attention to its limits and possibilities. It can help to relativize the Belgian presidency and to improve insights into the potential role of EU-presidents within the (...) decision-making of the European Union. (shrink)

Bringing readers from aww to awful! in a matter of seconds, I Don't Really Love You seamlessly blends images of charming pets with hilarious, soul-crushing captions about the existential dread that seems to permeate daily life. Darkly humorous one-liners, from "Birthdays don't matter" to "Inadequacy haunts me endlessly," will peek out from behind the forms of calm cats and happy-go-lucky puppies, creating an unexpected contrast that takes readers on a journey from delightful to depressing (and back again!) Pet lovers and (...) humor lovers will be captivated in equal measure, with more than 75 full-color photographs of cats and dogs in a range of breeds, alongside an off-beat, subversive voice. With the perfect attitude for our rapidly changing world, this quirky book will make readers laugh out loud (after sending them crawling under the covers to contemplate their existence). (shrink)

The remarkable movement known as Solidarity recently celebrated its twenty-fifth anniversary in Poland. This essay provides a theoretical appreciation of the values and principles that guided and undergirded the movement, which greatly contributed to the fall of communism in Central and Eastern Europe. This systematic overview of the ethic of the Solidarity movement fills a lacuna in the field of ethics because ethicists who are interested in the concept of solidarity have largely overlooked the Polish experience of the 1980s. This (...) essay attempts to describe the key ingredients of the Polish ethic of solidarity by analyzing both Polish treatises on the subject and accounts of events on the ground. It elaborates conceptual categories and describes characteristic features of the movement in order to provide a phenomenological account of the nature of solidarity embodied in Poland during this era. These categories and characteristics include unity among differences, the foundation of hope at the movement's roots, self-sacrifice and heroism, promoting the equality and dignity of all, the centrality of participation, the affirmation of "bread and freedom," an option for the poor, and the insistence on life in truth. Although this essay does not attempt to demonstrate the relevance of this "thick" ethic of solidarity to capitalist, democratic societies today, by way of conclusion it raises questions pertaining to the contemporary significance of the Polish ethic of solidarity. (shrink)

It can be tempting to think of affect as a matter of the present moment – a reaction, a feeling, an experience or engagement that unfolds right now. This paper will make the case that affect is better thought of as not only temporally extended but as saturated with temporality, especially with the past. In and through affectivity, concrete, ongoing history continues to weigh on present comportment. In order to spell this out, I sketch a Heidegger-inspired perspective. It revolves around (...) two claims. The first is that we should understand what Heidegger calls 'Befindlichkeit' (findingness) as radical situatedness. Affectivity is a matter of 'finding oneself' constellated – thrown – into the world in ways that outrun what an individual or collective might grasp and process. The second claim is that the temporal dimension, as a relatedness to the past, takes precedence in affect's situatedness. Key to affect is the way in which the past continues to hold sway over present comportment, collectively and individually. In order to articulate this perspective, it is important to overcome the idea that affect must be understood mainly in terms of feeling or experiential states of other kinds. Better suited to grasp the idea of findingness is the concept of 'disclosive posture', as proposed by Katherine Withy. I suggest that this notion should be put at the fore of a phenomenological approach to situated affectivity. (shrink)

Increasingly, commissioners and providers of services for people with intellectual disabilities are turning to assistive technology and telecare as a potential solution to the problem of the increased demand for services, brought about by an expanding population of people with intellectual disabilities in the context of relatively static or diminishing resources. While there are numerous potential benefits of assistive technology and telecare, both for service providers and service users, there are also a number of ethical issues. The aim of this (...) paper is to raise these issues and to set them within the ethical framework proposed by Beauchamp and Childress. There is a need for a wider debate as a first step in the development of strategies to address the issues raised in the paper. (shrink)

Epigenetics is currently one of the fastest-growing fields in the sciences. Epigenetic information not only controls DNA expression but links genetic factors with the environmental experiences that influence the traits and characteristics of an individual. What we eat, where we work, and how we live affects not only the activity of our genes but that of our offspring as well. This discovery has imposed a revolutionary theoretical shift on modern biology, especially on evolutionary theory. It has helped to uncover the (...) developmental processes leading to cancer, obesity, schizophrenia, alcoholism, and aging, and to facilitate associated medial applications such as stem cell therapy and cloning. Above the Gene, Beyond Biology explores how biologists in this booming field investigate and explain living systems. Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this "epigenetic turn" in the life sciences from a philosophical perspective. (shrink)

The paper examines the interplays between logic and politics in the Polish School of Logic starting from 1914. The Polish School of Logic flourished between 1920 and 1939. Philosophically, it was influenced by Kazimierz Twardowski (1866–1938). For Twardowski logic is fundamental for every kind of human activity, professional and private and this means that every argument should be formulated and proceed by correct inferential rules. These rules involve semiotics, formal logic and methodology of science. The paper shows how this position (...) was shared by Twardowski’s students, including Jan Łukasiewicz, Stanisław Leśniewski, Kazimierz Ajdukiewicz and Tadeusz Kotrabiński, as well as by the next generation of logicians and philosophers and especially by Alfred Tarski. These authors considered logic, philosophy and science as completely neutral with respect to politics and ideology but they also considered logical skills as indispensable in political activities. (shrink)

Sehen, Horen, Riechen, Schmecken, Tasten: Die Autorin fragt nach Entstehung, Begrundung und Folgen dieser tradierten Ordnung der Sinne. Sie fragt auch nach den abweichenden Varianten, die von der antiken Idee des Korpers als ganzheitliches Sensorium uber die hoheren Sinne des Mittelalters bis zu den sinnlichen Vermogen der Aufklarung, wie Einbildungskraft und Dichtungsvermogen, reichen. Im 18. Jahrhundert verstarkte sich zusammen mit der anthropologischen Aufwertung der Sinnlichkeit der Impuls zur Uberschreitung der Funfzahl der Sinne und zur Umordnung der uberkommenen Hierarchie. An Textbeispielen (...) von Platon, Ovid und Goethe untersucht die Autorin uberdies Zusammenhange, aber auch Widerspruche, die zwischen der europaischen Liebeskultur und der Bewertung von Auge und Ohr als hohere, von Geschmack, Geruch und Tasten als niedere Sinne bestehen. (shrink)

Higher-order logic, with its type-theoretic apparatus known as the simple theory of types (STT), has increasingly come to be employed in theorizing about properties, relations, and states of affairs—or ‘intensional entities’ for short. This paper argues against this employment of STT and offers an alternative: ordinal type theory (OTT). Very roughly, STT and OTT can be regarded as complementary simplifications of the ‘ramified theory of types’ outlined in the Introduction to Principia Mathematica (on a realist reading). While STT, understood as (...) a theory of intensional entities, retains the Fregean division of properties and relations into a multiplicity of categories according to their adicities and ‘input types’ and discards the division of intensional entities into different ‘orders’, OTT takes the opposite approach: it retains the hierarchy of orders (though with some modifications) and discards the categorisation of properties and relations according to their adicities and input types. In contrast to STT, this latter approach avoids intensional counterparts of the Epimenides and related paradoxes. Fundamental intensional entities lie at the base of the proposed hierarchy and are also given a prominent part to play in the individuation of non-fundamental intensional entities. (shrink)

By and large, the conditional connective in three-valued logic has two different functions. First, by means of a deduction theorem, it can express a specific relation of logical consequence in the logical language itself. Second, it can represent natural language structures such as "if/then'' or "implies''. This chapter surveys both approaches, shows why none of them will typically end up with a three-valued material conditional, and elaborates on connections to probabilistic reasoning.

International institutions such as UNESCO are deliberating on a new standard setting instrument for neurotechnologies. This will likely lead to the adoption of a soft law document which will be the first global document specifically tailored to neurotechnologies, setting the tone for further international or domestic regulations. While some stakeholders have been consulted, these developments have so far evaded the broader attention of the neuroscience, neurotech, and neuroethics communities. To initiate a broader debate, this target article puts to discussion twenty-five (...) considerations and desiderata for recognition by a future instrument. They are formulated at different levels of abstraction, from the big picture to technical details, seek to widen the perspective of preparatory reports and transcend the narrow debate about “neurorights” which overshadows many richer and more relevant aspects. These desiderata are not an exhaustive enumeration but a starting point for discussions about what deserves and what requires protection by an international instrument. (shrink)

Evidence-Based Medicine has little consideration for mechanisms and philosophers of science and medicine have recently made pleas to increase the place of mechanisms in the medical evidence hierarchy. However, in this debate the notions of mechanisms seem to be limited to 'mechanistic processes' and 'complex-systems mechanisms,' understood as 'componential causal systems'. I believe that this will not do full justice to how mechanisms are used in biological, psychological and social sciences and, consequently, in a more biopsychosocial approach to medicine. Here, (...) I propose, following (Kuorikoski, 2009), to pay more attention to 'abstract forms of interaction' mechanisms. The present work scrutinized review articles on depression and medically unexplained pain, which are considered to be of multifactorial pathogenesis, for their use of mechanisms. In review articles on these disorders there seemed to be a range of uses between more 'abstract forms of interaction' and 'componential causal system' mechanisms. I therefore propose to expand the notions of mechanisms considered in medicine to include that of more 'abstract forms of interaction' to better explain and manage biopsychosocial disorders. (shrink)

We introduce a cyclic proof system for the two-way alternation-free modal μ-calculus. The system manipulates one-sided Gentzen sequents and locally deals with the backwards modalities by allowing analytic applications of the cut rule. The global effect of backwards modalities on traces is handled by making the semantics relative to a specific strategy of the opponent in the evaluation game. This allows us to augment sequents by so-called trace atoms, describing traces that the proponent can construct against the opponent’s strategy. The (...) idea for trace atoms comes from Vardi’s reduction of alternating two-way automata to deterministic one-way automata. Using the multi-focus annotations introduced earlier by Marti and Venema, we turn this trace-based system into a path-based system. We prove that our system is sound for all sequents and complete for sequents not containing trace atoms. (shrink)

Niels Bohr and Philosophy of Physics: Twenty-First Century Perspectives examines the work, influences and legacy of the Nobel Prize physicist and philosopher of experiment Niels Bohr. While covering Bohr's groundbreaking contribution to quantum mechanics, this collection reveals the philosophers who influenced his work. Linking him to the pragmatist C.I. Lewis and the Danish philosopher Harald Høffding, it draws strong similarities between Bohr's philosophy and the Kantian way of thinking. Addressing the importance of Bohr's views of classical concepts, it discusses how (...) his interpretation of quantum mechanics now compares with a variety of issues that have arisen only since his lifetime, including decoherence and other non-collapse arguments. Balancing historical themes with contemporary ideas, Niels Bohrs and Philosophy of Physics reveals Bohr's on-going contribution to the philosophy of science and confirms his place in the history of philosophy. (shrink)