The Cartan equations defining simple spinors (renamed “pure” by C. Chevalley) are interpreted as equations of motion in compact momentum spaces, in a constructive approach in which at each step the dimensions of spinor space are doubled while those of momentum space increased by two. The construction is possible only in the frame of the geometry of simple or pure spinors, which imposes contraint equations on spinors with more than four components, and then momentum spaces result compact, isomorphic to invariant-mass-spheres (...) imbedded in each other, since the signatures result steadily Lorentzian; starting from dimension four (Minkowski) up to dimension ten with Clifford algebra ℂℓ(1, 9), where the construction naturally ends. The equations of motion met in the construction are most of those traditionally postulated ad hoc: from Weyl equations for neutrinos (and Maxwell's) to Majorana ones, to those for the electroweak model and for the nucleons interacting with the pseudoscalar pion, up to those for the 3 baryon-lepton families, steadily progressing from the description of lower energy phenomena to that of higher ones. The 3 division algebras: complex numbers, quaternions and octonions appear to be strictly correlated with Clifford algebras and then with this spinor-geometrical approach, from which they appear to gradually emerge in the construction, where they play a basic role for the physical interpretation: at the third step complex numbers generate U(1), possible origin of the electric charge and of the existence of charged—neutral fermion pairs, explaining also easily the opposite charges of proton-electron. Another U(1) appears to generate the strong charge at the fourth step. Quaternions generate the signature of space-time at the first step, the SU(2) internal symmetry of isospin and, in the gauge term, the SU(2) L one, of the electroweak model at the third step; they are also at the origin of 3 families; in number equal to that of quaternion imaginary units. At the fifth and last step octonions generate the SU(3) internal symmetry of flavour, with SU(2) isospin subgroup and, in the gauge term, the one of color, correlated with SU(2) L of the electroweak model. These 3 division algebras seem then to be at the origin of charges, families and of the groups of the Standard model. In this approach there seems to be no need of higher dimensional (>4) space-time, here generated by the four Poincaré translations, and dimensional reduction from ℂℓ(1,9) to ℂℓ(1,3) is equivalent to decoupling of the equations of motion. This spinor-geometrical approach is compatible with that based on strings, since these may be expressed bilinearly (as integrals) in terms of Majorana–Weyl simple or pure spinors which are admitted by ℂℓ(1, 9) = R(32). (shrink)

We are demonstrating that the Luttinger model with short range interaction can be treated as a type of Fermi liquid. In line with the main dogma of Landau’s theory one can define a fermion excitation renormalized by interaction and show that in terms of these fermions any excited state of the system is described by free particles. The fermions are a mixture of renormalized right and left electrons. The electric charge and chirality of the Landau quasi-particle is discussed.

We present a distributed control modeling approach for an automated manufacturing system based on the dynamics of one-dimensional cellular automata. This is inspired by the fact that both cellular automata and manufacturing systems are discrete dynamical systems where local interactions given among their elements can lead to complex dynamics, despite the simple rules governing such interactions. The cellular automaton model developed in this study focuses on two states of the resources of a manufacturing system, namely, busy or idle. However, (...) the interaction among the resources such as whether they are shared at different stages of the manufacturing process determines the global dynamics of the system. A procedure is shown to obtain the local evolution rule of the automaton based on the relationships among the resources and the material flow through the manufacturing process. The resulting distributed control of the manufacturing system appears to be heterarchical, and the evolution of the cellular automaton exhibits a Class II behavior for some given disordered initial conditions. (shrink)

Molecular vibrations and quantum tunneling may link ligand binding to the function of pharmacological receptors. The well‐established lock‐and‐key model explains a ligand's binding and recognition by a receptor; however, a general mechanism by which receptors translate binding into activation, inactivation, or modulation remains elusive. The Vibration Theory of Olfaction was proposed in the 1930s to explain this subset of receptor‐mediated phenomena by correlating odorant molecular vibrations to smell, but a mechanism was lacking. In the 1990s, inelastic electron tunneling was proposed (...) as a plausible mechanism for translating molecular vibration to odorant physiology. More recently, studies of ligands’ vibrational spectra and the use of deuterated ligand analogs have provided helpful information to study this admittedly controversial hypothesis in metabotropic receptors other than olfactory receptors. In the present work, based in part on published experiments from our laboratory using planarians as an experimental organism, I will present a rationale and possible experimental approach for extending this idea to ligand‐gated ion channels. (shrink)

We demonstrate that the quantum-mechanical description of composite physical systems of an arbitrary number of similar fermions in all their admissible states, mixed or pure, for all finite-dimensional Hilbert spaces, is not in conflict with Leibniz's Principle of the Identity of Indiscernibles (PII). We discern the fermions by means of physically meaningful, permutation-invariant categorical relations, i.e. relations independent of the quantum-mechanical probabilities. If, indeed, probabilistic relations are permitted as well, we argue that similar bosons can also be (...) discerned in all their admissible states; but their categorical discernibility turns out to be a state-dependent matter. In all demonstrated cases of discernibility, the fermions and the bosons are discerned (i) with only minimal assumptions on the interpretation of quantum mechanics; (ii) without appealing to metaphysical notions, such as Scotusian haecceitas, Lockean substrata, Postian transcendental individuality or Adamsian primitive thisness; and (iii) without revising the general framework of classical elementary predicate logic and standard set theory, thus without revising standard mathematics. This confutes: (a) the currently dominant view that, provided (i) and (ii), the quantum-mechanical description of such composite physical systems always conflicts with PII; and (b) that if PII can be saved at all, the only way to do it is by adopting one or other of the thick metaphysical notions mentioned above. Among the most general and influential arguments for the currently dominant view are those due to Schrodinger, Margenau, Cortes, Dalla Chiara, Di Francia, Redhead, French, Teller, Butterfield, Giuntini, Mittelstaedt, Castellani, Krause and Huggett. We review them succinctly and critically as well as related arguments by van Fraassen and Massimi. (shrink)

In this letter we demonstrate that the fermionic zero modes on a superconducting domain wall can be associated to an one dimensional \ supersymmetry that contains non-trivial topological charges. In addition, the system also possesses three distinct \ supersymmetries with non-trivial topological charges and we also study some duality transformations of the supersymmetric algebras.

We present a reformulation of loop quantum gravity with a cosmological constant and no matter as a Fermi-liquid theory. When the topological sector is deformed and large gauge symmetry is broken, we show that the Chern–Simons state reduces to Jacobson’s degenerate sector describing 1+1 dimensional propagating fermions with nonlocal interactions. The Hamiltonian admits a dual description which we realize in the simple BCS model of superconductivity. On one hand, Cooper pairs are interpreted as wormhole correlations at the de (...) Sitter horizon; their number yields the de Sitter entropy. On the other hand, BCS is mapped into a deformed conformal field theory reproducing the structure of quantum spin networks. When area measurements are performed, Cooper-pair insertions are activated on those edges of the spin network intersecting the given area, thus providing a description of quantum measurements in terms of excitations of a Fermi sea to superconducting levels. The cosmological constant problem is naturally addressed as a nonperturbative mass-gap effect of the true Fermi-liquid vacuum. (shrink)

Spacetime measurements and gravitational experiments are made by using objects, matter fields or particles and their mutual relationships. As a consequence, any operationally meaningful assertion about spacetime is in fact an assertion about the degrees of freedom of the matter (i.e. non gravitational) fields; those, say for definiteness, of the Standard Model of particle physics. As for any quantum theory, the dynamics of the matter fields can be described in terms of a unitary evolution of a state vector in a (...) Hilbert space. By writing the Hilbert space as a generic tensor product of “subsystems” we analyse the evolution of a state vector on an information theoretical basis and attempt to recover the usual spacetime relations from the information exchanges between these subsystems. We consider generic interacting second quantized models with a finite number of fermionic degrees of freedom and characterize on physical grounds the tensor product structure associated with the class of “localized systems” and therefore with “position”. We find that in the case of free theories no spacetime relation is operationally definable. On the contrary, by applying the same procedure to the simple interacting model of a one-dimensional Heisenberg spin chain we recover the tensor product structure usually associated with “position”. Finally, we discuss the possible role of gravity in this framework. (shrink)

We first relate the random matrix model to a Fokker-Planck Hamiltonian system, such that the correlation functions of the model are expressed as the vacuum expectation values of equal-time products of density operators. We then analyze the universality of the random matrix model by solving the Focker-Planck Hamiltonian system for large N. We use two equivalent methods to do this, namely the method of relating it to a system of interacting fermions in one space dimension and the method (...) of collective fields for large N matrix quantum mechanics. The final result using both these methods is the same Hamiltonian system of chiral bosons on a circle, which manifestly exhibits the universality of the random matrix model. (shrink)

In this article I will address the critical question of the constitution of global systems and the part played in such processes by what is often summarized as culture. I examine the important distinction between culture and globalization and culture as constitutive of global social relations. The need to cleave to a systemic treatment of globality is put, while noting the dangers that lie in one-dimensional accounts of global system constitution. To offset any such tendency I explore the constitution (...) of global systemness from a structurationist perspective. I outline the nature and significance of culture in the study of global systems, drawing attention to different literatures. Finally I underscore the importance of the cultural turn in the study of global systems and what has to be done to take full advantage of it.In what follows I will address the critical question of the constitution of global systems and the part played in such processes by what is conveniently – if sometimes unhelpfully – summarized as “culture”. By global systems I mean networks of interaction and meaning that transcend both societal and national frames of reference. I want to shift the emphasis away from an under-theorized focus on cultural globalization to a consideration of global systems as enacted in part through cultural processes. In other words, I do not want to conflate the conjunctional features of contemporary (cultural) globalization with culture as the realm of lived experience integral to the enactment of all social-systemic relations. In some respects this approach may be seen as part of a shift – perhaps a paradigm shift – in how we understand the space of the social, and in how, or whether, we construe the global as the constitutive of all social relations (Beck 2003; Shaw 2003). I will begin with a mild polemic against a well-known systemic account of world-making forces that highlights some of these issues. (shrink)

Most contemporary models of disease development consider the interaction between genotype and environment as static. The authors argue that because time is a key factor in genotype–environment interaction, this approach oversimplifies the pathology analysis and may lead to wrong conclusions. In reviewing the field, the authors suggest that the history of genotype–environment interactions plays an important role in the development of diseases and that this history may be analyzed using the phenotype as a proxy. Furthermore, a theoretical and experimental framework (...) is proposed based on the assumption that phenotypes do not change from one to another randomly but are interconnected and follow certain phenotype trajectories. It then follows that analysis of such phenotype trajectories might be useful to predict the future phenotypes including the onset of disease. In addition, an analysis of phenotype trajectories can be subsequently used to choose better control subjects in comparative studies reducing noise and bias in studies investigating disease mechanisms. (shrink)

Insight problem solving was investigated with the matchstick algebra problems developed by Knoblich, Ohlsson, Haider, and Rhenius (1999). These problems are false equations expressed with Roman numerals that can be made true bymoving one matchstick. In a first group participants examined a static two-dimensional representation of the false algebraic expression and told the experimenter which matchstick should be moved. In a second group, participants interacted with a three-dimensional representation of the false equation. Success rates in the static group (...) for different problem types replicated the pattern of data reported in Knoblich et al. (1999). However, participants in the interactive group were significantly more likely to achieve insight. Problem-solving success in the static group was best predicted by performance on a test of numeracy, whereas in the interactive group it was best predicted by performance on a test of visuo-spatial reasoning. Implications for process models of problem solving are discussed. (shrink)

A model for the structure of point-like fermions as tightly bound composite states is described. The model is based upon the premise that electromagnetism is the only fundamental interaction. The fundamental entity of the model is an object called the vorton. Vortons are semiclassical monopole configurations of electromagnetic charge and field, constructed to satisfy Maxwell's equations. Vortons carry topological charge and one unit each of two different kinds of angular momenta, and are placed in magnetically bound pair states having (...) angular momentum l=1/2. The topological charge prevents the mutual annihilation of the vorton pair. The helicity eigenstates of the vortons' intrinsic angular momenta form the basis for a set of internal quantum numbers for the pair which distinguish the different (point-like) pair states. Sixteen fourcomponent spinor states, eight leptonic and eight hadronic, are obtained. Eleven of these are identified with the quantum numbers of the experimentally known particles: e, ve, μ, vμ, τ, vτ; p, n, Λ, Λc, and b. Thus one new heavy lepton with its neutrino and three new quark states are predicted. Some possibilities for the extension of this model are discussed. (shrink)

The rise of dimensional analysis in the latter part of the nineteenth century occurred largely in the context of electromagnetism. It soon appeared that the subject, albeit seemingly straightforward, was in fact wrought with difficulties. These revealed deep conceptual issues regarding the character of physical quantities. Usually, whether or not these problems actually constituted inconsistencies was itself a matter of debate. In one instance, however, regarding the electrostatic dimensions of the magnetic pole, all protagonists agreed that the matter required (...) attention. A controversy ensued in 1882. Its resolution partly relied on the realization that it arose from differences between the scientific cultures prevalent on the Continent versus in Great Britain. These cultural differences concerned the possible relevance of the medium in which interactions involving magnetic poles take place, as well as the understanding of permeability in Ampère’s model of magnetism. The controversy around the electrostatic dimensions of the magnetic pole entailed crucial issues that were soon to play just as central a part in a wider debate about the dimensions of electromagnetic quantities in different systems of units. Why the latter topic was never raised during the 1882 controversy provides insights into the early understanding of dimensional analysis. (shrink)

The rise of dimensional analysis in the latter part of the nineteenth century occurred largely in the context of electromagnetism. It soon appeared that the subject, albeit seemingly straightforward, was in fact wrought with difficulties. These revealed deep conceptual issues regarding the character of physical quantities. Usually, whether or not these problems actually constituted inconsistencies was itself a matter of debate. In one instance, however, regarding the electrostatic dimensions of the magnetic pole, all protagonists agreed that the matter required (...) attention. A controversy ensued in 1882. Its resolution partly relied on the realization that it arose from differences between the scientific cultures prevalent on the Continent versus in Great Britain. These cultural differences concerned the possible relevance of the medium in which interactions involving magnetic poles take place, as well as the understanding of permeability in Ampère’s model of magnetism. The controversy around the electrostatic dimensions of the magnetic pole entailed crucial issues that were soon to play just as central a part in a wider debate about the dimensions of electromagnetic quantities in different systems of units. Why the latter topic was never raised during the 1882 controversy provides insights into the early understanding of dimensional analysis. (shrink)

Two‐dimensional semantics is probably the most significant development in contemporary philosophy of language. Among its various versions, it is Chalmers's epistemic two‐dimensionalism that received most widely discussions and most severe criticisms. Here I consider one such criticism, namely, “the nesting problem,” which concerns the interaction between modality and apriority. I propose a solution to the problem and defend it through comparison with other approaches in the literature, as well as rebut with some potential objections. It turns out that my (...) solution not only handles the interaction between modality and apriority naturally but also avoids many difficulties of other approaches. (shrink)

We generalize two of our previous results on abelian definable groups in p-adically closed fields [12, 13] to the non-abelian case. First, we show that if G is a definable group that is not definably compact, then G has a one-dimensional definable subgroup which is not definably compact. This is a p-adic analogue of the Peterzil–Steinhorn theorem for o-minimal theories [16]. Second, we show that if G is a group definable over the standard model $\mathbb {Q}_p$, then $G^0 = (...) G^{00}$. As an application, definably amenable groups over $\mathbb {Q}_p$ are open subgroups of algebraic groups, up to finite factors. We also prove that $G^0 = G^{00}$ when G is a definable subgroup of a linear algebraic group, over any model. (shrink)

This paper addresses the past, present and future aspects of African leadership and organizational ethics that have, are and will be key for any organization to sustain its systems and structures. Organizational ethics revolves around written and/or unwritten guidelines, ethical values, principles, rules and standards, that are drawn from the harmonious coexistence with the biosphere and it is how these elements are applied that dictates the style of leadership and the ethical thinking of the leaders. Africa has a wide range (...) of complexities which are compounded by, inter alia, tribal divisiveness, selfish leadership, wealth inequality, and massive unemployment. Africans tend to draw their leadership and ethical practices and reflections from the events in the environment with which they have interacted for many years. However, in order to fully address and understand the African perspective in leadership and organizational ethics, a broad comprehension of the African diverse and complex landscape is needed through unravelling of the three dimensional existence of the people. African ethics, developed over time, unifies organizations and leadership since it is part of life and is practised, sub-consciously or unconsciously, by the people as they transform from one practice to the other, and during intergenerational transitions. Globalization, liberalization, technological changes and advancement, and market changes are rapidly transforming the environment in which organizations operate. In such a situation, an effective and true leader cannot be rigid but should be flexible, with the ability to use different leadership styles whenever the situation calls for it. Only those leaders with a three-dimensional perspective live inspiring lives, live with a cause and adopt organizational ethics and leadership styles that will stand the test of time. Despite Africa being the cradle of humankind, leadership and organizational ethics is still in its infancy and wanting, even with the new generation of young leaders. The future outlook of African organizational ethics and leadership is to be found in the intersection of changes in technology, life style, demographics and geopolitics with new trends emerging in global polity and economy. (shrink)

In his most seminal book, Herbert Marcuse sharply objects to what he saw as pervasive one-dimensional thinking-the uncritical and conformist acceptance of existing structures, norms and behaviours. Originally published in 1964, One Dimensional Man quickly became one of the most important texts in the politically radical sixties. Marcuse's searing indictment of Western society remains as chillingly relevant today as it was at its first writing.

One of the most important texts of modern times, Herbert Marcuse's analysis and image of a one-dimensional man in a one-dimensional society has shaped many young radicals' way of seeing and experiencing life. Published in 1964, it fast became an ideological bible for the emergent New Left. As Douglas Kellner notes in his introduction, Marcuse's greatest work was a 'damning indictment of contemporary Western societies, capitalist and communist.' Yet it also expressed the hopes of a radical philosopher that (...) human freedom and happiness could be greatly expanded beyond the regimented thought and behaviour prevalent in established society. For those who held the reigns of power Marcuse's call to arms threatened civilization to its very core. For many others however, it represented a freedom hitherto unimaginable. (shrink)

One of the most important texts of modern times, Herbert Marcuse's analysis and image of a one-dimensional man in a one-dimensional society has shaped many young radicals' way of seeing and experiencing life. Published in 1964, it fast became an ideological bible for the emergent New Left. As Douglas Kellner notes in his introduction, Marcuse's greatest work was a 'damning indictment of contemporary Western societies, capitalist and communist.' Yet it also expressed the hopes of a radical philosopher that (...) human freedom and happiness could be greatly expanded beyond the regimented thought and behaviour prevalent in established society. For those who held the reigns of power Marcuse's call to arms threatened civilization to its very core. For many others however, it represented a freedom hitherto unimaginable. (shrink)

One of the most important texts of modern times, Herbert Marcuse's analysis and image of a one-dimensional man in a one-dimensional society has shaped many young radicals' way of seeing and experiencing life. Published in 1964, it fast became an ideological bible for the emergent New Left. As Douglas Kellner notes in his introduction, Marcuse's greatest work was a 'damning indictment of contemporary Western societies, capitalist and communist.' Yet it also expressed the hopes of a radical philosopher that (...) human freedom and happiness could be greatly expanded beyond the regimented thought and behaviour prevalent in established society. For those who held the reigns of power Marcuse's call to arms threatened civilization to its very core. For many others however, it represented a freedom hitherto unimaginable. (shrink)

Attachment is an emotional bond between two people where one seeks care from the other. In the prototypical case, the child attaches to their mother. The most recent theoretical developments point out that attachment is multidimensional – meaning that the phenomenon pertains to multiple domains related to the relationship with the caregiver. However, researchers have so far modeled attachment computationally by mostly adopting a classical categorical (as opposed to dimensional) standpoint that sees the system as controlling caregiver proximity. In (...) contrast, we adopt here adimensional perspective(DP) and consider dimensions to be the system’s set-goals. We hypothesize that the resulting multidimensional controller should lead to valid (or even better) models of the phenomenon. To start testing this hypothesis, we built a DP-informed agent-based model of attachment inspired by the widely-studied Strange Situation Procedure. In this context, child and mother show the nature of attachment bonds through their behavioral and emotional expressions. By modeling them as point-agents moving in a two-dimensional arena, we simulated child-mother interactions for the avoidant and ambivalent attachment dimensions. The generated dynamical patterns – characterized by the alternation between approach and exploration – matched those described in the attachment literature, thereby confirming the implementability and validity of the DP. (shrink)

In this paper we prove the following theorem: Any one-dimensional definably connected group G over an o-minimal structure is, as an abstract group, isomorphic to either pPp∞δ or δ.

The discrete Deffuant model and its alternatives is a family of stochastic spatial models for the dynamics of binary opinions on f issues. Another parameter is also incorporated that prevents interaction between two agents whenever their opinion profiles are at a Hamming distance greater than the confidence threshold θ. By numerical simulations, it was conjectured in (Adamopoulos and Scarlatos, Complexity 2012, 17, 43) that one‐dimensional models exhibit a phase transition at a critical value θ critical approximately equal to f/2. (...) We report on recent mathematical results on this problem that originates from the community of complex systems. © 2016 Wiley Periodicals, Inc. Complexity 21: 437–439, 2016. (shrink)

A complete list of one dimensional groups definable in the p-adic numbers is given, up to a finite index subgroup and a quotient by a finite subgroup.

According to international longitudinal studies, the quality of preschool education is of great importance for children’s further development. The modern research’s greatest interest in the field of studying the quality of preschool education is precisely the assessment of the relationship between the teacher and children as well as the teaching quality in kindergarten groups. In this regard, the Classroom Assessment Scoring System (CLASS) seems to be the one of the most relevant for the educational environment quality evaluation. The CLASS methodology (...) (which includes emotional support, classroom organization, and instrumental support) is based on the cultural-historical approach, which shows the interaction between students and adults as the main mechanism for child’s development. The aim of this study is to investigate the relationships between different aspects of the classroom organization quality in kindergarten groups and executive functions components (such as cognitive flexibility, inhibitory control, and working memory) in 5–6-year-old children. The quality of classroom interaction was measured by the CLASS. The study used the Dimensional Change Card Sort (DCCS) method to assess cognitive flexibility and the NEPSY-II subtests “Inhibition” to assess inhibitory control and “Memory for Designs” and “Sentences Repetition” to assess visuo-spatial and verbal working memory, respectively. The study was approved by the Ethics Committee of the Faculty of Psychology at Lomonosov Moscow State University. The study involved 26 kindergarten groups in Moscow. While conducting the research, extreme groups were identified (5 with low quality and 10 with high-quality levels of classroom interaction). Then, three kindergarten groups with low level (65 children) and three groups with high level (68 children) of interaction within classroom were selected and compared. The results revealed that children from groups with low level of classroom interaction have higher results in cognitive flexibility tasks when compared with children from groups with high level of interaction. Also, children from groups with high-quality classroom interaction demonstrated higher results in visuo-spatial working memory tasks and inhibitory control tasks as contrasted with children from low-quality groups. These findings attest to the importance of classroom interaction quality for the executive functions development in the preschool age. (shrink)

The Marcusean concept of one-dimensionality is used to explore contradictions of organized labor. Since the original 1964 publication of One-Dimensional Man, the labor movement has suffered significant losses in membership and power. This essay examines the current relevance of Marcuse’s description of the increasing integration and collusion of organized labor with business, the loss of the union’s role as radical/revolutionary subject, and the containment of organized labor as an oppositional force. The specific mechanisms found in the structure, culture, logic, (...) and legal constraints that characterize the deradicalization of organized labor are critically reviewed. (shrink)

Atomic-scale computer simulation has been used to study the thermally activated atomic transport of self-interstitial atoms in the form of planar clusters in pure Cu and f -Fe. There is strong evidence that such clusters are commonly formed in metals during irradiation with high-energy particles and play an important role in accumulation and spatial distribution of surviving defects. An extensive study of the mobility of SIA clusters containing two to 331 interstitials has been carried out using the molecular dynamics simulation (...) technique for the temperature range from 180 to 1200 K. The results obtained show that clusters larger than three to four SIAs are one-dimensionally mobile in both Cu and Fe. Large clusters of more than 100 SIAs in Cu and 300 SIAs in Fe have significantly reduced mobility. The problem of describing one-dimensional motion in three-dimensional space is discussed. An attempt is made to describe the mobility of SIA clusters within the approximation of 1D diffusion. For clusters in both metals the effective migration energy of 1D diffusion as estimated via the jump frequency of the cluster centre of mass is found to be independent of the number of SIAs in the clusters, although the cluster jump frequency decreases with increasing cluster size. Mechanisms of 1D mobility of interstitial clusters are discussed. (shrink)

The BTB domain is a protein–protein interaction motif that is found throughout eukaryotes. It determines a unique tri‐dimensional fold with a large interaction surface. The exposed residues are highly variable and can permit dimerization and oligomerization, as well as interaction with a number of other proteins. BTB‐containing proteins are numerous and control cellular processes that range from actin dynamics to cell‐cycle regulation. Here, we review findings in the field of transcriptional regulation to illustrate how the high variability of the (...) BTB has allowed related transcription factors to evolve different functional abilities. We then report how recent work has showed that, in spite of their high sequence divergence and apparently unrelated functions, many BTB‐containing proteins have at least one shared role: the recruitment of degradation targets to E3 ubiquitin ligase complexes. Taken together, these findings illustrate diverse and convergent functions of a versatile protein–protein interaction domain. BioEssays 28: 1194–1202, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Although we frequently acquire knowledge and skills through social interactions, the focus of most research on learning is on individual learning. Here we characterize Interaction Based Learning, which represents the acquisition of knowledge or skill through social interactions, and compare it to Observational Learning —learning by observation. To that end, we designed a movement synchronization paradigm whereby participants learned Tai-Chi inspired movement sequences from trained teachers in two separated sessions. We used a motion capture system to track the movement of (...) 40 dyads comprised of a teacher and learner, who were randomly divided into OL or IBL groups, and calculated time-varying synchrony of three-dimensional movement velocity. While in the IBL group both the learner and the teacher could see each other through a transparent glass, in the OL group dyads interacted through a one-way mirror, such that the learners observed the teacher, but the teacher could not see the learners. Results show that although the number of movements recalled was not different between groups, we found improved movement smoothness in the IBL compared to the OL group, indicating movement acquisition was better in the IBL group. In addition, we found that motor synchronization levels in dyads improved over time, indicating that movement synchronization can be learned and retained. In the first session, the IBL group, but not the OL group, showed a significant improvement in synchronization. This suggests that dyadic interaction is important for learning movement sequences, and that bidirectional communication of signals and mutual feedback are essential for the consolidation of motor learning. (shrink)

The new phase of science evolution is characterized by totality of subject and object of cognition and technology (high-hume). As a result, forming of network structure in a disciplinary matrix modern are «human dimensional» natural sciences and two paradigmal «nuclei» (attraktors). As a result, the complication of structure of disciplinary matrix and forming a few paradigm nuclei in modern «human dimensional» natural sciences are observed. In the process of social verification integration of scientific theories into the existent system (...) of mental and valued options of spiritual culture takes place. The attribute of classical science – ethics neutrality of scientific knowledge becomes an unattainable ideal. One of the trends in the evolution of theoretical epistemology is the study of migration mechanisms of generation of scientific knowledge from the sphere of its own logic and methodology of science in the field of sociology - the consideration of this process, as the resulting system of interactions of social structures and institutions. Ensuing ideas and settings become the dominant worldview of philosophical and technological civilization. -/- . (shrink)

This study explores to conceptualize and practicalize three-dimensional interaction model of internationalization from China’s higher education perspective. Applying documentary analysis, a qualitative method, and interviews, 15 international administrative staff and directors from eight sampled local universities were interviewed to present in-depth insights into the internationalization of the local higher education system in Beijing. The major findings are that strategic positioning in terms of the internationalization of local universities should be based on the following: top-level design of a national macro (...) internationalization strategy; a focus on the internal need for internationalization at the regional level; and understanding the distinctive advantages of internationalization at the local level. The choices for the internationalization of local universities should focus on the absolute advantages of the ‘scale’ of resources and rationally expand the relative advantages concerning the ‘structure’ of resources. Implementation of the strategy for internationalization of local universities should actively build on the competitive advantage of ‘strategic resource integration’. In conclusion, the need to combine national needs with regional development, the importance of combining connotation and capacity building, and of adhering to a combination of a top-level layout or design and local practice are explored and summarized. Finally, both the theoretical contribution and practical implications of this study are discussed. (shrink)

We investigate the one-dimensional dynamics of alternatives of the Axelrod model (ξ(t)), where t is the time, with k binary features and confidence parameter ε = 0, 1,…, k. Simultaneously, the simple Axelrod model is also critically examined. Specifically, for small and large ε, simulations suggest that the convergent model (ξ(t)) is emulated by a corresponding attractive model (η(t)) with the same parameters (conditional on bounded confidence). (η(t)) is more mathematically tractable than (ξ(t)), and the very definitions of the (...) two qualitative behaviors of cyclic particle systems (fluctuation and fixation) are applicable in special cases. Moreover, we observe a complementarity: for not too small k and equation image, (η(t)) fixates (each site has a final type independent of the possibly infinite size of the lattice), whereas (ξ(t)) fluctuates (each site changes type at arbitrarily larger times t as the size of the lattice increases). (shrink)

We consider definable topological spaces of dimension one in o-minimal structures, and state several equivalent conditions for when such a topological space \ \) is definably homeomorphic to an affine definable space with the induced subspace topology). One of the main results says that it is sufficient for X to be regular and decompose into finitely many definably connected components.