Mechanistic models are built using knowledge as the primary information source, with well-established biological and physical laws determining the causal relationships within the model. Once the causal structure of the model is determined, parameters must be defined in order to accurately reproduce relevant data. Determining parameters and their values is particularly challenging in the case of models of pathophysiology, for which data for calibration is sparse. Multiple data sources might be required, and data may not be in a uniform or (...) desirable format. We describe a calibration strategy to address the challenges of scarcity and heterogeneity of calibration data. Our strategy focuses on parameters whose initial values cannot be easily derived from the literature, and our goal is to determine the values of these parameters via calibration with constraints set by relevant data. When combined with a covariance matrix adaptation evolution strategy, this step-by-step approach can be applied to a wide range of biological models. We describe a stepwise, integrative and iterative approach to multiscale mechanistic model calibration, and provide an example of calibrating a pathophysiological lung adenocarcinoma model. Using the approach described here we illustrate the successful calibration of a complex knowledge-based mechanistic model using only the limited heterogeneous datasets publicly available in the literature. (shrink)

In the present meta-analysis, we examined the effect of cognitive training on the Executive Function (EF) of preschool children (age range: 3-6 years). We selected a final set of 32 studies from 27 papers with a total sample of 123 effect sizes. We found an overall effect of cognitive training for improving EF (g =.352; k = 123; p <.001), without significant difference between near and far transfer effects on executive domains. No significant additional outcome effects were found for behavioral- (...) and learning-related outcomes. Cognitive training programs for preschoolers are significantly more effective for developmentally at-risk children (ADHD or low socio-economic status) than for children with typical development and without risks. Other significant moderators were computerized versus non-computerized training, individual versus group sessions, and length of training. The number of sessions was not a significant moderator. This is the first demonstration of cognitive training far transfer effects among different executive processes. We discuss this result in relationship with the lower level of modularization of EFs in younger children. (shrink)

Several studies have testified to the importance of a responsive linguistic input for children’s language acquisition and development. In particular, maternal use of expansions, imitations, interpretations, and labels has been shown to promote both children’s language comprehension and production. From this perspective, the present study examined the semantically contingent linguistic input addressed to very preterm children’s comparing it to that directed to full-term children observed during a semi-structured play session when the children were 24 months of age. The relationships between (...) maternal contingent utterances and children’s communicative repertoires were also investigated. The main results showed that mothers of full-term children produced a higher proportion of semantically contingent utterances than those of very preterm children; moreover, this variable was associated with children’s more advanced communicative-linguistic outcomes. Overall, this study supports the interdependence between mothers’ use of certain linguistic strategies and children’s communicative-linguistic repertoire, extending this evidence to children born very preterm and suggesting the importance of considering the semantic contingency aspect of child-directed speech to support the communicative and linguistic development of these children. (shrink)

Phenomenology, New Materialism, and Advances In the Pulsatile Imaginary: Rites Of Disimagination brings together scholars from art history and image theory, literary studies and philosophy. Chapters of this volume engage with the overarching theme of imagination as a pulsatile force embedded in words, images, and all imaginative modes of instantiation of the work of art in their elemental aspects, expressed in visual arts, and literature, as well as bodily schemata of choreographic and musical performances. The papers employ contrasting and complementing (...) methods from literary studies and image theory, especially phenomenology and new materialism, such as G. Bachelard and M. Merleau-Ponty, G. Bataille, J. Kristeva, P. Lacoue-Labarthe and J. Sallis, G. Didi-Huberman, H. Belting and A. Warburg, J. Bennett and Jason M. Wirth, as well as performance studies. Chapters in this volume inquire into the imaginative forces that disrupt and disinhibit the traditional habits of imagination to create pulsatile imaginaries, i.e., a dynamic process of “emergence-resurgence” of image manifested in the act of creation and in perception. This process does not properly imply a destruction of image, but rather a withdrawal of image from the realm of representation to give way to new images and new imaginative experiences. The newly coined term “rite of disimagination” points out to this operation, consecutively implying imagining and disimaging that both denies, as well as validates image – it valorizes matter. The affirmation of the materiality of image is “the re-incarnation of image.”. (shrink)

This article examines the cameraless negatives revealing the imprints of four fingers obtained in Turin in February 1907 during the second of two séances with renowned medium Eusapia Palladino organized by physiologists Alberto Aggazzotti, Carlo Foà and Amedeo Hertlizka. By looking at the material and performative components of the séance, it presents spiritualist cameraless photography as a productive tool for rethinking and reframing the photographic medium from a cross-disciplinary perspective questioning medium specific histories and dominant genealogies.

Standard models of visual perception hold that vision is an inferential or interpretative process. Such models are said to be superior to competing, non-inferential views in explanatory power. In particular, they are said to be capable of explaining a number of otherwise mysterious, visual phenomena such as multi-stable perception. Multi-stable perception paradigmatically occurs in the presence of ambiguous figures, single images that can give rise to two or more distinct percepts. Different interpretations are said to produce the different percepts. In (...) this paper, I argue that a non-inferential account of visual perception is just as capable of explaining multi-stable perception. I propose an embedded understanding of vision, and show how the embedded account can, after properly qualifying them, use the explanatory resources of the inferential view to explain just what such a view explains. (shrink)

Ambiguous figures pose a problem for representationalists, particularly for representationalists who believe that the content of perceptual experience is non-conceptual (MacPherson in Nous 40(1):82–117, 2006). This is because, in viewing ambiguous figures, subjects have perceptual experiences that differ in phenomenal properties without differing in non-conceptual content. In this paper, I argue that ambiguous figures pose no problem for non-conceptual representationalists. I argue that aspect shifts do not presuppose or require the possession of sophisticated conceptual resources and that, although viewing ambiguous (...) figures often causes a change in phenomenal properties, this change is accompanied by a change in non-conceptual content. I illustrate the case by considering specific examples. (shrink)

L'origine dell'atto intenzionale e la reattività psichica e spirituale -- La costituzione genetica dell'Io personale e la scelta della relazione autentica -- L'intreccio tra volontà e dovere morale : la scelta di divenire un Sé e la dimensione dell'ascolto -- Dalla formazione personale al senso della comunità : la Bildung etica e l'etica della Bildung.

This paper explores the issue of performative spaces in the medieval Latin Church, examining the mindsets of the time and the ways practitioners adopted the Platonic notion of world harmony. We then look at the Palatine Chapel of Aachen in the light of the Plato’s doctrine. At the heart of this analysis will be the cosmological drama at the creation of the world, described by Ambrose as a chorus of the constitutive elements. It is from this image that the proto-model (...) of the Christian Church as ‘moving waters’ was derived, a vision shared by both the Eastern and the Western world. To this day, the Palatine chapel of Aquisgranum conveys the appearance of the Ambrosian vision of the primordial waters, with its renewed marble revetments imitating the cosmic waters. The church is designed according to propria dispositione, i. e. modularity. Augustine’s concept of modularity and his psychology of sound, space, movement, and time will be explored in the hypothetical inquiry into the dramatization of space at Aachen. Here, we find that the Chapel has two choreographies which unfold in the space like-stage set up as a synthesis of the arts shaped according to numbers. Relevant concepts to our topic will emerge in the analysis, such as concord, consonance and agreement, measure and movement – metaphors of the idea of a ‘dance’ that exceeds the character of a mere performance. (shrink)

Noyau de la future Articella, l’ Ars medicine est une collection de textes médicaux qui fut à la base de l’enseignement salernitain au xii e siècle ; en matière d’urologie ce programme prévoyait la lecture du Liber urinarum Theophili, traduction gréco-latine d’un texte byzantin à visée pratique. Lors de leur lecture de cet opuscule, les maîtres de Salerne utilisèrent aussi le Liber urinarum Isaac, monographie assez complète dont existait une version arabo-latine par Constantin l’Africain (fin xi e s.). Cet article (...) se propose d’évaluer l’importance doctrinale que recouvre l’œuvre d’Isaac dans les commentaires de Barthélemy et Maurus de Salerne. (shrink)

Approaches to foster motor creativity differ according to whether creative movements are assumed to be enacted creative ideas, or solutions to emerging motor problems that arise from task and environmental constraints. The twofold aim of the current study was to investigate whether an enriched physical education intervention delivered with a joint constraints-led and cognitive stimulation approach fosters motor creativity, and the responsiveness to the intervention is moderated by baseline motor and cognitive skills and sex; the intervention may benefit motor creativity (...) through gains in motor coordination, executive function, and creative thinking. Ninety-five children, aged 6–9 years, participated in a 6-month group randomized trial with specialist-led enriched PE vs. generalist-led conventional PE. Before and after the intervention, Bertsch’s Test of Motor Creativity, Movement Assessment Battery for Children, Random Number Generation task and Torrance Test of Creative Thinking were administered. Linear mixed models were run accounting for the random effects of data clusters. Multiple mediation analysis was performed to assess whether motor coordination, executive function and creative thinking mediated any improvement of motor creativity. Results showed that specialist-led enriched PE, compared to generalist-led conventional practice, elicited a more pronounced improvement in all motor creativity dimensions independently of baseline levels of motor and cognitive skills and sex; and improved motor creativity was partially mediated by improved motor coordination and, as regards motor flexibility, also by improved inhibitory ability. In conclusion, enriching PE with tailored manipulations of constraints and variability may enhance the ability to create multiple and original task-pertinent movements both directly and through indirect paths. The results are discussed extending to motor creativity a theoretical framework that distinguishes different creativity modes. The intervention may have fostered the generation of creative movements directly through the exposure to variation in constraints, activating the sensorimotor ‘flow’ mode of creativity that bypasses higher-order cognition, but also indirectly through a systematic and conscious convergence on solutions, activating the ‘deliberate’ mode of creativity that relies on inhibition to reject common or task-inappropriate movement categories. (shrink)

The paper aims to assess the theory of mind of sexual offenders. We administered to 21 sexual offenders and to 21 nonoffenders two classical first- and second-order ToM tasks, a selection of six Strange Stories, and a semi-structured interview, the Theory of Mind Assessment Scale , which provides a multi-dimensional evaluation of ToM, investigating first- vs. third-person and egocentric vs. allocentric perspectives. Results show that sexual offenders performed worse than controls on second-order ToM tasks, on Strange Stories and on each (...) of the Th.o.m.a.s dimensions, whereas they did as well as the control group on first-order ToM tasks. A detailed analysis of participants’ performance on Th.o.m.a.s. showed that sex offenders performed worse on the third-person than on the first-person ToM scale, and worse on the allocentric than on the egocentric perspective; these findings did not apply to the controls. Implications for future research and treatment are discussed. (shrink)

Can one see one thing as another without possessing a concept of it? The answer to this question is intuitively negative. This is because seeing x as F is usually taken to consist in the application of the concept F to x . Seeing the duck-rabbit figure as a duck figure, for instance, involves applying the concept DUCK to the figure; thus, one cannot see the figure as the figure of a duck unless one has the concept of a duck (...) and is able to deploy it when looking at the figure. Nearly by definition, then, one cannot see x as F without possessing a concept of F. Contrary to this line of reasoning, this article treats the question of whether we can see x as F without possessing a concept of F as an open and partially empirical question. Seeing x as F involves seeing x in a certain way, namely as F, and whether concepts are required in order to see something in a certain way is an open question. Accordingly, what follows offers a proposal for an alternative way of understanding seeing–as that does not appeal to concept application. (shrink)

According to a widespread interpretation, in the Investigations Wittgenstein adopted a deflationary or redundancy theory of truth. On this view, Wittgenstein’s pronouncements about truth should be understood in the light of his invocation of the equivalences ‘p’ is true = p and ‘p’ is false = not p. This paper shows that this interpretation does not do justice to Wittgenstein’s thoughts. I will be claiming that, in fact, in his second book Wittgenstein is returning to the pre-Tractarian notion of bipolarity, (...) and that his new development of this notion in the Investigations excludes the redundancy-deflationary reading. Wittgenstein’s thoughts about truth are instead compatible with another interpretative option: Wittgenstein remains faithful to his methodological pronouncements, and he merely presents us with platitudes about the notions of “true” and “false”. (shrink)

Philosophers of perception widely agree that sensory properties, like color, are represented in perceptual experience. Arguments are usually needed to establish that something other than sensory properties, for example three-dimensional objects or kind properties, are part of perceptual content. Call the idea that sensory properties are represented in perceptual experience the Sensation View (SV). Given its widespread acceptance, we may expect to find strong reasons for holding SV. In this paper, I argue that we lack such reasons: SV is largely (...) unjustified. We have surprisingly poor justification for thinking that sensory properties are represented in perception. By focusing on the case of vision, I show that an embedded understanding of visual perception, and empirical evidence in cognitive psychology, indicate that SV is far from warranted. (shrink)

This paper argues that there are three reasons why we should regard Wittgenstein's Tractatus as a forerunner of formal semantics: Wittgenstein is convinced that we can apply formal notions to natur...

In the 1990’s, Robotics began to design a new robot aimed at industries (primarily automotive) that worked and interacted with humans outside the cage, thereby replacing traditional _robots_ for some specific duties. This _robot_ is therefore called _co-bot_ (_collaborative_ and _robot)._ Also in the 1990’s, Robotics designed the _social robot_ (for which we propose the neologism _so-bot),_ aimed at assisting humans and keeping them company. The sociality of the _sobots_ lies in their ability to follow the rules of human social (...) life, make decisions independently, and respect the roles assigned to them. Scientific literature usually keeps the terms _collaborative_ and _social robot_ distinct as if they indicated different and separate concepts. We question this separation and affirm that to collaborate (from the Latin _cum-laboro_) means to interact with someone while respecting their nature. Collaboration is that particular form of sociality that relates to work activity. From this it follows that the _cobot_ is essentially social and that _cobots_ and _sobots_ belong to the same category that we call _co-s-bots_ (_collaborative social robots_). In other words, _cobots_ and _sobots_ are two types of _cosbots,_ as the flea and the elephant are two types of animals. The difference between _cobot_ and _sobot_ is given by the development of AI. Both are _potentially_ social, that is, _potentially_ capable of interacting and making decisions independently; but while the _cobot_ is social in potency, the _sobot_ is social ‘in act’. With Aristotelian terminology we can therefore say that the _cobot_ is a _sobot_ in power, while the _sobot_ is a _cobot_ in act. We call this new concept ‘_cobot ontology_’. Such an ontology makes it possible to classify _cobots_ according to the degree of development of AI, just as living beings are classified according to the level of intelligence developed.To teach the _cosbot_ to interact with humans, engineers use some results of neuroscientific research such as mirror neurons and the _embodied Mind_. The use of these models should encourage machine self-learning. Self-learning means autonomy, and autonomy needs strong AI development. It is becoming increasingly clear that autonomy is the condition of the sociality of the _sobot_. The article thus concludes that the relationship between _cobot_ and _sobot_ is the identification of a more general _robot_-_automaton_ (_rabota_-_automatos_) relationship which, in the writer’s opinion, is the essential basis and driving force behind the entire history of Robotics. (shrink)

This article analyses the Swedish TV series Hållbart näringsliv (HN) to study hegemonic discursive formations over the meaning of the climate crisis. Combining new materialist approaches in discourse studies with a political ecology understanding of the socio-ecological entanglement, we propose the concept of technocratic solutionism to understand how the neo-liberal green economy secures instrumentalist discourses on nature in the Swedish context. The discourse-theoretical analysis of nine HN episodes identifies four nodal points which articulate the technocratic solutionist discourse: capital’s leading role, (...) Nordic exceptionalism, substitutionalism and long-termism. We argue that the climate crisis can be understood as a materiality that dislocates capitalist assemblages, which then, in response, deploy a techno-solutionism discourse to protect the core principles of economic growth and profitability while marginalizing potential radical alternatives. (shrink)

This paper questions two prima facie plausible claims concerning switching in the presence of ambiguous figures. The first is the claim that reversing is an instantaneous process. The second is the claim that the ability to reverse demonstrates the interpretive, inferential and constructive nature of visual processing. Empirical studies show that optical and cerebral events related to switching protract in time in a way that clashes with its perceived instantaneity. The studies further suggest an alternative theory of reversing: according to (...) such alternative, seeing the same thing in multiple ways is a matter of uncovering what is already present to the senses through visual search. (shrink)

Albert Hirschman's possibilism originated from his work on development and democracy; at the same time, it offered tools for evaluating projects that Judith Tendler innovatively utilized in her professional work, where she interweaved theory and practice, methodology and ethics. Starting from observation in the field, comparisons, linkages, inverted sequences and unexpected consequences are really key elements in a type of evaluation that works toward improvement, "for a better world." The enduring vitality of the thinking of these forerunners is what motivates (...) the reconstruction of their intellectual trajectories: from the way of learning from the successes and failures of programs, to how to deal with such themes as complexity, mechanisms, uncertainty, change, that are at the core of current debates. The book aims at showing both the relevance of practical work for the advancement of social theory, and the need for a theoretical attitude - based on a capacity of being surprised - for the strengthening of democratic professionalism and the attainment of sound results. It will constitute a basic reading for social scientists, decision-makers, policy implementers, evaluators and students. (shrink)