Clustered regularly interspaced short palindromic repeats genome editing has already reinvented the direction of genetic and stem cell research. For more complex diseases it allows scientists to simultaneously create multiple genetic changes to a single cell. Technologies for correcting multiple mutations in an in vivo system are already in development. On the surface, the advent and use of gene editing technologies is a powerful tool to reduce human suffering by eradicating complex disease that has a genetic etiology. Gene drives are (...) CRISPR mediated alterations to genes that allow them to be passed on to subsequent populations at rates that approach one hundred per cent transmission. Therefore, from an anticipatory biomedical ethics perspective, it is possible to conceive gene drive being used with CRISPR to permanently ameliorate aberrant genes from wild-type populations containing mutations. However, there are also a number of possible side effects that could develop as the result of combining gene editing and gene drive technologies in an effort to eradicate complex diseases. In this paper, we critically analyse the hypothesis that the combination of CRISPR and gene drive will have a deleterious effect on human populations from an ethical perspective by developing an anticipatory ethical analysis of the implications for the use of CRISPR together with gene drive in humans. (shrink)

In this paper I survey some recent developments in experimental philosophy and discuss their bearing on two leading theories in epistemology: Contextualism and Interest Relative Invariantism. In the first part of the paper, I survey some general issues of how experimental philosophy may be relevant to assessing contextualism and IRI. In the second part, I discuss and critique some of the recent experimental work.

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 107 Heft: 2 Seiten: 691-710.

The prospect of replication of human beings through genetic manipulation has engendered one of the most controversial debates about reproduction in our society. Ideology is clearly influencing the direction of research and legislation on human cloning, which may present one of the greatest existential challenges to the meaning of creation. In this article, I argue that, in view of the possibility that human cloning and other emerging technologies could enhance physical and cognitive abilities, there is a need for a different (...) way of thinking about life, new technologies and creation. New scientific discoveries require a shift in the way psychology takes responsibility to help individuals and society. Today, psychology needs to follow the progress that humans are taking toward a transhuman stage of development as a transition to a later posthuman stage. (shrink)

The health emergency due to the COVID-19 pandemic revealed limitations in health systems worldwide, making it necessary to establish a bioethical framework that provides tools to drive health professionals’ decision-making amid scarce health resources. Bioethical models such as principlism, utilitarianism, and personalism seek to focus clinical decisions on respect for people’s rights and dignity, thus protecting the medical practice. Personalism provides a person-centered approach to respect for human dignity during health emergencies to avoid giving material meaning to the individual. Decision (...) criteria are required to face bioethical conflicts in clinical practice, reducing the legal, emotional, and ethical burden of decision-making in pandemic situations. (shrink)

A topological duality is presented for a wide class of lattice-ordered structures including lattice-ordered groups. In this new approach, which simplifies considerably previous results of the author, the dual space is obtained by endowing the Priestley space of the underlying lattice with two binary functions, linked by set-theoretical complement and acting as symmetrical partners. In the particular case of l-groups, one of these functions is the usual product of sets and the axiomatization of the dual space is given by very (...) simple first-order sentences, saying essentially that both functions are associative and that the space is a residuated semigroup with respect to each of them. (shrink)

The present article tries to emphasize the roll of the experimental logic in the process of education-learning of the methodology of the investigation. Its treatment usually appears as material for the later boarding of the explanation or the calls explanatory designs or explanatory reconnaissanc..

Using a standard trust game, we elicit trust and reciprocity measures in a representative sample of adult players in Montevideo, the capital city of Uruguay, a country that received a sizeable influx of Venezuelan and Cuban migrants, has lower internal disparities than other Latin American countries and exhibits relatively better levels of tolerance towards migrants. We find no statistically significant differences in trust levels of Uruguayans towards countrymen versus migrants and mixed results regarding reciprocity, with migrants exhibiting a flatter response (...) to trust than their local counterparts. (shrink)

Millikan [2000] has levelled a number of persuasive criticisms against Cummins's [1996] theory of mental representation. In this paper, I pave a middle path in the debate between Cummins [2000] and Millikan [2000] to answer two questions. How are representations applied to targets? How is the content of a representation determined? The result is a new theory of mental representation, which I call narrow structuralism.

Shors & Matzel propose that hippocampal LTP increases the effective salience of discrete external stimuli and thereby facilitates the induction of memories at distant places. In line with this suggestion, a neural network model of associative learning and hippocampal function assumes that LTP increases hippocampal error signals to the cortex, thereby facilitating stimulus configuration in association cortex. Computer simulations show that under these assumptions the model correctly describes the effect of LTP induction and blockade in classical discriminations and place learning.

En la actualidad el número de estudiantes con diversidad funcional que ha ingresado al sistema educativo colombiano es amplio, así pues, el punto neurálgico de esta revolución educativa es transformar paradigmas desde una perspectiva práctica. Aunado a esto, el docente juega un papel fundamental en la inclusión. Esta investigación se orientó a identificar los retos y realidades del docente en contextos escolares colombianos. En este sentido, se planteó partir de una metodología de corte cuantitativo con un diseño no experimental de (...) alcance descriptivo. Destacando que, una escuela para todos no es una utopía, es un espacio de los educandos y para los educandos donde convergen libremente una gama de particularidades y habilidades propias de una escuela humana e igualitaria. (shrink)

Intersecting systems of inequality are remarkably resistant to change. Many universities, however, seek National Science Foundation Institutional Transformation awards to change processes, procedures, and cultures to make science, technology, engineering, and mathematics departments more inclusive. In this article we describe a case study with observations for eight years of before, five during, and seven after intensive efforts to increase women through reducing barriers and increasing access to women. Finally, we reflect on flawed assumptions built into the proposal, the slow and (...) uneven change in the proportion of women over time, the strengths and weaknesses of numeric assessments, and the value of a longer view for seeing how seeds planted with promising practices initiated during the award may end with the funding but can reemerge and bear fruit when faculty who engage in equity work are in positions of authority later in their careers. (shrink)

Here we provide an overview of some of the central ethical issues related to the use of surgical robots. Subsequently we introduce an anticipatory ethical analysis of possible consequences for the use of robotic surgery. Anticipatory ethics aims at identifying ethical problems with emerging technologies while they are at the introductory stages for a wide range of stakeholders. Robotic surgery presents a range of positive possibilities, which include treating patients more safely and effectively to caring for patients with telesurgery at (...) remote locations. However, injuries and deaths caused by robotic surgical platforms (RSPs) pose roadblocks to full realization of this technology. Investment in RSPs by for-profits like hospitals requires a detailed stakeholder analysis that takes into account both institutional and patient perspectives. It will take carefully crafted policy and regulation based upon sound technical and ethical analysis to induce the widespread adoption of this surgical method. (shrink)

This research tackled the challenges public secondary schools in Sagbayan District, Bohol, faced regarding records management. The study employed a mixed research design, combining both descriptive-qualitative and descriptive- quantitative methods. The qualitative phase involved conducting in-depth interviews and focus group discussions with relevant stakeholders involved in records management. On the other hand, the quantitative phase utilized survey questionnaires to gather data from relevant stakeholders to determine the acceptability of the proposed MIS among end-users. The first phase findings revealed various challenges (...) in records management faced by the schools, such as inefficient manual record-keeping systems, difficulties in data retrieval, and the risk of data loss due to inadequate backup procedures. These challenges highlighted the need for a comprehensive, technology-driven solution to streamline records management processes and ensure data security. The evaluation results in the second phase showed that the developed Management Information System (MIS) was well-accepted among the end users. The absence of any significant difference in the level of acceptability among the participants further validated the system's suitability for addressing their specific needs. The successful implementation of the MIS proved to be an effective solution to the records management challenges faced by the public secondary schools in Sagbayan District, Bohol. (shrink)