The current use of animals to test for potential teratogenic effects of drugs and other chemicals dates back to the thalidomide disaster of the late 1950s and early 1960s. Controversy surrounds the following questions: 1. What was known about placental transfer of drugs when thalidomide was developed? 2. Was thalidomide tested on animals for teratogenicity prior to its release? 3. Would more animal testing have prevented the thalidomide disaster? 4. What lessons should be learned from the thalidomide disaster regarding animal (...) testing for teratogenicity? We review the literature in order to address these questions. (shrink)

This book brings together both new and previously published essays on the Greek political history of the fifth century BC and historiography. It examines the relationship between philosophy and social/political conditions, and includes a new analysis of Aristotle's views on slavery and a discussion of the practicality of Plato's political theories.

The requirement that animals be used in research and testing in order to protect humans was formalized in the Nuremberg Code and subsequent national and international laws, codes, and declarations. We review the history of these requirements and contrast what was known via science about animal models then with what is known now. We further analyze the predictive value of animal models when used as test subjects for human response to drugs and disease. We explore the use of animals (...) for models in toxicity testing as an example of the problem with using animal models. We conclude that the requirements for animal testing found in the Nuremberg Code were based on scientifically outdated principles, compromised by people with a vested interest in animal experimentation, serve no useful function, increase the cost of drug development, and prevent otherwise safe and efficacious drugs and therapies from being implemented. (shrink)

According to classical and postclassical sources, the early Greek turannoi were, by definition, illegitimate rulers who overturned existing political arrangements and installed rogue monarchic regimes in their place. And on this one fundamental point at least, modern observers of archaic turannides seem to have little quarrel with their ancient informants. To this day, it remains axiomatic that Cypselus, Peisistratus, and the rest were autocrats who gained power by usurpation. Whatever their individual accomplishments, they were still, in a word, "tyrants." Relying (...) mostly on evidence from the contemporary literary and material records, my paper aims to challenge this time-honored conventional wisdom and restore the first turannoi to the political mainstream. (shrink)

The article summarizes the main achievements of the historical and philosophical thought of Greece in the study of Byzantine philosophy. Modern Greek researchers make a significant contribution to the formation of a theoretical and methodological basis for the study of Byzantine philosophy. Based on this basis, we can discover the origins, essential features and characteristic antinomies of Byzantine philosophy. The article examines the generalizing works of Greek scientists, in which Byzantine philosophy is presented as a holistic phenomenon. Greek scholars perceive (...) Byzantine philosophy as an integral part of the history of national philosophical thought. Therefore, the position of modern Greek thinkers is interesting and has a special heuristic value. (shrink)

Authority and Tradition in Ancient Historiography. By John Marincola (Berkeley, Los Angeles, and London: University of California Press, 1997), xvi + 361 pp. £45.00, $64.95 cloth. Warriors into Traders: The Power of the Market in Early Greece. By David W. Tandy (Cambridge, New York, and Melbourne: Cambridge University Press, 1997), xv + 296 pp. $45.00 cloth.