The aging process involves changes in immune regulation, i.e. adaptive immunity declines whereas innate immunity becomes activated. NF‐κB signaling is the master regulator of the both immune systems. Two recent articles highlight the role of the NF‐κB system in aging and immune responses. Adler et al1 showed that the NF‐κB binding domain is the genetic regulatory motif which is most strongly associated with the aging process. Kwon et al2 studying HIV‐1 infection and subsequent immune deficiency process demonstrated that HIV‐1 Tat (...) protein binds to SIRT1 protein, a well‐known longevity factor, and inhibits the SIRT1‐mediated deacetylation of the p65 component of the NF‐κB complex. As a consequence, the transactivation efficiency of the NF‐κB factor was greatly potentiated, leading to the activation of immune system and later to the decline of adaptive immunity. These observations support the scenario where immune responses and aging process can be enforced by the potentiation of NF‐κB transactivation efficiency. Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF‐κB signaling, the major outcome of which is inflamm‐aging via proinflammatory responses. BioEssays 30:939–942, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

What did Immanuel Kant really think about love? This book is the first in-depth study of the concept of love in Kant's philosophy. It argues that love is much more important to Kant than previously thought, and that understanding love is actually essential for Kantian ethical life. Perhaps surprisingly, for Kant, love permeates human existence from the strongest impulses of nature to the highest ideals of morally deserved happiness.

Software piracy is a damaging and important moral issue, which is widely believed to be unchecked in particular areas of the globe. This cross-cultural study examines differences in morality and behavior toward software piracy in Singapore versus the United States, and reviews the cultural histories of Asia versus the United States to explore why these differences occur. The paper is based upon pilot data collected in the U.S. and Singapore, using a tradeoff analysis methodology and analysis. The data reveal some (...) fascinating interactions between the level of ethical transgression and the rewards or consequences which they produce. (shrink)

Leibovich et al. challenge the prevailing view that non-symbolic number sense is innate, that detection of numerosity is distinct from detection of continuous magnitude. In the present commentary, the authors' viewpoint is discussed in light of the integrative theory of numerical development along with implications for understanding mathematics disabilities.

Para San Juan de Ávila la salvación de las almas es el principal negocio de Dios que estará unido, dada su situación histórica, a la reforma de la Iglesia y de los pastores. La Iglesia y el sacramento del orden, tienen un origen y una realización concomitante, obran simultáneamente la salvación, ninguno de ellos es consecuencia del otro sino que ambos son en Cristo. El objetivo de este artículo es presentar la identidad eclesial del sacramento del orden desde la doctrina (...) de San Juan de Ávila. Las consecuencias de esta reflexión sobre la identidad eclesial del sacerdocio nos llevará a comprender la profundidad de la doctrina avilista y saber enriquecer la actual reflexión teológica. (shrink)

Media representations of environmental conflicts between companies and communities play an important role in influencing ideas about the rightful exploitation of natural resources. This article examines local newspapers' representations of fishers' claims over resource access in a conflict between fishers and the oil industry in Tabasco, Mexico. Our analysis is based on articles from two newspapers dating from 2003-2004 and 2007-2012, and ethnographic data from 2011-2012. Drawing on Boltanski and Thevenot's theory of justification, discussions on patrimonial collectivities, and studies of (...) media and social movements, we suggest that Tabascan newspapers reshape fishers' claims over resource access by portraying fisheries and oil as patrimony. Being an ambivalent vocabulary for the defence of space and locality within a conflict over natural-resource enclosure, the newspaper narratives of patrimony both invoke subaltern concerns and reconstrue state authority and local hierarchies. Furthermore, the newspaper narratives are interconnected with fisher leaders' narratives, in particular, while misrepresenting different fisher groups' arguments, and thereby contribute to political division among the fishers as a whole. (shrink)

For both John Rawls and Martha Nussbaum, the concept of love plays a significant role in moral psychology. Rawls views the sense of justice as grounded in parental love, and continuous with love of mankind. Nussbaum’s recent defence of patriotism revives the emotio n of love as essential for political contexts. I argue that love ought to play a substantial part in the shaping of global politics, and that a moral psychology of love based merely on a combination of Rawls’s (...) and Nussbaum’s accounts fails to produce an ad equate ground for conceptualizing moral motivation with respect to addressing transnational concerns of justice. I contend that by critically synthesizing Rawls’s and Nussbaum’s conceptions of love and moral psychology with resources from Kant’s ethics, it is possible to develop a more attractive, and potentially politically effective, conception of love of human beings in the framework of political liberalism. (shrink)

The popularization of neuroscientific ideas about learning—sometimes legitimate, sometimes merely commercial—poses a real challenge for classroom teachers who want to understand how children learn. Until teacher preparation programs are reconceived to incorporate relevant research from the neuro- and cognitive sciences, teachers need translation and guidance to effectively use information about the brain and cognition. Absent such guidance, teachers, schools, and school districts may waste time and money pursuing so called brain-based interventions that lack a firm basis in research. Meanwhile, the (...) success of our schools will continue to be narrowly defined by achievement standards that ignore knowledge of the neural and cognitive processes of learning. To achieve the goals of neuroeducation, its proponents must address unique ethical issues that neuroeducation raises for five different groups of individuals: a) practicing teachers, b) neuroscience researchers whose work could inform education, c) publishers and the popular media, d) educational policy-makers, and e) university-level teacher educators. We suggest ways in which these ethical challenges can be met and provide a model for teacher preparation that will enable teachers themselves to translate findings from the neuro-and cognitive sciences and use legitimate research to inform how they design and deliver effective instruction. (shrink)

It is commonplace that the modern world is more international than at any point in human history. Yet the sheer profusion of terms for describing political orders above the nation-state-including "international," "global," "transnational," and "cosmopolitan," among others-is but one indication of how conceptually complex this topic actually is. Taking a wide view of international projects in Europe since the eighteenth century, Nationalism and Internationalism Intertwined explores discourses and practices to challenge nation-centered histories and trace the entanglements that arise from international (...) cooperation. In this volume, a multidisciplinary group of scholars in history, political science, philosophy, computer science, and other fields ask how internationalism and adjacent concepts have been experienced, understood, constructed, debated, and redefined across different European political cultures. (shrink)

Love is an essential biological, psychological, sociological, and religious phenomenon. Using various conceptual models, philosophers have often distinguished between different types of love, such as self-love, romantic love, friendship love, love of God, and neighborly love. Psychologists and neuroscientists on the other hand have thus far focused predominantly on understanding the emotions and behavioral and neural mechanisms associated with romantic love and parental love. We do not yet know how the models construed by philosophers are related to actual experiences of (...) love, and to which extent they are merely nominal creations connecting phenomena that in fact have little to do with each other. We lack empirical knowledge of how different types of love are experienced as embodied feelings, and how these experiences are related to one another. Here we distinguished between 27 different types of love. Using self-report methods, we measured 1) how subjective feelings of different types of love are topographically embodied; 2) how different types of love are associated with self-reported emotional valence, strength of the bodily and mental experience, association with touch, time elapsed since last experienced, and controllability; and 3) how similar different types of love feel. Our study provides the first mapping of embodied experiences associated with different types of love. The results show that the subjective feelings associated with the love types form a continuum from strongly to weakly felt loves. (shrink)

Sex, love, and friendship play an integral role in Immanuel Kant’s conception of human life. Against common prejudices, Kant provides substantial contributions to the philosophical discussion of these topics. This unique collection of essays sheds light on how the notions function in Kant’s philosophy, both individually and in conjunction with each other. The essays examine intertwined issues such as theory of sexuality, marriage (including same-sex marriage), morality and sexual objectification, love and autonomy, love of human beings, the conceptual structure of (...) love, friendship, misanthropy, and the highest good. The contributors include internationally well-known experts in the field. They approach the topics diversely from historical, philosophical, critical, and interpretative perspectives. The collection will be an invaluable resource for Kant scholars and for anyone interested in affective social relations in the history of philosophy and beyond. (shrink)

Victor Klemperer, German philologist and Professor at the University of Dresden, bears testimony to his survival during the Nazi years in his Diaries (1933–1945). Progressively excluded from all social life because of his Jewish religion, Klemperer is forced to recognize himself as a non-subject by the end of the war, calling himself “Nobody” in reference to Ulysses with Polyphemus, the Cyclops. Our article aims to show the mental — cognitive and corporal — process underlying this recognition. Our study will explore (...) the two-pronged thrust of this process: faced with the inexorable destruction of his self, Klemperer has to acknowledge the limits of his analytical capacities. But this extreme experience will enable him to create somatic knowledge destined to recognize what he calls “thought of extinction”. To conclude, we show how this reasoning is based upon action language which consists in naming the body. (shrink)

Exploring teaching as an upper secondary school teacher through lived experience offers pedagogical insights that have been challenged over a period of 25 years, when neoliberal educational policies gradually transformed the conditions for teaching in Swedish schools. The article is grounded in the assumption that the teaching profession is complex and there are multiple tacit dimensions inherent in being and becoming a teacher. Several of these dimensions are captured by the notion of pedagogical tact and have to be learned through (...) practice. However, over the past few decades, the implementation of neoliberal policies in the Swedish education sector have changed the conditions for teaching, and created an area of tension between the teacher’s pedagogical alignment and the educational practices influenced by neoliberal values. The aim of the study is to describe how the author experienced these tensions, and what they meant for her becoming and being a teacher in three different pedagogical sites: a higher education preparatory program, a vocational preparatory program, and in adult education. The description is grounded in the lifeworld phenomenological approach and carried out through personal narrative. (shrink)

The foundations of AI design discourse are worth analyzing. Here, attention is paid to the nature of theory languages used in designing new AI technologies because the limits of these languages can clarify some fundamental questions in the development of AI. We discuss three types of theory language used in designing AI products: formal, computational, and natural. Formal languages, such as mathematics, logic, and programming languages, have fixed meanings and no actual-world semantics. They are context- and practically content-free. Computational languages (...) use terms referring to the actual world, i.e., to entities, events, and thoughts. Thus, computational languages have actual-world references and semantics. They are thus no longer context- or content-free. However, computational languages always have fixed meanings and, for this reason, limited domains of reference. Finally, unlike formal and computational languages, natural languages are creative, dynamic, and productive. Consequently, they can refer to an unlimited number of objects and their attributes in an unlimited number of domains. The differences between the three theory languages enable us to reflect on the traditional problems of strong and weak AI. (shrink)