There have long been calls from industry for guidance in implementing strategies for sustainable development. The Circular Economy represents the most recent attempt to conceptualize the integration of economic activity and environmental wellbeing in a sustainable way. This set of ideas has been adopted by China as the basis of their economic development, escalating the concept in minds of western policymakers and NGOs. This paper traces the conceptualisations and origins of the Circular Economy, tracing its meanings, and exploring its antecedents (...) in economics and ecology, and discusses how the Circular Economy has been operationalized in business and policy. The paper finds that while the Circular Economy places emphasis on the redesign of processes and cycling of materials, which may contribute to more sustainable business models, it also encapsulates tensions and limitations. These include an absence of the social dimension inherent in sustainable development that limits its ethical dimensions, and some unintended consequences. This leads us to propose a revised definition of the Circular Economy as “an economic model wherein planning, resourcing, procurement, production and reprocessing are designed and managed, as both process and output, to maximize ecosystem functioning and human well-being”. (shrink)

It is commonly supposed that metaphysical modal claims are to be evaluated with respect to a single domain of possible worlds: a claim is metaphysically necessary just in case it is true in every possible world, and metaphysically possible just in case it is true in some possible world. We argue that the standard understanding is incorrect; rather, whether a given claim is metaphysically necessary or possible is relative to which world is indicatively actual. We motivate our view by attention (...) to discussions in Salmon 1989 and Fine 2005, in which various data are taken to support rejecting the transitivity of accessibility and modal monism ; we argue that relativized metaphysical modality can accommodate these data compatible with both standard modal logic and modal monism. Noting an analogy with two-dimensional semantics, we argue that metaphysical modality has a complex structure, reflecting what is counterfactually possible, relative to each indicatively actual world. In arguing for the need for relativization, we are broadly on the same side as Crossley and Humberstone and Davies and Humberstone ; our contribution here is, first, to offer distinctively metaphysical reasons for relativization, and second, to show that relativization can be incorporated in ways minimally departing from standard modal logic. (shrink)

In recent work, Peter Hanks and Scott Soames argue that propositions are types whose tokens are acts, states, or events. Let’s call this view the type view. Hanks and Soames think that one of the virtues of the type view is that it allows them to explain why propositions have semantic properties. But, in this paper, we argue that their explanations aren’t satisfactory. In Section 2, we present the type view. In Section 3, we present one explanation—due to Hanks (2007, (...) 2011) and Soames (2010)—of why propositions have semantic properties. We criticize this first explanation in Section 4. In Section 5, we present another explanation—due to Soames (2104)—of why propositions have semantic properties. We criticize this second explanation in Section 6. (shrink)

Why Agamben? -- Key ideas -- Language and the negativity of being -- Infancy and archaeological method -- Potentiality and the task of the coming philosophy -- Politics : bare life and sovereign power -- The homeland of gesture : art and cinema -- The laboratory of literature -- Bearing witness and messianic time -- After Agamben.

Relativized Metaphysical Modality (RMM: Murray and Wilson, 'Relativized metaphysical modality', Oxford Studies in Metaphysics, 2012; Murray, Perspectives on Modal Metaphysics, 2017) exploits 'two-dimensionalist' resources to metaphysical, rather than epistemological, ends: the second dimension offers perspective-dependence without contingency, diverting attacks on 'Classical' analyses of modals (in effect, analyses validating S5 and the Barcan Formulae). Here, we extend the RMM program in two directions. First, we harvest resources for RMM from Lewis's 1980 'Context--Index' (CI) framework: (a) the ban in CI on binding (...) into context-arguments (akin to Kaplan's 'monstrosity' ban) projects a bright line between perspective-dependence and contingency; and (b) CI-postulated connections among meaning, content, truth, argument-structure, context, and modality collectively generate a 'Generalized Humphrey Problem' for any non-Classical analysis (examples covered include appeals to accessibility, contingent domains, and counterpart relations). Second, we sharpen the tools of RMM-based metaphysical analysis, and extend their domain of coverage across familiar anomalies for Classical modals: we revisit earlier RMM-based bulwarks for S5 (against 'Chisholm's Paradox' for moderate flexibility of essence, and nomological necessitarianism); and we now similarly shore up the Barcan Formulae (against the apparent contingency of existence and nonexistence). (shrink)

A qualitative analysis of societal silences, demonstrating how the unsaid directs social action and shapes individual and collective lives.

The new National Institutes of Health (NIH) Policy on the Use of a Single Institutional Review Board (sIRB) for Multi-Site Research was adopted primarily to simplify and speed the review of complex multisite clinical trials. However, speeding review requires overcoming a number of obstacles. Perhaps the most substantial obstacle is the time and effort needed to develop reliance agreements among the participating sites. We conducted 102 semistructured interviews with sIRB personnel, including directors, chairs, reviewers, and staff, from 20 IRBs that (...) acted as sIRBs for multisite research, including 6 commercial/independent sIRBs, and 10 university-based academic and 4 federal sIRBs. Almost without exception, the interviewees agreed that reliance agreements were complex, difficult to develop, and time-consuming. A major problem for relying sites was that different agreements specified different responsibilities for the relying sites. Attitudes differed about whether these problems will be resolved as IRB staff and managers become more experienced with sIRBs. However it is clear that the process of developing reliance agreements must be simplified. Federal assistance in standardizing at least some sections of reliance agreements might reduce the difficulties involved. (shrink)

More than any other thinker, Giorgio Agamben shows us that philosophy is also a matter of style and politics a matter of poetics. This book explores the unexpected and illuminating paths that his work traces across the territories of law and literature, linguistics, dance or cinema, in search of a new idea and practice of the community. It offers an irreplaceable introduction to one of the most fascinating thinkers of our time.'Jacques RanciereGathering some of the most important established and emerging (...) scholars to examine his body of work, this collection of essays seeks to explore Agamben's thought from these broader philosophical and literary concerns, underpinning its place within larger debates in continental philosophy. Including a contribution by Agamben himself, it is essential reading for anyone interested in his work.In the past five years, Giorgio Agamben has emerged as one of the most important continental philosophers. This burgeoning popularity of his work has largely been confined to a study of the homo sacer series. Yet these later 'political' works have their foundation in Agamben's earlier works on the philosophy of language, aesthetics and literature. From a philosophy of language and linguistics that leads to a broader theory of representation, Agamben develops a critical theory that attempts to explore the hiatuses and paradoxes that govern discursive practice across a broad range of disciplines. (shrink)

The project of naturalising phenomenology is examined within the larger context of the philosophy of science. Transcendental phenomenology, as defended by Husserl, in opposition to the naturalistic enterprise, reflects a particular way of thinking about philosophy and its relationship to the empirical sciences that stands as an obstacle to the project of naturalisation. This paper develops a critique of a basic assumption made in this conception of philosophy, namely that it is possible to ask and answer questions concerning knowledge in (...) the abstract, prior to and independently of the various investigative contexts which are the immediate concern of practicing scientists. To successfully naturalise phenomenology, we need to abandon this conception of philosophy. (shrink)

The Philosophical Quarterly, Volume 63, Issue 253, Page 837-839, October 2013.

Provides a comprehensive overview and introduction to the Routledge Handbook of Propositions.

The first sustained exploration of Simondon's work to be published in English. This collection of essays, including one by Simondon himself, outlines the central tenets of Simondon's thought, the implication of his thought for numerous disciplines and his relationship to other thinkers such as Heidegger, Deleuze and Canguilhem.Complete with a contextualising introduction and a glossary of technical terms, it offers an entry point to this important thinker and will appeal to people working in philosophy, philosophy of science, media studies, social (...) theory and political philosophy.Gilbert Simondon's work has recently come to prominence in America and around the Anglophone world, having been of great importance in France for many years. (shrink)

Agamben's vocabulary is both expansive and idiosyncratic, with words such as 'infancy', 'gesture' and 'profanation' given specific and complex meanings that can bewilder the new reader. Bringing together leading scholars in the field, including Steven DeCaroli, Justin Clemens, Claire Colebrook and Steven DeCaroli the 150 entries explain the key concepts in Agamben's work and his relationship with other thinkers, from Aristotle to Aby Warburg.

BackgroundUse of modified texture diets—thickening of liquids and modifying the texture of foods—in the hope of preventing aspiration, pneumonia and choking, has become central to the current management of dysphagia. The effectiveness of this intervention has been questioned. We examine requirements for a valid informed consent process for this approach and whether the need for informed consent for this treatment is always understood or applied by practitioners.Main textValid informed consent requires provision of accurate and balanced information, and that agreement is (...) given freely by someone who knows they have a choice. Current evidence, including surveys of practitioners and patients in different settings, suggests that practice in this area is often inadequate. This may be due to patients’ communication difficulties but also poor communication—and no real attempt to obtain consent—by practitioners before people are ‘put on’ modified texture diets. Even where discussion occurs, recommendations may be influenced by professional misconceptions about the efficacy of this treatment, which in turn may poison the well for the informed consent process. Patients cannot make appropriate decisions for themselves if the information provided is flawed and unbalanced. The voluntariness of patients’ decisions is also questionable if they are told ‘you must’, when ‘you might consider’ is more appropriate. Where the decision-making capacity of patients is in question, inappropriate judgements and recommendations may be made by substitute decision makers and courts unless based on accurate information.ConclusionResearch is required to examine the informed consent processes in different settings, but there is ample reason to suggest that current practice in this area is suboptimal. Staff need to reflect on their current practice regarding use of modified texture diets with an awareness of the current evidence and through the ‘lens’ of informed consent. Education is required for staff to clarify the importance of, and requirements for, valid informed consent and for decision making that reflects people’s preferences and values. (shrink)

At extreme altitude (>5,000 – 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia is protective. Ketone bodies, synthesised during relative starvation, protect tissues such as the brain from reduced oxygen availability by mechanisms including the reduced generation of reactive oxygen species, improved mitochondrial (...) efficiency and activation of the ATP‐sensitive potassium (KATP) channel. Amino acids released from skeletal muscle also protect cells from hypoxia, and may interact synergistically with ketones to offer added protection. We thus propose that weight loss in hypoxia is an adaptive response: the amino acids and ketone bodies made available act not only as metabolic substrates, but as metabolic modulators, protecting cells from the hypoxic challenge.Also watch the Video Abstract. (shrink)

A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

First published in 1953, this seminal introduction to political philosophy is intended for both the student of political theory and for the general reader. After an introduction which explains the nature and purpose of philosophy, Dr Murray provides a critical examination of the principle theories advanced by political philosophers from Plato to Marx, paying special attention to contemporary issues. The book also makes an attempt to define the essential issues of philosophical significance in contemporary politics, with special reference to the (...) conflict between political authority and individual rights, and to show how the different moral assumptions underlying authoritarian and democratic systems of government are ultimately based upon different theories of logic. (shrink)

Immunity was an institution of Roman and Frankish public law that conferred exemption from various kinds of state obligations. In Roman law, immunity might be granted to an individual, group, or community by the public authority, whether the Roman state itself or one of its constituent self-regulating bodies. It was not an institution with a fixed content; terms varied according to the discretion and powers of the grantor and the system of obligations from which relief was sought. Exemption might be (...) for a limited duration and was always liable to be revoked, especially by imperial authorities, a circumstance that makes it difficult to evaluate the role and extent of immunities in the late empire. Immunities conferred by the emperors are mentioned quite frequently in the legal sources of the fourth and fifth centuries in reference to exemptions from taxation and other public burdens. These imperial grants are generally regarded as the forerunners of Merovingian concessions. (shrink)