It is becoming increasingly common to find phenomena described as emergent. There are two sorts of philosophical analysis of emergence. Ontological analyses ground emergence in real, distinct, emergent properties. Epistemological analyses deny emergent properties and stress instead facts about our epistemic status. I review a standard worry for ontological analyses of emergence, that they entail a surfeit of metaphysics, and find that it can easily be sidestepped. I go on to present a new worry, that ontological emergentism entails a highly (...) implausible ontology, which is harder for the ontological emergentist to avoid. (shrink)

We discuss here a series of testable hypotheses concerning the role of chromosome folding into topologically associating domains (TADs). Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing. By defining which DNA elements preferentially contact each other, the segmentation of chromosomes into TADs may also underlie many properties of long‐range transcriptional regulation. Several observations suggest that TADs can (...) indeed provide a structural basis to regulatory landscapes, by controlling enhancer sharing and allocation. We also discuss how TADs may shape the evolution of chromosomes, by causing maintenance of synteny over large chromosomal segments. Finally we suggest a series of experiments to challenge these ideas and provide concrete examples illustrating how they could be practically applied. (shrink)

In her essay examining how rhetoric attends to an “explicitly nonhermeneutic, ethical dimension” of the relationship between self and other, Diane Davis argues that the act of attunement is vital to the rhetorical challenge of “keep[ing] hermeneutic interpretation from absorbing the strictly rhetorical gesture of the [other’s] approach, which interrupts the movement of appropriation and busts any illusion of having understood” (2005, 208, original hers). This comment is part of a larger conversation about ethical action in the face of radical (...) alterity, those marks and gestures of the other that “communicate more than I can comprehend, a ‘surplus’ of alterity that I can neither appropriate nor abdicate” (2005 .. (shrink)

Referring to Heard's influence on Western notables, Ellery Queen wrote, "Gerald Heard is the spiritual godfather of this Western movement.".

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