A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

The digital shift leads to increasing changes. Employees can deal with changes through informal learning that enables needs-based development. For successful informal learning, self-regulated learning is crucial, i.e., to set goals, plan, apply strategies, monitor, and regulate learning for example by applying resource strategies. However, existing SRL models all refer to formal learning settings. Because informal learning differs from formal learning, this study investigates whether SRL models can be transferred from formal learning environments into informal work settings. More precisely, are (...) all facets relevant, and what are the relational patterns? Because informal workplace learning occurs through interaction with the context, this study investigates the influence of context, i.e., organizational learning culture and job characteristics on SRL. Structural equation modeling of N = 170 employees in various industries showed the relevance of the self-reported metacognitive strategies planning, monitoring, and regulation; the resource strategies help-seeking and effort regulation; and deep processing strategy elaboration. However, there was no evidence for organization strategies. The learning strategies were associated with self-efficacy and mastery-approach goal orientation. Regarding context, results supported indirect effects over self-motivational beliefs of learning strategies. Organizational learning culture was connected with mastery-approach goal orientation, whereas job characteristics autonomy and feedback were related to self-efficacy, which were again related to SRL strategies. Therefore, context can empower employees not only to accomplish their tasks but to develop themselves by applying SRL strategies. The results are discussed, and practical implications are outlined. (shrink)

We examine the sequences A that are low for dimension, i.e. those for which the effective dimension relative to A is the same as the unrelativized effective dimension. Lowness for dimension is a weakening of lowness for randomness, a central notion in effective randomness. By considering analogues of characterizations of lowness for randomness, we show that lowness for dimension can be characterized in several ways. It is equivalent to lowishness for randomness, namely, that every Martin-Löf random sequence has effective dimension (...) 1 relative to A, and lowishness for K, namely, that the limit of KA/K is 1. We show that there is a perfect [Formula: see text]-class of low for dimension sequences. Since there are only countably many low for random sequences, many more sequences are low for dimension. Finally, we prove that every low for dimension is jump-traceable in order nε, for any ε > 0. (shrink)

BackgroundStory recall tests have shown variable sensitivity to rate of cognitive decline in individuals with Alzheimer’s disease biomarkers. Although SR tasks are typically scored by obtaining a sum of items recalled, item-level analyses may provide additional sensitivity to change and AD processes. Here, we examined the difficulty and discrimination indices of each item from the Logical Memory SR task, and determined if these metrics differed by recall conditions, story version, lexical categories, serial position, and amyloid status.Methodsn = 1,141 participants from (...) the Wisconsin Registry for Alzheimer’s Prevention longitudinal study who had item-level data were included in these analyses, as well as a subset of n = 338 who also had amyloid positron emission tomography imaging. LM data were categorized into four lexical categories, and by serial position. We calculated difficulty and discriminability/memorability by item, category, and serial position and ran separate repeated measures ANOVAs for each recall condition, lexical category, and serial position. For the subset with amyloid imaging, we used a two-sample t-test to examine whether amyloid positive and amyloid negative groups differed in difficulty or discrimination for the same summary metrics.ResultsIn the larger sample, items were more difficult in the delayed recall condition across both story A and story B. Item discrimination was higher at delayed than immediate recall, and proper names had better discrimination than any of the other lexical categories or serial position groups. In the subsample with amyloid PET imaging, proper names were more difficult for Aβ+ than Aβ−; items in the verb and “other” lexical categories and all serial positions from delayed recall were more discriminate for the Aβ+ group compared to the Aβ− group.ConclusionThis study provides empirical evidence that both LM stories are effective at discriminating ability levels and amyloid status, and that individual items vary in difficulty and discrimination by amyloid status, while total scores do not. These results can be informative for the future development of sensitive tasks or composite scores for early detection of cognitive decline. (shrink)

REBECCA TUVEL,VINCENT DUHAMEL | : La tentative de l’ancienne cheffe d’une section de la NAACP 1 Rachel Dolezal de passer de la race blanche à la race noire a occasionné une intense controverse. Son histoire est devenue célèbre au même moment où Caitlyn Jenner2 faisait la couverture de Vanity Fair, signe d’une acceptation grandissante de l’identité trans. Pourtant, les critiques adressées à Dolezal pour avoir caché sa race natale indiquent qu’il existe une perception sociale largement répandue selon laquelle il (...) n’est ni possible ni acceptable de changer de race de la manière dont on peut changer de sexe. Les considérations qui soutiennent le transgenrisme3 semblent s’appliquer également au transracialisme. Que Dolezal représente ou non un exemple authentique de personne transraciale, son histoire et la réaction publique qu’elle a suscitée peuvent fournir un cas instructif à étudier. | : Former NAACP chapter head Rachel Dolezal’s attempted transition from the white to the black race occasioned heated controversy. Her story gained notoriety at the same time that Caitlyn Jenner graced the cover of Vanity Fair, signaling a growing acceptance of transgender identity. Yet criticisms of Dolezal for misrepresenting her birth race indicate a widespread social perception that it is neither possible nor acceptable to change one’s race in the way it might be to change one’s sex. Considerations that support transgenderism seem to apply equally to transracialism. Although Dolezal herself may or may not represent a genuine case of a transracial person, her story and the public reaction to it serve helpful illustrative purposes. (shrink)

L'explosion depuis plus d'une vingtaine d'années maintenant du nombre de travaux historiques portant sur les femmes ou « le genre » n'a touché que tardivement le continent africain. Les chercheurs anglophones ont amorcé cependant un mouvement qui ne cesse de susciter de nouvelles recherches. Cette réflexion, à la croisée de l'histoire des missionnaires, de l'histoire des femmes et de l'histoire coloniale, a profondément renouvelé les connaissances et la compréhension de la place des fe...

L'explosion depuis plus d'une vingtaine d'années maintenant du nombre de travaux historiques portant sur les femmes ou « le genre » n'a touché que tardivement le continent africain. Les chercheurs anglophones ont amorcé cependant un mouvement qui ne cesse de susciter de nouvelles recherches. Cette réflexion, à la croisée de l'histoire des missionnaires, de l'histoire des femmes et de l'histoire coloniale, a profondément renouvelé les connaissances et la compréhension de la place des fe...

Quatre ans après le numéro « Voyageuses » de Clio HFS (n° 38, 2008), un collectif d’historien-ne-s de la littérature livre dans cet ouvrage une réflexion sur les spécificités du récit de voyage féminin. Sans rechercher l’existence d’une écriture féminine, et loin de tout « dogmatisme théorique », écrit la quatrième de couverture, les auteur-e-s analysent les écrits de voyageuses qui font dorénavant partie d’un canon féminin d’écritures viatiques en langues anglaise, française et allemande. Du...

A critical account of the case for historicism from Popper to Foucault, this volume, originally published in 1989, shows the viability of an historicist account of knowledge by replying to traditional objections and the need for defenses of realism and reference at the heart of most alternatives to historicism. The book provides insights to those in philosophy as well as literary criticism, intellectual history, history of science, and cultural criticism.

What roles do women play in world politics? Who are these women, and what impact do they have on international relations? D'Amico and Beckman have assembled a diverse array of contributors who provide a variety of answers. Some contributors consider women as national leaders and profile Chamorro, Gandhi, Thatcher, and Aquino as examples. Autobiographical essays and interviews describe the experiences of Margaret Anstee, Benazir Bhutto, Jeane Kirkpatrick, and Golda Meir. Other contributors analyze international women's movements, the roles of women in (...) the Green Movement and in the revolutionary movements in Cuba and Nicaragua, and the work of Jane Addams in the peace movement. Some analyze the attitudes and beliefs of America's leading opinion makers on the subject of women and men in leadership roles. Written for beginning students in comparative politics and international relations, their work is both fundamental as an introductory text and pioneering in scope and conception. (shrink)

My review of Cornelius Castoriadis' book Crossroads in the Labyrinth ended with the apt reference, I now see, to the emperor being naked. In Joel Whitebook's second review, largely irrelevant to my criticisms of Castoriadis, he fears, though he doesn't know me personally, that only the lack of psychological counseling can explain my uncontrolled anger against Castoriadis. Let me dignify his long distance psychoanalysis by passing over it in silence. Silence is also the best remedy for Whitebook's transcendental deduction that (...) I have a “pluralistic, localistic, discontinuous ontology.” Even if I knew what that was I find it amazing that he located it in a 10 page review. Perhaps Whitebook just “feels” the presence of this ontology along with evidence of my mental problems. (shrink)

This article studies the underinvestigated but fascinating issue of the sociological determinants of accounting misbehavior while focusing on an allegedly illicit accounting practice (i.e., restatement) in family- vs. nonfamily-controlled corporations. Under the framework of institutional anomie theory, we examined whether sociological structures (i.e., legal forces and cultural values) influence accounting errors inducing restatements. By applying a multivariate regression analysis to a sample of restating firms listed in 23 countries during the 2006 to 2014 period, we found that legal forces and (...) cultural values significantly moderate the severity of accounting errors. The results of this study suggest that investors, managers, and policymakers should more fully consider the sociological structures of societies when debating the feasibility of corporate misbehaviors, as combining firm-level and country-level analyses could help to predict a firm’s accounting misbehaviors, such as more severe accounting errors. (shrink)

Este artículo investiga las narraciones de 1 Sam 9 y 1 Sam 28 a la luz del trasfondo más amplio del contexto sacrificial en el primer libro de Samuel. En concreto, este estudio muestra cómo los episodios, unidos por la escena de un banquete y el reparto de la comida sagrada, constituyen las partes de un sistema simbólico definido que, en sus resultados, es capaz de describir, definir y dirigir las relaciones entre los participantes en el ritual y la deidad. (...) A través del ejemplo de los banquetes de Saúl, primero con Samuel y luego con una nigromante en la aldea de En Dor, el texto de 1Sam define una jerarquía precisa entre la práctica cultual y la monarquía naciente en Israel. (shrink)

, Lawrie Reznek argues that disease is not a natural kind term. I raise objections to Reznek's two central arguments for establishing that disease is not a natural kind. In criticizing his a priori, conceptual argument against naturalism, I argue that his conclusion rests on a weaker argument that appeals to the empirical diversity in the symptoms and manifestations of disease. I also raise questions about the account of natural kinds which Reznek utilizes and his point that conventions for classification (...) are excluded by there being natural kinds. Keywords: Disease, natural kind, value judgement CiteULike Connotea Del.icio.us What's this? (shrink)

This writer who has warned us of the “ideological” function of both the oeuvre and the author as unquestioned forms of discursive organization has gone quite far in constituting for both these “fictitious unities” the name (with all the problems of such a designation) Michel Foucault. One text under review, La Volonté de Savoir, is the methodological introduction of a projected five-volume history of sexuality. It will apparently circle back over that material which seems to have a special fascination for (...) Foucault: the gradual emergence of medicine as an institution, the birth of political economy, demography and linguistics as “human sciences,” the invention of incarceration and confinement for the control of the “other” in society (the mad, the libertine, the criminal) and that special violence that lurks beneath the power to control discourse. (shrink)

ExcerptDavid Graeber and David Wengrow, The Dawn of Everything: A New History of Humanity. New York: Farrar, Straus and Giroux, 2021. Pp. 704. The Dawn of Everything is not just a massive book in terms of its total number of pages but also in the amount of archaeological evidence discussed concerning human “prehistory.” The authors range over current disputes within their disciplines as well as discussing in some detail political philosophies of the seventeenth and eighteenth centuries. In spite of its (...) size and range, the book has been widely reviewed and has had a publication success rarely seen with academic works. Attention to it may be in part due to the publishing career of its co-author David Graeber, who tragically died in 2020 just before the book appeared in print. The reason I mention this point is that Graeber’s work had both an academic and non-academic audience, in such books as Bullshit Jobs: A Theory, Debt: The First 5,000 Years, and The Democracy Project: A History, a Crisis, a Movement. He also had a public profile during the Occupy Wall Street movement beginning in 2011, which highlighted his advocacy of anarchism. Graeber’s political philosophy plays a significant role in this book. (shrink)

In a political version of the old biological cliché “ontogeny recapitulates phylogeny” Cornelius Castoriadis seems to embody in his personal evolution fetal stages in the labor pains of the left since World War II. According to Dick Howard in the The Marxian Legacy Castoriadis was a youthful member of the Greek Communist Party where opposition to Stalinism lead him to Trotsky. After the war and the resistance he emerges in Paris studying philosophy and cuts his political teeth on the splits (...) and schisms within the political fantasy world of the IV International. He founds Socialisme ou Barbarie, abandons Trotskyism, moves through the Western Marxist tradition and after more splits and more journals he ends up, after May 68, a practicing psychoanalyst. (shrink)

As far as I know, this is the first book-length study of Ernst Tugendhat in English. That is a bit of a surprise since Tugendhat is the last of Heidegger's students who went on to develop a significantly distinct philosophical approach, and it was one closer to the practice of philosophy in the United States and England than in Germany. The fact that this book is the author's expanded translation from the Italian probably indicates that this lack of attention to (...) Tugendhat remains in the English-speaking philosophical community. But we have to start somewhere, and this book is a useful…. (shrink)

Nicolau de Cusa é conhecido por suas teorias a respeito do conhecimento, principalmente por sua obra A douta ignorância. Nela e em outras, sempre dentro de uma visão medieval, vê-se que a.sabedoria cusana é uma tentativa de alcançar incansavelmente o inalcançável. Para tanto são de grande importância os símbolos matemáticos.

Foucault has spoken recently of the profound disruption in the domain of knowledge at every level of contemporary theory. “From the beginning of this century psychoanalytic, linguistic and ethnographic research has ousted the subject from the laws of his desires, from the forms of his speech, from the rules of his actions and from the systems of his mythical discourses.” It has become increasingly more important to deal with the thrust of these developments at the level of theory, not under (...) the rubric of some “structuralist” ideology, but as to their true content and meaning. The obstruction until now has been its lack of a “history”. (shrink)

Trends in the history of social science dedicated to the study of crime and punishment are presented as a case study supporting F.A. Hayek's theory of social change. Designing effective social institutions and public policies first requires an accurate vision of how society operates. An accurate model of society further requires scientific methods uniquely suited for the study of human beings as purposeful agents and the study of human institutions as complex social phenomena. If guided by faulty methods, theories are (...) inaccurate and policy outcomes veer from their intentions. Hayek termed such outcomes "abuses of reason". Aiming to replicate the objectivity of physical sciences via formal modeling and statistical measurement, economists throughout the 20th century imposed an excessively technical vision of human decision-making. Policy failures and social problems resulted. This paper argues that the historical trends of applied social science dedicated to crime and punishment can be understood similarly. Formal modeling and statistical measurement continuously displaced methods more attuned to human intentionality and social complexity. In result, amidst a long-run history of intellectual and political change, US law enforcement and criminal punishment policies became technocratic, and outcomes became disjointed from their stated intentions to promote social order and welfare. (shrink)

The foremost Italian philosopher of the first half of the 20th century, Croce's influence extended to every aspect of Italian intellectual life. This collection explores the depth, originality, and significance of his thought.

The proportionality standard demands a meaningful link between the severity of crimes and the punishments received for them. This article investigates the compatibility between this philosophical d...

Contemporary Continental Philosophy steps back from current debates comparing Continental and analytic philosophy and carefully, yet critically outlines the tradition’s main philosophical views on epistemology and ontology. Forgoing obscure paraphrases, D’Amico provides a detailed, clear account and assessment of the tradition from its founding by Husserl and Heidegger to its challenge by Derrida and Foucault. Though intended as a survey of this tradition throughout the twentieth century, this study’s focus is on the philosophical problems which gave it birth and even (...) now continue to shape it.The book reexamines Husserl as an early critic of epistemological naturalism whose grasp of the philosophical importance of the theory of meaning was largely ignored. Heidegger’s contrasting effort to revive ontology is examined in terms of his distinction between ontic and ontological questions. In contrast with many earlier studies, the author outlines confusions engendered by the misappropriation of the distinct philosophical agendas of Husserl and Heidegger by such famous figures as Sartre and Merleau-Ponty. The book is also original in its emphasis on how social externalism in epistemology, inspired by Karl Mannheim, influenced this tradition’s structuralist and Marxist phases. The philosophical defenses of a theory of interpretation by Gadamer and Habermas are closely examined and assessed and the study concludes with a a probing yet balanced account of Foucault and Derrida as critics of philosophical autonomy. The book concludes by reassessing this century-long divide between the analytic and Continental traditions and its implication for the future of philosophy. (shrink)