Although Bastin et al. propose a useful model for thinking about the structure of memory and memory deficits, their distinction between entities and relational encoding is incompatible with data showing that even individual objects – prototypical “entities” – are made up of distinct features which require binding. Thus, “entity” and “relational” brain regions may need to solve fundamentally the same problems.

T. Kuhn’s theory of scientific revolutions has repeatedly been the subject of criticism. It is important to note that Kuhn pays very limited attention to the phenomenon of the scientific revolution itself, comparing the revolution either with a religious conversion or with a gestalt switch. Such comparisons, however, are very superficial. This paper outlines a new understanding of the scientific revolution as a result of the resonance of the intellectual trends of the early modern period. It was the quasi-simultaneous action (...) of various factors that led to revolutionary changes in natural philosophy, which, in turn, gave rise to the actual scientific revolution. In addition, the article shows that the Copernican Revolution cannot be described within the model of scientific revolution developed by T. Kuhn. Ptolemy’s theory was mathematically constructed so that it could not make inaccurate predictions of planetary motion, because – as we are now clear – the function characterizing the trajectory of planetary motion was actually represented as a Fourier series. The Copernican revolution was not a Kuhn-type scientific revolution, nor was it caused by the empirical failures of Ptolemaic astronomy. Events unfolded according to a different scheme. Copernicus set out to carry out the principle of the uniform circular motion of the planets more consistently than had been done in Ptolemy’s theory, at the same time presenting to this theory those requirements of an aesthetic and methodological order, which the cognitively fragmented system of Ptolemy, for all its flexibility, could not satisfy and, by the conditions of its creation, could not satisfy. In addition, the article shows that Copernicus, in constructing his heliocentric theory, was essentially seeking answers to the challenges that Alberti’s artificial perspective and Nicholas of Cusa’s theological speculation posed to the visual experience in the sixteenth century. (shrink)

The article is the study of some aspects of the methodology of scientific knowledge that F. Bacon addressed in his treatise “New Organon” (1620) and in other works in one way or another related to his work on the project of the Instauratio Magna Scientiarum. The article focuses on the following three questions: Bacon’s attitude to Aristotle’s legacy, the context of Bacon’s doctrine of idols and the reasons for the English philosopher to choose a fragmented (aphoristic) form of presentation of (...) his ideas in the “New Organon” and in some other works. Based on an analysis of Bacon’s works related to the above project, it was shown that his statements about Aristotle and his philosophy were differentiated depending on whether the corresponding text was intended for printing or served as a working draft. In the latter case, the estimates of Aristotle by Bacon were more stringent. Baconian criticism of Aristotelianism was formed in the context of the development by the English philosopher of the doctrine of the idols of knowledge. The article shows that developing this doctrine, Bacon proceeded from the idea of mass insanity of the human race (insania publica), which has ancient roots and was shared by a number of contemporaries of F. Bacon. At the same time, the latter considered Aristotle as the creator of “a kind of art of insanity (artemque quondam insaniae componere)”. As a cure for “insania universalis”, Bacon proposed a new method (the “new organon”) of cognition, and the presentation of his ideas in the form of separate, but conceptually related aphorisms, as a way of activating the reader’s thought process. (shrink)

The article formulates some aspects concerning the nature and structure of scientific revolutions. As a reference example, the scientific (more precisely, natural-philosophical) revolution of the 16th-17th centuries (SR1) was taken, which in turn became part of the intellectual revolution of the Early Modern period. It is shown that SR1 is not at all monodirectional and not predetermined in its milestones process, when the break with the Aristotelian tradition automatically cleared the way to the new science and philosophy. In reality, there (...) was an intellectual war, the outcome of which was by no means known to any of the opposing sides in advance. In the article eight factors are noted that contributed to the SR1: 1) weakening ideological control on the part of the Church; 2) chaotization and fragmentation of intellectual space; 3) the redundancy of the intellectual resource for the emergence of innovative theories and practices; 4) the presence of intellectual reserve (the legacy of classical Antiquity and the Hellenistic era, as well as the scholastic method); 5) the flow of new information not embedded in traditional world picture and practices; 6) weakening the requirements for the validity of the hypotheses put forward and the rigor of reasoning, declining (delution) the rationality of cognitive activity and behavior; 7) local breakthrough (as seed impulse) in one of the areas of knowledge (heliocentric theory); 8) the possibility of developments a nd tendencies of the proper natural-philosophical revolution to develop in the tideway (in a shell) of innovative concepts, methodologies and practices that have arisen in unscientific spheres (culture, politics, economics, theology, etc.). (shrink)

The relevance of the article is due to the fact that in the modern world, various utopian concepts do not lose their ideological strength, which for more than two centuries have significantly influenced public consciousness and have caused significant transformations in the socio-cultural life of mankind. The connection among social utopias and Christian eschatology has been noticed for a long time, and the thoughts expressed on this occasion by Protopresbyter Alexander Schmemann in articles and diary entries can contribute to a (...) better understanding of deep cognitive processes that largely determine modern social realities. The purpose of the study was based on the analysis of the works of this worthy representative of the philosophy of the Russian diaspora, comparing the traditional religious eschatological "prototype" and later views on the "end of history". These views contributed to the development of utopianism and ideologism in the public mind. The authors focus attention on the antinomical nature of Christian eschatology, in contrast to the various socio-utopian modifications that define social ideals in a field transcendental to everyday human activities. The striving of religious thinking towards the "non-worldly" ideal, as Protopresbyter Alexander Schmemann believed, made it possible to form a Christian's attitude to earthly life, which inevitably required a qualitative transformation corresponding to the notion of the ultimate goal. However, over time, the Christian faith paid less and less attention to the eschatological dimension of human life, which contributed to the formation of new eschatologies seeking their social ideals in the immediate givenness of earthly life and affirming the belief in the possibility of their empirical achievement. The authors of the article come to the conclusion that the most important factor in the formation and development of the "ideological faith" in the public consciousness, the concept of which is defined in the most general terms in the works of Protopresbyter Alexander Schmemann, was the isolation of the dominant ideological structures based on social utopian ideas, from traditional faith grounds. Thus, ideologies ceased to be functional aspects of concrete historical religions, lost their official character and themselves became the foundation for pseudo-religious creativity. (shrink)

We focus here on the intercalary heterochromatin (IH) of Drosophila melanogaster and, in particular, its molecular properties. In the polytene chromosomes of Drosophila, IH is represented by a reproducible set of dense bands scattered along the euchromatic arms. IH contains mainly unique DNA sequences, and shares certain features with other heterochromatin types such as pericentric, telomeric, and PEV‐induced heterochromatin, the inactive mammalian X‐chromosome and the heterochromatized male chromosome set in coccids. These features are transcriptional silencing, chromatin compactness, late DNA replication, (...) underrreplication or elimination in somatic cells, and formation of the heterochromatin state in early embryogenesis. Post‐translational modification of histones and the specific nonhistone protein complexes are shown to participate in the establishment and maintenance of silencing for all heterochromatin types. Many IH regions contain binding sites for HP1 and/or Pc‐G proteins and all the regions are sites of heterochromatin‐associated SuUR protein. Some IH regions are known to contain homeotic genes. Summarizing these data, we suggest that IH regions comprise stable inactivated genes, whose silencing is developmentally programmed. BioEssays 25:1040–1051, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The most enigmatic feature of polytene chromosomes is their banding pattern, the genetic organization of which has been a very attractive puzzle for many years. Recent genome‐wide protein mapping efforts have produced a wealth of data for the chromosome proteins of Drosophila cells. Based on their specific protein composition, the chromosomes comprise two types of bands, as well as interbands. These differ in terms of time of replication and specific types of proteins. The interbands are characterized by their association with (...) “active” chromatin proteins, nucleosome remodeling, and origin recognition complexes, and so they have three functions: acting as binding sites for RNA pol II, initiation of replication and nucleosome remodeling of short fragments of DNA. The borders and organization of the same band and interband regions are largely identical, irrespective of the cell type studied. This demonstrates that the banding pattern is a universal principle of the organization of interphase polytene and non‐polytene chromosomes.Editor's suggested further reading in BioEssaysCaught in the act: Rapid, symbiont‐driven evolution AbstractFunction and evolution of sex determination mechanisms, genes and pathways in insects Abstract. (shrink)

David Earl Over is a leading cognitive scientist and, with his firm grounding in philosophical logic, he also exerts a powerful influence on the psychology of reasoning. He is responsible for not only a large body of empirical work and accompanying theory, but for advancing a major shift in thinking about reasoning, commonly known as the 'new paradigm' in the psychology of human reasoning. Over's signature mix of philosophical logic and experimental psychology has inspired generations of researchers, psychologists, and philosophers (...) alike over more than a quarter of a century. The chapters in this volume, written by a leading group of contributors including a number who helped shape the psychology of reasoning as we know it today, each take their starting point from the key themes of Over's ground-breaking work. The essays in this collection explore a wide range of central topics--such as rationality, bias, dual processes, and dual systems--as well as contemporary psychological and philosophical theories of conditionals. It concludes with an engaging new chapter, authored by David Over himself, which details and analyses the new paradigm psychology of reasoning. This book is therefore important reading for scholars, researchers, and advanced students in psychology, philosophy, and the cognitive sciences, including those who are not familiar with Over's thought already. (shrink)

This paper reports a study of the main key components of influence on the stability of transportation enterprises in the market. A model for evaluating the effectiveness of innovation activity in the transport industry, which takes into account indicators of expenditures on innovations, has been built. It makes it possible to determine the effectiveness of introduced innovations, which indicates the appropriate level of innovation potential and the ways that the enterprise must take to increase it. The main directions of innovative (...) development of transportation enterprises were investigated. The assessment of the economic stability of transportation enterprises in the market has established that the current state of development of enterprises is characterized by a weak level of their innovative activity. A systematic approach to the introduction of innovative technologies by a transportation enterprise in the market has been devised. This approach makes it possible to determine the required level of enterprise stability and to form a relationship between the level of innovative technologies and their stages of implementation under conditions of environmental variability. This makes it possible to increase competitive advantages, improve the efficiency of production and economic activity of enterprises. The practical implementation of the proposed model for evaluating the effectiveness of innovation activity in the transport industry has been carried out, which made it possible to allocate the most important indicators of innovation activity for the enterprise. These include specific efficiency of innovation; unit costs of innovation; innovative potential of the enterprise (defined as the proportion of own innovative developments). According to the study results, it is determined that the specific efficiency of innovations (SEI) exerts the greatest influence, which, with an increase by 1 %, provides an increase in financial stability by 1.48 %. (shrink)

Species, or ‘the Species Problem’, is a topic in science, in the philosophy of science, and in general philosophy. There is not one, but many, species problems, and these are dealt with in this volume. Species are often thought of as units of biology, to be used in ecology, conservation, classification, and theory. The chapters in this book present opposing views on the current philosophical and conceptual issues of the Species Problem in biology. -/- Divided into four sections Theories and (...) Concepts, Practice and Methods, Ranks, Trees and Names, and Metaphysics and Epistemologies, the book is authored by systematists, philosophers, historians and working biologists, many leaders in their fields. Topics include Essentialism and individuals, speciation modes, theory and the species rank, nomenclature and diagnosis, scale of species, and ecology, conservation, and species. -/- Species Problems and Beyond aims to clarify the contemporary issues of the Species Problem. It is ideal for use in upper-level seminars and courses in Evolutionary Biology, Philosophy of Science, Philosophy of Biology, Systematics and Taxonomy, and Phylogenetics/Cladistics, and for any scholar in these fields. (shrink)

In this text, I intend to follow Franklin Leopoldo e Silva’s reflections on the Teaching of Philosophy in Secondary Schools. Along the way, I try to show the central role that Franklin Leopoldo e Silva attributes to the History of Philosophy in order to understand the Teaching of Philosophy, with regard to both the function and the content of this teaching, and how this ensures the fundamental role for the critical power of Philosophy in the formation of high school students.

Stress is one of the most powerful experiences to influence health and disease. Through epigenetic mechanisms, stress may generate a footprint that propagates to subsequent generations. Programming by prenatal stress or adverse experience in parents, grandparents, or earlier generations may thus be a critical determinant of lifetime health trajectories. Changes in regulation of microRNAs (miRNAs) by stress may enhance the vulnerability to certain pathogenic factors. This review explores the hypothesis that miRNAs represent stress‐responsive elements in epigenetic regulation that are potentially (...) heritable. Recent findings suggest that miRNAs are key players linking adverse early environments or ancestral stress with disease risk, thus they represent useful predictive disease biomarkers. Since miRNA signatures of disease are potentially heritable, big data management platforms will be vital to harness multi‐generational information and capture succinct yet potent biomarkers capable of directing preventative treatments. This feature would offer a unique window of opportunity to advance personalized medicine. (shrink)

This study aimed to understand the expressions of fear in the journeys of health professionals who worked in the confrontation of coronavirus disease 2019 (COVID‐19), in the city of Manaus, in the Brazilian Western Amazon. This is an exploratory qualitative study that adopts interpretive description as a method to generate informed knowledge responsive to the needs of the practice. We included 56 participants, comprising 23 health managers and 33 health workers (middle and higher level) of different professional categories. The results (...) revealed three circles of experience: (1) knowledge and professional experience in dealing with the disease (unknown–known–experienced); (2) the growing proximity to death and loss (predicted–witnessed–suffered); and (3) the involvement and proximity to whatever affects the individual, their emotions, and personal transformations in the face of the threat (the collective, the neighbor, and oneself). Our results suggest that health professionals who worked during the COVID‐19 pandemic in Manaus experienced insecurity, dread, and fear, illustrating the complexity of developing their activities in the front line of care and management during the different phases of the pandemic. A contribution of the study is precisely that of capturing this complexity, which suggests the impossibility of analyzing fear only in its simple manifestation, or in each circle of experience. (shrink)

As cognitive enhancement research advances, important ethical questions regarding individual autonomy and freedom are raised. Advocates of cognitive enhancement frequently adopt a procedural approach to autonomy, arguing that enhancers improve an individual’s reasoning capabilities, which are quintessential to being an autonomous agent. On the other hand, critics adopt a more nuanced approach by considering matters of authenticity and self-identity, which go beyond the mere assessment of one’s reasoning capacities. Both positions, nevertheless, require further philosophical scrutiny. In this paper, we investigate (...) the ethics of cognitive enhancement through the lenses of political and philosophical arguments about autonomy and freedom. In so doing, we contend that a substantive, relational account of individual autonomy offers a more holistic understanding of the ethical concerns of cognitive enhancement. (shrink)

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

The article refutes the widespread view that Dostoevsky's Christian beliefs were strictly Orthodox. It is proved that Dostoevsky's religious and philosophical searches' central tendency is the criticism of historical, ecclesiastical Christianity as a false, distorted form of the teaching of Jesus Christ and the desire to restore this teaching in its original purity. Modern researchers of the history of early Christianity find more and more arguments in favor of the fact that the actual teaching of Jesus Christ is contained in (...) that religious movement, which the church called the Gnostic heresy. The exact philosophical expression of the teaching of Christ was received in the later works of J.G. Fichte, whose ideas had a strong influence on the Russian writer. Like Fichte, Dostoevsky understands Christ as the first person who showed the possibility of revealing God in himself and gaining divine omnipotence and eternal life directly in earthly reality. In this sense, every person can become like Christ. Dostoevsky's main characters walk the path of Christ and show how difficult this path is. The article shows that Dostoevsky used in his work not only the philosophical version of true Christianity developed by German philosophy, but also the key motives of the Gnostic myth, primarily the idea that our world, filled with evil and suffering, is created not by the supreme, good God-Father, but by the evil Demiurge, the Devil. (shrink)

This article addresses the role of auditory-related verbs in the work of Jean-Luc Nancy and Pierre Schaeffer in order to shed light on a broader tendency in French thought. Through a comparative reading of the ways in which Nancy, in Listening, and Schaeffer, in Treatise on Musical Objects, mobilize verbs such as écouter and entendre, I connect the issue of language to debates about descriptive and prescriptive approaches towards listening. Drawing on the Dictionary of Untranslatables, I argue that Nancy's and (...) Schaeffer's engagements with listening can be mapped onto historical modes of framing politics and ethics, which are also characterized by descriptive and prescriptive approaches. By showing how theories of listening connect to political and ethical debates, this study discusses the ideological instrumentalization of listening as opposed to more descriptive and exploratory forms of engagement in the auditory and the faculty of the ear. (shrink)

Igor Aleksander and Helen B. Morton, Int. J. Mach. Conscious. 06, 67 (2014). DOI: 10.1142/S1793843014400113.

In 2008 pharmaceutical companies spent over $12 billion on product promotion and detailing aimed at U.S. health care practitioners. Drug and device manufacturers rely on a workforce of detailers and physician speakers to reach health care practitioners and nudge their prescribing habits. To prevent undue influence and protect the public fisc, a number of states began regulating these marketing practices, requiring companies to disclose all gifts to practitioners, prohibiting the commercialized sale of prescription data, and prohibiting certain gifts altogether. The (...) 2010 enactment of the Physician Payment Sunshine Act marks the first Congressional involvement in the regulation of disclosure related to pharmaceutical marketing. Overall, the Act improves transparency in pharmaceutical marketing to physicians and expands the regulation of disclosure of pharmaceutical marketing activities in important substantive ways. (shrink)

Many philosophers deny that happiness can be equated with pleasurable experiences. Nozick introduced an experience machine thought experiment to support the idea that happiness requires pleasurable experiences that are “in contact with reality.” In this thought experiment, people can choose to plug into a machine that induces exclusively pleasurable experiences. We test Nozick’s hypothesis that people will reject this offer. We also contrast Nozick’s experience machine scenario with scenarios that are less artificial, and offer options which are less invasive or (...) disruptive than being connected to a machine, specifically scenarios in which people are offered an experience pill or a pill that improves overall functioning. (shrink)

This chapter presents some important facets of the scholastic background to Descartes’s conception of infinity. In particular, this chapter considers Francisco Suárez’s role in the late medieval debate over the concept of the relationship between God’s status as a perfect being and God’s status as an infinite being. Although I do not argue that Descartes knew Suárez’s position when he originally wrote the Meditations, I show that Suárez’s position lies behind Caterus’s criticisms of Descartes in the Objections and Replies that (...) Descartes published with the Meditations. Thus, knowledge of Suárez’s position is important for assessing both the reception and success of Descartes’s proofs of God’s existence in the Meditations. (shrink)

This paper relates to a formal statement of the mechanisms that are thought minimally necessary to underpin consciousness. This is expressed in the form of axioms. We deem this to be useful if there is ever to be clarity in answering questions about whether this or the other organism is or is not conscious. As usual, axioms are ways of making formal statements of intuitive beliefs and looking, again formally, at the consequences of such beliefs. The use of this style (...) of exposition does not entail a claim to provide a mathematically rigorous formal deductive system. Conventional mathematical notation is used to achieve clarity, although this is elaborated with natural language in an attempt to reduce terseness. In our view, making the approach axiomatic is synonymous with building clear usable tests for consciousness and is therefore a central feature of the paper. The extended scope of this approach is to lay down some essential properties that should be considered when designing machines that could be said to be conscious. In the broader discussion about the nature of consciousness and its neurological mechanisms, it may seem to some that axiomatisation is premature and continues to beg many questions. However, the approach is meant to be open- ended so that others can build further axiomatic clarifications that address the very large number of questions which, in the search for a formal basis for consciousness, still remain to be answered. Of course, in discussions about consciousness many will also argue that the subject is not one that may ever be formally addressed by means of axioms. The view taken in this paper is 'let's try to do it and see how far it gets'. (shrink)

I reconstruct Aristotle’s analytical procedure in Prior Analytics I.45 and its metalogical implications. Aristotle’s analysis unfolds three groups of syllogisms: symmetrically analysable, asymmetrically analysable, and non-analysable syllogisms. From the first and the third group could be extracted 27 combinations of the two mutually non-derivable deductive rules. Aristotle’s reduced deductive system in APr. I.7 with the two moods in the first figure (traditionally called Barbara and Celarent) follows this pattern. I demonstrate that the deductive system with Barbara and Celarent is just (...) one of 27 possible complete deductive systems with the two mutually non-derivable syllogistic rules. On top of that, given the fact that there are two combinations of mutually non-derivable conversion rules, I conclude that Prior Analytics hides in itself 54 complete deductive systems with a minimal number of mutually non-derivable rules. Finally, it is commented what might be the role of analysis; to what extent Aristotle could be aware of possibilities presented here; why he still prefers only one deductive system to many others with the same deductive power. (shrink)

This article summarizes the question of finding effective solutions to ensure the excellence of modern business through the introduction of managerial innovations. The main purpose of the study is to improve the theoretical and methodological approach to the implementation of managerial innovations in the system of modern business solutions. Systematization of literature sources and approaches to solving the problem of improving business management through the introduction of managerial innovations indicates the widespread use of methodological approaches and methods of managerial innovation, (...) but much management issues to ensure business excellence, justification of new opportunities for its development remain unnoticed. The urgency of solving this scientific problem is that in conditions of growing uncertainty and risk, accelerating the transformation of business, the importance of ensuring its perfection in the long term economic development of Ukraine is growing. The methodological tools of research methods were a system of methods used to obtain the final results of the study: generalization and comparative analysis – to clarify the essence of the concept of «managerial innovation»; abstract-logical – to reveal the relationship between the use of information and communication technologies, business excellence and implementation of management innovations; system-analytical – in developing a model of business excellence based on the use of modern information and communication technologies. The object of research is the industrial enterprises of the modern economy of Ukraine, because they are the basis of economic formation, a source of replenishment of the country budget and form the export orientation of business. The article presents the results of abstract-logical analysis of the blocks of business excellence, which showed that at the present stage of its development, the introduction of managerial innovations should be associated with the digital transformation of business. The results of the system-analytical analysis are presented, which are the basis for the development of an economic model for business excellence. The results of the study can be useful for business structures (and in particular, business units of the industrial complex of Ukraine), which seek to increase the efficiency of decision-making in today's digital business transformation. (shrink)