A myriad of coordinated signals control cellular differentiation. Reprogramming the cell's proteome drives global changes in cell morphology and function that define cell phenotype. A switch in alternative splicing of many pre‐mRNAs encoding neuronal‐specific proteins accompanies neuronal differentiation. Three groups recently showed that the global splicing repressor, polypyrimidine track‐binding protein (PTB), regulates this switch.1-3 Although a subset of neuronal genes are turned on in both non‐neuronal and neuronal cells, restricted expression of PTB in non‐neuronal cells diverts their mRNAs to nonsense‐mediated (...) decay and prevents protein expression. When the PTB brake is released, the cell splices like a neuron. BioEssays 30:1–4, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

The method of metaphysic -- The results of metaphysics -- The freedom of man -- Moral philosophy -- Political philosophy -- Green and his critics.

Published in 1900, this is a collection of one of Britain's most prolific metaphysic thinkers of the 19th century. Fairbrother introduces Thomas Hill Greens moral philosophy on themes such as politics and virtue whilst relating it back to the philosophy of ancient Greece that first inspired Green.