This study adopted an empirical method to investigate lay people’s attitudes toward the bioethical issues of human-animal chimeric brains. The results of online surveys showed that (1) people did not entirely reject chimeric brain research, but showed slightly more negative responses than ordinary animal testing; and that (2) their ethical concerns arose in connection with the perception that chimerism in the brain would humanize the animal. This means that people’s psychology was consistent with the ethical argument that crossing the human-animal (...) boundary would bring moral confusion to our society. Meanwhile, it was not in line with another argument that moral status depended on having high capacities, and that chimerism would cause a problem if it enhanced animals’ capacities. Furthermore, this study analyzed additional psychological factors related to people’s moral judgment and the relationship among those factors. Several psychological factors, such as the perception that chimeric brain research is unnatural, were identified as mediating the relationship between perception of animal humanization and ethical concerns about creating and using chimeric brains. Introducing an empirical approach to the ethics of human-animal chimeric brains brought two findings: (1) this study informed us of socially shared intuition regarding this novel technology; and (2) it unveiled the psychological processes behind people’s ethical concerns in more detail than they spontaneously mentioned. These findings will help to build normative arguments and future policies that are understandable and acceptable to society. (shrink)

While I agree with the distinction between expedient and proper ways of action, I find Jagiello et al.'s account of “stance switching” debatable. Fundamental to theories of cultural evolution is the fact that the shared environment is indefinitely rich, in which individuals are provided with opportunities for learning to tune themselves to specific affordances that are relevant to emerging situations.

In his attempt to find cognitive traits that set humans apart from nonhuman primates with respect to tool use, Vaesen overlooks the primacy of the environment toward the use of which behavior evolves. The occurrence of a particular behavior is a result of how that behavior has evolved in a complex and changing environment selected by a unique population.

Husserl’s notion of “sense” has often been interpreted through a Fregean lens. I will show that Husserl saw it as an acquaintance with the background or horizon of perceptual objects. He understands reason (Vernunft) as prescribing rules for performance with regard to perceptual objects. Thus Husserl’s view has a wider scope of experience than Kant’s sense of it as a pre-reflective acquaintance with one’s environment. After Ideas I Husserl develops these notions as part of his theory of the intersubjective world. (...) Heidegger takes over the insights of Husserl and brings out the performative turn inherent in phenomenology by critiquing Husserl’s orientation to theoretical perceptual experience. The reference of performative expressions is not determined by the contents but by performance. What is disclosed in the phenomenological notion of sense is the background against which human existence is to be understood. (shrink)

Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates (...) and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress. (shrink)

In this paper, I will focus on the phenomenological notion of sense which Husserl calls in Ideen I noematic sense. My reading of Ideen I is based on the interpretation of noema as “object as it is intended”. This notion is developed from “filling sense” in LU. Similar to the Russellian “knowledge by acquaintance”, Husserl means by this notion the direct intuitive acquaintance with an intentional object. However, unlike Russell, Husserl doesn’t restrict this notion to sense data, but extend it (...) to the acquaintance with the perspective way of appearance of an intentional object (Erscheinungsweise, Abschattungen). This is because, unlike Frege, Husserl includes not only intension (Materie), but also illocutionary force (Aktqualität) into his notion of sense (LU, 6. Untersuchung, p. 617). This performative notion of sense requires him to take account of the acquaintance with the background of speech acts as a constitutive part of the broadest notion of sense (Ideen I, p. 233f., 322). If a conjecture e.g. about the back side of a cube: “the back side must be a square”, changes through a perception into a claim about it: “this side is indeed a square”, the change of the illocutionary forces, that is, the “filling sense” of the perception is expressed not by intentional materials (side, square etc.), but by indexicals, modal verbs or tenses, which are understood in a direct acquaintance with the perspective appearance of the cube. Thus, “the changing noematic way of appearance of the whole object as sense” (Husserliana vol. XI, p. 333) is the background or horizon, in implicit acquaintance with which illocutionary forces (Aktqualität in LU, noetischer Charakter in Ideen I) of propositional attitudes towards perceptual objects can be understood. (shrink)

Abstract: Die Geisteswissenschaften grenzen sich von den physikalischen Naturwissenschaften durch ihre Bezogenheit auf das menschliche Leben ab. „Covering laws“ können zwar menschliche Handlungen statistisch erklären, aber dabei wird die Subjektivität einzelner Handelnder nicht berücksichtigt. Dagegen kann die Einfühlung oder der Nachvollzug als hermeneutische Methode der Geisteswissenschaften für eine Theorie der Zuschreibung der Ich-Stellungnahme gehalten werden. Bei dieser Zuschreibung handelt es sich aber nicht um die im solipsistischen Bewusstsein abgekapselte Subjektivität, sondern um die lebensweltliche Subjektivität des im eigenen Leib verkörperten Ichs. (...) Die Lebenswelt lässt sich als intersubjektiv geteilter Hintergrund des Sprechaktes verkörperter Ichs interpretieren. In diesem Sinne basiert die Logik der Geisteswissenschaften auf der lebensweltlichen Subjektivität. (shrink)

Was heißt die existenziale Analytik? Um diese Grundfrage der Fundamentalontologie zu beantworten, geht der Autor von der Problematik des Ich-Sagens aus. Während der Marburger Vorlesungen entstand der Begriff Dasein durch Heideggers Umdeutung der aristotelischen Seele anhand des leiblich-lebensweltlichen Subjektivitätsbegriffs Husserls. Dabei entwickelte Heidegger mittels des Diltheyschen Begriffs Bedeutsamkeit das Noema als Zeug hermeneutisch weiter. Um das Sein eines Ich durch Handlungsprädikate auszulegen, ist es notwendig, mit der Bedeutsamkeit der Welt vorbegrifflich vertraut zu sein. Das Verstehen als Weltvertrautheit ist das Existenzial, (...) d. h. die Bedingung der Möglichkeit für das Ich-Sagen. So schlägt der Autor vor, die Schemata: Das Umwillen seiner , das Wovor und das Um-zu als Schematismus der Handlung zu deuten. Darüber hinaus wird untersucht, warum die geschichtliche Rationalität trotz seiner Aufnahme der praktischen Philosophie Aristoteles’ und Kants von Heidegger vernachlässigt wurde. (shrink)

BackgroundThe objective of this study was to describe, through measurement of physical activity and observation of free outdoor play, the relation between children’s free play and the spatial layout of the playground. To accomplish this, we altered the spatial layout of the same playground to see how the layout affects the play activity and the physical activity levels in the same children.MethodsParticipants were six young children. Participants’ physical activity level and the duration of different types of action that occurred in (...) each area and their transitions were compared before and after the alteration of the play-equipment layout using the data from accelerometers and video recordings.ResultsA significant increase in physical activity occurred after the spatial layout alteration, which was related to action differences. Before the alteration, children tended to play in a similar manner for a given play area; however, after the alteration, pronounced interindividual variation in play activity across children was observed.ConclusionThe present pilot study found that in free play situations in the outdoor playground, the spatial layout of playground affects the pattern of play activity and the physical activity levels of young children. (shrink)