Les trois modèles d'intégration politique au sein de l'espace francophone sont analysés d'un point de vue japonais. Le premier est « le modèle républicain » de tolérance ou le modèle français de « nation citoyenne ». Le second est le modèle nord-américain de « multiculturalisme » respectueux de la différence et de l'Autre. Et le troisième est le modèle antillais d'identité créole, identité multiple et composite forgée par un processus ininterrompu de rencontres et de métissages culturels. Ces modèles sont confrontés (...) les uns aux autres du point de vue de la gestion des sociétés pluriculturelles.Three models of political integration are compared in the francophone space. The French Republican model is compared with the North America’s multicultural model and with the Creole model born in the Caribbean. Whereas the second model seems to take into account ethnicity differentiation, it doe not propose, like the first one, any values to develop cultural diversity and solidarity. The Creole model is said to be very useful theoretically but does not offer a political alternative. (shrink)

This essay analyzes the formation of sect Shinto in the second half of the nineteenth century. It is pointed out that the Shinto sects that constituted sect Shinto were constructed on the basis of preexisting infrastructures, which had developed in response to the profound social changes accompa- nying the modernization process of the Bakumatsu and Meiji periods. Sect Shinto took shape in a cross3re between the impact of modernization from below, and the vicissitudes of Meiji religious policy from above. The (...) essay further proposes to distinguish between two types of Shinto religious move- ments: Shinto sects, characterized by a typical “dish-structure,” and Shinto- derived New Religions, displaying a “tree-structure.” Of these two types, groups of the 3rst type were shaped more directly by Meiji religious policy than the latter, which 3rst arose as “founded religions” and adapted to Meiji policy only later, in the course of their institutionalization. (shrink)

Lysosomal positioning is an important factor in regulating cellular responses, including autophagy. Because proteins encoded by disease‐responsible genes are involved in lysosomal trafficking, proper intracellular lysosomal trafficking is thought to be essential for cellular homeostasis. In the past few years, the mechanisms of lysosomal trafficking have been elucidated with a focus on adapter proteins linking motor proteins to lysosomes. Here, we outline recent findings on the mechanisms of lysosomal trafficking by focusing on adapter protein c‐Jun NH2‐terminal kinase‐interacting protein (JIP) 4, (...) which plays a central role in this process, and other JIP4 functions and JIP family proteins. Additionally, we discuss neuronal diseases associated with aberrance in the JIP family protein. Accumulating evidence suggests that chemical manipulation of lysosomal positioning may be a therapeutic approach for these neuronal diseases. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

I approach Murasaki Shikibu’s marvelous literary pearl The Tale of Genji (Genji Monogatari) as analogous to glistening orbs that “come out of the disease of suffering oysters,” the suffering being the death of her beloved husband Fujiwara no Nobutaka (950?–1001). In addition to drawing evidence from the novel itself, I have relied on Murasaki’s lesser-known Poetic Memoirs and Diary that offer important insights into her state of mind and circumspect literary style. The Lotus Sūtra is the key that unlocks (...) Murasaki’s philosophical intent, with its use of parables and poems to provoke deeper understandings of Buddhism and personal realizations. The Buddhist principle of impermanence (Sanskrit anitya; Japanese mujōkan) serves as both the aesthetic of aware and an unavoidable fact that residents of the Heian court (like those in the Lotus Sūtra’s Burning House) choose to ignore or escape by reveling in superficial pursuits of beauty and political power. Various characters in the novel attempt to follow the path to the epistemological awakening the author Murasaki sought for herself. (shrink)