ABSTRACT An overview of some of the main modes of making images of natural objects and processes, as they have appeared in the history of science, leads to two main conclusions. First, the dichotomies that have traditionally distinguished, for example, art from science, museums from laboratories, and geometrical from algebraic methods have produced a poverty of understanding of visualization. It is at the intersections of these dichotomies where much of the creative work of science occurs, and it is into those (...) intersections that this Focus section leads us. Second, the section suggests that we need to understand images as arguments. Generalizing, we need to develop a “materialized epistemology” that reunites sensual with ideational knowing. Recent work in the history of science is already pointing the way and producing a dramatically new historiography. (shrink)

In this paper I argue that Martha Nussbaum's Aristotelian analysis of compassion and pity is faulty, largely because she fails to distinguish between an emotion's basic constitutive conditions and the associated constitutive or "intrinsic" norms, "extrinsic" normative conditions, for instance, instrumental and moral considerations, and the causal conditions under which emotion is most likely to be experienced. I also argue that her defense of compassion and pity as morally valuable emotions is inadequate because she treats a wide variety of objections (...) as all stemming from a common commitment to a Stoic conception of the good. I argue that these objections can be construed as neutral between conceptions of the good. I conclude by arguing that construed in this way there are nonetheless plausible replies to these objections. (shrink)

From the point of view of non-classical logics, Heyting's implication is the smallest implication for which the deduction theorem holds. This book studies properties of logical systems having some of the classical connectives and implication in the neighbourhood of Heyt ing's implication. I have not included anything on entailment, al though it belongs to this neighbourhood, mainly because of the appearance of the Anderson-Belnap book on entailment. In the later chapters of this book, I have included material that might be (...) of interest to the intuitionist mathematician. Originally, I intended to include more material in that spirit but I decided against it. There is no coherent body of material to include that builds naturally on the present book. There are some serious results on topological models, second order Beth and Kripke models, theories of types, etc., but it would require further research to be able to present a general theory, possibly using sheaves. That would have postponed pUblication for too long. I would like to dedicate this book to my colleagues, Professors G. Kreisel, M.O. Rabin and D. Scott. I have benefited greatly from Professor Kreisel's criticism and suggestions. Professor Rabin's fun damental results on decidability and undecidability provided the powerful tools used in obtaining the majority of the results reported in this book. Professor Scott's approach to non-classical logics and especially his analysis of the Scott consequence relation makes it possible to present Heyting's logic as a beautiful, integral part of non-classical logics. (shrink)

Whether prose or poetry, how does a text come to mean what it does? A functional-semantic approach to text analysis, such as is illustrated in this book, offers a revealing look at the resources of language at work in the creation of meaning, and a unique perspective on the text as object of study. Believing the best way to learn about text linguistics is through the analysis of full texts, the author includes analyses of texts, both spoken and written, drawn (...) from a variety of genres, including examples of religious and political discourse. In the first section, the author provides an overview suitable to those who are new to the theory and methodology of Systemic Functional Grammar and Rhetorical Structure Theory. Building on this foundation, section two presents the findings from several case studies in text analysis, demonstrating how to conduct indepth functional-semantic analysis of selected texts. This second section will benefit both beginners and those who have already had some background in the study of linguistics. Text Linguistics is the ideal choice for those who are learning about text linguistics, and functional approaches to language study. (shrink)

Whether prose or poetry, how does a text come to mean what it does? A functional-semantic approach to text analysis, such as is illustrated in this book, offers a revealing look at the resources of language at work in the creation of meaning, and a unique perspective on the text as object of study. Believing the best way to learn about text linguistics is through the analysis of full texts, the author includes analyses of texts, both spoken and written, drawn (...) from a variety of genres, including examples of religious and political discourse. In the first section, the author provides an overview suitable to those who are new to the theory and methodology of Systemic Functional Grammar and Rhetorical Structure Theory. Building on this foundation, section two presents the findings from several case studies in text analysis, demonstrating how to conduct indepth functional-semantic analysis of selected texts. This second section will benefit both beginners and those who have already had some background in the study of linguistics. Text Linguistics is the ideal choice for those who are learning about text linguistics, and functional approaches to language study. (shrink)

The goal of this two-part series of papers is to show that constructive logic with strong negation N is definitionally equivalent to a certain axiomatic extension NFL ew of the substructural logic FL ew. The main result of Part I of this series [41] shows that the equivalent variety semantics of N and the equivalent variety semantics of NFL ew are term equivalent. In this paper, the term equivalence result of Part I [41] is lifted to the setting of deductive (...) systems to establish the definitional equivalence of the logics N and NFL ew. It follows from the definitional equivalence of these systems that constructive logic with strong negation is a substructural logic. (shrink)

The article defects priority idiological and centenary positions of the Ukrainian society in the 19th century. The acceptance of consciousness and self-relevant is characterized by a comprehensive analysis. The aim and the tasks: вy working out ethical and philosophical literature, to justify the establishment of dignity of personality in the conditions of domestic cultural and socio-political selfdetermination of the late twentieth century.Research methods are the main methods of research are historical, structuralfunctional, systemic and comparative. To solve specific research tasks also (...) used the principles of systemicity, objectivity, ascension from abstract to concrete, etcEmphades of a new state in ethical and phylosophic keys, analyzes the values of Ukrainians, slogans, native ideas are analyzed. Research results: Scientifically illustrated embodies of the national self-release of the Ukrainian society: Selfrelease of the Naziological State Ukraine: Sovereignty of Ukraine (1985-1991 gg.); Nassional State Formation of Ukraine in the conditions of socio-purity and socioeconomic neoperedelenost (1992-1996 gg.); Creation of oligarchata as a diverse manifestation of a democratic regime in Ukraine (1996-2004 gg.); Polarization of the Farility (2005-2014 gg.); Thick ethape, which is purely formally defined as "post-revolutionary". The author exemplary aspects of the social realities of the reorganization, and the presentation of honor and dignity of the license. Discussion. It is condemned that for the self-release of the national state, the slide of restructuring of steel, the significant income from the public discourse of the topics of repressions, reversed to the families of the species of culture, science, public expressions, popularization of the creativity of the dyspasses and diaspree Figur. Conclusion. In such a way, the protest in the second half of the 1980s is Pastepeno Gladenna, which has received the introduction of privacy in its own participants.Many were re-enriched, rising from the laurel of the prison establishment, the inside of the country, and in the finishing of the bobs for Naziovnoye venereal, the rule of law and market economy. The dignity of a person on the day of restructuring, in the whole, was disturbed from the ancestors of the historical objects of the maintenance of the specialty – Ego Simbiosis with such categories, as freedom, will be, independence. (shrink)

The article analyzes the dignity of a person in secular and Orthodox aspects. The authors argue that every phenomenon of the material and spiritual world is objectively inherent in internal contradictions, so it is not an exception and an idea of human dignity in secular and religious contexts. The research methods are comprehensive and based on the philosophical, anthropological and philosophical and cultural analysis of human dignity in secular and Orthodox dimensions. Discussion. The concepts of «secular» (universal) and «Christian» morality (...) are characterized and distinguished. The authors argue that the latter comes from a supernatural source, from a moral law, the basis of which is the belief in the immortality of the human spirit. Christian morality provides such norms of behavior of people in which the biblical moral commandments are observed.The roots of the universal morality are in a culture that has produced a humanistic outlook, within which a person is recognized as self -sufficient value, capable of asserting his dignity, transforming himself and the world without the intervention of a transcendental super -sensory nature (God). The universal morality is the principles and norms that regulate the behavior of people, the activities of their communities, associations in terms of universally recognized ideas about good and evil, honesty and disobedience, honesty and dishonesty. Finally, the article suggests that, despite the differences, and sometimes contradictions in the understanding of the essential manifestations of human dignity between secular and Christian contexts, quite obvious to both aspects is the understanding that the leading place should be occupied by the personality that manifests itself manifestation and individual aspiration, in the depths of its own consciousness and in its desire for free self -determination and creativity, as a prerequisite for the affirmation of one’s dignity. (shrink)

The development of gene expression profiling and next-generation sequencing technologies have steered oncogenomics to the forefront of precision medicine. This created a need for harmonious cooperation between clinicians and researchers to increase access to precision oncology, despite multiple implementation challenges being encountered. The aim is to apply personalised treatment strategies early in cancer management, targeting tumour subtypes and actionable gene variants within the individual’s broader clinical risk profile and wellbeing. A knowledge-generating database linked to the South African Medical Research Council’s (...) Genomic Centre has been created for the application of personalised medicine, using an integrated service and research approach. Insights gained from patient experiences related to tumour heterogeneity, access to targeted therapies and incidental findings of pathogenic germline variants in tumour DNA, provided practice-changing evidence for the implementation of a cost-minimisation pathology-supported genetic testing strategy. Integrating clinical care with genomic research through data sharing advances personalised medicine and maximises precision oncology benefits. (shrink)

_The purpose_ of this article is to explain in religious, secular, and post-secular contexts the functional potential of conceptualizing the miracle as a text or message with a motivational effect. _Theoretical basis._ Max Weber, Ernst Tugendhat, Alexander Geppert and Till Kössler analysed the processes of enchantment and disenchantment of the world on a philosophical basis. The representatives of the Frankfurt school (Theodor Adorno, Max Horkheimer, Walter Benjamin) and their followers describe the cultural processes of post-secularism (Jürgen Habermas, Peter Sloterdijk) in (...) detail. The logic of cultural and social representation of amazing events and their descriptions can be realized by combining hermeneutic analysis with a functionalist approach based on the model of Niklas Luhmann and the discursive ethics of Karl-Otto Apel. _Originality._ Desired cultural, social and political situations in society often arise unexpectedly and suddenly, which provokes to characterize them as a miracle. However, at the basis of the emergence of such situations are the rules of social communication, in particular those that provide for asymmetric communication with questions that await answers. A miracle appears at the moment of transformation of asymmetric communication into a symmetrical one: each specific miracle-phenomenon needs its own metaphorical understanding and interpretation as a message. _Conclusions._ The article proposes an analysis of miracle phenomenon in its cosmological, anthropological and educational implications. Some tendencies fixed by communicative turn of the contemporary philosophy are also contributed to considering the miracle in its objective and subjective representations. The semantics of the miracle is analysed according to the relevant problem fields. The functionality of miracle is examined on its ability to show orientation for the contemporary societies with their tendency to post-secularity. The fusion of Pre-modernity and Late Modernity is taking into account when the semantics of miracle is described accordingly to their communication functionality. The enchanting and disenchanting dialectic is explained on semantics of miracle as a world and cosmic events. (shrink)

ch. 1. Ontologii︠a︡ razuma -- ch. 2. Gnoseologii︠a︡ razuma.

The very claim of the historical instance of the Fourth Industrial Revolution (4IR) is increasingly being subjected to critical interrogation from a variety of cultural and ideological perspectives. From an Afrocentric theory of history, this questioning of the ontology of the 4IR is sharpened by Africa’s experience of the claimed progressive mutation of global industrial progress from the “first” to this “fourth” revolution. Africa experienced the first industrial revolution as a European revolution in the exploitation of her natural and human (...) resources, as well as the despoliation of her cultural-epistemic sovereignty. The challenge to fully engage in the theorisation of this 4IR, given the overwhelming and inexorable effects of its digital technologies on the personhood, sociality and geopolitical state of Africa has exposed the critical need for a set of rigorous Africanist analytical tools and epistemological approaches capable of guiding Africa’s appropriation of this techno-social revolution. This essay introduces the collection of research papers that have been selected for their endeavour to meet this challenge. It is highlighted that all of them move from a unique approach that asserts that technological progress is historical-cultural and socially embedded. Some of them address the question of the historico-ontological status of the 4IR innovatively with original African methodological tools, while others demonstrate how an African epistemology can be applied to issues such a digital virtual communities and robotics. This contribution to the bourgeoning field of African Philosophy of Technology is admired as work in progress. (shrink)

Much has changed in maternal-fetal medicine since the early 2000s, when the previous ethical frameworks for fetal therapy trials were established. We applaud Hendriks and colleagues for taking on t...

Context: The majority of contemporary enactivist work is influenced by the philosophical biology of Hans Jonas. Jonas credits all living organisms with experience that involves particular “existential” structures: nascent forms of concern for self-preservation and desire for objects and outcomes that promote well-being. We argue that Jonas’s attitude towards living systems involves a problematic anthropomorphism that threatens to place enactivism at odds with cognitive science, and undermine its legitimate aims to become a new paradigm for scientific investigation and understanding of (...) the mind. Problem: Enactivism needs to address the tension between its Jonasian influences and its aspirations to become a new paradigm for cognitive science. By relying on Jonasian phenomenology, contemporary enactivism obscures alternative ways in which phenomenology can be more smoothly integrated with cognitive science. Method: We outline the historical relationship between enactivism and phenomenology, and explain why anthropomorphism is problematic for a research program that aspires to become a new paradigm for cognitive science. We examine the roots of Jonas’s existential interpretation of biological facts, and describe how and why Jonas himself understood his project as founded on an anthropomorphic assumption that is incompatible with a crucial methodological assumption of scientific enquiry: the prohibition of unexplained natural purposes. We describe the way in which phenomenology can be integrated into Maturana’s autopoietic theory, and use this as an example of how an alternative, non-anthropomorphic science of the biological roots of cognition might proceed. Results: Our analysis reveals a crucial tension between Jonas’s influence on enactivism and enactivism’s paradigmatic aspirations. This suggests the possibility of, and need to investigate, other ways of integrating phenomenology with cognitive science that do not succumb to this tension. Implications: In light of this, enactivists should either eliminate the Jonasian inference from properties of our human experience to properties of the experience of all living organisms, or articulate an alternative conception of scientific enquiry that can tolerate the anthropomorphism this inference entails. The Maturanian view we present in the article’s final section constitutes a possible framework within which enactivist tools and concepts can be used to understand cognition and phenomenology, and that does not involve a problematic anthropomorphism. Constructivist content: Any constructivist approach that aims for integration with current scientific practice must either avoid the type of anthropomorphic inference on which Jonas bases his work, or specify a new conception of scientific enquiry that renders anthropomorphism unproblematic. (shrink)

I first discuss Kit Fine's distinctive 'schema-based' approach to metaphysical theorizing, which aims to identify general principles accommodating any intelligible application of the notion(s), by attention to his accounts of essence and dependence. I then raise some specific concerns about the general principles Fine takes to schematically characterize these notions. In particular, I present various counterexamples to Fine's essence-based account of ontological dependence. The problem, roughly speaking, is that Fine supposes that an object's essence makes reference to just what it (...) ontologically depends on, but various cases suggest that an object's essence can also make reference to what ontologically depends on it. As such, Fine's account of ontological dependence is subject to the same objection he raises against modal accounts of essence and dependence---that is, of being insufficiently ecumenical. (shrink)

Unlike inert objects, organisms and their cells have the ability to initiate activity by themselves and thus change their properties or states even in the absence of an external cause. This crucial difference led us to search for principles suitable for the study organisms. We propose that cells follow the default state of proliferation with variation and motility, a principle of biological inertia. This means that in the presence of sufficient nutrients, cells will express their default state. We also propose (...) a principle of variation that addresses two central features of organisms, variation and historicity. To address interdependence between parts, we use a third principle, the principle of organization, more specifically, the notion of the closure of constraints. Within this theoretical framework, constraints are specific theoretical entities defined by their relative stability with respect to the processes they constrain. Constraints are mutually dependent in an organized system and act on the default state.Here we discuss the application and articulation of these principles for mathematical modeling of morphogenesis in a specific case, that of mammary ductal morphogenesis, with an emphasis on the default state. Our model has both a biological component, the cells, and a physical component, the matrix that contains collagen fibers. Cells are agents that move and proliferate unless constrained; they exert mechanical forces that act (i) on collagen fibers and (ii) on other cells. As fibers are organized, they constrain the cells’ ability to move and to proliferate. This model exhibits a circularity that can be interpreted in terms of the closure of constraints. Implementing our mathematical model shows that constraints to the default state are sufficient to explain the formation of mammary epithelial structures. Finally, the success of this modeling effort suggests a stepwise approach whereby additional constraints imposed by the tissue and the organism can be examined in silico and rigorously tested by in vitro and in vivo experiments, in accordance with the organicist perspective we embrace. (shrink)

From Buñuel and Dali’s Un Chien Andalou to recent works by Danish filmmaker Nicolas Winding Refn, the cinematic destruction of the eye has become iconic due to its striking effect upon film spectators’ visceral experiences as well as its ability to influence their symbolic or fetishistic desires. By exploiting the natural discomfort and disgust produced by these types of images and then situating them within an aesthetic and psychoanalytic framework, Refn and other filmmakers provide a visual showcase for a unique (...) type of cinematic violence, one which demands that viewers reappraise the value of their own eyes as well as the values which reflect social attitudes towards law enforcement, crime, and justice. (shrink)