The nonobese diabetic (NOD) mouse spontaneously develops an autoimmune diabetes that shares many immunogenetic features with human insulin-dependent diabetes mellitus (IDDM), type 1 diabetes. The mononuclear cell infiltrates in the islet, which results in the development of insulitis (a prerequisite step for the development of diabetes) are primarily composed of T cells. It is now well accepted that these T cells play important roles in initiating and propagating an autoimmune process, which in turn destroys insulin-producing islet β cells in the (...) pancreas. T cells are subdivided into CD4+ helper T cells and CD8+ cytotoxic T cells. CD4+ T cells are further subdivided into Th1 and Th2 cells based on profiles of cytokine production, and these two T-cell populations counterregulate each other. Because many autoimmune diseases are Th1 T-cell mediated, current studies have focused on manipulating the Th1/Th2 imbalance to suppress the autoimmune process in the NOD model. Furthermore, the incidence of disease is much higher in females than that in males, suggesting an involvement of sex-steroid hormones in the development of diabetes. Understanding insights of the mechanism of immune-mediated islet cell destruction and the interaction between the immune and the neuroendocrine system may, therefore, provide new therapeutic means of preventing this chronic debilitating disease. BioEssays 20:750–757, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

東アジア世界のなかで日本思想史はいかに構築できるか...古代から現代までを網羅した概説、待望の増補版。.

This book is an excellent book on business ethics and will be an invaluable resource for all readers who are keen to learn about the business ethics and key characteristics of a successful company. It focuses on the case study of a global company, Johnson & Johnson (J&J), which oversees more than 250 operating units throughout the world. Through extensive interviews with top executives at J&J's headquarters, including Masami Atarashi and Mitsuo Hirose and attending workshops, Prof Hiroo Takahashi acquired (...) an in-depth understanding of the management style of J&J, grasped the company's ethics and the code of business conduct which is shared by J&J's members throughout the world. (shrink)

Based on the concept of data physicalization, we developed Vital + Morph, an interactive surface for remote connection and awareness of clinical data. It enables users located in remote places to monitor and feel the vital signs measured from a hospitalized person through shape-change. We propose shape-changing interfaces as a way of making data physicalization a richer, intriguing and memorable experience that communicates complex information and insights about data. To demonstrate and validate our proposed concept, we developed an exploratory study (...) about the design and its implications. For evaluating the social impact of shape-changing interfaces in the context of remote monitoring, we presented Vital + Morph in several Media Art festivals. We collected and analyzed the feedback from the visitors during the exhibitions, and discussed the possibilities of the proposed system. A preliminary evaluation shows how shape-changing displays are perceived by users, which establishes not only the potential benefits but also highlights the concerns that several users have raised. Through this study, we aim to contribute to the design of remote monitoring systems by providing a novel approach for displaying clinical data that consider the richness of the physical world. In today’s information-driven society, we should not just focus on how abstract data are collected and analyzed, but also on how it can be presented and incorporated into our daily lives. (shrink)

Assistive Device Art derives from the integration of Assistive Technology and Art, involving the mediation of sensorimotor functions and perception from both, psychophysical methods and conceptual mechanics of sensory embodiment. This paper describes the concept of ADA and its origins by observing the phenomena that surround the aesthetics of prosthesis-related art. It also analyzes one case study, the Echolocation Headphones, relating its provenience and performance to this new conceptual and psychophysical approach of tool design. This ADA tool is designed to (...) aid human echolocation. They facilitate the experience of sonic vision, as a way of reflecting and learning about the construct of our spatial perception. Echolocation Headphones are a pair of opaque goggles which disable the participant’s vision. This device emits a focused sound beam which activates the space with directional acoustic reflection, giving the user the ability to navigate and perceive space through audition. The directional properties of parametric sound provide the participant a focal echo, similar to the focal point of vision. This study analyzes the effectiveness of this wearable sensory extension for aiding auditory spatial location in three experiments; optimal sound type and distance for object location, perceptual resolution by just noticeable difference, and goal-directed spatial navigation for open pathway detection, all conducted at the Virtual Reality Lab of the University of Tsukuba, Japan. The Echolocation Headphones have been designed for a diverse participant base. They have both the potential to aid auditory spatial perception for the visually impaired and to train sighted individuals in gaining human echolocation abilities. Furthermore, this Assistive Device artwork instigates participants to contemplate on the plasticity of their sensorimotor architecture. (shrink)

In this study, we propose the Ankle-Worn Sensor Sleeve to help people maintain their health. Furthermore, our approach uses this sensor sleeve to improve walking motivation by making the walking motion more sensible. In this research, we pursue the design of a wearable device that users can wear as a “shoe accessory,” with the aim of promoting people’s walking motivation. This device is ankle-worn and generates electricity using the physical flexion and extension of the ankle, detects and acquires the amount (...) of electricity generated, and uses the resulting power to produce sound and light feedback while walking. The Sleeve is designed to support health problems, such as locomotive syndrome and dementia, which are caused by physical inactivity. This article presents the results of a questionnaire survey conducted on 172 people who experienced or observed the device during exhibitions. The results reveal that this device increased people’s interest and motivation to walk, including those who did not like to walk. (shrink)

The idMirror project consists of a tablet computer, specially equipped with a small mirror and a newly developed android app. The Android application uses face recognition to detect the location of the user’s face in relation to the device and based on this renders a computer graphic at the location of his or her reflection. The goal of the idMirror project setting as a research tool was to make an exploratory study on cultural differences at exhibition venues. For this study, (...) we have analyzed 150 participants’ face images aged between 18 and 75; among them, 50 participants’ face images collected in Europe, 50 participants’ face images collected in the USA, and 50 participants’ face images collected in Japan. We found global exhibitions a good research platform for random sampling of the subjects. For the study, we examined the first 50 participants at each exhibition and we found some significant differences. Through the explanatory study in the form of an art installation, we wanted to learn if the facial expression upon one’s own self-observation is a function of gender and place of exhibition setting origin. (shrink)

In tennis, service requires a variety of complicated movements. Given the importance of taking the initiative to obtain points in a tennis match, it is crucial to make full use of speed and spin rate of service. Generally, a service that requires a higher spin rate would slow down, and a service that has increased speed would have a decreased spin rate. For players who are disadvantaged in height, although controlling spin rate is essential, slowing down service speed should be (...) avoided. For these players, the challenge of service is to improve the speed without decreasing the spin rate. Players must also be trained to build physical strength required for this skill. It is not uncommon to work on physical training without a racket; however, few studies have reported on the effects of cultivated physical strength on on-court tennis performance. Therefore, this study aimed to propose physical measurements that could be used as indices to improve service performance in 58 elite Japanese junior male players. To test service performance, we used TrackMan tennis radar device to assess speed, spin rate, impact height, and impact depth. To test physical strength, we measured 5- and 20-m sprint, broad jump, medicine ball throw. We used a significant multiple regression equation to predict the first service speed obtained from the broad jump and the Medicine ball throw. Additionally, a strong correlation was obtained between the predicted and measured values. In addition to physical strength, we suggest that the depth of the impact point is important for improving the first service speed. However, we were not able to identify the physical strength test items that improve service spin rate. Other item should be examined in the future to determine the physical strength associated with spin rate. This result could help connect physical training and service performance. (shrink)

The Bird Song Diamond project is a series of multifaceted and multidisciplinary installations with the aim of bringing contemporary research on bird communication to a large public audience. Using art and technology to create immersive experiences, BSD allows large audiences to embody bird communication rather than passively observe. In particular, BSD Mimic, a system for mimicking bird song, asks participants to grapple with both audition and vocalization of birdsong. The use of interactive installations for public outreach provides unique experiences to (...) a diverse audience, while providing direct feedback for artists and researchers interested in the success of such outreach. By following an iterative design process, both artists and researchers have been able to evaluate the effectiveness of each installation for promoting audience engagement with the subject matter. The execution and evaluation of each iteration of BSD is described throughout the paper. In addition, the process of interdisciplinary collaboration in our project has led to a more defined role of the artist as a facilitator of specialists. BSD Mimic has also led to further questions about the nature of audience collaboration for an engaged experience. (shrink)

カミの言葉から人の言葉へ。声の伝達から文字による記録へ。思想はどのように記録され、何を媒介にして人びとに伝えられてきたのか。その実態と変遷をさぐる。.

秩序と規範はいかにもたらされ、どのようにいだかれるか。イエ、クニ、社会、「国家」など、さまざまな位相における秩序と規範のあり方、時代のなかでのその変容について検証する。.

いま、なぜ日本の思想なのか。出発点としての問いかけ。近代において日本思想の研究が立ち上がって行く過程、日本的なるものへの問い、多様な「日本」観などを検討する。.