Pharmaceutical supply chains are often highly complex with conflicting objectives of social welfare and profit maximization. Furthermore, there are various stakeholders including pharmaceutical manufacturer, distributors, retailers, patients, and the government. In this paper, we consider a two-stage supply chain consisting of one pharmaceutical manufacturer and a pharmacy with online and offline channels. We focus on four price cap models: no price cap regulation, pharmaceutical manufacturer’s price cap regulation, pharmacy price cap regulation, and linkage price cap regulation. We apply game theory, (...) investigate how the price cap regulations affect the firms’ pricing, and evaluate the economic performance and social welfare of the dual-channel pharmaceutical supply chain. Our findings show that first, like the single-channel pharmaceutical supply chain, the profit of the regulated firm always decreases and the profit of the unregulated firm always increases when they are under one-sided price cap regulations. Second, the impacts of the linkage price cap regulation on the supply chain are more complicated depending on the linkage coefficient and market share. Overall, our findings can provide theoretical and practical insights to help the government devise price cap regulations for complex modern pharmaceutical supply chains. (shrink)

This work motivates the Combined Model for Combining Ideals, which Larry Temkin introduces in “sketch” form in Rethinking the Good, and goes on to begin filling in the details of the sketch. It argues that the Combined Model for Combining Ideals is most plausible when there are upper and lower caps on the extent to which an ideal can add to or subtract from the overall goodness of an outcome, but the caps for different values can (...) and should differ. (shrink)

The goal of this chapter is to offer the first detailed critical assessments of the CAPS model from a philosophical perspective. I will argue for the following claim: using technical language, the CAPS model re-describes and finds supporting evidence for basic platitudes of commonsense folk psychology.

Abstract Normative criteria for evaluations of economic and social outcomes are often formulated in terms of social welfare functions which are essentially and importantly non-satiable. However, there are good reasons to consider certain normative criteria and many policy objectives to be capped, i.e. bounded, and thus satiable provided sufficient resources are made available for their satisfaction. Inspired by the Foster–Greer–Thorbecke class of indicators, this paper uses an interdisciplinary approach to develop a model for assessing outcomes in terms of capped (...) objectives based on an understanding of individual shortfalls from the objective, denoted needs. We present an indicator to measure need satisfaction in a population of individuals with heterogeneous needs and highlight an aggregation problem under scarcity. For such situations, we develop three ways in which the indicator can be weighted that reflect respectively concerns over the frequency, depth and severity of the need shortfalls and show that normative evaluations based on these weighting schemes can conflict, yielding mutually inconsistent outcome rankings. The indicator can be adapted to measure a wide variety of phenomena, e.g. health needs, education shortfalls, deprivation, etc., and it is suited for targeting exercises and other policy implementations. In particular, it allows for exogenous weighting schemes, i.e. weights that can incorporate non-shortfall characteristics relevant for the evaluation, e.g. age, gender, ethnicity, etc. The indicator thus enables new ways for researchers to promote and study satiable objectives in a wide variety of contexts relevant to economic and social policy, e.g. human development programs, poverty reduction, healthcare policies, etc. (shrink)

https://revistes.uab.cat/enrahonar/article/view/v37-tobin.

For the past decade and a half, Aristotelians have tried to counter the following criticism articulated by John Doris: if we look at personality and social psychology research, we must conclude that we generally neither have, nor have the capacity to develop, character traits of the kind envisioned by Aristotle and his followers. Some defenses of Aristotelian virtue ethics proceed by trying to insulate it from this challenge, while others have tried to dissipate the force of Doris's critique by showing (...) how virtue ethics and recent findings in personality psychology share surprisingly extensive common ground. For example, in their 2009 books, Daniel Russell and Nancy Snow both argue that the empirical research regarding character complements - not undermines - virtue ethics. Specifically, each argues that the situationally sensitive Cognitive-Affective Personality System developed by Walter Mischel and Yuichi Shoda can be integrated into a virtue ethical moral philosophy and theory of character. In this paper, I raise several objections to their attempts to use the CAPS model to rehabilitate Aristotelian virtue ethics and argue that, as a result, this model has not been shown to have the promise Snow and Russell allege it has. (shrink)

We empirically tested Hemelrijk's agent-based model, in which dyadic agonistic interaction between primate-group subjects determines their spatial distribution and whether or not the dominant subject has a central position with respect to the other subjects. We studied a group of captive red-capped mangabeys that met the optimal conditions for testing this model. We analyzed the spatial distribution of the subjects in relation to their rank in the dominance hierarchy and the results confirmed the validity of this model. (...) In accordance with Hemelrijk's model, the group studied showed an ambiguity-reducing strategy that led to non-central spatial positioning on the part of the dominant subject, thus confirming the model indirectly. Nevertheless, for the model to be confirmed directly, the group has to adopt a risk-sensitive strategy so that observers can study whether dominant subjects develop spatial centrality. Our study also demonstrated that agent-based models are a good tool for the study of certain complex behaviors observed in primates because these explanatory models can help formulate suggestive hypotheses for exploring new lines of research in primatology. Keywords: Dominance-hierarchy rank; spatial distribution; Cercocebus torquatus ; agent-based models. (shrink)

We empirically tested Hemelrijk’s agent-based model, in which dyadic agonistic interaction between primate-group subjects determines their spatial distribution and whether or not the dominant subject has a central position with respect to the other subjects. We studied a group of captive red-capped mangabeys that met the optimal conditions for testing this model. We analyzed the spatial distribution of the subjects in relation to their rank in the dominance hierarchy and the results confirmed the validity of this model. (...) In accordance with Hemelrijk’s model, the group studied showed an ambiguity-reducing strategy that led to non-central spatial positioning on the part of the dominant subject, thus confirming the model indirectly. Nevertheless, for the model to be confirmed directly, the group has to adopt a risk-sensitive strategy so that observers can study whether dominant subjects develop spatial centrality. Our study also demonstrated that agent-based models are a good tool for the study of certain complex behaviors observed in primates because these explanatory models can help formulate suggestive hypotheses for exploring new lines of research in primatology. Keywords: Dominance-hierarchy rank; spatial distribution;Cercocebus torquatus; agent-based models. (shrink)

User intent classification is a vital component of a question-answering system or a task-based dialogue system. In order to understand the goals of users’ questions or discourses, the system categorizes user text into a set of pre-defined user intent categories. User questions or discourses are usually short in length and lack sufficient context; thus, it is difficult to extract deep semantic information from these types of text and the accuracy of user intent classification may be affected. To better identify user (...) intents, this paper proposes a BERT-Cap hybrid neural network model with focal loss for user intent classification to capture user intents in dialogue. The model uses multiple transformer encoder blocks to encode user utterances and initializes encoder parameters with a pre-trained BERT. Then, it extracts essential features using a capsule network with dynamic routing after utterances encoding. Experiment results on four publicly available datasets show that our model BERT-Cap achieves a F1 score of 0.967 and an accuracy of 0.967, outperforming a number of baseline methods, indicating its effectiveness in user intent classification. (shrink)

Almost 40 years since the discovery of microtubule dynamic instability, the molecular mechanisms underlying microtubule dynamics remain an area of intense research interest. The “standard model” of microtubule dynamics implicates a “cap” of GTP‐bound tubulin dimers at the growing microtubule end as the main determinant of microtubule stability. Loss of the GTP‐cap leads to microtubule “catastrophe,” a switch‐like transition from microtubule growth to shrinkage. However, recent studies, using biochemical in vitro reconstitution, cryo‐EM, and computational modeling approaches, challenge the simple (...) GTP‐cap model. Instead, a new perspective on the mechanisms of microtubule dynamics is emerging. In this view, highly dynamic transitions between different structural conformations of the growing microtubule end – which may or may not be directly linked to the nucleotide content at the microtubule end – ultimately drive microtubule catastrophe. (shrink)

According to situationists, the available empirical psychological data show that prevalent conceptions of virtue are ‘empirically inadequate.’ The charge is ambiguous. I begin by differentiating four families of empirical inadequacy charges, explaining the conceptual connections among the families, and showing how different situationists press different versions of the charges from each family. Then I explain how the empirical psychological model known as the ‘cognitive affective personality system,’ or ‘CAPS model,’ enables distinct responses to these varied charges. The (...) CAPS response has come under fire, though, and I close by responding to the five main challenges raised against it. (shrink)

We empirically tested Hemelrijk’s agent-based model, in which dyadic agonistic interaction between primate-group subjects determines their spatial distribution and whether or not the dominant subject has a central position with respect to the other subjects. We studied a group of captive red-capped mangabeys that met the optimal conditions for testing this model. We analyzed the spatial distribution of the subjects in relation to their rank in the dominance hierarchy and the results confirmed the validity of this model. (...) In accordance with Hemelrijk’s model, the group studied showed an ambiguity-reducing strategy that led to non-central spatial positioning on the part of the dominant subject, thus confirming the model indirectly. Nevertheless, for the model to be confirmed directly, the group has to adopt a risk-sensitive strategy so that observers can study whether dominant subjects develop spatial centrality. Our study also demonstrated that agent-based models are a good tool for the study of certain complex behaviors observed in primates because these explanatory models can help formulate suggestive hypotheses for exploring new lines of research in primatology. Keywords: Dominance-hierarchy rank; spatial distribution; Cercocebus torquatus; agent-based models. (shrink)

Product configuration is a key enabling technology for mass customization production. Previous studies mainly focus on the solving technologies for obtaining a feasible configuration or optimal configuration but ignore environmental factors like CO2 emissions, especially the environmental regulations from international organizations. In this article, we address product configuration optimization problems considering both carbon cap and carbon tax regulations. A two-stage approach that combines both Particle Swarm Optimization and a greedy algorithm is presented to solve the product configuration problems with carbon (...) emission concerns. A case study of a configurable ranger-drilling machine is illustrated to demonstrate the effectiveness of the presented approach. The impacts of carbon cap and carbon tax regulations on configuration results are compared. Further, the models are extended to analyze the effects of single-sourcing and multisourcing on product configuration. The analysis shows that multisourcing in combination with carbon tax regulation can facilitate a manufacturer to provide more green and low-carbon customized products for customers. Numerical experiments are conducted to validate the effectiveness of the model and the efficiency of the proposed solution method. (shrink)

In literature, the firm’s selection of dual-product strategy under cap-and-trade regulation and the optimal emission reduction decisions are not well studied, especially through an analytical approach. We develop a theoretic model to investigate the firm’s selection on three product strategies in the presence of cap-and-trade policy, including two single product strategies and a dual-product strategy, and identify two types of consumers: consumers with low-carbon preference and regular consumers. Our analysis shows that, in the absence of cap-and-trade policy, it is (...) optimal to adopt dual-product strategy, but in the presence of this policy, it is optimal to adopt dual-product strategy or low-carbon product strategy. Compared with ordinary product strategy, adopting a low-carbon product strategy or dual-product strategy benefits the firm under cap-and-trade regulation. The additional cost of producing low-carbon product has an impact on the firm’s product strategy selection under cap-and-trade regulation. When it falls below a certain threshold, it is optimal to adopt a dual-product strategy; otherwise, it is optimal to adopt a low-carbon product strategy. Our research can provide reference for firm’s decision-making and government’s policy formulation. (shrink)

The current research explores the women participation in SMEs business by using Probit model. The rapid absorption of women into the labor market has been influenced by several factors. The rapid economic growth was due largely to important growth in the SMEs business, where substantial and proportionally larger increase of female workers has been registered. Among all sectors of the economy, the SMEs have recorded the highest growth rate during the last decade. The increase in the female labor force (...) participation in SMES business may also be attributable to improving economic incentives in employment and policies favoring the employment of women. In addition, the combined effects of increased years of schooling, access to family planning services, improved maternal and child care, leading to arise in the average age at marriage, have allowed women to take advantage of the increased employment opportunities. Survey was conducted from 300 women in SMEs business in rural Sindh by using simple random technique from four districts, Shikarpur, Jacobabad, Kandhkot/Kashmore and Larkana Districts. Questionnaire was the basic tool to find out the major challenges of rural women as an entrepreneur business. It was revealed that there is great potential of rural women I doing the various entrepreneur business like in Kandhkot, Jacobabad, Rali, Ajrak and Sindhi caps they are very much unique and they were generating income from their families. It was further revealed that the rural women is less confident and their husbands were always given them hard time once they are exposing themselves to outside the boundaries of the house. The biggest challenges which they were facing they were doing all business in house, lack of marketing facilities, Karo Kari criminal activities and they were deprived from the basic rights. This study contributes and explores the Rural Women challenges in SMEs business and how these critical unethical problems we can overcome like KARO KARI, and other various social issues growth. (shrink)

This paper describes a computer simulation of reading that is strongly driven by eye fixation data from human readers. The simulation, READER, is a natural language understanding system that reads a text word by word and whose processing cycles on each word have some correspondence with the human gaze duration on that word. READER operates within a newly developed information processing architecture, a Collaborative, Activation‐based, Production System (CAPS) that permits the modeling of the temporal properties of human comprehension. (...) class='Hi'>CAPS allows for concurrent, collaborative execution of processes operating at different levels of analysis. As READER encounters each successive word, the word is operated on by processes at the levels of word encoding, lexical access, syntactic and semantic analysis, and referential and schema‐level processes. Like human readers, READER uses a strategy of immediacy of comprehension, attempting to interpret each word as soon as it is encountered, rather than unnecessarily buffering information. A major contribution of this simulation is its use of human performance characteristics in constraining and determining the model's mechanisms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Center Blossoms, Part 1:The Pneumatological Fruit of the Incarnate Word in Bonaventure's BreviloquiumBr. Thomas A. Piolata OFM Cap. (bio)This paper asks the following question: What is the fruit of Saint Bonaventure's theological focus on Christ as the center of all theology? While Bonaventure's christocentric vision has rightly received ample scholarly attention and recognition, a clear and robust explication of the fruit—i.e., the culmination or goal—of this vision yet (...) remains to be articulated.1 The above question has not received a full answer. There is thus a lacuna and a need within the secondary literature on the Seraphic Doctor's thought. This study addresses and begins to remedy this lacuna. It offers a preliminary answer to the above question.2 To this end, I will argue that Bonaventure's christocentrism yields a theology that accentuates the Spirit's role in salvation—a pneumatological soteriology.To argue this point, I focus principally on Bonaventure's systematic masterpiece, the Breviloquium. I have chosen this text for two principal reasons. The first reason: the Breviloquium makes manifest the Seraphic [End Page 195] Doctor's distinctive christocentrism.3 After all, in a work consisting of seven parts,4 it is precisely Part 4—De incarnatione Verbi—that constitutes the text's undeniable structural center. Bonaventure's treatment of the Incarnate Word constitutes, as Part 4 of the text, the centerpiece of the seven-part theological synthesis developed in the Breviloquium.The second reason: the Breviloquium makes explicit the inherent— and specifically pneumatological—fruitfulness of Bonaventure's christocentrism. Significantly, that is, the centrality of Christ in the text does not end in Christ. Already in Part 4, the text's structural center, the centrality of Christ culminates and finds its fullness in a pneumatological, pentecostal reflection: "Postremo, ut inflammaret ad caritatem, misit [Christus] ignem Spiritus sancti in die Pentecostes."5 These words reveal the pneumatological climax of Christ's mission. They are taken from the tenth and final chapter of Part 4, where Bonaventure makes explicit reference to the "Spiritus sanctus" nine times.6 This pentecostal conclusion and cluster of references to the Spirit imbues this final chapter of Part 4 De incarnatione Verbi with a pronounced pneumatological accent and culmination. The centrality of the Incarnate Word already—within its own structure—begins to blossom into the Spirit. Indeed, the centrality of Christ is a blossoming center.This pneumatological apogee of the centrality of Christ does not go unnoticed by Joshua Benson in his careful study of the Breviloquium's Christology. Benson utilizes as a structural hermeneutic Bonaventure's triadic division of ortus, progressus/modus, and status/fructus introduced in the prologue of the text,7 and arrives at the following synthesis: "This chapter [Chapter 10 of Part 4] is the ultimate fructus of Bonaventure's investigation of the incarnate Word and also establishes Christ further as the ortus of the life of grace that Bonaventure will examine in part 5 [De gratia Spiritus sancti]."8 Benson thus eventually concludes: "The paschal mystery is the foundation for the pneumatological mystery of the church."9 [End Page 196]Ultimately, then, Benson's comments bear witness to the inherent trajectory of the Breviloquium's distinctive christocentrism. Indeed, the center not only anticipates, but even reaches into the subsequent parts that follow: Part 4 does not stand alone as an isolated monad, but betrays directionality, a movement toward the Spirit. Put differently, the text's undeniable christic center is a vibrant center that bears fruit, a center that breathes forth the mystery of the Spirit. In a word, the center blossoms: pneumatological presence pulsates within and so blossoms forth from the reality of the Incarnate Word.This insight motivates the present study. After all, it is this basic insight that lies at the genesis of, formulates an initial answer to, and evinces the theological gravity within the very question that opened this essay: What is the fruit of Bonaventure's theological focus on Christ the center? Answering this question constitutes the goal of this study. To answer it, I will explicate the—pneumatological—fruit of Christ the center. In brief, the answer I propose lies in what I will... (shrink)

Background Trust is an essential phenomenon of relationship between patients and healthcare professionals and can be described as an accepted vulnerability to the power of another person over something that one cares about in virtue of goodwill toward the trustor. This characterization of interpersonal trust appears to be adequate for patients suffering from chronic illness. Trust is especially important in the context of chronic cardiovascular diseases as one of the main global health problems. Research Aim The purpose of the qualitative (...) study was to gain a deeper understanding of how people with chronic cardiovascular disease experience and make sense of trust in healthcare professionals. Research Design Eleven semi-structured interviews with participants analysed using interpretative phenomenological analysis to explore in detail their lived experience of trust as a relational phenomenon. Participants and Research Context Participants with chronic cardiovascular disease were purposively recruited from inpatients on the cardiology ward of the university hospital located in central Slovakia. Ethical Considerations The study was approved by the faculty ethics committee. Participants gave their written informed consent. Findings Four Interrelated Group Experiential Themes Sense of co-existence; Belief in competence; Will to help; Ontological security with eight subthemes were identified. The findings describe the participants' experience with trust in healthcare professionals as a phenomenon of close co-existence, which is rooted in the participants’ vulnerability and dependence on the goodwill and competence of health professionals to help with the consequence of (re)establishing a sense of ontological security in the situation of chronic illness. Conclusion Findings will contribute to an in-depth understanding of trust as an existential dimension of human co-existence and an ethical requirement of healthcare practice, inspire patient empowerment interventions, support adherence to treatment, and person-centred care. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:NEWMAN'S PSYCHOLOGICAL DISCOVERY: THE ILLATIVE SENSE (Continued) VI THE FACULTIES OF COGNITION AND APPETITION Since the Grammar of Assent gives us a phenorhenological analysis of the art of thinking and often refers to the influence of other faculties in our reasoning processes, it will be very instructive to examine what the author holds about our faculties of cognition and appetition. This will make us better acquainted with the nature (...) of the illative sense. I. THE SENSES 1. The External Senses and their Objects. We had already arrived at the conclusion that Newman rejects the mere subjectivity of our knowledge. When he writes about this matter he explicitly deals with sensation or sensuous cognition. Although he takes exception to the word "immediate perception," 1 we may nevertheless call him an adherent of direct or immediate realism according to Scholastic terminology, because he emphatically excludes the intervention of a reasoning process from sense perception and uses the term "mediate perception" only to express the instrumentality of experience. In this meaning our perception of external objects is mediate or indirect indeed.2 The fact is that as early as 1839 he wrote in his University Sermons: "Of the material we have direct knowledge through the senses"3 and in 1843: "The senses are direct, immediate, and ordinary informants, and act spontaneously without any will or effort on our part."4 On the importance of sense perception for our mental activities he writes in a series of hitherto unpublished notes, entitled Elements of Thought:6 "I grant or I assume that the soul would not think without some external stimulus; that if it were cut off from all communication from the external world, it would pass this life in a sort of torpor... But then, as soon as it is roused, it reflects upon itself, and thereby gains a number of ideas..." 1. See supra V, 14.2. Supra V, 14.3. P. 205. 4.P. 303 ; cf. Gramm., p. 260. 5.See the unpublished Philosophical Papers, note Fcbr. 24, 1859. 40 DR. ZENO, OJM. CAP.41 Apart from the passages already referred to, Newman nowhere enlarges on the doctrine about the senses. He does not speak about the distinctions between sensible objects; he does not explain the difference between sensation and perception, and uses those terms promiscuously.6 There are no statements on the subject which contradict current Scholastic notions, although sometimes his vague terminology may be an occasion for misunderstandings. For instance, some passages in connection with "images" and "impressions," when read apart from the context, would appear to imply that he identifies them with the Scholastic species a sensibili accepta. However, we shall show further on that. Newman means something quite different. He deals with these species and the so-called sensibilia per acci· dens by the way when describing our knowledge of God7 and teaching that we have evidence of the presence of individuals or substances in the phenomena which occur to our senses. We picture those things to ourselves in those phenomena. They are like pictures, he says, but at the same time "they give us no exact measure or character of the unknown things beyond them." "Therefore when we speak of our having a picture of the things which are perceived through the senses, we mean a certain representation, true as far as it goes, but not adequate." 2. The Internal Senses and their Objects. Newman nowhere gives a distinction between external and internal senses, but nevertheless he speaks about those faculties of the mind which by the Scholastics are called the internal senses. These philosophers distinguish a common sense or rather a central sense (sensus communis), which unites the impressions of the external senses into one whole, makes us conscious of the conditions of our body and notifies to us the sensations of our external as well as internal senses; — the imagination or the faculty which preserves and reproduces things perceived; — the sensuous memory, i. e., the power to retain and to reproduce sense images; — and the vis aestimativa or the instinctive faculty, which discovers without any intellectual means, what is good and what is bad for our welfare. 6.It would seem that he generally... (shrink)

Résumé À l’intérieur du mouvement social des intermittents et précaires, « l’expertise CAP » (Conséquences de l’Application du Protocole du 26 juin 2003) est une nouvelle appréhension d’un possible quotidien du Nous. C’est la construction collective d’un savoir sur la réalité d’une réglementation mouvante qui exclut. Par le biais vivant de leur récit, trois intermittentes CAP nous narrent leurs pratiques, leurs émotions, leurs doutes sur la mise en place d’une expertise qui fournit une connaissance dynamique de ce que les gens (...) vivent. Elle est fondée sur le triptyque : entraide, échanges, mobilisation des premiers concernés, à la différence de l’expertise traditionnelle, fondée sur le savoir académique de l’expert unique délégué par l’État. De ce fait, les premiers concernés deviennent les premiers experts de la réalité sociale. (shrink)

This paper describes ways in which political speakers define and legitimize future policies by construing different policy options in terms of ‘privileged’ and ‘oppositional’ futures. Privileged and oppositional futures are conceptual projections of alternative policy visions occurring in quasi-dialogic chunks of speech, revealing specific evidential, mood, and modality patterns. Privileged future involves the speaker’s preferred, or at least acknowledged vision and is articulated through absolute modality and evidential markers which derive from factual evidence, history, and reason. Oppositional future involves an (...) antagonistic and plainly threatening vision, expressed by probabilistic modality and (usually) the interrogative mood. Following the principle of psychological consistency in belief, oppositional future is normally communicated first, allowing for a swift and strong response from the privileged future expressed in the speaker-preferred vision. (shrink)

This paper is a tentative attempt to identify some basic-level conceptual and theoretical problems underlying the mainstream genre theory, which adversely affect the analysis of rapidly evolving, complex and hybrid genres in the modern communicative space. Having discussed these problems, I go on to I argue that the space of contemporary public communication should be viewed as not only an “analytic problem”, but also/rather a domain whose explorations could potentially revise the existing principles of genre theory. In particular, I suggest (...) such explorations should focus on the conception of genres as abstractions, activators and realizers of context, flexible macrostructures, social field entities, assigners of interpersonal roles. Notwithstanding a possible advancement of genre theory resulting from this approach, I conclude that it is only a first and admittedly uncertain step in trying to establish a sound theoretical framework for communicative genres in the modern discourse space. (shrink)

À l’intérieur même de la mouvance cartésienne du second xviie siècle, la notion de santé est loin d’être univoque. À l’aide des œuvres des trois « médecins cartésiens », Regius, Louis de La Forge et Daniel Duncan, auxquelles nous conférons une valeur heuristique, nous souhaitons mettre en évidence que ce foisonnement s’enracine dans l’œuvre même de René Descartes et qu’il révèle une pluralité d’orientations métaphysiques.

À l’intérieur même de la mouvance cartésienne du second xviie siècle, la notion de santé est loin d’être univoque. À l’aide des œuvres des trois « médecins cartésiens », Regius, Louis de La Forge et Daniel Duncan, auxquelles nous conférons une valeur heuristique, nous souhaitons mettre en évidence que ce foisonnement s’enracine dans l’œuvre même de René Descartes et qu’il révèle une pluralité d’orientations métaphysiques.

Pragmatics, Micropragmatics, Macropragmatics The paper addresses the distinction between micropragmatics and macropragmatics. It is postulated that this differentiation, a consequence of a number of controversies surrounding the core field of pragmatics, does manifest a number of conceptual merits and methodological feasibility. The article also aims to elaborate on the four concepts central to the methodology of pragmatics, i.e. deixis, presupposition, implicature and speech acts, from an essentially ‘micropragmatic’ perspective, describing their contribution to the proposition of an utterance, its illocutionary force, (...) and a wide range of effects the utterance may produce. At the same time, however, three relativities-regularities are indicated and presented as prompts for an integrated study of intentionality at the macro level of discourse/text. (shrink)

Background:Dignity is a fundamental concept in healthcare. The symptoms of multiple sclerosis have a negative effect on dignity. Understanding of lived experience of dignity in people with multiple...

Dignity is one of the essential values and central concepts in nursing care. Dignity can be threatened due to radical life changes; therefore, this idiographic case study aimed to explore the sense of dignity experienced by a woman with multiple sclerosis. An interpretative phenomenological analysis was adopted, using data collected through a face‐to‐face semistructured interview with Emily, a 45‐year‐old woman. The study was approved by the local ethics committee. Six personal experiential themes were identified: To be ruled by a sick (...) body; Silent progression; Loss of independence as a burden for the family; Will to fight for the meaning of life; Maintaining dignity‐in‐relation; Dignified care in a period of greater vulnerability. Emily's dignity is based on the effort to fight for a meaningful life, utilization of her full potential, maintain independence in activities of daily living and support in relationships. Continuous changes in functional ability, loss of self‐control and an uncertain future have a negative impact on the experience of her dignity. In the context of dignified health care, she considers individual care and maintaining autonomy important. The idiographic case study can contribute to a better understanding of the experience of a woman suffering from multiple sclerosis. It is possible to carry out interventions that aim to support her dignity, improve her quality of life and contribute to individually oriented health care. (shrink)

The confrontations of stakeholder visions about agriculture and food production has become a focal point in the public sphere, coinciding with a diversification of agrifood models. This study analyzes the debates stemming from the coexistence of these models, particularly during the initial term of neoliberal-centrist Emmanuel Macron’s presidency in France. Employing collective monitoring from 2017 to 2021, a corpus of 958 online news and blog articles was compiled. Using a computational analysis, we reveal the framings and controversies emerging from this (...) media discourse. The macro-structuring of discourse on model coexistence revolves around scientific, economic and political framings. Coexistence is a complex of debates based on specific frames associated with specific arenas and actor configurations: growth of organic agriculture, transformations of agrifood systems, sciences of production and impacts, livestock and meat diet controversies, agroecological innovations, CAP reform criticism, discourse of peasant agriculture and State-Profession _co-gestion_. Employing global sentiment analysis and focusing on salient controversies, namely EGAlim law, pesticide regulations, and agribashing, we show the shift from conciliation to a hardening of debates. Finally, we discuss the causes and consequences of this trend. The political will to support the transition of agriculture remains influenced by the _co-gestion_ system, an inherited configuration of decision-makers instrumental in the agricultural modernization. As a consequence, significant agricultural challenges, particularly highlighted in the scientific macro-frame, persist unresolved. This lock-in of the agrifood system is based on defensive strategies that challenge the democratic debate about food and agricultural practices. (shrink)

Let P be a forcing notion and $G\subseteq P$ its generic subset. Suppose that we have in $V[G]$ a $\kappa{-}$ complete ultrafilter1,2W over $\kappa $. Set $U=W\cap V$.

If there is no inner model with a cardinal $\kappa$ such that $o = \kappa^{++}$ then the set $K \cap H_{\omega_1}$ is definable over H$_{\omega_1}$ by a $\Delta_4$ formula, and the set $\{J_\alpha[\mathscr{U}] : \alpha < \omega_1\}$ of countable initial segments of the core model $K = L[\mathscr{U}]$ is definable over $H_{\omega_1}$ by a $\Pi_3$ formula. We show that if there is an inner model with infinitely many measurable cardinals then there is a model in which (...) $\{J_\alpha [\mathscr{U}] : \alpha < \omega_1\}$ is not definable by any $\Sigma_3$ formula, and $K \cap H_{\omega_1}$ is not definable by any boolean combination of $\Sigma_3$ formulas. (shrink)

This book first reviews Miller's theory of Mixed Traits, as developed in his 2013 book Moral Character: An Empirical Theory. It then engages extensively with situations, the CAPS model in social psychology, and the Big Five Model in personality psychology. It ends by taking up implications for his view in meta-ethics (a modified error theory) and normative ethics (a challenge for virtue ethics).