Mary Astell (1666-1731) relies on a Cartesian account of the self to argue that both men and women are essentially thinking things and, hence, that both should perfect their minds or intellects. This account of the self might seem to ignore the inescapable fact that we have bodies. I argue that Astell accommodates the self’s embodiment along three dimensions. First, she tempers her sharp distinction between mind and body by insisting on their union. Second, she argues that the mind-body union (...) is good, at least when the body obeys the mind. Third, though Astell identifies the self with the mind, she identifies the person with the combination of mind and body. (shrink)

Although the biological bases of forgetting remain obscure, the consensus among cognitive psychologists emphasizes interference processes, rejecting decay in accounting for memory loss. In contrast to this view, recent advances in understanding the neurobiology of long-term memory maintenance lead us to propose that a brain-wide well-regulated decay process, occurring mostly during sleep, systematically removes selected memories. Down-regulation of this decay process can increase the life expectancy of a memory and may eventually prevent its loss. Memory interference usually (...) occurs during certain active processing phases, such as encoding and retrieval, and will be stronger in brain areas with minimal sensory integration and less pattern separation. In areas with efficient pattern separation, such as the hippocampus, interference-driven forgetting will be minimal, and, consequently, decay will cause most forgetting. (shrink)

The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro-muscle transcription factor: MYOD. UPF1 achieves this through its RING-like domain, which confers ubiquitin E3 ligase activity. Feng et al. provide evidence that the ability of UPF1 to destabilize MYOD represses myogenesis. In the future, it will be important (...) to define other protein substrates of UPF1-driven ubiquitination and to determine whether this biochemical activity is responsible for some of UPF1's previously defined biological functions, including in development and stress responses. The exciting findings presented by Feng et al. open up the possibility that protein turnover and RNA turnover are coupled processes. The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Here we discuss a new role for UPF1—it is directly involved in protein decay. This hidden talent raises the possibility that protein turnover and RNA turnover are coupled processes. (shrink)

Corporate social responsibility (CSR) activities have become increasingly prevalent in retail settings. In franchised organizations, franchisors typically design and coordinate these activities, leaving operational execution to franchisees. Meanwhile, franchisors may introduce new corporate-led CSR activities over time. Even though changes to CSR activities may refocus outlets’ attention on a CSR initiative, they may also disrupt an outlet’s ongoing CSR routines. Using a longitudinal, secondary dataset consisting of an eight-year panel for a national, franchised restaurant chain, we examine CSR performance dynamics (...) in the presence of two distinct types of CSR activities: an ongoing CSR routine and a distinct, temporary CSR campaign. We find that, when resuming the CSR routine after a temporary CSR campaign, outlets’ performance in CSR routines drops significantly (i.e., immediate decay), then improves gradually (i.e., protracted recovery). We also consider the moderating role of an outlet’s experience, finding that experience stabilizes these decay and recovery cycles. Our findings represent a first step in developing a longitudinal understanding of how a firm’s short-term CSR campaigns may impact ongoing CSR routines, thus contributing to the knowledge of CSR activity development and routinization. (shrink)

The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro-muscle transcription factor: MYOD. UPF1 achieves this through its RING-like domain, which confers ubiquitin E3 ligase activity. Feng et al. provide evidence that the ability of UPF1 to destabilize MYOD represses myogenesis. In the future, it will be important (...) to define other protein substrates of UPF1-driven ubiquitination and to determine whether this biochemical activity is responsible for some of UPF1's previously defined biological functions, including in development and stress responses. The exciting findings presented by Feng et al. open up the possibility that protein turnover and RNA turnover are coupled processes. The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Here we discuss a new role for UPF1—it is directly involved in protein decay. This hidden talent raises the possibility that protein turnover and RNA turnover are coupled processes. (shrink)

Dutch decline is usually studied as a topic in economic history: when did it really start, what shape did it take? In this article an attempt is made to show the actual awareness of the strengths and weaknesses of the Dutch economy, in the terms used by participants in three public debates. The classical Dutch discourse of decay and decline evolved in response to national and international political reality. The Bickerse Beroerten debate of 1650 shows the conflict between neo-Roman (...) and neo-Athenian tendencies. Subsequently, the explanation of Dutch decline (the effect of luxury) by the Anglo-Dutch pamphleteer Bernard Mandeville is shown to be markedly different from his advice to the English (to allow luxury). Finally, the 1630s Dutch debate between Lieven de Beaufort and his critics represents the maturing of the Dutch vocabulary of decline, including its failure to take into account the organisational preconditions of modern society. (shrink)

Climate change and the failure of crops are significant but overlooked events in the history of heredity. Bad weather and dangerously low harvests provided momentum and urgency for answers to questions about how best to improve and acclimatize staple varieties. In the 1790s, a series of crop failures in Britain led to the popularization of and widespread debate over Thomas Andrew Knight’s suggestion that poor weather was in fact largely unconnected to the bad harvests. Rather, Knight argued, Britain’s older varieties—particularly (...) its fruit trees—were coming to the natural end of their lifespans. At a period when Britain was trying to maximize its agricultural land usage, Knight campaigned that his fellow farmers ought to set aside land and resources in order to cultivate new varieties—an expensive and time-consuming procedure—in order to avoid disaster. In this paper, I argue that Knight’s lifelong commitment to his position demonstrates the role played by changes in climate and weather on popular understandings of plant heredity. Further, drawing upon the historiography of Britain’s climate and agriculture, I show that despite reliable weather and good harvests, Knight’s campaign survived for several decades before the continued health of Britain’s trees was finally treated as sufficient evidence to dispense with Knight’s warnings. This case provides a means of thinking about the history of heredity as it is shaped and impacted by changes in climate and local conditions. (shrink)

In Social Decay and Transformation social and political critic Samuel Farber presents an analysis of social decline that has been missing from the contemporary scene: a view from the Left, one which draws from the ideas and traditions of the Enlightenment's left wing. Using a comparative approach to situate his theoretical conclusions in historical circumstances, Farber looks at the working class and temperance movements, civil rights rebellions and the Black Panthers, and the cultural revolutions of 1920s Russia and the (...) Bolsheviks. Providing carefully reasoned interrogations of contemporary thinkers such as James C. Scott and Robin D. G. Kelley, Farber clarifies the discussions on social decay currently taking place, adding an important voice of the Left to the current debate. (shrink)

The authors discuss sonic decay as a compositional, performative and installation practice. Building off of the recording of a six hour performance, Andrew Stanford and Ezra Teboul assembled a short eight minute audio response which comes in two separate files. In addition to online links to the pieces, this paper provides a description of the compositional process along with an analysis of the response’s content and format. It then relates those to the greater concepts of sonic materialism, sound objects, (...) and the parallax view, and places the piece in the context of relevant and contemporary sound-based art works. Sonic Decay was installed and performed at the 2014 International Žižek Studies Conference in Cincinnati, Ohio. (shrink)

Why has the spread of fake news taken grip on society so quickly? Why has there been a significant increase in violence among those who disagree on issues? Why is it that increasingly our society is shutting down speech they disagree with rather than engage in civil debate? This book explores each of these issues and traces their connection to the same root cause: the decay of truth in education. It presents a compelling case that documents how educational institutions (...) and political institutions alike have abandoned truth as a primary virtue. In doing so, our society has waded deeply into an environment loaded with deceit, distraction, and delusion. The targets of this critique range across political, religious, and social groups as this is a societal-level outcome of the educational malaise towards truth. The book underscores topics of practical interest and considers real opportunities for each individual to take to help restore truth as a virtue in education and in society. (shrink)

About 22 years ago, the physics world was briefly rocked by claims of evidence for a new “5 th force”, based on reanalysis of data from an early 20 th century experiment. Baron Roland von Eötvös, a Hungarian nobleman, had performed extensive measurements of the correlation between inertial mass and gravitational mass and published them in 1922. The lead article in the January 6, 1986 issue of Physical Review Letters had the unassuming title: "A Reanalysis of the Eötvös Experiment" by (...) Ephriam Fischbach, et al. Two days later the New York Times ran an article with the headline: "Hints of Fifth Force in Universe Challenge Galileo's Findings" describing the possible implications of Fischbach's work. (shrink)

Considered the most important work of Walter Ong's career, Ramus, Method, and the Decay of Dialogue is an elegant review of the history of Ramist scholarship ...

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Renaissance logician, philosopher, humanist, and teacher, Peter Ramus (1515-72) is best known for his attack on Aristotelian logic, his radical pedagogical theories, and his new interpretation for the canon of rhetoric. His work, published in Latin and translated into many languages, has influenced the study of Renaissance literature, rhetoric, education, logic, and--more recently--media studies. Considered the most important work of Walter Ong's career, Ramus, Method, and the Decay of Dialogue is an elegant review of the history of Ramist scholarship (...) and Ramus's quarrels with Aristotle. A key influence on Marshall McLuhan, with whom Ong enjoys the status of honorary guru among technophiles, this challenging study remains the most detailed account of Ramus's method ever published. Out of print for more than a decade, this book--with a new foreword by Adrian Johns--is a canonical text for enthusiasts of media, Renaissance literature, and intellectual history. (shrink)

Nonsense‐mediated RNA decay (NMD) represents an established quality control checkpoint for gene expression that protects cells from consequences of gene mutations and errors during RNA biogenesis that lead to premature termination during translation. Characterization of NMD‐sensitive transcriptomes has revealed, however, that NMD targets not only aberrant transcripts but also a broad array of mRNA isoforms expressed from many endogenous genes. NMD is thus emerging as a master regulator that drives both fine and coarse adjustments in steady‐state RNA levels in (...) the cell. Importantly, while NMD activity is subject to autoregulation as a means to maintain homeostasis, modulation of the pathway by external cues provides a means to reprogram gene expression and drive important biological processes. Finally, the unanticipated observation that transcripts predicted to lack protein‐coding capacity are also sensitive to this translation‐dependent surveillance mechanism implicates NMD in regulating RNA function in new and diverse ways. (shrink)

Testimonies about aphantasia are still surprisingly rare, more than a century after Galton. It is therefore difficult to understand how a person devoid of (a kind of) imagination actually thinks. In order to outline "what it is like" to be aphantasic, I will start by compiling two qualitative interviews with aphantasics that I will then compare with other testimonies collected in literature and online. The fact that aphantasia is poorly documented may also explain why few philosophers (with the notable exception (...) of Phillips 2014) seem to take this phenomenon seriously – contrary to others phenomena such as blindsight for instance. To redress the balance, the second part of this paper will consider three debates to which aphantasia could contribute. (shrink)

We study the deviations from the exponential decay law, both in quantum field theory (QFT) and quantum mechanics (QM), for an unstable particle which can decay in (at least) two decay channels. After a review of general properties of non-exponential decay in QFT and QM, we evaluate in both cases the decay probability that the unstable particle decays in a given channel in the time interval between t and t+dt. An important quantity is the ratio (...) of the probability of decay into the first and the second channel: this ratio is constant in the Breit-Wigner limit (in which the decay law is exponential) and equals the quantity Γ1/Γ2, where Γ1 and Γ2 are the respective tree-level decay widths. However, in the full treatment (both for QFT and QM) it is an oscillating function around the mean value Γ1/Γ2 and the deviations from this mean value can be sizable. Technically, we study the decay properties in QFT in the context of a superrenormalizable Lagrangian with scalar particles and in QM in the context of Lee Hamiltonians, which deliver formally analogous expressions to the QFT case. (shrink)

The author confronts the place of today's world in the context of human history. He focuses on such major issues of the twentieth century as human progress, fanaticism, & science.