Stuttering is a disorder characterized by intermittent loss of volitional control of speech movements. This hypothesis and theory article focuses on the proposal that stuttering may be related to an impairment of the energy supply to neurons. Findings from electroencephalography, brain imaging, genetics, and biochemistry are reviewed: Analyses of the EEG spectra at rest have repeatedly reported reduced power in the beta band, which is compatible with indications of reduced metabolism. Studies of the absolute level of regional cerebral blood flow (...) show conflicting findings, with two studies reporting reduced rCBF in the frontal lobe, and two studies, based on a different method, reporting no group differences. This contradiction has not yet been resolved. The pattern of reduction in the studies reporting reduced rCBF corresponds to the regional pattern of the glycolytic index. High regional GI indicates high reliance on non-oxidative metabolism, i.e., glycolysis. Variants of the gene ARNT2 have been associated with stuttering. This gene is primarily expressed in the brain, with a pattern roughly corresponding to the pattern of regional GI. A central function of the ARNT2 protein is to act as one part of a sensor system indicating low levels of oxygen in brain tissue and to activate appropriate responses, including activation of glycolysis. It has been established that genes related to the functions of the lysosomes are implicated in some cases of stuttering. It is possible that these gene variants result in a reduced peak rate of energy supply to neurons. Lastly, there are indications of interactions between the metabolic system and the dopamine system: for example, it is known that acute hypoxia results in an elevated tonic level of dopamine in the synapses. Will mild chronic limitations of energy supply also result in elevated levels of dopamine? The indications of such interaction effects suggest that the metabolic theory of stuttering should be explored in parallel with the exploration of the dopaminergic theory. (shrink)

L’agence d’expertise indépendante INDEX, constituée d’architectes, d’artistes et de chercheurs, enquête sur les violences d’État en France et depuis la France. Dans cet entretien, iels expliquent comment iels réinvestissent politiquement la notion d’expertise dans les enquêtes policières, racontent leurs liens avec le collectif Forensic Architecture, explicitent ce qu’iels entendent par « vérité » dans les enquêtes en sources ouvertes et ce qu’iels mettent en place pour permettre une plus grande dissémination des outils de l’OSINT.

This chapter contains sections titled: Introduction Against Writing The Hole in the Argument Spotting the Defense of Philosophical Writing A Sociology of Symbols The Psychological Power of Symbols.

Bibliographic records published by the British Education Index (BEI) between 1957 and 2000 are analysed in the context of a history of the BEI's changing presentation of information about the field. The value of frequency counts for BEI subject terms is discussed, in relation to their potential for revealing trends in the fields of educational studies and information management.

This chapter contains sections titled: “The world is everything that is the case” The Substance of the World Logical Atomism “The proposition only asserts something, in so far as it is a picture” A Very Short History of Logical Atomism Wittgenstein's Motivations The Critique of Logical Atomism Coda Further reading.

This chapter contains section titled: Notes.

This chapter contains sections titled: Life of Nietzsche Nineteenth‐century Europe Romanticism and German Idealism Pessimism German Politics The Text.