Three questions of major historical interest may be asked concerning the neglect and the rediscovery of Mendel's work.1. Why was it so little noticed between its publication in 1866 and its rediscovery in 1900?2. What factors determined its rediscovery?3. What factors favoured the rapid growth of Mendelian genetics?It is with the second and third of these questions that this paper is concerned.

The classical view of the gene prevailing during the 1910s and 1930s comprehended the gene as the indivisible unit of genetic transmission, genetic recombination, gene mutation and gene function. The discovery of intragenic recombination in the early 1940s led to the neoclassical concept of the gene, which prevailed until the 1970s. In this view the gene or cistron, as it was now called, was divided into its constituent parts, the mutons and recons, materially identified as nucleotides. Each cistron was believed (...) to be responsible for the synthesis of one single mRNA and concurrently for one single polypeptide. The discoveries of DNA technology, beginning in the early 1970s, have led to the second revolution in the concept of the gene in which none of the classical or neoclassical criteria for the definition of the gene hold strictly true. These are the discoveries concerning gene repetition and overlapping, movable genes, complex promoters, multiple polyadenylation sites, polyprotein genes, editing of the primary transcript, pseudogenes and gene nesting. Thus, despite the fact that our comprehension of the structure and organization of the genetic material has greatly increased, we are left with a rather , open and general concept of the gene. This article discusses past and present contemplations of genes, genomes, genotypes and phenotypes as well as the most recent advances of the study of the organization of genomes. (shrink)

Taking a set of central issues from ancient Greek medicine and biology, this book studies firstly, the interaction between scientific theorising and folklore or popular assumptions; secondly, the ideological character of scientific inquiry. Topics of interest in the philosphy and sociology of science illuminated here include the relationship between primitive thought and early science, the roles of the consensus on the scientific community, tradition and the authority of the written text, in the development of science.

This ambitious and important book, first published in 2001, provides a truly general account of Francis Bacon as a philosopher. It describes how Bacon transformed the values that had underpinned philosophical culture since antiquity by rejecting the traditional idea of a philosopher as someone engaged in contemplation of the cosmos. The book explores in detail how and why Bacon attempted to transform the largely esoteric discipline of natural philosophy into a public practice through a program in which practical science provided (...) a model that inspired many from the seventeenth to the twentieth centuries. Stephen Gaukroger shows that this reform of natural philosophy was dependent on the creation of a new philosophical persona: a natural philosopher shaped through submission to the dictates of Baconian method. This book will be recognized as a major contribution to Baconian scholarship, of special interest to historians of early-modern philosophy, science, and ideas. (shrink)