Philosophical Theology and East-West Dialogue is a unique philosophical and theological analysis of certain key interactions between Eastern and Western thinkers. The book on the one hand contrasts general traits of Eastern, Buddhist thought and Western, Greek thought. However, in doing so it focuses on influential philosophers and theologians who manifest particular instances of wider issues. The result is a careful examination of basic questions that offers both broad implications and concrete specificity in its approach. The book itself is an (...) instance of East-West dialogue. Independently of each other both authors had previously engaged in serious cross-cultural studies. The Japanese Inagaki had researched Western science and philosophy, then written in Japanese comparative studies of Japanese thought. The North American Jennings had researched Japanese theology. They brought these backgrounds together, dialoguing with each other until the present study emerged. Several creative Japanese thinkers, as well as important Westerners, are taken up. The study follows the lead of many Eastern impulses, but it also critically utilizes Western methods. Contemporary thinking on religious plurality is carefully examined. This new study is a must for those interested in philosophy and theology in general, and East-West interaction in particular. (shrink)

Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF network.

In this article, incoherent results of the associations between subjective well-being and economic status at multiple social levels are shown. Although individual-level positive associations are shown within developed countries, national-level associations disappear among developed countries. Group/area-level associations, meanwhile, do exist within Japanese societies. From these inconsistent phenomena, a sociocultural unit is proposed, within which well-being of people is collectively shared based on mutual reciprocity. The simple addition of social scientific results themselves cannot reconstruct the whole range of phenomena. Humanities could (...) be considered as the glue, which adds sociocultural meanings to the generalized scientific results. (shrink)

Kagawa Tyohiko, who was a well known Christian leader and social reformer, is re-evaluated from the perspective of a public philosophy, and as an example of the possibilities for collaboration and conflict between science and the religious humanities in East Asia. His last book, Cosmic Purpose, which appears to be a kind of natural theology, is analyzed from the perspective of the hidden topic of human evil. By considering Kagawa's deep religious sensibility and conscience, the book can be interpreted to (...) reflect on the wrong directionality selected by modern Japan's leaders that resulted in the tragic war. (shrink)

Nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway, mediated by nicotinamide phosphoribosyltransferase (NAMPT), a key NAD+ biosynthetic enzyme, plays a pivotal role in controlling many biological processes, such as metabolism, circadian rhythm, inflammation, and aging. Over the past decade, NAMPT‐mediated NAD+ biosynthesis, together with its key downstream mediator, namely the NAD+‐dependent protein deacetylase SIRT1, has been demonstrated to regulate glucose and lipid metabolism in a tissue‐dependent manner. These discoveries have provided novel mechanistic and therapeutic insights into obesity and its metabolic complications, such (...) as insulin resistance, an important risk factor for developing type 2 diabetes and cardiovascular disease. This review will focus on the importance of adipose tissue NAMPT‐mediated NAD+ biosynthesis and SIRT1 in the pathophysiology of obesity and insulin resistance. We will also critically explore translational and clinical aspects of adipose tissue NAD+ biology. (shrink)

This work is a partial translation of Watsuji’s major systematic work, Ethics originally published in three volumes, in 1937, 1942, and 1949. The original work comprises an introduction and four chapters, and the translation presents the Introduction as Part 1, “Introductory Essays”; chapter 1 as Part 2, “The Fundamental Structure of Human Existence”; and chapter 2 as Part 3, “The Spatio-Temporal Structure of Human Being.” Chapters 3 and 4 in the original work, which are left untranslated, are titled respectively “Ethical (...) Organizations” and “Historico-Climate Structure of Human Existence.” According to the systemic plan of Watsuji, ethics, which is practically identical with the whole of philosophy, should not be limited to the consideration of the principles of morality, but should contain the investigation of various human communities, and reflection on the historical movements in which these communities have been formed. In other words, ethics should also contain social philosophy and the philosophy of history. (shrink)

The informational humidity model (IHM) classifies a message into two modes, and describes communication and community in a novel aspect. At first, a flame message, dry information vs. wet information, is introduced. Dry information is the message content itself, whereas wet information is the attributes of the message sender. Second, the characteristics of communities are defined by two factors: the message sender’s personal specifications, and personal identification. These factors affect the humidity of the community, which corresponds to two phases of (...) knowledge creation. In a rather wet community, members easily specify other members. This is effective for managing memberships and changing knowledge from tacit to formal. In a rather dry community, members barely identify with other members at all. This method is suitable for the formal-to-tacit phase of knowledge creation. Finally, it is discussed how social intelligence should be designed and what features are needed to support knowledge-creating communities. (shrink)

Cultural similarities and differences in facial expressions have been a controversial issue in the field of facial communications. A key step in addressing the debate regarding the cultural dependency of emotional expression is to characterize the visual features of specific facial expressions in individual cultures. Here we developed an image analysis framework for this purpose using convolutional neural networks that through training learned visual features critical for classification. We analyzed photographs of facial expressions derived from two databases, each developed in (...) a different country, in which corresponding emotion labels were available. While the CNNs reached high rates of correct results that were far above chance after training with each database, they showed many misclassifications when they analyzed faces from the database that was not used for training. These results suggest that facial features useful for classifying facial expressions differed between the databases. The selectivity of computational units in the CNNs to action units of the face varied across the facial expressions. Importantly, the AU selectivity often differed drastically between the CNNs trained with the different databases. Similarity and dissimilarity of these tuning profiles partly explained the pattern of misclassifications, suggesting that the AUs are important for characterizing the facial features and differ between the two countries. The AU tuning profiles, especially those reduced by principal component analysis, are compact summaries useful for comparisons across different databases, and thus might advance our understanding of universality vs. specificity of facial expressions across cultures. (shrink)

Background: Dementia is one the major problems of aging societies, and, novel and effective non-drug therapies are required as interventions in the oldest-old to prevent cognitive decline.Objective: This study aims to examine the efficacy and safety of reminiscence using immersive virtual reality focusing on anxiety that often appears with cognitive decline. The secondary objective is to reveal the preference for VR image types for reminiscence: live-action or computer graphics.Methods: This was a pilot, open-label, and randomized crossover study which was conducted (...) on January 2020 at a single nursing home. The subjects were randomly divided into two groups in equal numbers, and they alternately viewed two types of VR images themed on the mid- to late Showa era in Japan. In group A, the CG images were viewed first, and then the LA images were viewed. In group B, the images were viewed in the opposite order. Before VR viewing, subjects responded to Mini-Mental State Examination Japanese version and State-Trait Anxiety Inventory Japanese version. After viewing the first and second VR, subjects responded to STAI and the numerical rating scale for satisfaction and side effects.Results: Ten subjects participated in this study. The values of analyses are presented in the mean. The age was 87.1 years, and the MMSE was 28.5. The total STAI score before VR viewing was 36.1, but it significantly decreased to 26.8 after the first VR viewing, and further decreased to 23.4 after the second VR viewing. The NRS score for satisfaction tended to be higher after viewing LA in group A vs. 8.6, P = 0.0993), while in group B, the score after CG was slightly lower than that after LA. There were no serious side effects.Conclusions: This study suggests that iVR reminiscence can reduce anxiety in the oldest-old without causing serious side effects. Furthermore, the impacts might be better with LA images. (shrink)

時代の肌理に触れると同時に、時代を超える感度を研ぎ澄ますには、哲学という経験の刷新が必須となる。今、哲学に何を希望できるのか?自分自身が今を生きる一個の希望となるように、哲学それ自身が変貌しなければな らない。.

感情の取り締まり(ポリシング)、トランス排除、宗教右派からポストトゥルースまで。透徹した思考に貫かれた論考群。.