Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF network.

The “Human Genome Project” was completed in 2003, shifting the focus to proteome and transcriptome research. One approach to proteomics involves the comprehensive visualization of the localization of proteins in all tissues and organs. We discuss in situ phospho‐protein atlases, which are systematized representations of the localization of proteins. Protein atlases provide important information about the identity and presence of proteins in specific organs, tissues and cells under physiological and pathological conditions. Antibody‐based immunohistochemical analysis is a powerful method for generating (...) a protein atlas. However, it is difficult to localize phosphorylated proteins under in vivo physiological conditions, even with immunohistochemistry, because these proteins tend to be dephosphorylated or phosphorylated due to the experimental manipulations. We also discuss an improved immunohistochemical method for precisely detecting phosphorylated protein, using the detection of phosphorylated ERK1/2 as an example. We consider that it is possible and useful to generate a phospho‐protein atlas. (shrink)

It is argued in the target article that hemispheric lateralization is advantageous when faced with conflicting choices. As decision-making processes must have been subject to a strong selection pressure, the sensitivity of response latencies could suggest a modular and hierarchical organization of behavioral execution, as was formulated by Tinbergen (1951).

Revisiting Guattari's visits to Japan in the 1980s during the country's ‘bubble economy’, this paper investigates from a personal perspective the Radio Homerun mini-FM station as well as other stops on Guattari's Tokyo ‘pilgrimage’. Guattari's reception and influence in Japan is contextualised through the writer Kõbõ Abe and philosopher Kiyoteru Hanada, in addition to the groundbreaking work of Tetsuo Kogawa, against the backdrop of the rise of postmodernism. Similarities between Guattari's sense of Japan and Brazil are then broached.

In the Paññ?sa-j?taka transmitted in central Thailand, there are as many as eight stories of self-sacrifice, where a bodhisatta declares that he carried out his self-sacrifice not to get the achievement of a s?vaka or paccekabuddha but to attain omniscience. Such declaration is rare in the P?li Nik?yas and their commentaries. In the same way, parallel or similar kinds of stories in the av?d?nas or j?takas transmitted in Sanskrit and Chinese do not refer to the disengagement from the achievement of (...) a s?vaka or paccekabuddha, with the exception of the story of K?ñcanas?ra. Since the direct source of the bodhisatta’s declarations including the reference to the achievement does not seem to exist in the P?li Nik?yas and their commentaries, there is a possibility that the bodhisatta’s declarations found in the Paññ?sa-j?taka are derived from a very old origin which is shared with the story of K?ñcanas?ra. (shrink)

We cannot directly perceive and experience objects of words such as “ apūrva ” “ devatā ,” and “ svarga ,” while objects of words such as “cow” and “horse” are perceptible. Therefore in the Indian linguistic context, some assert that there are two categories of words. However, a grammarian philosopher Bhartṛhari (450 CE) in the second book of his Vākyapadīya , introduces a verse stating that there is no difference between them. Other Indian thinkers as well deal with this (...) issue in various contexts. This paper aims at exploring the ideas expressed in Bhartṛhari’s verse and the related arguments found in other treatises of different schools. It consists of discussions of the followingt: (1) Bhartṛhari’s Vākyapadīya 2.119 and its commentarial texts; (2) Kumārila’s Criticism; (3) The Nyāya context; (4) The Sāṃkhya and the Buddhist context; (5) Related grammatical passages and the background of the Vākyapadīya 2.119; and (6) Conclusion. (shrink)

Introduction: Physical distancing under the coronavirus disease 2019 pandemic had a significant impact on lifestyles, including exercise routines. In this study, we examined the relationship between mental health and addictive behaviors, such as excessive exercise and the use of image and performance enhancing drugs across 12 sport disciplines.Materials and methods: A large cross-sectional sample of the adult population was surveyed. The mean age was 33.09. The number of male participants was 668. The use of IPEDs was assessed in conjunction with (...) psychometric measures such as the Exercise Addiction Inventory and the Appearance Anxiety Inventory. The participants were grouped into activity group and non-activity group according to the presence or absence of their exercise habits. The results were compared between these groups, as well as across sport disciplines, while taking into account the relationship between different psychological measures and IPEDs consumption.Results: The frequency of IPEDs use was higher among AG than NAG, although AG participants reported less history of addictions than NAG. The logistic regression analysis revealed that scores equal to or above cutoff points, in both the EAI and AAI, predicted the IPEDs use. Regarding the differences across the various sport disciplines, those who were involved in practicing Weight Lifting and Cross Fit were found to be more at risk of excessive exercising and more inclined to use a wide range of IPEDs.Conclusions: Although exercise could help to increase well-being and prevent addictions during the COVID-19 pandemic, our results show that those in the AG are particularly vulnerable to excessive IPEDs use. Sport disciplines associated with higher EAI and AAI scores have also shown a higher tendency to excessive IPEDs use. Furthermore, the factor of having above the cutoff scores in EAI or AAI in each sport could indicate larger IPEDs consumption regardless of the discipline. In light of the current findings, it is necessary to better define the “non-excessive” levels of exercise in various sport disciplines and an adequate intake of IPEDs to ensure the safety and well-being of people during a pandemic. (shrink)

Being Time invites a deep consideration of the personal experience of temporality in music, focusing on the perceptual role of the listener. Through individual case studies, this book centers on musical works that deal with time in radical ways. These include pieces by Morton Feldman, James Saunders, Chiyoko Szlavnics, Ryoji Ikeda, Toshiya Tsunoda, Laurie Spiegel, and André O. Möller. Multiple perspectives are explored through a series of encounters, initially between an individual and a work, and subsequently with each author's (...) varying experiences of temporarilty. The authors compare their responses to features such as repetition, speed, duration, and scale from a perceptual standpoint, drawing in reflections on aspects such as musical memory and anticipation. The observations made in this book are accessible and relevant to readers who are interested in exploring issues of temporality from a broad range of disciplinary perspectives."--Back cover. (shrink)

Nonfictional field recording is a genre of music which offers a glimpse of art beyond our late-capitalist age. The ongoing ecocide which we, in a state of abject detachment, are witnessing and abetting calls out for artists to reconnect and reengage with the nonhuman world that has been deemed valueless by our civilization. Countering the disenchantment of nature wrought by scientism, human-centrism, and above all capitalism necessitates a dissolving of the barriers we set up between ourselves and our environment, a (...) task which can be only accomplished via religion or art: an art—like field recording—which affords reconnecting its audience with the enchantment of the ignored world surrounding them. In this article, Toshiya Tsunoda’s exemplary Somashikiba —recorded in locations forgotten by civilization—will be examined via interpretive tools adapted from Ueda Shizuteru’s Kyoto School aesthetics and Takahashi Mutsuo’s poetics. Ueda’s philosophy offers a way of understanding perception which eliminates the subject-object division. Takahashi’s project of recovering the spirituality of place through poetry is a model of historically and politically engaged art. Looking, as these contemporary Japanese thinkers have done, to the precapitalist, pre-formalist past to rediscover art’s function as a medium which reconfigures the listener’s perception of reality, I argue for the urgency of sound art such as Tsunoda’s which aids in the re-enchantment of the world to a future beyond capitalist, humanist “civilization.”. (shrink)