The pituitary hormone prolactin (PRL) is best known for its role in the regulation of lactation. Recent evidence furthermore indicates PRL is required for normal reproduction in rodents. Here, we report on the insertion of two transposon-like DNA sequences in the human prolactin gene, which together function as an alternative promoter directing extrapituitary PRL expression. Indeed, the transposable elements contain transcription factor binding sites that have been shown to mediate PRL transcription in human uterine decidualised endometrial cells and lymphocytes. We (...) hypothesize that the transposon insertion event has resulted in divergent (pituitary versus extrapituitary) expression of prolactin in primates, and in differential actions of pituitary versus extrapituitary prolactin in lactation versus pregnancy respectively. Importantly, the TE insertion might provide a context for some of the conflicting results obtained in studies of PRL function in mice and man. (shrink)

In his introductory textbook, Philosophy of natural science, Hempel presents, as an illustration and a starting point for an analysis of the processes of inventing and testing scientific theories, an account of the researches of Semmelweis the Hungarian physician who, in the middle of the xixth century, discovered the cause of puerperal fever and an effective method of prevention. The account does not involve anything that is factually untrue, but it is quite succinct, leaving out many important aspects of (...) the case. Our thesis is that, although those omissions are justified in view of the aims of the account, they are also convenient to Hempel, because they help to propagate an image of science which goes much beyond the processes of invention and test. It is an image which reflects the positivist conception of science, and thus, whatever the intentions of the author, contributes to the dissemination and strengthening of that conception, but which, at least in this case, does not correspond to reality. To demonstrate the thesis, we give an account of the parts of Semmelweis's story omitted by Hempel, and we show how they do not fit in with the positivist image of science. Along the way, we distinguish three types of critique of positivist historiography: the Kuhnian, the post-modern, and the engagé. In the conclusion, we present some considerations concerning the medical research of today. -/- . (shrink)

This paper adapts Kuhn’s conceptual framework to developmental episodes in the theory and practice of medicine. Previous attempts to understand the reception of Ignaz Semmelweis’s work on puerperal fever in Kuhnian terms are used as a starting point. The author identifies some limitations of these attempts and proposes a new way of understanding the core Kuhnian notions of “paradigm,” “progress,” and “revolution” in the context of a socially embedded technoscience such as medicine.

This chapter relocates the debate about the theoretical virtues to the empirical level and argues that the question of whether the virtues (and what virtues, if any) have epistemic import is best answered empirically, through an examination of actual scientific theories and hypotheses in the history of science. As a concrete example of this approach, the chapter discusses a case study from the mid-nineteenth-century debate about the transmissibility of puerperal fever. It argues that this case shows that the virtues (...) are at least sometimes epistemic, but also that neither scientific realists nor anti-realists get it quite right: the virtues, even if epistemic, are not necessarily truth-conducive, but neither are they merely pragmatic. It also argues that the discussion of puerperal fever shows that the virtue question, as it is currently featured in the scientific realism debate, ought to be reformulated. We should examine not just whether a given scientific theory has virtues or not, but rather how debates among competing theories, all of which have some virtues, get resolved. (shrink)

Semmelweis’s investigations of puerperal fever are some of the most interesting in the history of medicine. This paper considers Hempel’s analysis of the Semmelweis case. It argues that this analysis is inadequate and needs to be supplemented by some Kuhnian ideas. Kuhn’s notion of paradigm needs to be modified to apply to medicine in order to take account of the classification schemes involved in medical theorising. However with a suitable modification it provides an explanation of Semmelweis’s failure which is (...) argued to be superior to some of the external reasons often given. Despite this success in applying Kuhn’s ideas to medicine, it is argued that these ideas must be further modified to take account of the fact that medicine is not a natural science but primarily a practice designed to prevent and cure diseases. (shrink)

Semmelweis’s investigations of puerperal fever are some of the most interesting in the history of medicine. This paper considers Hempel’s analysis of the Semmelweis case. It argues that this analysis is inadequate and needs to be supplemented by some Kuhnian ideas. Kuhn’s notion of paradigm needs to be modified to apply to medicine in order to take account of the classification schemes involved in medical theorising. However with a suitable modification it provides an explanation of Semmelweis’s failure which is (...) argued to be superior to some of the external reasons often given. Despite this success in applying Kuhn’s ideas to medicine, it is argued that these ideas must be further modified to take account of the fact that medicine is not a natural science but primarily a practice designed to prevent and cure diseases. (shrink)

Peter Lipton argues that inference to the best explanation involves the selection of a hypothesis on the basis of its loveliness. I argue that in optimal cases of IBE we may be able to eliminate all but one of the hypotheses. In such cases we have a form of eliminative induction takes place, which I call ‘Holmesian inference’. I argue that Lipton’s example in which Ignaz Semmelweis identified a cause of puerperal fever better illustrates Holmesian inference than Liptonian IBE. (...) I consider in detail the conditions under which Holmesian inference is possible and conclude by considering the epistemological relations between Holmesian inference and Liptonian IBE.Keywords: Inference to the best explanation; Peter Lipton; Abduction; Holmesian inference; Eliminative induction. (shrink)

Abduction is considered the most powerful, but also the most controversially discussed type of inference. Based on an analysis of Peirce’s retroduction, Lipton’s Inference to the Best Explanation and other theories, a new theory of abduction is proposed. It considers abduction not as intrinsically explanatory but as intrinsically conditional: for a given fact, abduction allows one to infer a fact that implies it. There are three types of abduction: Selective abduction selects an already known conditional whose consequent is the given (...) fact and infers that its antecedent is true. Conditional-creative abduction creates a new conditional in which the given fact is the consequent and a defined fact is the antecedent that implies the given fact. Propositional-conditional-creative abduction assumes that the given fact is implied by a hitherto undefined fact and thus creates a new conditional with a new proposition as antecedent. The execution of abductive inferences is specified by theory-specific patterns. Each pattern consists of a set of rules for both generating and justifying abductive conclusions and covers the complete inference process. Consequently, abductive inferences can be formalised iff the whole pattern can be formalised. The empirical consistency of the proposed theory is demonstrated by a case study of Semmelweis' research on puerperal fever. (shrink)

Semmelweis’s discovery of the cause of puerperal fever around the middle of the 19th century counts among the paradigm cases of scientific discovery. For several decades, philosophers of science have used the episode to illustrate, appraise and compare views of proper scientific methodology.Here I argue that the episode can be profitably reexamined in light of two cognate notions: causal reasoning and mechanisms. Semmelweis used several causal reasoning strategies both to support his own and to reject competing hypotheses. However, these (...) strategies have gone unappreciated in the existing literature. I show that a causal reasoning approach makes sense of the multitude of tables in Semmelweis’s main text, which in later editions were often abridged because they appeared redundant.Moreover, the existing literature tends to focus on Semmelweis’s clinical intervention and on the extent to which it alone confirms his theoretical conclusions. This neglects Semmelweis’s efforts to show by animal experiments that his clinical results are in agreement with a demonstrable mechanism of puerperal fever pathogenesis. I argue that the full evidential force of Semmelweis’s argument can only be appreciated if both his clinical and his laboratory investigations are taken into account. (shrink)

The standard underdetermination argument relies on the assumption that empirical evidence is the only epistemic constraint on theory-choice. One prominent response to this has been the invocation of theoretical virtues, properties of our scientific theories that scientific realists take to be epistemic in nature and that are such that, if they are had by our theories, make it more likely for those theories to be true. It thus becomes a main goal for scientific realists to establish a link between the (...) theoretical virtues and truth. However, despite the fact that the virtues are frequently invoked in response to underdetermination arguments, how to do so has not been addressed in any detail. In this chapter, I will spell out the most promising approach in making this link: an account according to which the question of whether the virtues are epistemic is answered empirically, through an examination of cases of epistemically successful (and unsuccessful) theories. I will illustrate how this approach works concretely by discussing a case-study from mid-nineteenth century Britain concerning the debate about the transmissibility of puerperal fever. After showing how some specific virtues are put to work in this case, I will explain what is required in order to make a more general argument for the epistemic potential of the theoretical virtues. I then argue that putting the virtue-question on empirical grounds is enough to undermine the anti-realist position on underdetermination – regardless of whether, in fact, the virtues turn out to be epistemically potent or not. (shrink)

A doutora Sonia Maria Oliveira de Barros, professora da Escola de Enfermagem USP, organizou o volume sobre os cuidados no ciclo gravídico-puerperal. A obra aborda os conteúdos programáticos das disciplinas de saúde materna das melhores instituições de ensino brasileiras na área de enfermagem. O objetivo é ensinar sobre a assistência de enfermagem obstétrica na gravidez, tanto no parto quanto no puerpério. O caráter didático dos livros se revela na linguagem clara e na sugestão de atividades de reflexão e fixação (...) dos assuntos discutidos. Todos os capítulos convidam os leitores a refletirem sobre o tema, contribuindo para melhor apreensão das informações. Organizado pelas doutoras Taka Oguisso e Elma Lourdes Campos Pavone Zoboli, ambas também da Escola de Enfermagem da USP, 'Ética e bioética' discute fundamentos da ética, as responsabilidades legais dos profissionais da enfermagem, bioética e políticas públicas. Destaca-se, no livro, a abordagem acerca dos dilemas emergentes no campo da ética, tema bastante atual nas discussões acadêmicas. O livro é um recurso de pesquisa, leitura e apoio para docentes e discentes interessados em se aprofundar em um campo atualmente restrito a poucos estudiosos da área, apesar de sua grande importância na atuação dos profissionais. (shrink)