The T/t locus was a major focus of study by mouse geneticists during the 20th century. In the 70s, as the study of cell surface antigens controlling transplantation antigens was taking off, several laboratories hypothesized that alleles of this locus would control cell surface antigens important for embryonic development. One such antigen, the embryonal carcinoma F9 antigen was said to be an example. Other antigens were described on sperm and embryos that were said to be controlled by alleles at the (...) T/t complex. These findings were later found to be false. The history of the findings and their refutation is described. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Engaging the Doctrine of Israel: A Christian Israelology in Dialogue with Ongoing Judaism by Matthew LeveringJustin Schembri O.P.Engaging the Doctrine of Israel: A Christian Israelology in Dialogue with Ongoing Judaism by Matthew Levering (Eugene, OR: Cascade, 2021), 547 pp.Engaging the Doctrine of Israel not only presents an interesting take on an old and complex problem but also is intriguing in its basic thesis and overall development. In this (...) book, Levering attempts, and succeeds, to marry a scripturally grounded dialogue with ongoing Judaism with the necessary presuppositions of Christian dogmatics. He does so in order to understand the central realities of God's biblical people Israel and to shine a light on how these realities must inform Christian thought (3).Such a volume fills a gap in research, since Christian dogmatic studies [End Page 1437] often suffer a lack of appreciating just how important understanding "Israel's covenantal life" is for Christian doctrine (3). Thus, while Levering tells us that this book is "the dogmatic sequel" to his Engaging the Doctrine of Marriage (1), the content of the book cannot be divorced from its scriptural foundation, nor from a contemporary dialogue with Israel.After an ample introduction (1–47), Levering begins his treatment of the matter by explaining the necessary hermeneutical framework in which such an engagement can take place (48–109). This foundational chapter not only provides the grounding for the chapters that follow but also examines the pitfalls to avoid in dialoging with ongoing Israel. In particular, Levering finds a balance in the need for both Christians and Jews to retain core beliefs and a recognition that both sides have suffered from unnecessary and painful biases that have hurt dialogue in the past (52–53).Since Levering is writing from the point of view of a Christian, he is right to point out that a healthy and fruitful dialogue with Judaism in the present moment requires both a solid foundation in Christian doctrine and an acknowledgement of how the New Testament has been misused to reject and subject the Jewish people to injustice over the centuries. Thus, in agreement with the author, I too think that Christian–Jewish dialogue plays a vital role not only in healing such biases but also in bridging needless gaps between the two groups (108–109).This crucial chapter is followed by an examination of six different areas (110–443) in which Levering engages with Israel's doctrine through a Christian lens. In each case, a similar format is found in the sense that Levering first introduces the topic and then engages with different Jewish and Christian scholars in order to elicit a more robust space for dialogue to happen. Each topic of study, then, is brought to a conclusion wherein Levering explicates both the pitfalls to be avoided and what truth can Christians glean.The first area to be discussed is creation (110–46). In this chapter, Levering examines why is it important for both Jews and Christians alike to affirm that omnipotent God created creation ex nihilo. The author is right to point out that if God did not create creation out of nothing, then God is not omnipotent but rather merely a "powerful finite being" (111).While I would have like to see a more robust exegetical analysis on Gen 1:1–2 (especially with regards to bǝrē'šît, since it is not so certain that this prepositional phrase should be interpreted temporally), the author is right to move beyond the metaphysical question of creation ex nihilo, to point out that creation is "also rooted in God's speaking, and thus his Word," since creation must be understood as the way in which God establishes "a dialogic communion" (124) with creation. After all, it is the Word which is [End Page 1438] fundamental; God speaks and practically invites creation to take its place amongst the grooves that God has made.What is more is that this Word, as Levering acknowledges, is both divine and human, since it is the Word of God written in human language. Thus, in Scripture, we cannot escape the "divine–human collaboration" (145) that is willed by... (shrink)

In Morality and Socially Constructed Norms, Valentini searches for a unifying principle that underlies whatever genuine obligations we might have to obey the norms of any and all social practices, ranging from line queueing norms, through offsides rules in soccer, to obligations not to break the law. I argue that this search is driven, and distorted, by a commitment to what Bernard Williams labeled the ‘morality system’. Once we see this, we should question the value of the unifying project. Most (...) social norms can be considered on their own terms, as part of a rich and variegated ethical life, without subsuming them under the question of whether others’ moral rights are at stake. Similarly, political obligation needs to be understood in relation to the practical activity of politics, not as an abstract moral quandary. (shrink)

The study provides an insight into the structural features of the famous VIII century Buddhist treatise Tattvasaṅgrāha by Śāntarakṣita with regard to the text’s main purpose ( prayojana ) as it is treated in Kamalaśīla’s commentary Pañjikā. Any text along with its referential (representational) function of conveying message - meaning to the addressee, or its expressive function, reflecting the author's attitude to what is communicated, also performs the ‘appellative’ function, encouraging the recipient of the message to act. This function which (...) could also be called praxiological was always significant in Indian text culture, since from the times of Veda-s it was embedded in its very core. This function is of paramount importance in the case of Indian religious and philosophical texts, whose main aim is to convince and transform the consciousness of their percipients. Along with linear models of message transfer, Sanskrit texts could demonstrate non-linear semantic structures, transmitting the main idea of the text indirectly. It is exactly how one should perceive the message of Śāntarakṣita’s Tattvasaṅgrāha according to the suggested by Śāntarakṣita’s prominent student Kamalaśīla in his Pañjikā -commentary to the treatise. He proposes to consider Tattvasaṅgrāha not as a thematically heterogeneous encyclopaedic or doxographic work, whose main objective is to refute different non-Buddhist views (as it is often treated by scholars now), but as a text, which by its very design exposes one of the most important Buddhist principles - the law of the dependent origination ( pratītyasamutpāda ). The themes, discussed in a number of the chapters of Tattvasaṅgrāha, indeed, appear to have direct correlation with the characteristics of pratītyasamutpāda given to it in Śālistamba-sūtra - an early Mahāyāna text, which explains this universal law. Kamalaśīla suggests looking at Tattvasaṅgrāha as at one big unit-sentence - mahāvākya, with the exposition of pratītyasamutpāda as its unitary purpose-meaning ( abhidheya ). In this context, the treatise functions as a praxiological tool for the ‘installing’ into the consciousness of the text’s addressee the knowledge of ‘true principles’ (tattva-s) of pratītyasamutpāda. This interpretation of the main message of the text raises also a question of the adequate translation of the name of the treatise into other languages, because, according to Kamalaśīla, ‘ Tattvasaṅgrāha’ means the ‘Assembly of Principles-(tattva’-s)’ which specify precisely pratītyasamutpāda (pratītyasamutpāda-viśeṣaṇāni tattvāni). (shrink)

Agronomic science or technoscience has an important role in contemporary times and is the focus of necessary philosophical investigations. The present study aimed to relate Gadamerian philosophical hermeneutics with the Laudanian concept of philosophy of science, also applied to the philosophy of technology within the agronomic context. The central question to be answered is: can Gadamerian philosophical hermeneutics apply to the understanding of agronomy? Given this, central references and commentators were selected, dividing the dialogue between the authors and the argumentation (...) into the following points: sciences, technologies, and Gadamerian philosophical hermeneutics; agronomic traditions and their Laudanian progress; reaching the final possibility of intersections between Gadamer and Laudan, when reflecting on agronomy, especially on the theme of traditions. (shrink)

The compound eyes of insects exhibit stunning variation in size, structure, and function, which has allowed these animals to use their vision to adapt to a huge range of different environments and lifestyles, and evolve complex behaviors. Much of our knowledge of eye development has been learned from Drosophila, while visual adaptations and behaviors are often more striking and better understood from studies of other insects. However, recent studies in Drosophila and other insects, including bees, beetles, and butterflies, have begun (...) to address this gap by revealing the genetic and developmental bases of differences in eye morphology and key new aspects of compound eye structure and function. Furthermore, technical advances have facilitated the generation of high‐resolution connectomic data from different insect species that enhances our understanding of visual information processing, and the impact of changes in these processes on the evolution of vision and behavior. Here, we review these recent breakthroughs and propose that future integrated research from the development to function of visual systems within and among insect species represents a great opportunity to understand the remarkable diversification of insect eyes and vision. (shrink)

The study deals with some of the central issues concerning the notion of death as discussed in Theravāda (Pāli Buddhism) as well as Mahāyāna Buddhism. What is the sense that death is regarded as an instance of duḥkha (Sanskrit) or dukkha (Pāli)? The research claims that here, firstly, the word duḥkha/dukkha is used as an adjective (which means ‘unsatisfactory’) rather than a noun (which means 'pain' or 'suffering'). Secondly, by death, the Buddha did not mean the act of dying but (...) the experience of someone's death or the idea of death. The Buddha also talked about deathlessness as the goal. Here, deathlessness does not amount to accepting something eternal but developing a proper perspective towards death by meditations such as that on impurity ( аśubhabhāvanā ) and contemplation on death ( maraṇānussati ). If the cessation of the cycle of rebirths and re-deaths ( punarmṛtyu ) is the ultimate goal that the arhat (Sanskrit), or arahant (Pāli), achieves, then the same should apply to Tathāgata. In that case, the problem suggests itself: how could the question of Tathāgata’s existence after death be accounted for as an unanswerable ( avyākṛta )? The study opines that the reason behind this is the profound, immeasurable, unfathomable nature attributed to Tathāgata. The research also discusses the basic difference between the attitudes on death in Śrāvakayāna and Mahāyāna. Lastly, it deals with the question of whether termination of one’s own life is permissible in Buddhism under certain conditions. (shrink)

Catholic doctrine makes metaphysical claims about the Eucharist, but the distinctive language of “transubstantiation” is often treated as an historically contingent, and disposable, way of articulating these claims. Attempts to translate the metaphysics implied by “transubstantiation” into other terminology should begin by attending to the semantic assumptions of those who first articulated it. This chapter argues that the notion of substantial predication in realist semantics helps communicate a metaphysical claim which even well-intended efforts at translation into other semantic frameworks often (...) fail to capture. An implication of the argument is that, not only does realist semantics help us understand the Catholic doctrine of transubstantiation, but the Catholic doctrine of transubstantiation helps us recapture realist semantics and the Aristotelian notion of substance. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:From Báñez with Love:A Response to a Response by Taylor Patrick O'NeillJames Dominic Rooney O.P.From where I stand, the traditional options of Molinism and Báñezianism seem logically exhaustive possible accounts of the way in which God can cause people to love him, under the influence of grace, while at the same time being able to affirm that those people remain free. Either God's giving efficacious grace to an individual (...) is such as to cause that individual to act a certain way, merely in virtue of giving that grace to that individual, or it is not. If that grace is not intrinsically efficacious, then you need to explain the way in which God can cause an action by giving grace which does not require grace to be intrinsically efficacious. On the latter front, Molinists aim to affirm that human beings are free even while acting under the influence of God's grace, and hold that God's grace is not such as to make it that one could not have done otherwise. They explain this by appeal to counterfactual truths about what human beings would do, metaphysically prior to and independent of God's subsequent decisions to give or withhold grace. These "counterfactuals of freedom" are central to Molinist accounts of freedom, since the truth of these counterfactuals alone secures the fact that human beings are acting freely even when God gives them grace and causes them to perform certain actions. Those human beings could have acted otherwise. Conversely, since God knows these truths, he can use them in order to give grace to an individual at those times when he knows it will be efficacious.To me, the Molinist view is a non-starter. What these truths consist in, what grounds them, how God uses them—I find the critiques compelling [End Page 675] and Molinist answers to these questions metaphysically problematic.1 I am committed to finding a Báñezian solution, therefore, to the riddle. From my perspective, the mystery of predestination invites confusion ultimately because the issue is a subtle philosophical, not a theological, problem. The resolution to the riddle of grace and free will can come only through an adequate account of the nature of human freedom. And I remain unsatisfied by a lack of philosophical clarity among Báñezian authors on the nature of freedom. In a recent paper, I therefore posed a problem for Báñezianism that resembles what is called the "grounding problem" for Molinism: where do the truths about alternative possibilities come from? And I illustrated the problem in the context of the account of grace given by one famous defender of the view, Fr. Réginald Garrigou-Lagrange, whose work in turn was recently promoted by Taylor Patrick O'Neill.In short, Garrigou-Lagrange appears to accept that there need to be alternative possibilities if human action is to be free. He gives an accounting of those possibilities as follows. On one side, when I sin, Garrigou-Lagrange argues that God's denial of efficacious grace, even though this denial occurs prior to anything I do or could have done, does not necessitate my sin because I performed the sin by means of my normally operating volitional and intellectual capacities (which God merely refrained from interfering in), and I had alternative possibilities provided by the possibility of God providing efficacious grace. Then, on the other, when I do good, he appeals at many points to non-culpable "defects" regarding my intellectual or volitional capacities as grounding those alternative possibilities that I could have sinned even when acting under efficacious grace. In both cases, my acts are still metaphysically contingent. However, neither case provides a sufficient grounding for alternative possibilities (I argued), because I had no relevant control over God's decision to deny efficacious grace, nor were those "defects" in light of which I could have sinned under my control. Instead, I argued that Garrigou-Lagrange's account of humans having alternative possibilities for action would be successful only if there were facts about what I would have done under sufficient grace, truths prior to and independent of God's decision to give efficacious... (shrink)

Inspired by the third chapter of Anselm's Proslogion, twentieth century philosophers including Charles Hartshorne and Alvin Plantinga developed “modal” ontological arguments for the existence of God. Such arguments use modal logic to infer God's existence from the premises that (i) God's existence is possible and (ii) if God exists, He exists necessarily. Like other ontological arguments, modal arguments have won few converts to theism; many commentators consider them question‐begging or liable to parody. This article details how recent attempts to defend (...) these arguments have tried to overcome these difficulties by drawing on modern accounts of the epistemology and metaphysics of modality. (shrink)

In their article, Crutchfield and Redinger (2024) outline the conditions that they have identified as situations in which it is ethically permissible to use chemical restraints, defined as medicati...

Informed consent is ethically incomplete and should be redefined as empowered consent. This essay challenges theoretical assumptions of the value of informed consent in light of substantial evidence of its failure in clinical practice and questions the continued emphasis on autonomy as the primary ethical justification for the practice of consent in health care. Human dignity—rather than autonomy—is advanced from a nursing ethics perspective as a preferred justification for consent practices in health care. The adequacy of an ethic of obligation (...) (namely, principlism) as the dominant theoretical lens for recognising and responding to persistent problems in consent practices is also reconsidered. A feminist empowerment framework is adopted as an alternative ethical theory to principlism and is advanced as a more practical and complete lens for examining the concept and context of consent in health care. To accomplish this, the three leading conceptions of informed consent are overviewed, followed by a feminist critique to reveal practical problems with each of them. The need for a language change from informed to empowered consent is strongly considered. Implications for consent activities in clinical practice are reviewed with focused discussion on the need for greater role clarity for all involved in consent—beyond and inclusive of the patient‐physician dyad, as the practice and improvement of consent is necessarily a transdisciplinary endeavour. Specific concrete and practical recommendations for leveraging nursing expertise in this space are presented. Perhaps what is most needed in the discourse and practice of consent in health care is nursing. (shrink)

Purpose The purpose of this paper is to investigate perceived stressors and coping behaviours in student nurses on a pre-registration programme of study. Stress in student nurses has been identified with decreased emotional well-being and poor academic achievement. The significance of stress and coping behaviours in students during training has implications for education and practice. Design/methodology/approach The present study recruited 87 pre-registration student nurses in a cross-sectional design. Bivariate and multivariate analyses assessed the differences in field and year of study (...) and the students’ perceived stress and coping behaviours. Findings The findings showed that stress is a significant issue in nurse training. Fifty-three per cent of the participants had levels higher than the mean. Interestingly, the present study found that high-perceived stress was associated with avoidance behaviours. The most common type of perceived stress and ranked by highest factor were from written assignments and a lack of professional skills and knowledge. Their peer group and everyday life activities were shown as potential ways of coping with stressors. Thus, it seems reasonable to focus support on decreasing avoidant and enhancing stress-reducing behaviours. Practical implications Psychological stress and coping behaviours must be considered together, as perceived stress is bound by the ability to ameliorate stress by managing helpful and unhelpful behaviours. Originality/value The findings may suggest that a potential benefit could come from the provision of helpful strategies such as peer group support and reduction of avoidant behaviours. Also, there seems to be a need for greater mental health literacy in dealing with stress during training. (shrink)

info:eu-repo/semantics/publishedVersion.

Westworld is a television series on HBO (2016–present), based on a movie of the same name by Michael Crichton. The plot of the show is wide-reaching. The first season shows us an adult theme park where android “hosts” serve the wealthy “guests.” Seasons two and three show the attempt of the hosts to escape this servitude, and then, in a twist, help humans do the same outside of the parks. This chapter links all three seasons of Westworld to theories of (...) colonization. First, it explores the types of colonialism as they pertain to Westworld. Then it looks at the various scopes of colonization in Westworld – the colonization of space, time, and psychic space. Next, it explores the psychology of colonizers and the colonized as it pertains to the show. Lastly, it explores possible forms of liberation from colonization that the show has to offer. (shrink)

"Resilience in the academic setting has been named as academic resilience and been defined as an increased probability of academic success despite stressful events and conditions" [Mitchell, 2021] p1474 based on the Academic Resilience Scale (ARS‐30) [Cassidy, 2016].

Recent reports and papers on chimeric research highlight the promise of chimeric models of human neuropsychiatric disorders to ameliorate human suffering due to autism spectrum disorders, depression, and schizophrenia. These calls, however, typically do not acknowledge, much less address, criticisms of model creation and validation, or concerns about scientific conduct more generally. The ethical justification for the use of nonhuman animals in research depends on the production of benefits to humans based on such research. But the assessment and production of (...) benefits are highly uncertain and rife with both practical and conceptual challenges. This essay provides a general framework for classifying the benefits of biomedical research and then focuses on two factors that directly impact—and threaten—the production of knowledge in research that models neuropsychiatric disorders. (shrink)

This essay makes a case for the metaphysical status of the human fetus. I argue that personhood begins at conception as opposed to at some point in the post-conception continuum. However, there is a deep division over this matter. Defenders of the pro-life position grant that life begins at conception. In contrast, defenders of the pro-choice position deny that life begins at conception. Even if it were the case that life begins at conception, proponents of abortion claim that a woman’s (...) bodily autonomy should come first over protecting the fetus’s life. Contemporary discussions regarding this matter continue to lack a clear and adequate account of why we continue to face a stalemate in terms of settling the issue of the metaphysical status of the human fetus. In section I, I discuss what I call the less central issues that stand in the way when it comes to addressing the main question of the personhood of the human fetus. In section II, I discuss the personhood problem as it relates to the fetus. In section III, I sketch out a conception- grounded theory of fetal personhood. In section IV, I consider some objections. In section V, I discuss the origin problem as it relates to the fetus within the broader context of the challenge, we face in answering the question of the nature of life. Finally, in section VI, I conclude this paper by claiming that conception plays a decisive metaphysical role in the personhood status of the fetus. (shrink)

The publication presents for the first time the B. Baradin’s theses to A. Dorzhiev’s lecture that was supposed to be delivered at the international Buddhist exhibition in Leningrad in 1927. A. Dorzhiev was a famous Buryat lama who received the academic title of Geshe (the highest philosophical academic degree in the Gelug tradition of Tibetan Buddhism) upon completion of his philosophical education in the monasteries of Mongolia and Tibet. After 1918, he was involved in organizational issues of the Buddhist Sangha (...) in Russia. B. Baradin was an academic scientist and public figure, a professor at St. Petersburg University, and the author of studies on the history and teachings of Tibetan Buddhism. After the revolution of 1917, he began working in Buryatia in various administrative positions, focusing on the organization of the scientific and cultural life of the Republic. Their main idea is that the modern world consists of the two equal parts - East and West, unification of which is possible and even necessary for the further development of humanity. The system-forming teaching of the East is Buddhism; and the lecture hold on those aspects of Buddhist philosophy that could be compared with the teachings of the West. Four points are highlighted: 1) Buddhism is comparable to Darwin’s theory in that both consider humans in the context of all living beings in an evolutionary manner; 2) Buddhism, like science, accepts the determinism principle; 3) the Buddhist concept of shunya is similar to the relativistic principles of physics; and 4) the system of Buddhist psychotechniques is similar to the theory of reflexology. B. Baradin concludes that Indo-Buddhist culture and European culture are complementary and their rapprochement will bring us closer to a truly universal culture. The theses mentioned here are, apparently, the first systematic exposition of the views of neo-Buddhists-renewalists on the points of convergence between Buddhist and Western cultures. (shrink)

Volume 20, Issue 5, June 2020, Page 18-20.

Completing the systematic henadological interpretation of Proсlus’ Platonic Theology begun in The Intelligible Gods in the Platonic Theology of Proclus (“Méthexis” 21, 2008, pp. 131-143) and The Second Intelligible Triad and the Intelligible-Intellective Gods (“Méthexis” 23, 2010, pp. 137-157), the present article concerns the conditions of the emergence of fully mediated, diacritical multiplicity out of the polycentric henadic manifold. The product of the activity of the intellective Gods (that is, the product of the intellective activity of Gods as such), in (...) resolving the contradiction between existential uniqueness and universalizable potencies in the divine natures, also grounds the human exercise of philosophical cognition in the founding self-analysis of divine individuals. (shrink)

This book provides a discussion of the philosophy of being according to three major traditions in Western philosophy, the Analytic, the Continental, and the Thomistic. The origin of the point of view of each of these traditions is associated with a seminal figure, Gottlob Frege, Immanuel Kant, and Thomas Aquinas, respectively. The questions addressed in this book are constitutional for the philosophy of being, considering the meaning of being, the relationship between thinking and being, and the methods for using thought (...) to access being. On the one hand, the book honors diversity and pluralism, as it highlights how the three traditions may be clearly and distinctly differentiated regarding the philosophy of being. On the other hand, it honors a sense of solidarity and ecumenism, as it demonstrates how the methods and focal points of these traditions constitute, and continue to shape, the development of Western philosophy. This book contributes toward an essential overview of Western metaphysics and will be of particular interest to those working in the history of philosophy and in the philosophy of being. (shrink)

The relationship between humanity and the soil is an increasingly important topic in social theory. However, conceptualisations of the soil developed by anticolonial thinkers at the high point of the movement for self-determination between the 1940s and the 1970s have remained largely ignored. This is a shame, not least because theorists like Eric Williams, Walter Rodney, Suzanne Césaire and Amílcar Cabral were concerned with the soil. Building on recent work on human-soil relations and decolonial ecology, we argue that these four (...) thinkers conceptualised the connection between soil, empire, and anticolonial revolt. Williams and Rodney ground understanding of soil degradation in global relations of economic power, while Césaire and Cabral reconceptualise postcolonial nationhood in terms of the mutability and diversity of the soil. The article concludes by suggesting that these two anticolonial counterpoints, global connectivity and more-than-human identification, anticipate and deepen contemporary attempts to decolonise ecological thinking. (shrink)