IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

Este artículo de revisión examina la importancia que tienen las comunidades microbianas que colonizan los ambien­tes y equipos de procesado de alimentos formando biopelículas o biofilms en la persistencia microbiana en la industria alimen­taria y consecuentemente, en la seguridad y la calidad de los alimentos. La atención se centra especialmente en biopelículas formadas por microorganismos no deseados, es decir, microor­ganismos alterantes y patógenos. Se presenta información so­bre la variabilidad intraespecífica en la formación, la ecología y la arquitectura de las biopelículas, (...) y los factores que influyen en su formación. Asimismo, se resume la información disponible sobre nuevos agentes o estrategias para el control de la forma­ción o eliminación de biopelículas. (shrink)

Las aminas biógenas son compuestos nitrogenados de pequeño tamaño con actividad biológica que se forman por la descarboxilación enzimática de ciertos aminoácidos. Las aminas biógenas se encuentran presentes en todos los seres vivos, en los que participan en procesos biológicas de gran importancia. Sin em­bargo, debido al metabolismo de algunos microorganismos, estos compuestos se pueden acumular en alimentos en concentraciones elevadas, constituyendo un riesgo para la salud de los consumido­res. Para que las aminas biógenas alcancen estas concentraciones elevadas en los (...) alimentos se requiere, como condición indispensa­ble, la presencia de microrganismos productores, por lo que se han desarrollado diferentes métodos para detectar la presencia de los mismos. Entre estos métodos, aquellos basados en técnicas inde­pendientes de cultivo, como la PCR, presentan ventajas como su gran especificidad, el hecho de ser rápidos y de fácil realización, y que en muchos casos ni siquiera es necesario un tratamiento previo de la muestra, lo que facilita su incorporación a las plantas de elabo­ración. En este trabajo se describen algunos de los métodos dispo­nibles en la actualidad para la detección de microorganismos pro­ductores de aminas biógenas, así como sus posibles aplicaciones. (shrink)

Background:The first wave of the COVID-19 pandemic caused a shortage of qualified nurses in Spain. As a result, the government authorized the hiring of senior students.Objectives:To explore the ethical dilemmas and ethical conflicts experienced by final-year nursing students who worked during the first outbreak of the COVID-19 pandemic in Spain.Research design:A qualitative exploratory study was conducted using purposive sampling. Semi-structured interviews were carried out using a question guide. Interviews took place via a private video chat room platform. A thematic, inductive (...) analysis was performed of the information gathered.Participants and research context:Eighteen nursing students were recruited from two universities of Madrid, aged between 18 and 65 years old, enrolled in the fourth year of nursing studies and who were hired under a relief contract for health professionals during the pandemic.Ethical considerations:The present study was carried out in accordance with the Declaration of Helsinki, and the study was approved by the Local Ethics Committee of Universidad Rey Juan Carlos.Results:Three specific themes emerged: (a) coping with patient triage, (b) difficulties in providing end-of-life care, and (c) coping with patient death. Nursing students participated in the process of patient selection for resource allocation and ICU bed occupancy. They were shown how to care for patients who were not admitted to the ICU, in their last moments and were faced with the difficulties of applying end-of-life care. Finally, the nursing students were confronted with the death of their patients, in overwhelming numbers and under adverse conditions.Conclusions:These findings can help shed light on the ethical dilemmas and ethical conflicts faced by novice nursing students, incorporated into the workforce during the COVID-19 pandemic. Moreover, it was described that students may normalize the death due to the exhaustion and overwhelmed routine. (shrink)

The aim of the present study was to assess the impact of past traumatic war experiences on preadolescents in the Gaza Strip, which could be useful for psychological intervention with current and future child victims. Participants were 521 preadolescents from United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) schools, aged 11 and 13 years old. Sections I to IV from Iraqi Version-Arabic of Harvard Trauma Questionnaire was used to assess trauma experiences and Post-Traumatic Stress (...) Disorder (PTSD). The results show that the preadolescents in the Gaza Strip witnessed the destruction of their homes and the murder of family members and friends. A quarter of the individuals assessed either suffered torture or witnessed others undergoing it, including sexual assaults. Almost half of them experienced a lack of food and clean water. The traumatic and torture experiences seriously affected preadolescents’ mental health as 26.29% met criteria for the diagnosis of PTSD. The data analysis revealed two PTSD modalities, with the severity of impact depending on whether social implications were involved. Further research is required to check whether these two modalities fit to PTSD and complex PTSD. Understanding the effects of past wars on preadolescents in Gaza and distinguishing between different PTSD types could enhance comprehension of the impacts of current attacks on child victims. It can also aid in determining the type of intervention needed to minimize the impact on the mental health of Palestinian youth, enhancing their resilience through psychological and social support. (shrink)

Ayda Ignez Arruda was a key figure in the development of the Brazilian school of Paraconsistent logic and the first person to write a historical survey of the field. Despite her importa...

Chromosome segregation requires the ordered separation of the newly replicated chromosomes between the two daughter cells. In most cells, this requires nuclear envelope (NE) disassembly during mitotic entry and its reformation at mitotic exit. Nuclear envelope breakdown (NEB) results in the mixture of two cellular compartments. This process is controlled through phosphorylation of multiple targets by cyclin‐dependent kinase 1 (Cdk1)‐cyclin B complexes as well as other mitotic enzymes. Experimental evidence also suggests that nucleo‐cytoplasmic transport of critical cell cycle regulators such (...) as Cdk1‐cyclin B complexes or Greatwall, a kinase responsible for the inactivation of PP2A phosphatases, plays a major role in maintaining the boost of mitotic phosphorylation thus preventing the potential mitotic collapse derived from NEB. These data suggest the relevance of nucleo‐cytoplasmic transport not only to communicate cytoplasmic and nuclear compartments during interphase, but also to prepare cells for the mixture of these two compartments during mitosis. (shrink)

Wilhelm Ostwald, Ernst Mach y Pierre Duhem se encuentran entre los más relevantes críticos del atomismo de finales del siglo XIX. Repasamos y analizamos los argumentos que aducen dichos autores para oponerse a la concepción atomista de la materia. Mostramos cómo esos argumentos surgen de posiciones filosóficas de fondo sobre el fundamento de la naturaleza, el objeto de la ciencia y el papel de la metafísica. Comparamos dichas posiciones filosóficas. Y enmarcamos la crítica del atomismo en el problema epistemológico más (...) general de la explicación para mostrar la tensión entre explicación y experiencia, y su relación con la metafísica. (shrink)

La introducción al ensayo relaciona la escritura y la supervivencia en Unamuno y en Lledó -en el primero como voluntad multidimensional y en el segundo como memoria viva colectiva- y después compendia la vida y la obra de Emilio Lledó El ensayo comenta varios textos de la obra de Lledó Memoria de la ética acerca de la muerte y de la existencia extendida en la época clásica de la cultura y la filosofía griegas. Como conclusión, y a partir del epicureísmo (...) de Lledó, se reafirma una cierta distinción entre las propuestas de una teoría de la vida post-mortem basada en la pervivencia por la memoria y otra que apunta a la vida perdurable por el impulso del ánimo o thymós. (shrink)

In this essay I propose two theories of truth and show how they deal with semantic paradoxes. Their most salient feature is that they are based on a gametheoretic understanding of logic and meaning. “Truth”, therefore, is understood dialogically, as agreement between parts. I compare this proposal with a similar one already existing in the literature —Dutilh Novaes and French 2018—, and highlight the advantages of mine. The theories of truth I present are non-trivial, substructural (in a sense to be (...) clarified) and capture strong intuitions about truth. Some philosophical recommendations in favor of our understanding of Dialogics are delivered along the way. (shrink)

Cybersecurity aggregates are numerical data obtained by aggregation on features along a database of cybersecurity reports. These aggregates are obtained by integration of time-stamped tables using some recent results of non-standard calculus. Time-series of aggregates are shown to contain relevant information about the concrete system dealt with. Trend time series is also forecasted using known data-driven methods. Although absolute forecasting of trend time series is not obtained, a directional forecasting of trend time series is achieved thence validated by means of (...) a rolling cross validation scheme on a public database of Scareware reports. (shrink)

This book brings together previously unpublished work which looks at issues concerning the foundations and applications of a prominent branch of virtue epistemology: “performance-based epistemology”. The chapters in Part I examine some foundational issues in the conceptual framework of PBE: the relations between apt success and luck; the connection between aptness and a safety condition for knowledge; the fallibility of competences; the kind of reliability needed for knowledge and justification; the nature of epistemic agency; and some ways of enriching the (...) basic conceptual framework of PBE. The chapters in Part II discuss the application of PBE to outstanding problems in contemporary epistemology, such as the nature of a priori intuition; internalist objections to epistemic externalism; the roles that epistemic agency is meant to play in the acquisition of knowledge; the value of second-order reflection; the nature of some epistemic incompetences; and the problem of epistemic circularity. (shrink)

This critical appraisal of Juan Comesaña’s Being Rational and Being Right is divided into three sections: Section I describes the fundamental features of “Experientialism,” the theory of basic rationality developed and defended in the book; Section II briefly indicates how the chapters of the book unfold; and Section III describes and examines one problematic issue concerning how Experientialism interacts with the liberalism/conservatism debate in the theory of justification.

In this paper, I develop a problem I call the “Conditional Position Problem” that arises for Ernest Sosa’s externalist epistemology. The problem is that, due to a phenomenon of epistemic circularity, one is unable to attain the reflective knowledge that one is justified in believing that perception is reliable, and is confined to the merely conditional position that one is so justified if perception is reliable. The problem is similar but different from a problem that Barry Stroud has tried to (...) formulate. However, because of space limitations I cannot explain in detail what makes the two problems different. The structure of the paper is as follows: first, I explain the structural features of Sosa’s epistemology that allow the problem to arise; I also describe the normative task that is thwarted by the Conditional Position Problem; then I expound the problem itself. I proceed to examine one response that Sosa can give based on a simple inferential manoeuvre and explain why that response fails; then I examine another response he can give based on a complex form of self-support, and explain why this response also fails. I conclude explaining why the problem I present is specifically a problem for externalism. In an appendix, I very briefly describe what I take to be the main reason that justifies my claim that Stroud's problem is not the same as the problem I develop. (shrink)

El Anti-Excepcionalismo Lógico afirma que la Lógica es como cualquier otra ciencia. Si esta afirmación es cierta, entonces ella no sólo es revisable, sino que además todo lo que se puede decir sobre las ciencias aplica, mutatis mutandis, para la misma. El propósito de este artículo es explorar esta consecuencia del Anti-Excepcionalismo Lógico, acercando a la Filosofía de la Lógica el marco teórico de las Máquinas Nomológicas de Nancy Cartwright. De acuerdo con esta visión, lo que hay de verdadero en (...) las teorías científicas no está en el mundo sino en sus modelos: sistemas altamente controlados, estables, artificiales y específicos, dentro de los cuales se manifiestan regularidades sistematizables y enseñables. Mi afirmación es que lo mismo puede decirse de la Lógica: ella no captura las Leyes del Pensamiento o de la Razón, porque el pensamiento y la razón no están gobernados necesariamente por leyes. Sobre lo que sí puede decirse que versan las Leyes de la Lógica son metafísicas posibles: historias acerca de qué son las proposiciones, el pensamiento, la verdad y la validez. A fin de ilustrar y defender esta tesis, presento un ejemplo de Máquina Nomológica de la Lógica Clásica, basada en una lectura original del Tractatus de Wittgenstein, e investigo algunas de sus consecuencias. Mi conclusión es que esta imagen de la Lógica impacta en el problema de la revisión de la Lógica Clásica, en la medida en que muestra que dicha revisión no necesariamente responde a un proceso racional de adecuación de la teoría a los hechos porque los “hechos” relevantes no son anteriores a la teoría misma, sino que están moldeados y conducidos por ella. Palabras clave: Anti-Excepcionalismo Lógico, Abductivismo, Máquinas Nomológicas, Revisión Lógica, Filosofía de la Lógica. (shrink)

According to the broaden-and-build theory of positive emotions, the frequency of positive emotions is associated with the development of positive attitudes, cognitions, and behaviors in organizational contexts. However, positive and negative attitudes at work might also be influenced by different personal and job resources. While emotional intelligence has been significantly associated with positive job attitudes and personal well-being, no studies have yet examined the joint role of teacher happiness and emotional intelligence in key teacher job attitudes. The present study assesses (...) whether emotional intelligence interacts with levels of teacher happiness to jointly explain important teacher job attitudes. A total sample of 685 teaching professionals filled out a battery of scales including subjective happiness, emotional intelligence, job satisfaction, and turnover intention. Our results revealed that subjective happiness was significantly associated with both higher job satisfaction and lower turnover intention. Likewise, emotional intelligence was positively related to happiness and job satisfaction, and negatively related to turnover intention. Finally, interaction analysis showed the main effects of happiness and emotional intelligence in explaining teacher job attitudes. Beyond the main effects, the interaction effects of happiness and emotional intelligence were significant in predicting all teachers' job attitude indicators, even controlling for the effects of their sociodemographic variables. This work expands our knowledge about the role of teachers' positive emotions in the development of positive work attitudes, and also supports the inclusion of emotional skills in future teacher preparation programs as resources to facilitate work-related well-being. (shrink)

Los videojuegos tienen una presencia creciente en nuestra vida, pero desde siempre se los ha considerado un elemento de ocio y nada más. Pese a que se ha demostrado que jugando con ellos se pueden adquirir una gran cantidad de aprendizajes, en los ámbitos académicos hay resistencias a considerarlos algo más que pasatiempos. Para arrojar un poco de luz a este tema, en este trabajo se plantea el uso de los videojuegos como una herramienta educativa más, con un enorme potencial (...) en el caso de la Didáctica de la Geografía y la Historia. (shrink)

In this article, we analyze the patterns of culture of honor within Spanish families. Each member of 271 Spanish four-member families completed a questionnaire containing scales for the culture of honor and for sociodemographic variables. The results show that intra-family similarities emerge. However, path analyses show that the gender and birth order of the child are relevant in predicting this similarity. In particular, the first-born child converges with their mother to a higher extent than the father regardless of their gender. (...) However, for the second-born child both parents instill their ideas about culture of honor in a gender congruent way. Furthermore, there are higher similarities within younger families, indicating a stronger influence from parents to children. Results are discussed in view of social role and gender social learning theories. (shrink)

Este artículo propone que Palacios enuncia los elementos esenciales para un esbozo sistemático de una antropología filosófica, no exenta de las influencias de los pensadores de su época, principalmente racistas y evolucionistas, pero se separa de estos al intentar dar una visión panorámica del mesti..

El Problema de la Adopción afirma que ciertas leyes lógicas no pueden ser adoptadas. El argumento constituye un desafío al antiexcepcionalismo lógico, en la medida en que este último debe poder justificar su afirmación de que la teoría lógica en ejercicio puede revisarse. El propósito de este artículo es responder al desafío, utilizando como unidad de análisis el concepto de Taxonomía Lexical propuesto por Kuhn. Como mostraremos, una visión sociológicamente enriquecida de las teorías científicas y la naturaleza de sus cambios (...) permite dar cuenta de un antiexcepcionalismo lógico que evita el Problema de la Adopción. (shrink)

The main purpose of this study was to analyze the presence and current situation of the game of skittles throughout the northern route of the Camino de Santiago. Thus, we considered its current practice, modalities, where it is played, and its different manifestations as an informal and formal game, comparing it with other traditional games on this pilgrimage route. To do this, a mixed qualitative-quantitative study was designed with 89 participants, constituting an informant for each municipality through which the Northern (...) Way passes. An ad hoc questionnaire was used for the data collection, which was processed through content analysis by expert judges and by using the IBM-SPSS statistical package. The results of the study show notable skittles activity on the Northern Camino, reflected in the number of skittles alleys, the number of clubs, associations, and peñas participating in federated leagues, and the wide range of varieties of skittles currently active on the Camino. The relationship between skittles and local culture, both symbols of identity in these northern Spanish regions, made it possible to preserve the traditional heritage in these places, keeping it alive today, despite the push toward new and more attractive leisure and sport trends. (shrink)

On the assumption that shame is a universal emotion, cross-cultural research on shame relies on translations assumed to be equivalent in meaning. Our studies here questioned that assumption. In three studies,shamewas compared to its translations in Spanish and in Malayalam. American English speakers usedshamefor the emotional reaction to moral failures and its use correlated positively withguilt, whereasvergüenzaandnanakeduwere used less for moral stories and their use correlated less with the guilt words. In comparison with Spanish and Malayalam speakers’ ratings of their (...) translations, American English speakers ratedshameandguiltto be more similar to each other. (shrink)

This work was my theses to get the MA in Philosophy. Their focus is the ethics implied in digital culture and networked society. Themes are Ethics, culture, technology, political control, autonomous systems.

RESUMEN Analizar el papel del centro universitario en la articulación con la universidad médica en la búsqueda de entornos saludables y su contribución al desarrollo local en el municipio Yaguajay, constituye el propósito fundamental del presente trabajo, para el que se realizó una revisión documental de numerosos documentos y entrevistas a los principales líderes y a la población. El fomento de prácticas y estilos de vida sanos, la integración y capacitación de actores sociales, el desarrollo de la ciencia, la innovación (...) tecnológica y del potencial científico productivo, junto a la sostenibilidad ambiental, fueron algunos de los resultados evidenciados. Se constató que la universidad en el territorio trabajó por incentivar una cultura saludable, por unificar esfuerzos, coordinar acciones, involucrar sectores, consolidar alianzas interinstitucionales dentro y fuera de la esfera sanitaria, con lo que se demostró la fortaleza de la promoción de salud dentro de los procesos de desarrollo local. ABSTRACT To analyze the role of the university center in the coordination with the medical university in the search of healthy environments and its contribution to the local development in the municipality Yaguajay, constitutes the fundamental intention of the present work, for which a documentary review of numerous documents was carried out and interviews to the principal leaders and the population. The promotion of practices and healthy life styles, the integration and training of social actors, the development of the science, the technological innovation and of the productive scientific potential, along with the environmental sustainability, were some of the demonstrated results. It was stated that the university at the territory was employed for encouraging a healthy culture, for unifying efforts, coordinating actions, involving sectors, consolidating inter-institutional alliances inside and out of the sanitary sphere, with what there was demonstrated the fortitude of the promotion of health inside the processes of local development. (shrink)

Reseña de "Punto de inflexión: Crisis climática y ecológica” de Pamela Poo.