While heredity is predominantly controlled by what deoxyribonucleic acid (DNA) sequences are passed from parents to their offspring, a small but growing number of traits have been shown to be regulated in part by the non‐genetic inheritance of information. Transgenerational epigenetic inheritance is defined as heritable information passed from parents to their offspring without changing the DNA sequence. Work of the past seven decades has transitioned what was previously viewed as rare phenomenology, into well‐established paradigms by which numerous traits can (...) be modulated. For the most part, studies in model organisms have correlated transgenerational epigenetic inheritance phenotypes with changes in epigenetic modifications. The next steps for this field will entail transitioning from correlative studies to causal ones. Here, we delineate the major molecules that have been implicated in transgenerational epigenetic inheritance in both mammalian and non‐mammalian models, speculate on additional molecules that could be involved, and highlight some of the tools which might help transition this field from correlation to causation. (shrink)

This paper provides a detailed discussion of the questions relating to the role of the researcher in relation to the researched when the researcher and the researched are both of Muslim origin. Issues relating to questions of objectivity, transparency, bias and interpretation are elaborated upon as part of the analysis of impacts and outcomes in relation to methodological process. It is argued that, ultimately, the subjective positions of researcher and researched are less important than the objective nature of the research (...) process. The intention of this paper is to convey, to other Muslim and non-Muslim social researchers engaged in research on Islam and Muslims, how to avoid or identify the range of risks and pitfalls that may emerge in operationalising and evaluating social research in a highly charged political, cultural and social research arena. (shrink)

In this paper I shall be looking at the state of science before and after the 17th century especially with regard to the question of the nature of scientific knowledge, specifically scientific paradigms. I will argue that some of the major differences between modern science and pre-modern science are due to (i) methodological changes, (ii) the rise of paradigmatic monism in modern science as opposed to paradigmatic pluralism in pre-modern science, (iii) the integration of science with technology after the 17th (...) century. These changes, I maintain, also redefine the role of scientific knowledge in society and culture, and bring in its wake certain problems and challenges, which in turn elicit different types of responses. Pre-modern science, I argue, are admirably suited to play a cultural and religious role, partly because of a lack of a pragmatic criterion of knowledge, and the emphasis on rational coherence. This makes enchantment of nature through science, possible. However, with the further evolution of science, especially the introduction of the experimental method and the emphasis on empiricism in the 17th century, scientific knowledge now has to conform to different criteria of knowledge -pragmatic in partleading to 'paradigmatic monism' and the consequent loss of enchantment in our conception of nature. The rise of the new science beginning in the 17th century thus brings in its wake a new set of epistemological and cultural challenges which were met with in different ways. I will then comment on the different types of responses made against the rise of the new science. (shrink)

Name der Zeitschrift: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Jahrgang: 2013 Heft: 197 Seiten: 65-77.

Authentic leadership has appeared as a significant field of research. Building on social exchange theory that explicates how individuals mutually mechanize reciprocation and eventually establish a trust-based relationship, we postulated a positive relationship between authentic leadership and followers' organizational citizenship behaviors (OCB). Based on a two-wave time-lagged design, the data were obtained from 270 employees working in the private banking sector of Pakistan. We found that authentic leadership is positively associated with subordinate’s OCB, as well as, leads to a higher (...) level of both affective and cognitive-based followers' trust. The results also indicated that both affective and cognitive-based trust positively mediated the relationship between authentic leadership and OCB. The implication for theory and practice are discussed. (shrink)

Vaccination is an important tool for handling healthcare programs both in developed and developing countries. The current global scenario calls for a more‐efficacious, acceptable, cost‐effective and reliable method of immunization for many fatal diseases. It is hoped that the adoption of oral vaccines will help to provide an effective vaccination strategy, especially in developing countries. Mucosal immunity generated by oral vaccines can serve as a strong first line of defense against most of the pathogens infecting through the mucosal lining. Advances (...) in elucidating the mechanism of action of oral vaccines will facilitate the design of more effective, new generation vaccines. There are promising developments in the use of different agents to effectively deliver the vaccine candidate. It is hoped that ongoing research may be able to set another cardinal point, after polio vaccine, in eradicating infectious diseases. BioEssays 29:591–604, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The twenty-first century has seen an increase in ethical misconduct at the workplace, highlighting the need to stimulate discussion on the role of work ethics. The objective of the current study is to extend the literature on work ethics by examining the role of Islamic work ethic in enhancing the task performance of employees. The current study proposes that psychological capital mediates the relationship between Islamic work ethic and task performance. It is also proposed that ethical leadership might act as (...) a boundary condition that boosts the positive relationship between Islamic work ethic and psychological capital. Data were collected in three-time lags from employees working in the service sector of Pakistan through the questionnaire. The results supported the mediation and moderation hypothesis, confirming that psychological capital mediates the relationship between Islamic work ethic and task performance. Ethical leadership moderates the relationship between Islamic work ethic and psychological capital. The results offer implications for theory and practice. Limitations and future research directions are also discussed. (shrink)

South Asian regional integration is seemingly confronting many challenges. The aim of this paper is to identify those challenges and also look for prospects. Although regional integration in South Asia has adopted a kind of institutionalization, it is yet to deliver any concrete outcomes. High-politics and the not-so-conducive regional economic structures hinder any effectual culmination. However, constructivism, as a theory, is given due credence in this paper when looking for future prospects. The paper highlights the issues, and attempts to offer (...) certain policy directions by analyzing the challenges and identifying the prospects in the on-going integration/cooperation process. (shrink)

RésuméDepuis Ibn Mattawayh et Mānkdīm jusqu'à George Hourani et Marie Bernand, les spécialistes ont montré un intérêt constant pour la théorie de la connaissance d' ʿAbd al-Jabbār, intérêt plus grand encore depuis la parution des textes de Muʿtazilites tardifs comme leKitāb al-Muʿtamad fī Uṣūl al-Dīnd'Ibn al-Malāḥimī, et leKitāb Taṣaffuḥ al-Adillade son maître Abū al-Ḥusayn al-Baṣrī. Cet article examine la théorie de la connaissance immédiate d' ʿAbd al-Jabbār à partir de sonMughnī, ainsi que de textes écrits par ses élèves ou par (...) des Muʿtazilites tardifs. Est aussi étudié le rapport entre cette théorie et les arguments théologiques d'ʿAbd al-Jabbār. Ce travail est divisé en deux parties: en premier lieu, j'étudie la définition de la connaissance immédiate par ʿAbd al-Jabbār et les réactions de ses successeurs; en second lieu, j'analyse sa conception des types de connaissance immédiate étroitement liés à ses arguments théologiques. Et à partir de là, je montre comment le désaccord à propos du contenu de cette connaissance est à l'origine du débat opposant les théologiens musulmans (mutakallimūn) à propos de la validité de certains arguments théologiques. (shrink)

This article explores the diverse experiences of Turkish rural migrant women in the city and how city living enters the definition of gender and the distribution of power in the migrant household. It draws on data collected in an ethnographic study of migrants in Ankara, Turkey, and examines whether this migration improves or deteriorates migrant women's position in the family. Specifically, it identifies four groups of migrant women and speculates on some of the factors that shape their diverse experiences. The (...) data reveal that city living affects the position of migrant women to varying degrees, depending on their particular Islamic sect; the demands made on them to assure family survival and achievement; and, to some extent, their age, socioeconomic status, educational level, position in the life cycle, and the status and economic wealth of the wife's family and the wife's relationship with it. (shrink)

We investigate and analyze the dynamics of hepatitis B with various infection phases and multiple routes of transmission. We formulate the model and then fractionalize it using the concept of fractional calculus. For the purpose of fractionalizing, we use the Caputo–Fabrizio operator. Once we develop the model under consideration, existence and uniqueness analysis will be discussed. We use fixed point theory for the existence and uniqueness analysis. We also prove that the model under consideration possesses a bounded and positive solution. (...) We then find the basic reproductive number to perform the steady-state analysis and to show that the fractional-order epidemiological model is locally and globally asymptotically stable under certain conditions. For the local and global analysis, we use linearization, mean value theorem, and fractional Barbalat’s lemma, respectively. Finally, we perform some numerical findings to support the analytical work with the help of graphical representations. (shrink)

This paper attempts to examine the paradigm shift in ASEAN from a state-based to a people-based organization. We argue that by adopting a people-based organization, ASEAN now enters an era of Neo-Communitarianism replacing the Old Communitarianism of the old generation of ASEAN. By using communitarian perspectives, we look at the continuities and changes in ASEAN with regard to how it deals with issues involving their members. Three important issues namely the debates on intervention principle; the adoption of the three pillars (...) of the ASEAN Community; and the inclusion of human rights are seen as the signposts where ASEAN departs from their Old to a Neo-Communitarianism. Although there have been a lot of challenges to the realization of the people-based organization, we see that the dynamics of debates and the active participation of the community in the debates show good prospects for the new paradigm to realize. In this paper, we use debate on the formation of ASEAN Intergovernmental Commission on Human Rights (ICHR), to show the involvements of people in setting the agendas for the future ASEAN. (shrink)

There is a growing demand for information and computational technology for surgeons help with surgical planning as well as prosthetics design. The two-dimensional images are registered to the three-dimensional (3D) model for high efficiency. To reconstruct the 3D model of knee joint including bone structure and main soft tissue structure, the evaluation and analysis of sports injury and rehabilitation treatment are detailed in this study. Mimics 10.0 was used to reconstruct the bone structure, ligament, and meniscus according to the pulse (...) diffusion-weighted imaging sequence (PDWI) and stir sequences of magnetic resonance imaging (MRI). Excluding congenital malformations and diseases of the skeletal muscle system, MRI scanning was performed on bilateral knee joints. Proton weighted sequence (PDWI sequence) and stir pulse sequence were selected for MRI. The models were imported into Geomagic Studio 11 software for refinement and modification, and 3D registration of bone structure and main soft tissue structure was performed to construct a digital model of knee joint bone structure and accessory cartilage and ligament structure. The 3D knee joint model including bone, meniscus, and collateral ligament was established. Reconstruction and image registration based on mimics and Geomagic Studio can build a 3D model of knee joint with satisfactory morphology, which can meet the requirements of teaching, motion simulation, and biomechanical analysis. (shrink)

The concept of knowledge and its implication to national development, with reference to Malaysia; and analysis from Islamic viewpoint.

In this article, I will view realist and non-realist accounts of scientific models within the larger context of the cultural significance of scientific knowledge. I begin by looking at the historical context and origins of the problem of scientific realism, and claim that it is originally of cultural and not only philosophical, significance. The cultural significance of debates on the epistemological status of scientific models is then related to the question of ‘intelligibility’ and how science, through models, can give us (...) knowledge of the world by presenting us with an ‘intelligible account/picture of the world’, thus fulfilling its cultural-epistemic role. Realists typically assert that science can perform this role, while non-realists deny this. The various strategies adopted by realists and non-realists in making good their respective claims, is then traced to their cultural motivations. Finally I discuss the cultural implications of adopting realist or non-realist views of models through a discussion of the views of Rorty, Gellner, Van Fraassen and Clifford Hooker on the cultural significance of scientific knowledge.Keywords: Models; Intelligibility; Scientific realism; Culture. (shrink)

BackgroundThe research shows a growing trend in using an electronic platform to supplement or replace traditional paper-based informed consent processes. Instead of the traditionally written informed consent document, electronic informed consent may be used to assess the research subject’s comprehension of the information presented. By doing so, respect for persons as one of the research ethical principles can be upheld. Furthermore, these electronic methods may reduce potential airborne infection exposures, particularly during the pandemic, thereby adhering to the beneficence and nonmaleficence (...) principle. This scoping review aims to identify the ethics related criteria that have been included in electronic informed consent processes and to synthesize and map these criteria to research ethics principles, in order to identify the gaps, if any, in current electronic informed consent processes.MethodsThe search was performed based on internet search and three main databases: PubMed, SCOPUS and EBSCO. PRISMA Extension for Scoping Reviews : Checklist and Explanation guideline was used to report this work.ResultsOf 34 studies that met the inclusion criteria, 242 essential original constructs were collated, and 7 concepts were derived. Digital content showed the highest percentage of collated original constructs followed by accessibility, comprehension engagement, autonomy, confidentiality, language, and parental consent. Twenty-five new items were synthesized for eConsent criteria which may provide guidance for ethical review of research involving eConsent.ConclusionThe current study adds significant value to the corpus of knowledge in research ethics by providing ethical criteria on electronic informed consent based on evidence-based data. The new synthesized items in the criteria can be readily used as an initial guide by the IRB/rec members during a review process on electronic informed consent and useful to the future preparation of a checklist. (shrink)

This article provides a Foucauldian perspective on the racialised biopolitics of Islamophobia in the global north. It is argued that a pervasive, wide-ranging racialised logos is being used to unde...

“Toba Tek Singh,” which describes the exchange of mental asylum inmates between India and Pakistan in the wake of partition, was perhaps Saadat Hasan Manto’s most well-known short story. Manto’s work was coloured by his experience of mental illness, including alcohol addiction and possible depressive disorder. This essay attempts to use “Toba Tek Singh” as a lens through which to shine an integrative light on the role of mental illness in Manto’s work and life, by discussing his personal experiences, themes (...) of mental illness in the story, and the implications of his writing in the historical context of post-partition South Asia. (shrink)

“Toba Tek Singh,” which describes the exchange of mental asylum inmates between India and Pakistan in the wake of partition, was perhaps Saadat Hasan Manto’s most well-known short story. Manto’s work was coloured by his experience of mental illness, including alcohol addiction and possible depressive disorder. This essay attempts to use “Toba Tek Singh” as a lens through which to shine an integrative light on the role of mental illness in Manto’s work and life, by discussing his personal experiences, themes (...) of mental illness in the story, and the implications of his writing in the historical context of post-partition South Asia. (shrink)

“Toba Tek Singh,” which describes the exchange of mental asylum inmates between India and Pakistan in the wake of partition, was perhaps Saadat Hasan Manto’s most well-known short story. Manto’s work was coloured by his experience of mental illness, including alcohol addiction and possible depressive disorder. This essay attempts to use “Toba Tek Singh” as a lens through which to shine an integrative light on the role of mental illness in Manto’s work and life, by discussing his personal experiences, themes (...) of mental illness in the story, and the implications of his writing in the historical context of post-partition South Asia. (shrink)

Que pourraient se dire nos deux philosophes-psychologues, Nietzsche et William James, au sujet de la philosophie elle-même? Leurs paroles pourraient-elles se croiser quelque part dans un univers philosophique âgé de plus de deux millénaires? Ces deux hommes, l'un inventeur du terme de "bon européen" et l'autre, considéré comme le philosophe américain par excellence et le plus européen des philosophes américains, ont-ils quelques mots à partager? Que peut-il y avoir en commun chez ces deux philosophes, sauf à être considérés par Mussolini (...) comme ses maîtres de philosophie à côté de Sorel? Ou bien, plus précisément, quels sont les points convergents et divergents par rapport au sens qu'ils attribuent à la philosophie? Et enfin, dans quelle mesure peut-on parler d'un pragmatisme nietzschéen? Y a-t-il des éléments dans la pensée de Nietzsche nous permettant de faire un rapprochement entre sa pensée et le pragmatisme? C'est à ces questions que nous tâcherons de répondre dans ce livre. (shrink)

Kur’ân-ı Kerîm lafızlarının eda keyfiyetlerini ihtiva eden kıraatler İslâmî ilimlerin birçoğunun önemli mevzuları arasında yer almaktadır. Özellikle tefsir ilminin temel konularından olan kıraatler söz konusu ilmin sembol şahsiyetlerinden olan Zemahşerî’nin (öl. 538/1144) tefsirinde de kayda değer bir yer işgal etmektedir. el-Keşşâf tefsirinde kıraat ihtilaflarına sıkça müracaat eden Zemahşerî’nin kıraatler konusundaki yaklaşımı kendisinden sonraki müfessirleri de etkilemesi yönüyle önem arz etmektedir. O, ele aldığı kıraatlerin bazen hüccet bazen de nispet yönüne temas etmektedir. Kıraatlere daha çok lügavî açıdan yaklaşan Zemahşerî, ilgili kıraatlerin (...) özellikle dilde hüccetliği üzerinde durmaktadır. Bununla birlikte çoğu zaman bahse konu ettiği telaffuzla okuyan isimleri zikretmeyi de ihmal etmemektedir. Onun zikrettikleri arasında sahih kıraat sahibi imamlar (kıraat-i aşere imamları), şâz kıraat imamları ve seleften kıraati ile meşhur şahıslar yer almaktadır. Müfessirin bu tavrı onun meseleye vukûfiyetini de ortaya koymaktadır. el-Keşşâf’ta sahih kıraatlerin yanında birçok şâz kıraate de yer verilmektedir. Müfessir zaman zaman -sahih olsun şâz olsun- bazı telaffuzların naklî temeline de inmekte, ilgili telaffuzu tâbiîne, sahabeye hatta Hz. Peygamber’e nispet etmektedir. Ancak bu nispet esnasında bir sorun göze çarpmaktadır. O da söz konusu telaffuz şekillerinin sıhhati meselesidir. Zira bir kıraatin sahih olabilmesi için onun kıraatçiler nezdinde makbul bir senetle gelmesi, Arapça’ya ve Hz. Osman tarafından yazdırılan mushaflardan birinin imlasına uygun olması gerekmektedir. Müfessir birçok yerde sadece “Hz. Peygamber’in kıraati bu şekildedir.” gibi kesin ve net ifadeler kullanmakta, ele aldığı telaffuz şekli hakkında bir değerlendirme ya da bir kaynağa atıfta bulunma ihtiyacı hissetmemektedir. Mevzubahis tefsirde Hz. Peygamber’in okuduğu söylenen şâz kıraatler Yazma Eserler Kurumu (YEK) tarafından neşredilen Keşşâf Tefsiri mütercimlerinin de dikkatini çekmiş, konuyu değerlendirdikleri “el-Keşşâf’ta Kıraatler” başlığı altında şu cümleye yer vermişlerdir: “Bunların en ilginci herhalde Hz. Peygamber’e nispet edilen -fakat mütevâtir kıraatlerde yer almayan- kıraatlerdir.” Bu tespit, el-Keşşâf’ta yer alan bu kıraatlerin derinlemesine incelenmesini gerekli kılmaktadır. Ancak önemine rağmen ilgili konuda yapılmış bir çalışmaya rastlanılmamıştır. Bu çalışmada el-Keşşâf tefsirinde Hz. Peygamber’e nispet edilen kıraatlerin tespit, teyit ve tenkidi hedeflenmektedir. Öncelikle eserde bahsedilen bu kıraatlerin sayısı, kaynak ve isnatları tespit edilmiş, daha sonra bunların kıraat imamları arasında ne şekilde karşılık bulduğu ortaya konulmuştur. Tespitlerimize göre Zemahşerî bir kıraatin Hz. Peygamber’e nispetine özel bir önem vermemekte, rivayet ve kıraatin sıhhat ve şöhretine bakmamaktadır. Onun bu yaklaşımı hadisçiler nezdinde de kıraatçiler nezdinde de kabul görmemiştir. (shrink)