It has long been thought that transmembrane cell‐surface receptors, such as receptor tyrosine kinases and cytokine receptors, among others, are activated by ligand binding through ligand‐induced dimerization of the receptors. However, there is growing evidence that prior to ligand binding, various transmembrane receptors have a preformed, yet inactive, dimeric structure on the cell surface. Various studies also demonstrate that during transmembrane signaling, ligand binding to the extracellular domain of receptor dimers induces a rotation of transmembrane domains, followed by rearrangement and/or (...) activation of intracellular domains. The paper here describes transmembrane cell‐surface receptors that are known or proposed to exist in dimeric form prior to ligand binding, and discusses how these preformed dimers are activated by ligand binding. (shrink)

Using the concepts of chaotic dynamical systems, we present an interpretation of dynamic neural activity found in cortical and subcortical areas. The discovery of chaotic itinerancy in high-dimensional dynamical systems with and without a noise term has motivated a new interpretation of this dynamic neural activity, cast in terms of the high-dimensional transitory dynamics among “exotic” attractors. This interpretation is quite different from the conventional one, cast in terms of simple behavior on low-dimensional attractors. Skarda and Freeman (1987) presented evidence (...) in support of the conclusion that animals cannot memorize odor without chaotic activity of neuron populations. Following their work, we study the role of chaotic dynamics in biological information processing, perception, and memory. We propose a new coding scheme of information in chaos-driven contracting systems we refer to as Cantor coding. Since these systems are found in the hippocampal formation and also in the olfactory system, the proposed coding scheme should be of biological significance. Based on these intensive studies, a hypothesis regarding the formation of episodic memory is given. Key Words: Cantor coding; chaotic itinerancy; dynamic aspects of the brain; dynamic associative memory; episodic memory; high-dimensional dynamical systems; SCND attractors. (shrink)

We propose a new dynamical mechanism for information processing in mind and brain. We emphasize that a hermeneutic process is one of the key processes manifesting the functions of the brain and that it can be formulated as an itinerant motion in ultrahigh dimensional dynamical systems, which may give a new realm of the dynamic information processing. Our discussions are based on the notion of chaotic information processing and the observations of biological chaos.

Das Problem der Intersubjektivitiit Intersubjektivität ist Husserl schon seit der Darstellung der Ideen I in Zusammenhang mit dem Problem der phiinomenologischen phänomenologischen Reduk tion sehr stark bewusst und wird, wie die neue VerOffentlichung Veröffentlichung 'Zur Phänome Phiinome nologie der Intersubjektivität'l Intersubjektivitiit'l ausdrücklich ausdrucklich zeigt, zeit seines Lebens in seinem Denken mit mehr oder weniger Intensitiit Intensität behandelt. Bekanntlich hat Husserl Hussed die Einfühlungslehre EinfUhlungslehre in seinem spiiten späten Versuch mit der 'Selbstobjektivation' 'Selbstobjektivation',, 'Selbstauslegung' des absoluten, anonymen, transzen 2 dentalen ego (...) erkliirt. erklärt. Gerade auf diesen Punkt konzentriert sich zutreffende Kritik und zeigt die Unvermeidbarkeit des transzendentalen Solipsismus; was als Grund für fUr echte echte Intersubjektivitiit Intersubjektivität gesucht gesucht wird, wird, niimlich nämlich die die Gleichursprunglich Gleichursprünglich keit keit von von Subjekten, Subjekten, fUhrt führt schliesslich schliesslich auf auf den den Weg der Radikalisierung der trans zendentalen Reduktion und der Erklärung Erkliirung mit der immanenten Zeitigung des transzendentalen ego in die 'einseitige Verlagerung des Gewichts auf ein konsti tuierendes Ur-Ich, dem kein ebenso ursprungliches ursprüngliches Du gegenübersteht, gegeniibersteht,...'3. (shrink)

L’avocat japonais a été institué en 1872 à l’image de l’avocat français, au cours du mouvement de modernisation qui a suivi l’ouverture du pays. Mais l’état d’esprit y était et reste celui de la bureaucratie judiciaire. L’avocat n’a obtenu son indépendance qu’en 1949. Malgré les apparences, son rôle ne semble pas suffisamment développé pour permettre à la Justice d’avancer pleinement dans le sens de la protection des droits et libertés. Après avoir dressé un aperçu général de l’évolution et de l’état (...) actuel de la profession d’avocat, nous examinerons la possibilité d’étendre ses fonctions à de nouvelles activités. (shrink)

To understand the public opinion concerning the genethics in culturally different populations, we conducted two focus groups in Japan, with one focus group each in China and Panama between April 2008 and August 2009. Generally, the participants in Japan were more cautious to disclose their personal thinking in a clear manner. Most participants in China and Panama hoped to have children free from any genetic disease if at all possible. The major difference between China and Panama seems to be whether (...) or not they will accept the issue of genetic abortion. Compared to China and Panama, fewer participants accepted a reprogenetics procedure in Japan. ―A goal of genetic counseling is to reduce the number of patients of genetic disease‖ is supported to a greater degree in China and Panama than in Japan. Most participants in China as well as Panama, and fewer participants in Japan accepted the concept of sharing genetic information with relatives, even though it is useful for preventing a possible genetic risk. The difference of the answers for the questions is depending on the cultural and value diversity in each country, while some of them are related into a paucity of knowing the principle of biogenetics. Education as to medical genetics and the principle of bioethics is most important to make genetics more accessible to the general public. (shrink)

We consider the significance of high-dimensional transitory dynamics in the brain and mind. In particular, we highlight the roles of high-dimensional chaotic dynamical systems as an “adequate language” (Gelfand 1989), which should possess both explanatory and predictive power of description. We discuss the methods of description of dynamic behavior of the brain. These methods have been adopted to capture the averaged or deterministic complexity, and further to allow for discussion of a new approach to capture the complexity of the deviation (...) from such an averaged complexity and also the complexity of interactive modes. We also give arguments in defense of our models for dynamic memory with chaotic itinerancy and Cantor coding. In addition, we discuss the reality that a model of the brain and mind should reflect. (shrink)

A novel method to quantize systems of damped motion is proposed in the frameworks of canonical quantization and path integral quantization. It can be afforded by considering a Lagrangian multiplied by a time-dependent function, which may represent an effective interaction with “environment.”.

Kampis proposes the study of chaotic itinerancy, pointing out its significance in domains of cognitive science and philosophy. He has discovered in the concept of chaotic itinerancy the possibility for a new dynamical approach that elucidates mental states with a physical basis. This approach may therefore provide the means to go beyond the connectionist approach. In accordance with his theory, I here highlight three issues regarding chaotic itinerancy: transitory dynamics, diversity, and self-modifying system.

I would like to emphasize the significance of chaotic dynamics at both local and macroscopic levels in the cortex. The basic notions dealt with in this commentary will be noise-induced order, chaotic “itinerancy” and dissipative structure. Wright & Laley's theory would be partially misleading, since emergent nonlinearity rather than the linearity at even a macroscopic level can actually subserve cortical functions.

Social epidemiology has made a powerful case that health determined not just by individual-level factors such as our genetic make-up, access to medical services, or lifestyle choices, but also by social conditions, including the economy, law, and culture. Indeed, at the level of populations, evidence suggests that these “structural” factors are the predominant influences on health. Legal scholars in public health, including those in the health and human rights movement, have contended that human rights, laws, and legal practices are powerfully (...) linked to health. Social epidemiology and health-oriented legal scholarship are complementary in their focus and their research needs. Legal scholarship has identified plausible ways in which legal and human rights factors could be influencing health, but empirical evidence has been limited. (shrink)

Social epidemiology has made a powerful case that health determined not just by individual-level factors such as our genetic make-up, access to medical services, or lifestyle choices, but also by social conditions, including the economy, law, and culture. Indeed, at the level of populations, evidence suggests that these “structural” factors are thepredominantinfluences on health. Legal scholars in public health, including those in the health and human rights movement, have contended that human rights, laws, and legal practices are powerfully linked to (...) health. Social epidemiology and health-oriented legal scholarship are complementary in their focus and their research needs. Legal scholarship has identified plausible ways in which legal and human rights factors could be influencing health, but empirical evidence has been limited. (shrink)

Behavioral economics has potential to offer novel solutions to some of today's most pressing public health problems: How do we persuade people to eat healthy and lose weight? How can health professionals communicate health risks in a way that is heeded? How can food labeling be modified to inform healthy food choices? Behavioral Economics and Public Health is the first book to apply the groundbreaking insights of behavioral economics to the persisting problems of health behaviors and behavior change. In addition (...) to providing a primer on the behavioral economics principles that are most relevant to public health, this book offers details on how these principles can be employed to mitigating the world's greatest health threats, including obesity, smoking, risky sexual behavior, and excessive drinking. With contributions from an international team of scholars from psychology, economics, marketing, public health, and medicine, this book is a trailblazing new approach to the most difficult and important problems of our time. (shrink)

This book is a collection of all the papers published in the special issue “Artificial Intelligence, Robots, and Philosophy,” Journal of Philosophy of Life, Vol.13, No.1, 2023, pp.1-146. The authors discuss a variety of topics such as science fiction and space ethics, the philosophy of artificial intelligence, the ethics of autonomous agents, and virtuous robots. Through their discussions, readers are able to think deeply about the essence of modern technology and the future of humanity. All papers were invited and completed (...) in spring 2020, though because of the Covid-19 pandemic and other problems, the publication was delayed until this year. I apologize to the authors and potential readers for the delay. I hope that readers will enjoy these arguments on digital technology and its relationship with philosophy. *** -/- Contents*** -/- Introduction : Descartes and Artificial Intelligence; Masahiro Morioka*** -/- Isaac Asimov and the Current State of Space Science Fiction : In the Light of Space Ethics; Shin-ichiro Inaba*** -/- Artificial Intelligence and Contemporary Philosophy : Heidegger, Jonas, and Slime Mold; Masahiro Morioka*** -/- Implications of Automating Science : The Possibility of Artificial Creativity and the Future of Science; Makoto Kureha*** -/- Why Autonomous Agents Should Not Be Built for War; István Zoltán Zárdai*** -/- Wheat and Pepper : Interactions Between Technology and Humans; Minao Kukita*** -/- Clockwork Courage : A Defense of Virtuous Robots; Shimpei Okamoto*** -/- Reconstructing Agency from Choice; Yuko Murakami*** -/- Gushing Prose : Will Machines Ever be Able to Translate as Badly as Humans?; Rossa Ó Muireartaigh***. (shrink)

法に対して合理的で批判的な姿勢を吹き込もうとする試み。ハート=ドゥオーキン論争以降の「法実証主義の現代的展開」を描き出す。本書ではとくに、ハートの理論的継承者であるラズおよびマーモーの議論に注目する。 .