Prostaglandin (PG) D2 and PGE2 are positional isomers; however, they sometimes exhibit opposite physiological functions, such as in cancer development. Because DP receptors are considered to be a duplicated copy of EP2 receptors, PGD2 and PGE2 cross‐react with both receptors. These prostanoids may act as biased agonists for each receptor. In reviewing this field, a hypothesis was proposed to explain the opposed effects of these prostanoids from the viewpoints of the evolution of, mutations in, and biased activities of their receptors. (...) Previous findings showing more mutations/variations in DP receptors than EP2 receptors among individuals worldwide indicate that DP receptors are still in a rapid evolutionary stage. The opposing effects of these prostanoids on cancer development may be attributed to the biased activity of PGE2 for DP receptors, which may incidentally develop during the process of the old ligand, PGE2 gaining selectivity to newly diverged DP receptors. (shrink)

最後の仕事を失敗に終えた、名批評家・小林秀雄。そのスタイルを多角的に検討し、批評とは何か、批評を支える「原理」について考える.

戦後日本を代表する知識人・丸山眞男が陥った「憂鬱」の正体とは? 日本の近代化に潜む真実を暴き、「憂鬱」を卒業する方途を探る。.

A one-dimensional scattering problem off a δ-shaped potential is solved analytically and the time development of a wave packet is derived from the time-dependent Schrödinger equation. The exact and explicit expression of the scattered wave packet supplies us with interesting information about the “time delay” by potential scattering in the asymptotic region. It is demonstrated that a wave packet scattered by a spin-flipping potential can give us quite a different value for the delay times from that obtained without spin-degrees of (...) freedom. (shrink)

BackgroundEach individual’s unique health-related beliefs can greatly impact the patient-clinician relationship. When there is a conflict between the patient’s preferences and recommended medical care, it can create a serious ethical dilemma, especially in an emergency setting, and dramatically alter this important relationship.Case presentationA 56-year-old man, who remained comatose after out-of-hospital cardiac arrest, was rushed to our hospital. The patient was scheduled for emergency coronary angiography when his adolescent daughter reported that she and her father held sincere beliefs against radiation exposure. (...) We were concerned that she did not fully understand the potential consequences if her father did not receive the recommended treatment. A physician provided her with in depth information regarding the risks and benefits of the treatment. While we did not want to disregard her statement, we opted to save the patient’s life due to concerns about the validity of her report.ConclusionsVariations in beliefs regarding medical care force clinicians to incorporate patient beliefs into medical practice. However, an emergency may require a completely different approach. When faced with a patient in a life-threatening condition and unconscious, we should take action to prioritize saving their life, unless we are highly certain about the validity of their advance directives. (shrink)

The philosopher and author of How Should We Live? presents “a clear and provocative discussion of issues such as boredom, hypocrisy, evil, and innocence”. In this book, John Kekes draws on anthropology, history, and literature to offer practical insights into the common predicaments we all face in our daily lives. Each chapter offers new ways of thinking about a common, fundamental problem, such as facing difficult choices, uncontrollable contingencies, complex evaluations, the failures of justice, the miasma of boredom, and the (...) inescapable hypocrisies of social life. In each case, Kekes discusses how others in different times and cultures have approached similar issues. Kekes examines what is good, bad, instructive, and dangerous in the Hindu caste system, Balinese role-morality, the sexually charged politics of the Shilluk, the religious passion of Cortes and Simone Weil, the fate of Colonel Hiromichi Yahara during and after the battle for Okinawa, the ritual human sacrifices of the Aztecs, and the tragedies to which innocence may lead. In doing so, he enlarges our understanding of the possibilities available to us as we struggle with the common obstacles of modern life. (shrink)