IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

The theory of the four stages happens to be a conjectural history with which the evolutionary interpretation of the process of civilization began, especially dynamic in the Scottish Enlightenment. The incidence in England and France of the work of the Jesuit J. de Acosta up to the English and Scottish Enlightenment is addressed, paying special attention first to the English translation by E. Grimstone, based on the French version by R. Regnault. Likewise, the use of Acosta is examined in detail (...) in a French political encyclopedia widespread in Europe, translated into several languages, also by Grimstone into English. Finally, the original components of the theory of the four stages in Acosta and D'Avity are examined, in its three Spanish, French and English versions as precursors of anthropological theory. (shrink)

Is it ethical or not to enhance the characteristics and capacities of human beings, making use of technological incorporations in their biology? This article presents arguments from both position pros and cons, about technological incorporations in human bodies. The denaturalization of technologically enhanced humans is discussed; A discussion is raised about the impact of these technologies on the population inequality; We present a contrast between whether the research is for treatment or enhancement purposes. Some of the repercussions on a society (...) of humans are analyzed, both hyper connected and technologically enhanced. Some of the future challenges that societies with technologically enhanced humans must face are presented. In conclusion, the development of technologies, within a regulatory and normative framework, to enhancing the characteristics and capacities of human beings is ethical. Because technologically enhanced humans are part of the NBIC convergence, and the NBIC convergence will generate new knowledge that will surely be used to develop clean and safe energy sources, preventive medical treatments that will eliminate diseases such as cancer and HIV, and design strategies to the conservation and decontamination of the planet. (shrink)