Chromatin structure and dynamics regulate key cellular processes such as DNA replication, transcription, repair, remodeling, and gene expression, wherein different protein factors interact with the nucleosomes. In these events, DNA and RNA polymerases, chromatin remodeling enzymes and transcription factors interact with nucleosomes, either in a DNA‐sequence‐specific manner and/or by recognizing different structural features on the nucleosome. The molecular details of the recognition of a nucleosome by different viral proteins, remodeling enzymes, histone post‐translational modifiers, and RNA polymerase II, have been explored (...) in the recent past. The present review puts forth critical insights into the basic mechanisms of nucleosome recognition by the various protein factors and the role of distinct surface epitopes on a nucleosome. These determinants of the underlying specificity include features such as the acidic patch, arginine anchor, histone post‐translational modifications, core DNA, DNA lesions, and linker DNA. (shrink)

This paper presents a new solution to the well-known exchange paradox, or what is sometimes referred to as the two-envelope paradox. Many recent commentators have analyzed the paradox in terms of the agent’s biased concern for the contents of his own arbitrarily chosen envelope, claiming that such bias violates the manifest symmetry of the situation. Such analyses, however, fail to make clear exactly how the symmetry of the situation is violated by the agent’s hypothetical conclusion that he ought to switch (...) envelopes on the assumption that his own envelope contains some specific amount of money. In this paper, I offer an explanation of this fact based on the idea that the agent’s deliberations are not only constrained by the epistemic symmetry reflected in the agent’s uniform ignorance as to the contents of the two envelopes, but also by a deeper methodological symmetry that manifests itself in the intuition that the two envelopes constitute equally legitimate sources of potential information. I interpret this intuition as implying that the agent’s final decision should reflect a point of rational equilibrium arrived at through an iterated process of counterfactual self-reflection, whereby the agent takes account of what he would have thought had he instead chosen the other envelope. I provide a formal model of this method of counterfactual self-reflection and show, in particular, that it cannot issue in the paradoxical conclusion that the agent ought to switch regardless of how much money is in his envelope. In this way, by correcting for the bias in the agent’s reasoning, the paradox is resolved. (shrink)

One well-known objection to the principle of maximum entropy is the so-called Judy Benjamin problem, first introduced by van Fraassen. The problem turns on the apparently puzzling fact that, on the basis of information relating an event’s conditional probability, the maximum entropy distribution will almost always assign to the event conditionalized on a probability strictly less than that assigned to it by the uniform distribution. In this article, I present an analysis of the Judy Benjamin problem that can help to (...) make sense of this seemingly odd feature of maximum entropy inference. My analysis is based on the claim that, in applying the principle of maximum entropy, Judy Benjamin is not acting out of a concern to maximize uncertainty in the face of new evidence, but is rather exercising a certain brand of epistemic charity towards her informant. This epistemic charity takes the form of an assumption on the part of Judy Benjamin that her informant’s evidential report leaves out no relevant information. Such a reconceptualization of the motives underlying Judy Benjamin’s appeal to the principle of maximum entropy can help to further our understanding of the true epistemological grounds of this principle and correct a common misapprehension regarding its relationship to the principle of insufficient reason. 1Introduction2The Principle of Maximum Entropy3An Apologia for Judy Benjamin4Conclusion: Entropy and Insufficient Reason. (shrink)

In this paper, we provide a Bayesian analysis of the well-known surprise exam paradox. Central to our analysis is a probabilistic account of what it means for the student to accept the teacher's announcement that he will receive a surprise exam. According to this account, the student can be said to have accepted the teacher's announcement provided he adopts a subjective probability distribution relative to which he expects to receive the exam on a day on which he expects not to (...) receive it. We show that as long as expectation is not equated with subjective certainty there will be contexts in which it is possible for the student to accept the teacher's announcement, in this sense. In addition, we show how a Bayesian modeling of the scenario can yield plausible explanations of the following three intuitive claims: (1) the teacher's announcement becomes easier to accept the more days there are in class; (2) a strict interpretation of the teacher's announcement does not provide the student with any categorical information as to the date of the exam; and (3) the teacher's announcement contains less information about the date of the exam the more days there are in class. To conclude, we show how the surprise exam paradox can be seen as one among the larger class of paradoxes of doxastic fallibilism, foremost among which is the paradox of the preface. (shrink)

The technique of minimizing information (infomin) has been commonly employed as a general method for both choosing and updating a subjective probability function. We argue that, in a wide class of cases, the use of infomin methods fails to cohere with our standard conception of rational degrees of belief. We introduce the notion of a deceptive updating method and argue that non-deceptiveness is a necessary condition for rational coherence. Infomin has been criticized on the grounds that there are no higher (...) order probabilities that ‘support’ it, but the appeal to higher order probabilities is a substantial assumption that some might reject. Our elementary arguments from deceptiveness do not rely on this assumption. While deceptiveness implies lack of higher order support, the converse does not, in general, hold, which indicates that deceptiveness is a more objectionable property. We offer a new proof of the claim that infomin updating of any strictly-positive prior with respect to conditional-probability constraints is deceptive. In the case of expected-value constraints, infomin updating of the uniform prior is deceptive for some random variables but not for others. We establish both a necessary condition and a sufficient condition (which extends the scope of the phenomenon beyond cases previously considered) for deceptiveness in this setting. Along the way, we clarify the relation which obtains between the strong notion of higher order support, in which the higher order probability is defined over the full space of first order probabilities, and the apparently weaker notion, in which it is defined over some smaller parameter space. We show that under certain natural assumptions, the two are equivalent. Finally, we offer an interpretation of Jaynes, according to which his own appeal to infomin methods avoids the incoherencies discussed in this paper. (shrink)

Japan has more robots than any other country with robots contributing to many areas of society, including manufacturing, healthcare, and entertainment. However, few studies have examined Japanese attitudes toward robots, and none has used implicit measures. This study compares attitudes among the faculty of a US and a Japanese university. Although the Japanese faculty reported many more experiences with robots, implicit measures indicated both faculties had more pleasant associations with humans. In addition, although the US faculty reported people were more (...) threatening than robots, implicit measures indicated both faculties associated weapons more strongly with robots than with humans. Despite the media’s hype about Japan’s robot ‘craze,’ response similarities suggest factors other than attitude better explain robot adoption. These include differences in history and religion, personal and human identity, economic structure, professional specialization, and government policy. Japanese robotics offers a unique reference from which other nations may learn. (shrink)

Gene expression is an inherently complex process and errors often occur during the transcription and processing of mRNAs. Several surveillance mechanisms have evolved to check the fidelity at each step of mRNA manufacture. Two recent reports describe the identification of a novel pathway in eukaryotes that recognizes and degrades mRNAs that lack a stop codon.1,2 The non‐stop decay mechanism releases ribosomes stalled at the 3′ end of a mRNA and stimulates the exosome to rapidly degrade the transcript. BioEssays 24:785–788, 2002. (...) © 2002 Wiley Periodicals, Inc. (shrink)

We argue that in spite of their apparent dissimilarity, the methodologies employed in the a priori and a posteriori assessment of probabilities can both be justified by appeal to a single principle of inductive reasoning, viz., the principle of symmetry. The difference between these two methodologies consists in the way in which information about the single-trial probabilities in a repeatable chance process is extracted from the constraints imposed by this principle. In the case of a posteriori reasoning, these constraints inform (...) the analysis by fixing an a posteriori determinant of the probabilities, whereas, in the case of a priori reasoning, they imply certain claims which then serve as the basis for subsequent probabilistic deductions. In a given context of inquiry, the particular form which a priori or a posteriori reason may take depends, in large part, on the strength of the underlying symmetry assumed: the stronger the symmetry, the more information can be acquired a priori and the less information about the long-run behavior of the process is needed for an a posteriori assessment of the probabilities. In the context of this framework, frequency-based reasoning emerges as a limiting case of a posteriori reasoning, and reasoning about simple games of chance, as a limiting case of a priori reasoning. Between these two extremes, both a priori and a posteriori reasoning can take a variety of intermediate forms. (shrink)

Judgments of symmetry lay at the heart of the classical theory of probability. It was by direct appeal to the symmetries exhibited by the processes underlying simple games of chance that the earliest theorists of probability were able to justify the initial assumptions of equiprobability which allowed them to compute the probabilities of more complex events using combinatorial methods, i.e., by simply counting cases. Nevertheless, in spite of the role that symmetry played in the earliest writings on the subject, in (...) light of the fact it is only in highly contrived settings that a direct appeal to symmetries can suffice to determine the probabilities of events, many philosophers have been led to conclude that the concept of symmetry itself has, at best, a limited role to play in a general theory of probability. In this essay, I argue that this view of the matter is mistaken, and that judgments of symmetry, in fact, have an indispensible role to play in all probabilistic reasoning. In chapter 1, I provide a detailed account of symmetry-based reasoning and argue against the view that the judgments of relevance on which such reasoning is based must be construed in subjective terms if symmetry-based reasoning is to be applied to deterministic processes. In chapter 2, I argue that the two most plausible proposals for how to avoid an appeal to symmetry in the assignment of probabilities (viz., those which are based on a priori principles of epistemic conservatism or the observed frequencies of events) must themselves rely on implicit assumptions of symmetry if they are to defend themselves against the charges of incoherency and arbitrariness. In chapter 3, I consider a decision-theoretic example of symmetry-based reasoning, in which the appeal to symmetry arises in the context of an agent's choice of a deliberative methodology. In this context, the principle of symmetry amounts to the requirement that the agent avoid adopting a biased deliberative methodology, i.e., one which treats two equally legitimate sources of information differently. In the specific context of the exchange paradox, I propose an account of how biased information is to be handled, which, despite suffering from some important defects, does, I believe, capture some of our general intuitions about how a rational agent ought to adjust his expectations to correct for the effects of bias. (shrink)

Biodiesel was produced by transesterification of waste olive oil with methanol and Novozym®435. The effect of the molar ratio of methanol to triolein, mode of methanol addition, reaction temperature, and mixing speed on biodiesel yield was determined. The effect of different acyl acceptors and/or solvents on biodiesel yield was also evaluated. Finally, the efficacy of Novozym®435 was determined by reusing the enzyme after washing it with a solvent.

Greek antiquity saw the development of two distinct systems of logic: Aristotle’s theory of the categorical syllogism and the Stoic theory of the hypothetical syllogism. Some ancient logicians argued that hypothetical syllogistic is more fundamental than categorical syllogistic on the grounds that the latter relies on modes of propositional reasoning such asreductio ad absurdum. Peripatetic logicians, by contrast, sought to establish the priority of categorical over hypothetical syllogistic by reducing various modes of propositional reasoning to categorical form. In the 17th (...) century, this Peripatetic program of reducing hypothetical to categorical logic was championed by Gottfried Wilhelm Leibniz. In an essay titledSpecimina calculi rationalis, Leibniz develops a theory of propositional terms that allows him to derive the rule ofreductio ad absurdumin a purely categorical calculus in which every proposition is of the formA is B. We reconstruct Leibniz’s categorical calculus and show that it is strong enough to establish not only the rule ofreductio ad absurdum, but all the laws of classical propositional logic. Moreover, we show that the propositional logic generated by the nonmonotonic variant of Leibniz’s categorical calculus is a natural system of relevance logic known as RMI$_{{}_ \to ^\neg }$. (shrink)

Corporate governance has come to be recognised as a cornerstone of economic reforms seeking to promote stability and growth in developing countries. The Asian crisis of the 1997 was viewed as having roots in poor governance and hence national governments as well as international organisations have sought to promote a strengthening of governance mechanisms. This article investigates governance reforms in India over the last decade. The paper reviews changes in Indian governance codes that indicate a preference of adoption of Anglo-American (...) governance models. A survey of ownership structures of Indian listed companies reveals a mixture of governance mechanisms and a persistence of the "business house model" of governance. The paper concludes that despite external pressures towards an "Anglo-Americanisation" of governance practice, the outcomes thus far reveal the emergence of a diversity of governance mechanisms arising in a path-dependent fashion. (shrink)

TheGenerales Inquisitiones de Analysi Notionum et Veritatumis Leibniz’s most substantive work in the area of logic. Leibniz’s central aim in this treatise is to develop a symbolic calculus of terms that is capable of underwriting all valid modes of syllogistic and propositional reasoning. The present paper provides a systematic reconstruction of the calculus developed by Leibniz in theGenerales Inquisitiones. We investigate the most significant logical features of this calculus and prove that it is both sound and complete with respect to (...) a simple class of enriched Boolean algebras which we call auto-Boolean algebras. Moreover, we show that Leibniz’s calculus can reproduce all the laws of classical propositional logic, thus allowing Leibniz to achieve his goal of reducing propositional reasoning to algebraic reasoning about terms. (shrink)

Emotions are multimodal processes that play a crucial role in our everyday lives. Recognizing emotions is becoming more critical in a wide range of application domains such as healthcare, education, human-computer interaction, Virtual Reality, intelligent agents, entertainment, and more. Facial macro-expressions or intense facial expressions are the most common modalities in recognizing emotional states. However, since facial expressions can be voluntarily controlled, they may not accurately represent emotional states. Earlier studies have shown that facial micro-expressions are more reliable than facial (...) macro-expressions for revealing emotions. They are subtle, involuntary movements responding to external stimuli that cannot be controlled. This paper proposes using facial micro-expressions combined with brain and physiological signals to more reliably detect underlying emotions. We describe our models for measuring arousal and valence levels from a combination of facial micro-expressions, Electroencephalography (EEG) signals, galvanic skin responses (GSR), and Photoplethysmography (PPG) signals. We then evaluate our model using the DEAP dataset and our own dataset based on a subject-independent approach. Lastly, we discuss our results, the limitations of our work, and how these limitations could be overcome. We also discuss future directions for using facial micro-expressions and physiological signals in emotion recognition. (shrink)

The present study sought to clarify the impact of executive and social functioning on challenging behavior and the downstream influence of challenging behavior on quality of life and functioning in a large transdiagnostic sample. Understanding these relationships is crucial for developing and designing tailored intervention strategies. In a cross-sectional study, parent informants of 2,004 children completed measures of executive and social functioning, challenging behavior, child and family quality of life, and reported on functional impacts of challenging behavior. Using structural (path) (...) modeling, analyses evaluated the associations between executive and social functioning, including emotion regulation and risk avoidance, with overall and specific types of challenging behavior. Structural models also examined the influence of challenging behavior on child and family quality of life, including measures of the immediate and extended environment, and functional impacts on the parent/child as well as interactions with the medical/legal systems. Finally, mediational models explored the direct and indirect effects of executive and social functioning on quality of life and impact measures via challenging behavior. Results indicated that executive functioning accounts for substantial variance (R2 = 0.47) in challenging behavior. In turn, challenging behavior accounts for substantial variance in child and family quality of life (R2 = 0.36) and parent/child impacts (R2 = 0.31). Exploratory mediational models identified direct effects from executive and social functioning measures on quality of life and functional impacts and indirect effects for executive functioning via challenging behavior. These findings support the development of new intervention strategies and suggest the need to measure executive functioning when assessing and tailoring the treatment of challenging behavior in clinical practice. (shrink)

In photoreceptors of a dark adapted eye, the inward flux of sodium and calcium ions in the outer segment is balanced by the outward flux of potassium ions. But in the presence of light the creation of cyclic guanosine monophosphate in the outer segment decreases. Due to low concentration of cG the channels in the outer segment open relatively less and thus the influx of calcium ion decreases, leading finally to hyperpolarization of the photoreceptors. We have analyzed theoretically the effect (...) of oxidizing iron ions on the photoreceptors. In order to explain the effects of iron-induced oxidative stress, the different molecules and ions involved in phototransduction are quantified leading to a differential equation for calculating the electroretinogram a-wave voltage. The theoretical results are compared with published experimental data. In the presence of light, the iron ions could push outward the similarly charged calcium ions resulting in a small increase in the amount of inward calcium flux. Again, the presence of iron ions generates Reactive Oxygen Species, and ROS could attract the calcium ions which also increases the calcium flux. This will result in a reduction in the amplitude and slope of the a-wave voltage in the electroretinogram. These results are parametrized in terms of calcium ion concentrations. As the amplitude of the a-wave shows how much electrical signal is produced, its reduction indicates reduction in the visual signal. Thus, the increase in iron ions could explain the reduction in the electrical signal due to iron-induced oxidative stress. (shrink)

Proper utilization of antenatal and postnatal care services plays an important role in reducing the maternal mortality ratio and infant mortality rate. This paper assesses the utilization of health care services during pregnancy, delivery and post-delivery among rural women in Uttar Pradesh and examines its determinants. Data from a baseline survey of UP Community Mobilization project was utilized. A cross-sectional sample of currently married women who delivered a baby 15 months prior to the survey was included. Information was collected from (...) 2208 women spread over five districts of UP. Information on socio-demography characteristics, utilization of antenatal care, delivery and postnatal care services was collected. To examine the determinants of utilization of maternal health services, the variables included were three ANC visits, institutional delivery and PNC within 42 days of delivery. Separate multilevel random intercept logistic regressions were used to account for clustering at a block and gram panchayat level after adjusting for covariates. Eighty-three percent of women had any ANC. Of them, 61% reported three or more ANC visits. Although 68% of women delivered in a health facility, 29% stayed for at least 48 h. Any PNC within 42 days after delivery was reported by 26% of women. In the adjusted analysis, women with increasing number of contacts with the health worker during the antenatal period, women exposed to mass-media and non-marginalized women were more likely to have at least three ANC visits during pregnancy. Non-marginalized women and women with at least three ANC visits were more likely than their counterparts to deliver in an institution. Contacts with health worker during pregnancy, marginalization, at least three ANC visits and institutional delivery were the strong determinants for utilization of PNC services. Self-help group membership had no association with the utilization of maternal health services. Utilization of maternal health services was low. Contact with the health worker and marginalization emerged as important factors for utilization of services. Although not associated with the utilization, SHGs can be used for delivering health care messages within and beyond the group. (shrink)

Employee performance plays a crucial role in the productivity of organizations, especially in the hospitality industry in Malaysia. This work performance is influenced by leadership style, and finding the type of leadership style that is suitable to apply to employees is crucial, especially in the midst of the COVID-19 pandemic. Transformational leadership theory is selected for this study in determining leadership styles. There are four dimensions under transformational leadership theory, namely idealized influence, individualized consideration, inspirational motivation and intellectual stimulation. Data (...) were collected online from 400 employees working in the hospitality industry in Malaysia and analyzed using partial least square structure equation modeling. The findings show that only two dimensions of transformational leadership, namely idealized influence and inspirational motivation, have a significant positive influence on employee performance. Implications in the context of human resource management and recommendations to increase employee performance are also discussed. (shrink)

Anubav Vasudevan characterized van Fraassen’s “Infomin” solution to the Judy Benjamin Problem (i.e. the solution by way of minimizing the Kullback-Leibler divergence between the posterior and prior) as an implementation of a “brand of epistemic charity” taking “the form of an assumption on the part of Judy Benjamin that her informant’s evidential report leaves out no relevant information”. After an analysis of the example that led Vasudevan to this way of thinking about Infomin, as well as of a (...) new one that supports the rival position of Douven and Romeijn in favor of minimizing the inverse Kullback-Leibler divergence between the posterior and the prior, we come to a different and more enlightening characterization of Infomin’s implicit assumptions. (shrink)