Eleonore Stump insightfully develops Aquinas’s theodicy to account for a significant source of human suffering, namely the undermining of desires of the heart. Stump argues that what justifies God in allowing such suffering are benefits made available to the sufferer through her suffering that can defeat the suffering by contributing to the fulfillment of her heart’s desires. We summarize Stump’s arguments for why such suffering requires defeat and how it is defeated. We identify three problems with Stump’s account of how (...) such suffering is defeated and offer solutions to each. We defend and strengthen Stump’s response to the hardest cases for her view, and explain what her view demands of God. (shrink)

Phage DNA packaging occurs by DNA translocation into a prohead. Terminases are enzymes which initiate DNA packaging by cutting the DNA concatemer, and they are closely fitted structurally to the portal vertex of the prohead to form a ‘packasome’. Analysis among a number of phages supports an active role of the terminases in coupling ATP hydrolysis to DNA translocation through the portal. In phage T4 the small terminase subunit promotes a sequence‐specific terminase gene amplification within the chromosome. This link between (...) recombination and packaging suggests a DNA synapsis mechanism by the terminase to control packaging initiation, formally homologous to eukaryotic chromosome segregation. (shrink)

Isidore Etymologiae Vol. II. Books XI-XX.

We use the format of a hypothetical case study to review issues related to pharmaceutical product approval and physician prescribing practices. In this case, a new FDA-approved drug is recommended for a patient who subsequently experiences an adverse event that may or may not be related to the prescription. This case raises a number of ethical and legal considerations physicians routinely face when deciding whether to recommend such drugs for their patients. Despite the need for ongoing observation by the regulatory (...) apparatus, physicians should be cognizant of the limitations of the drug approval system and the post-approval prescription drug surveillance system. We discuss physicians’ ethical obligations when faced with a newly approved drug, including seeking out independent sources of learning, reporting adverse effects, and notifying patients about limitations in available knowledge about therapeutic recommendations. (shrink)

The AMA Council on Ethical and Judicial Affairs (CEJA) has written a position paper on how social medical use challenges medical professionalism. The report offers persuasive ethical and practical guidelines for nonclinical internet use, specifically for social networking.This commentary provides a framework from which to apply these guidelines, but adds that there may be important situations in which physicians are not able to act in accordance. The guidelines call for professional reporting of questionable online portrayals or behaviors, but this commentary (...) argues that this may be not only cumbersome to implement, but may violate aspects of constitutional rights. While online social networking may in many ways be a new application of old challenges, there may be other aspects that require novel approaches to medical professionalism. (shrink)

Restructured health care reimbursement systems and new requirements for nonprofit hospitals are transforming the U.S. health system, creating opportunities for enhanced integration of public health and health care goals. This article explores the role of public health practitioners and lawyers in this moment of transformation. We argue that the population perspective and structural strategies that characterize public health can add value to the health care system but could get lost in translation as changes to tax requirements and payment systems are (...) rapidly implemented. We urge public health leaders to take a more active role in hospital assessments of community health needs and evaluation of the patient outcomes for which providers are accountable. (shrink)

Professor Lindsay [Class. Rev. XLII. , p. 20] has drawn attention to a Celtic paralle to Aquilo, the Black Wind . A less remote parallel was found by Salmasius [Plin. Exerc. in Solinum , p. 1258D] in the gloss melatnboros uulturnus, on which he makes the following comment: ‘Glossae nostrae nondum editae: ‘ Septenirio, ΚЄρκίίας, Circius, Χωρupbs, Chaurus. Eaedem Glossae Volturnum Graece exponunt. An Volturnum quasi Volturinum idest nigrum dictum earum putauit auctor? Sed haec expositio conuenit Aquiloni, qui est (...) μέλαςβορέαςƋς, unde et Aquilo id est aquilus uentus, casco uocabulo niger. ’He adds that the wind Volturnus was really so called because it blew towards Rome from Volturnum. (shrink)

Since Teuffel's Römische Literatur mentions s.v. Varius the famous entry in the Monte Cassino MS. incipit thvestes varii, but ignores its occurrence in a Benevento MS. , it may be well to give some account of the latter codex. For I read with amusement a recent article in this journal in which the writer severely censured Mr. Garrod's ignorance of the entry in Paris 7530, but revealed his own ignorance by assuming that it was the scribe of the Paris MS. (...) who had the lost tragedy of Varius before him. (shrink)

Lvcilivs 11191 is preserved for us in Isid. Etym. XIX, iv, 10, where, amongst the articles of a ship's equipment, the plummet of Herodotus is mentioned, with this illustration from Lucilius:Hunc catapiratem puer eodem deforet unctum,plumbi paucillum rudus linique mataxam.

The abbreviation-symbols of the Romans, found in ancient uncial MSS., may be roughly divided into three classes: Those peculiar to juristic writing, e.g. R.P. ‘res priuata’ , Q.D.R.A. ‘qua de re agitur.’ They are properly called ‘notae iuris.’ They abound in the famous Verona MS. of Gaius. A few used in histories, etc., e.g. R.P. 'respublica' , Q. ‘Quintus’ . Valerius Probus, who compiled a manual of ancient Notae, calls this class ‘notae publicae’. They appear in such MSS. as the (...) codex Puteanus of Livy ; and since they have been transferred into modern editions of the Latin historians, etc., no one is at a loss to interpret them nowadays, although they puzzled mediaeval scribes. Symbols of ordinary words of frequent occurrence in any type of literature, e.g. Q. ‘que.’ It is this class which is the subject of this article. (shrink)

Amph. prol. 90–91. In the Amphitruo Plautus runs great risk of giving oflence by bringing Jupiter on the stage. In the prologue he conciliates the audience by saying that this Jupiter is no god but a mere actor. : 26 sqq. Etenim ille quois hue iussu uenio Iuppiter Non minu' quam uostrum quiuis formidat malum: Humana matre natus, humano patre, Mirari non est aequom sibi si praetimet.

In the 'nineties the Celtic philologist, Whitley Stokes, told us in Common-room, that he once awoke muttering an incomplete stanza: Like an ogress making progress Through the spare-ribs of a child. Could anyone complete it for him ? A former Newdigate prizeman, after reflexion, produced this: Stern endeavour will be ever By some welcome find beguiled, Like an ogress making progress Through the spare-ribs of a child.

Mrs. Dall, in her article A Seventh-Century English Edition of Virgil , shows that Virgil glosses taken from marginalia in the same MS. of the poems often preserve something of their original coherence in the two kindred glossaries, Affatim and the Second Amplonian, in spite of all the reshuffling of these two collections. Thus a small group of Virgil items appears in Affatim on p. 491 of Goetz's apograph : Carecta, Crateras, etc. The second last of this ‘Virgil cluster’ is (...) Cada: vasa vinaria. It appears also in Ampl. II. Ca[t]da: vas vinaria, and in Ampl. I. Cada: vasa vinaria, and is apparently taken , ultimately or immediately, from a marginal annotation on Aen. 1, 195 ‘uina bonus quae deinde cadis onerarat Acestes’ for in the Virgil Glossary printed by Goetz in C.G.L. IV. 427–470 we find Cadis: vasis vinariis. (shrink)

The line is preserved in a passage of Consentius ‘De Barbarismis et Metaplasmis’ : sicut Lucilius ‘ore corupto’; dempsit enim unam litteram per metaplasmum, r; et Ennius ‘huic statuam,’ etc.

Charisivs, in his chapter on Adverbs, cites for Hispane a line of Ennius' Annals : Hispane, non Romane memoretis loqui me. Professor Norden , the apostle of Combinations-forschung, combines this fact with another fact mentioned by Livy , the celebre per Hispaniam responsum of a Spanish town to a Roman embassy. But why does he ignore a third fact which must be brought into any combination that can be convincing—the quotation of this line of Ennius by Festus in a paragraph (...) which apparently deals with Graeco-Roman affinities ? (shrink)

Caper in his section on the preposition ex cited Ennius, Ann. 309:nauibus explebant sese terrasque replebant,and declared that Virgil used the verb with this antique sense in Aen. 6, 545:discedam; explebo numerum reddarque tenebris,i.e. ‘minuam vestrum numerum.’This we are told in Servius' note, which begins: Ut diximus supra, explebo est minuam. Thilo gives no reference to any such previous words of Servius, and I have failed to find them. Can it be that Servius has carelessly transcribed a note of Donatus, (...) and that Donatus had discussed ex minuens at Geo. 2, 65, or 4, 145? Donatus' note on Terence, Hec. 755, is Explere exinanire Terentianum est; the passage of Terence is:eas ad mulieres huc intro atque istuc iusiurandum idempolliceare illis: exple animum îs teque hoc crimine expedi,i.e., relieve their mind of suspicion against Pamphilus and free yourself from this charge. The phrase recurs in the next Scene :illis modo explete animum.i atque exple animum îs, coge ut credant. (shrink)

In the Glossary-codex, Vat. Lat. 1469, written in the year 908, fol. 83 has been assigned to ‘glossae collectae.’ They begin : In Passione Apostolorum. Iussit eum inaumachia cathomis consumi. Cathomis: uirgis nodosis. Hie naumachia forum signat Romanorum quod Prorostris dicitur eo quod rostra, etc.. In Sancto Sebastiano. Saturnus apocatasticus : id est dispositor et destructor fatorum. Annus tuus ex diametro susceptus est. Diametrum est, etc. ‘Glossae collectae’ from the Bible and from Jerome's prefaces come next.