The T/t locus was a major focus of study by mouse geneticists during the 20th century. In the 70s, as the study of cell surface antigens controlling transplantation antigens was taking off, several laboratories hypothesized that alleles of this locus would control cell surface antigens important for embryonic development. One such antigen, the embryonal carcinoma F9 antigen was said to be an example. Other antigens were described on sperm and embryos that were said to be controlled by alleles at the (...) T/t complex. These findings were later found to be false. The history of the findings and their refutation is described. (shrink)

Beliefs have genealogies. Can tracing a belief’s genealogy illuminate the epistemic quality of the belief? This paper sets out a general epistemology of genealogies. As it turns out, genealogies for beliefs come in two sorts: those that trace a belief to some mental event that doubles as evidence for the belief and those that do not. The former have the potential to undercut the belief, rebut the belief, or—importantly—both. The latter have the potential to reinforce the belief or rebut the (...) belief but—importantly—not undercut it. The ultimate conclusion is that there is a role for genealogies in the epistemic appraisal of our beliefs, but this role will be circumscribed by the availability of clear and compelling genealogies. (shrink)

In Morality and Socially Constructed Norms, Valentini searches for a unifying principle that underlies whatever genuine obligations we might have to obey the norms of any and all social practices, ranging from line queueing norms, through offsides rules in soccer, to obligations not to break the law. I argue that this search is driven, and distorted, by a commitment to what Bernard Williams labeled the ‘morality system’. Once we see this, we should question the value of the unifying project. Most (...) social norms can be considered on their own terms, as part of a rich and variegated ethical life, without subsuming them under the question of whether others’ moral rights are at stake. Similarly, political obligation needs to be understood in relation to the practical activity of politics, not as an abstract moral quandary. (shrink)

Agronomic science or technoscience has an important role in contemporary times and is the focus of necessary philosophical investigations. The present study aimed to relate Gadamerian philosophical hermeneutics with the Laudanian concept of philosophy of science, also applied to the philosophy of technology within the agronomic context. The central question to be answered is: can Gadamerian philosophical hermeneutics apply to the understanding of agronomy? Given this, central references and commentators were selected, dividing the dialogue between the authors and the argumentation (...) into the following points: sciences, technologies, and Gadamerian philosophical hermeneutics; agronomic traditions and their Laudanian progress; reaching the final possibility of intersections between Gadamer and Laudan, when reflecting on agronomy, especially on the theme of traditions. (shrink)

The study deals with some of the central issues concerning the notion of death as discussed in Theravāda (Pāli Buddhism) as well as Mahāyāna Buddhism. What is the sense that death is regarded as an instance of duḥkha (Sanskrit) or dukkha (Pāli)? The research claims that here, firstly, the word duḥkha/dukkha is used as an adjective (which means ‘unsatisfactory’) rather than a noun (which means 'pain' or 'suffering'). Secondly, by death, the Buddha did not mean the act of dying but (...) the experience of someone's death or the idea of death. The Buddha also talked about deathlessness as the goal. Here, deathlessness does not amount to accepting something eternal but developing a proper perspective towards death by meditations such as that on impurity ( аśubhabhāvanā ) and contemplation on death ( maraṇānussati ). If the cessation of the cycle of rebirths and re-deaths ( punarmṛtyu ) is the ultimate goal that the arhat (Sanskrit), or arahant (Pāli), achieves, then the same should apply to Tathāgata. In that case, the problem suggests itself: how could the question of Tathāgata’s existence after death be accounted for as an unanswerable ( avyākṛta )? The study opines that the reason behind this is the profound, immeasurable, unfathomable nature attributed to Tathāgata. The research also discusses the basic difference between the attitudes on death in Śrāvakayāna and Mahāyāna. Lastly, it deals with the question of whether termination of one’s own life is permissible in Buddhism under certain conditions. (shrink)

Inspired by the third chapter of Anselm's Proslogion, twentieth century philosophers including Charles Hartshorne and Alvin Plantinga developed “modal” ontological arguments for the existence of God. Such arguments use modal logic to infer God's existence from the premises that (i) God's existence is possible and (ii) if God exists, He exists necessarily. Like other ontological arguments, modal arguments have won few converts to theism; many commentators consider them question‐begging or liable to parody. This article details how recent attempts to defend (...) these arguments have tried to overcome these difficulties by drawing on modern accounts of the epistemology and metaphysics of modality. (shrink)

Informed consent is ethically incomplete and should be redefined as empowered consent. This essay challenges theoretical assumptions of the value of informed consent in light of substantial evidence of its failure in clinical practice and questions the continued emphasis on autonomy as the primary ethical justification for the practice of consent in health care. Human dignity—rather than autonomy—is advanced from a nursing ethics perspective as a preferred justification for consent practices in health care. The adequacy of an ethic of obligation (...) (namely, principlism) as the dominant theoretical lens for recognising and responding to persistent problems in consent practices is also reconsidered. A feminist empowerment framework is adopted as an alternative ethical theory to principlism and is advanced as a more practical and complete lens for examining the concept and context of consent in health care. To accomplish this, the three leading conceptions of informed consent are overviewed, followed by a feminist critique to reveal practical problems with each of them. The need for a language change from informed to empowered consent is strongly considered. Implications for consent activities in clinical practice are reviewed with focused discussion on the need for greater role clarity for all involved in consent—beyond and inclusive of the patient‐physician dyad, as the practice and improvement of consent is necessarily a transdisciplinary endeavour. Specific concrete and practical recommendations for leveraging nursing expertise in this space are presented. Perhaps what is most needed in the discourse and practice of consent in health care is nursing. (shrink)

The purpose of this article is to provide a case against certain claims made by modal skeptics with a specific application to the debate about whether conceivability is the right notion to employ in justifying the move from some state of affairs being conceivable to its being metaphysically possible. Does conceivability provide adequate, defeasible grounds for inferring metaphysical possibility? If not, is there a better approach that employs a replacement for conceivability? I argue that conceivability should be abandoned in favor (...) of rational intuitions understood in a way I hope to make clear and precise. To accomplish this purpose, I begin by examing the general way conceivability has been related to metaphysical possibility and opt for a replacement for conceivability. Next, I make clear and precise what I mean by that replacement—rational intuitions. Third, I present three representative accounts of modal knowledge offered by Timothy O’Connor, George Bealer, and Edmund Husserl. O’Connor’s account is externalist, Bealer’s is a hybrid between an internalist and externalist view, and Husserl’s is a purely internalist perspective. While all three are plausible perspectives, I will criticize and reject the first two accounts and argue that Husserl’s way out of modal skepticism is successful. I conclude that Husserl’s employment of rational intuition made precise by his notions of eidetic and categorial intuition, provides a rigorous, fruitful way to ground modal knowledge in general, and de re and de dicto possibility in particular. (shrink)

The role of animals in the realm of sport is the focus of this special issue which delves into the nuanced intersections of sport, animals, and ethics. For millennia, humans have forged multifacete...

Tracing Walter Benjamin's convergences with, and divergences from, influential German theorist Carl Schmitt, this edited collection places his thinking in the context of broader 20th century political philosophy of his time, and examines the question of whether Benjamin presents the possibility for a distinctive political theology, mapping the coordinates of this question without collapsing the tensions internal to Benjamin's thought. This volume brings together a host of multifaceted contributions that explore why Benjamin has been a fertile source for thinking about (...) political theology and the possibilities that this new perspective brings to light. (shrink)

Recent reports and papers on chimeric research highlight the promise of chimeric models of human neuropsychiatric disorders to ameliorate human suffering due to autism spectrum disorders, depression, and schizophrenia. These calls, however, typically do not acknowledge, much less address, criticisms of model creation and validation, or concerns about scientific conduct more generally. The ethical justification for the use of nonhuman animals in research depends on the production of benefits to humans based on such research. But the assessment and production of (...) benefits are highly uncertain and rife with both practical and conceptual challenges. This essay provides a general framework for classifying the benefits of biomedical research and then focuses on two factors that directly impact—and threaten—the production of knowledge in research that models neuropsychiatric disorders. (shrink)

This essay makes a case for the metaphysical status of the human fetus. I argue that personhood begins at conception as opposed to at some point in the post-conception continuum. However, there is a deep division over this matter. Defenders of the pro-life position grant that life begins at conception. In contrast, defenders of the pro-choice position deny that life begins at conception. Even if it were the case that life begins at conception, proponents of abortion claim that a woman’s (...) bodily autonomy should come first over protecting the fetus’s life. Contemporary discussions regarding this matter continue to lack a clear and adequate account of why we continue to face a stalemate in terms of settling the issue of the metaphysical status of the human fetus. In section I, I discuss what I call the less central issues that stand in the way when it comes to addressing the main question of the personhood of the human fetus. In section II, I discuss the personhood problem as it relates to the fetus. In section III, I sketch out a conception- grounded theory of fetal personhood. In section IV, I consider some objections. In section V, I discuss the origin problem as it relates to the fetus within the broader context of the challenge, we face in answering the question of the nature of life. Finally, in section VI, I conclude this paper by claiming that conception plays a decisive metaphysical role in the personhood status of the fetus. (shrink)

The publication presents for the first time the B. Baradin’s theses to A. Dorzhiev’s lecture that was supposed to be delivered at the international Buddhist exhibition in Leningrad in 1927. A. Dorzhiev was a famous Buryat lama who received the academic title of Geshe (the highest philosophical academic degree in the Gelug tradition of Tibetan Buddhism) upon completion of his philosophical education in the monasteries of Mongolia and Tibet. After 1918, he was involved in organizational issues of the Buddhist Sangha (...) in Russia. B. Baradin was an academic scientist and public figure, a professor at St. Petersburg University, and the author of studies on the history and teachings of Tibetan Buddhism. After the revolution of 1917, he began working in Buryatia in various administrative positions, focusing on the organization of the scientific and cultural life of the Republic. Their main idea is that the modern world consists of the two equal parts - East and West, unification of which is possible and even necessary for the further development of humanity. The system-forming teaching of the East is Buddhism; and the lecture hold on those aspects of Buddhist philosophy that could be compared with the teachings of the West. Four points are highlighted: 1) Buddhism is comparable to Darwin’s theory in that both consider humans in the context of all living beings in an evolutionary manner; 2) Buddhism, like science, accepts the determinism principle; 3) the Buddhist concept of shunya is similar to the relativistic principles of physics; and 4) the system of Buddhist psychotechniques is similar to the theory of reflexology. B. Baradin concludes that Indo-Buddhist culture and European culture are complementary and their rapprochement will bring us closer to a truly universal culture. The theses mentioned here are, apparently, the first systematic exposition of the views of neo-Buddhists-renewalists on the points of convergence between Buddhist and Western cultures. (shrink)

Completing the systematic henadological interpretation of Proсlus’ Platonic Theology begun in The Intelligible Gods in the Platonic Theology of Proclus (“Méthexis” 21, 2008, pp. 131-143) and The Second Intelligible Triad and the Intelligible-Intellective Gods (“Méthexis” 23, 2010, pp. 137-157), the present article concerns the conditions of the emergence of fully mediated, diacritical multiplicity out of the polycentric henadic manifold. The product of the activity of the intellective Gods (that is, the product of the intellective activity of Gods as such), in (...) resolving the contradiction between existential uniqueness and universalizable potencies in the divine natures, also grounds the human exercise of philosophical cognition in the founding self-analysis of divine individuals. (shrink)

This chapter contains sections titled: The Question of Violence in South Africa Albert Luthuli Nelson Mandela Steve Biko Conclusion.

This book provides a discussion of the philosophy of being according to three major traditions in Western philosophy, the Analytic, the Continental, and the Thomistic. The origin of the point of view of each of these traditions is associated with a seminal figure, Gottlob Frege, Immanuel Kant, and Thomas Aquinas, respectively. The questions addressed in this book are constitutional for the philosophy of being, considering the meaning of being, the relationship between thinking and being, and the methods for using thought (...) to access being. On the one hand, the book honors diversity and pluralism, as it highlights how the three traditions may be clearly and distinctly differentiated regarding the philosophy of being. On the other hand, it honors a sense of solidarity and ecumenism, as it demonstrates how the methods and focal points of these traditions constitute, and continue to shape, the development of Western philosophy. This book contributes toward an essential overview of Western metaphysics and will be of particular interest to those working in the history of philosophy and in the philosophy of being. (shrink)

Drawing on the distinction between dominance and prestige as two evolutionarily grounded strategies for attaining status in human groups, this essay examines an underappreciated feature of Donald Trump's appeal to the millions of American voters who elected him president in 2016—his uncanny ability to channel primal dominance. Like the alpha male of a chimpanzee colony, Trump leads through intimidation, bluster, and threat, and through the establishment of short-term, opportunistic relationships with other high-status agents. Whereas domain-specific expertise confers status in the (...) prestige paradigm, dominant leaders derogate expertise in order to establish a direct, authoritarian connection to their constituency. Trump's leadership style derives readily from his personality makeup, which entails a combustible temperament mixture of high extraversion and low agreeableness, a motivational agenda centered on extreme narcissism, and an internalized life story that tracks the exploits of an intrepid warrior who must forever fight to win in a Hobbesian world of carnage. (shrink)

The relationship between humanity and the soil is an increasingly important topic in social theory. However, conceptualisations of the soil developed by anticolonial thinkers at the high point of the movement for self-determination between the 1940s and the 1970s have remained largely ignored. This is a shame, not least because theorists like Eric Williams, Walter Rodney, Suzanne Césaire and Amílcar Cabral were concerned with the soil. Building on recent work on human-soil relations and decolonial ecology, we argue that these four (...) thinkers conceptualised the connection between soil, empire, and anticolonial revolt. Williams and Rodney ground understanding of soil degradation in global relations of economic power, while Césaire and Cabral reconceptualise postcolonial nationhood in terms of the mutability and diversity of the soil. The article concludes by suggesting that these two anticolonial counterpoints, global connectivity and more-than-human identification, anticipate and deepen contemporary attempts to decolonise ecological thinking. (shrink)

Some critics claim that ontological arguments are dialectically ineffective against sceptics, whatever the sceptics’ broader metaphysical commitments. In this paper, I examine and contest arguments for this conclusion. I suggest that such critics overlook important claims about God’s nature (viz. divine simplicity and divine inimitability) typically advanced by proponents of ontological arguments who endorse classical theism. I reformulate two representative ontological arguments in light of this characterization of God, arguing that for philosophers prepared to endorse Meinongianism or modal Platonism, alongside (...) divine simplicity and inimitability, such arguments are not invalid, question-begging, or obviously liable to parody. Accordingly, two species of ontological argument may possess some persuasive force, albeit for a select audience. (shrink)

The author clarifies the existential philosophy that is implicit in Kurt Goldstein's philosophy of organism (Goldstein, 1963; 1995). Situated in response to the growing trend that psychological phenomena are reducible to the nervous system, the author argues for the reverse: that the significance of nervous system activity can only be understood by viewing it as background to foreground performances. Like the organization of perception into meaningful figure-- ground Gestalts, the existential modes of embodiment, sociality, temporality, spatiality, and attunement are organized (...) together to accomplish foreground performances. It is only within this context that the activity of the nervous system may be understood as significant or insignificant. Speech is given as an example. The article concludes with a commentary on how the trend of reducing psychological phenomena to neurological phenomena has impaired our understanding of brain disorders and psychological disorders. (shrink)

In their article, Crutchfield and Redinger (2024) outline the conditions that they have identified as situations in which it is ethically permissible to use chemical restraints, defined as medicati...